{"id":"https://openalex.org/W15380574","doi":"https://doi.org/10.4049/jimmunol.190.supp.52.26","title":"Ikaros directly upregulates transcription of B lineage-specific genes in human B cell leukemia (P4412)","display_name":"Ikaros directly upregulates transcription of B lineage-specific genes in human B cell leukemia (P4412)","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W15380574","doi":"https://doi.org/10.4049/jimmunol.190.supp.52.26","mag":"15380574"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.190.supp.52.26","doi":"https://doi.org/10.4049/jimmunol.190.supp.52.26","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.190.supp.52.26","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072518893","display_name":"Sinisa Dovat","orcid":"https://orcid.org/0000-0003-3906-6165","observed_orcids":["https://orcid.org/0000-0003-3906-6165"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sinisa Dovat","raw_affiliation_strings":["Pediatrics, Pennsylvania State Univ. Col. of Med. , Hershey, PA","1Pediatrics, Pennsylvania State Univ. Col. of Med., Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Pennsylvania State Univ. Col. of Med. , Hershey, PA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"1Pediatrics, Pennsylvania State Univ. Col. of Med., Hershey, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077299625","display_name":"Chunhua Song","orcid":"https://orcid.org/0000-0002-4081-2543","observed_orcids":["https://orcid.org/0000-0002-4081-2543"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunhua Song","raw_affiliation_strings":["Pediatrics, Pennsylvania State Univ. Col. of Med. , Hershey, PA","1Pediatrics, Pennsylvania State Univ. Col. of Med., Hershey, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Pennsylvania State Univ. Col. of Med. , Hershey, PA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"1Pediatrics, Pennsylvania State Univ. Col. of Med., Hershey, PA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087655461","display_name":"Kimberly J. Payne","orcid":"https://orcid.org/0000-0002-7025-5821","observed_orcids":["https://orcid.org/0000-0002-7025-5821"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Payne","raw_affiliation_strings":["Loma Linda Univ. , Loma Linda, CA","2Loma Linda Univ., Loma Linda, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda Univ. , Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"2Loma Linda Univ., Loma Linda, CA","institution_ids":["https://openalex.org/I26347476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"190","issue":"Supplement_1","first_page":"52.26","last_page":"52.26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ikaros","display_name":"Ikaros","score":0.9760000109672546},{"id":"https://openalex.org/keywords/ikzf1","display_name":"IKZF1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/pre-b-all","display_name":"pre-B ALL","score":0.6909999847412109},{"id":"https://openalex.org/keywords/b-cell-differentiation","display_name":"B cell differentiation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/casein-kinase-2","display_name":"casein kinase 2","score":0.8220000267028809},{"id":"https://openalex.org/keywords/protein-dephosphorylation","display_name":"protein dephosphorylation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7770000100135803},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/nalm-6-cells","display_name":"Nalm-6 cells","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.719468891620636},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.622378408908844},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6012542843818665},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.590191125869751},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4720861613750458},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4679139256477356},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4636456072330475},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4618386924266815},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4364062547683716},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3953325152397156},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3622193932533264},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3278559744358063},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.261857807636261},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.190.supp.52.26","doi":"https://doi.org/10.4049/jimmunol.190.supp.52.26","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.190.supp.52.26","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1156693005","https://openalex.org/W2550848110","https://openalex.org/W2336930830","https://openalex.org/W4313381806","https://openalex.org/W2570597871","https://openalex.org/W2341394478","https://openalex.org/W2093209955","https://openalex.org/W1582550332","https://openalex.org/W2483032490","https://openalex.org/W4389019172"],"abstract_inverted_index":{"Abstract":[0],"Ikaros":[1,26,41,55,76,87,111,126,154,177],"encodes":[2],"a":[3,9,15,148,180,205],"DNA-binding":[4],"protein":[5],"that":[6,54,75,176,202],"functions":[7,178],"as":[8,105,107,179],"master":[10],"regulator":[11,182],"of":[12,25,40,60,79,86,98,110,117,125,132,140,159,165,183,192],"hematopoiesis":[13,32],"and":[14,33,127,170,212],"tumor":[16,42],"suppressor":[17,43],"in":[18,36,67,91,95,123,137,152,196,208,213],"pre-B":[19,142],"acute":[20],"lymphoblastic":[21],"leukemia":[22,69],"(B-ALL).":[23],"Loss":[24],"function":[27],"is":[28,45],"associated":[29],"with":[30,147],"impaired":[31],"high-risk":[34],"B-ALL":[35,92],"humans.":[37],"The":[38,115,198],"mechanism":[39],"activity":[44],"unknown.":[46],"Using":[47],"quantitative":[48],"chromatin":[49],"immunoprecipitation":[50],"(qChIP)":[51],"we":[52],"demonstrate":[53],"binds":[56],"to":[57,112,156],"the":[58,133,141,157,190],"promoters":[59,158],"genes":[61,136,195],"required":[62],"for":[63],"B":[64,81,101,134,160,166,184,193,209],"cell":[65,102,144,167,171,185,210],"differentiation":[66,103,168,186,211],"primary":[68],"cells.":[70],"Luciferase":[71],"reporter":[72],"assays":[73],"demonstrated":[74],"activates":[77],"transcription":[78,97,164,191],"these":[80,99],"lineage-specific":[82,135,194],"genes.":[83],"Increased":[84],"expression":[85],"via":[88],"retroviral":[89],"transduction":[90],"cells":[93],"resulted":[94,122,151],"increased":[96,108,153,163],"critical":[100,206],"genes,":[104,162,169],"well":[106],"binding":[109,155],"their":[113],"promoters.":[114],"inhibition":[116],"Casein":[118],"Kinase":[119],"II":[120],"(CK2)":[121],"dephosphorylation":[124],"enhanced":[128],"Ikaros-mediated":[129],"transcriptional":[130],"activation":[131],"B-ALL.":[138,197],"Treatment":[139],"ALL":[143],"line,":[145],"Nalm6,":[146],"CK2":[149,203],"inhibitor,":[150],"lineage":[161],"cycle":[172],"arrest.":[173],"Results":[174],"suggest":[175,201],"positive":[181],"by":[187],"directly":[188],"upregulating":[189],"presented":[199],"data":[200],"has":[204],"role":[207],"leukemogenesis.":[214]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
