{"id":"https://openalex.org/W1538708347","doi":"https://doi.org/10.21236/ada462820","title":"Development of Biologically Based Therapies for Basal-Like Tumors","display_name":"Development of Biologically Based Therapies for Basal-Like Tumors","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W1538708347","doi":"https://doi.org/10.21236/ada462820","mag":"1538708347"},"language":"en","primary_location":{"id":"doi:10.21236/ada462820","doi":"https://doi.org/10.21236/ada462820","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada462820","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002773659","display_name":"Katherine A. Hoadley","orcid":"https://orcid.org/0000-0002-1216-477X","observed_orcids":["https://orcid.org/0000-0002-1216-477X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Katherine A. Hoadley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002773659"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.13940000534057617,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":1.0},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9950000047683716},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.7089999914169312},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.718999981880188},{"id":"https://openalex.org/keywords/estrogen-receptor-negative","display_name":"estrogen receptor-negative","score":0.4950000047683716},{"id":"https://openalex.org/keywords/her2-negative","display_name":"HER2-negative","score":0.9580000042915344},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.473655104637146},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3639841675758362},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33648455142974854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3350684344768524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30816322565078735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2085009217262268},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21236/ada462820","doi":"https://doi.org/10.21236/ada462820","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada462820","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},{"id":"pmh:ADA458484","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA458484","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"},{"id":"pmh:ADA462820","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA462820","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W246916078","https://openalex.org/W1483520515","https://openalex.org/W1510554288","https://openalex.org/W1546709038","https://openalex.org/W1549647993","https://openalex.org/W1576826397","https://openalex.org/W1590794385","https://openalex.org/W1797430954","https://openalex.org/W1964321121","https://openalex.org/W1973363825","https://openalex.org/W1974527689","https://openalex.org/W1978916359","https://openalex.org/W1999463736","https://openalex.org/W2012300394","https://openalex.org/W2016903147","https://openalex.org/W2019175855","https://openalex.org/W2024654932","https://openalex.org/W2037202264","https://openalex.org/W2039135884","https://openalex.org/W2041098455","https://openalex.org/W2049475256","https://openalex.org/W2052111639","https://openalex.org/W2064047613","https://openalex.org/W2065504565","https://openalex.org/W2071110838","https://openalex.org/W2072772580","https://openalex.org/W2072981858","https://openalex.org/W2074446011","https://openalex.org/W2074465378","https://openalex.org/W2077945404","https://openalex.org/W2080840400","https://openalex.org/W2084817237","https://openalex.org/W2097430258","https://openalex.org/W2099335989","https://openalex.org/W2099462532","https://openalex.org/W2102161352","https://openalex.org/W2103245988","https://openalex.org/W2109276980","https://openalex.org/W2109528117","https://openalex.org/W2110177539","https://openalex.org/W2112893608","https://openalex.org/W2115199224","https://openalex.org/W2123175319","https://openalex.org/W2124792927","https://openalex.org/W2125797780","https://openalex.org/W2127938920","https://openalex.org/W2131994307","https://openalex.org/W2137355132","https://openalex.org/W2138167831","https://openalex.org/W2138317169","https://openalex.org/W2140677023","https://openalex.org/W2142460765","https://openalex.org/W2145444267","https://openalex.org/W2145539398","https://openalex.org/W2146973482","https://openalex.org/W2148320836","https://openalex.org/W2150926065","https://openalex.org/W2153225678","https://openalex.org/W2154142993","https://openalex.org/W2156251518","https://openalex.org/W2157795344","https://openalex.org/W2157840751","https://openalex.org/W2158118614","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2160450758","https://openalex.org/W2162453996","https://openalex.org/W2163402367","https://openalex.org/W2165432902","https://openalex.org/W2169332099"],"related_works":["https://openalex.org/W6944385361","https://openalex.org/W2125420434","https://openalex.org/W7162184577","https://openalex.org/W3010635529","https://openalex.org/W55741879","https://openalex.org/W2146975086","https://openalex.org/W2016905164","https://openalex.org/W4232375284","https://openalex.org/W2169862472","https://openalex.org/W2050684389"],"abstract_inverted_index":{"The":[0,24,59,100],"basal-like":[1,45,60,81,91,101,138,169,197],"subtype":[2],"of":[3,26,37,44,89,118,178,187],"breast":[4,38,139,164],"cancer":[5,39,140],"is":[6,15,29,84,127],"both":[7],"estrogen":[8],"receptor":[9],"and":[10,13,46,156],"HER2":[11],"negative":[12],"therefore":[14],"not":[16,94],"effectively":[17],"treated":[18,50],"by":[19],"hormonal":[20],"therapy":[21,78],"or":[22,147],"trastuzamab.":[23],"purpose":[25],"this":[27,35,179],"research":[28],"to":[30,55,66,108,113,158,184,200,204],"identify":[31,205],"treatment":[32,207],"options":[33],"for":[34,129,176],"subset":[36],"patients.":[40],"Breast":[41],"cell":[42,61,102],"lines":[43,62,103],"luminal":[47,69,98,115],"origin":[48],"were":[49,63,121],"with":[51,123,142,146],"five":[52],"different":[53],"chemotherapeutics":[54],"determine":[56],"sensitivity":[57,107],"levels.":[58],"more":[64],"sensitive":[65],"carboplatin":[67],"than":[68],"lines.":[70,116],"Next,":[71],"we":[72],"focused":[73],"on":[74],"identifying":[75],"a":[76,130,143],"biologic":[77],"targeting":[79],"the":[80,90,97,114,190],"subtype.":[82],"HER1/EGFR":[83],"expressed":[85,95],"in":[86,96,162,189],"approximately":[87],"50%":[88],"tumors":[92],"while":[93],"tumors.":[99],"showed":[104],"an":[105],"increased":[106],"several":[109],"EGFR":[110,120,151,188],"inhibitors":[111],"compared":[112],"Combinations":[117],"two":[119,163],"synergistic":[122],"carboplatin.":[124,149],"This":[125,193],"work":[126,194],"support":[128],"clinical":[131],"trial":[132],"at":[133],"UNO,":[134],"which":[135],"will":[136],"treat":[137],"patients":[141],"HER1":[144],"inhibitor":[145],"without":[148],"An":[150],"activation":[152,177],"signature":[153],"was":[154],"identified":[155],"shown":[157],"predict":[159],"poor":[160],"outcome":[161],"tumor":[165],"data":[166],"sets.":[167],"In":[168],"tumors,":[170],"there":[171],"may":[172,198],"be":[173,185,201],"many":[174,182],"mechanisms":[175],"pathway":[180],"but":[181],"appear":[183],"downstream":[186],"RAS-MEK-ERK":[191],"pathway.":[192],"shows":[195],"that":[196],"need":[199],"further":[202],"stratified":[203],"successful":[206],"regimens.":[208]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
