{"id":"https://openalex.org/W1537824430","doi":null,"title":"Quantifying the dynamics of viruses and the cellular immune response of the host","display_name":"Quantifying the dynamics of viruses and the cellular immune response of the host","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W1537824430","mag":"1537824430"},"language":"en","primary_location":{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/34135","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/34135","pdf_url":"https://dspace.library.uu.nl/handle/1874/34135","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/34135","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046525106","display_name":"Christian Lorenz Althaus","orcid":"https://orcid.org/0000-0002-5230-6760","observed_orcids":["https://orcid.org/0000-0002-5230-6760"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christian L. Althaus","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5230-6760","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046525106"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.17489999532699585,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.5870000123977661},{"id":"https://openalex.org/keywords/viral-dynamics","display_name":"viral dynamics","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/chronic-hiv-infection","display_name":"chronic HIV infection","score":0.746999979019165},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.5849999785423279},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.8410000205039978},{"id":"https://openalex.org/keywords/viral-mutations","display_name":"viral mutations","score":0.49900001287460327},{"id":"https://openalex.org/keywords/host-species-differences","display_name":"host species differences","score":0.628000020980835},{"id":"https://openalex.org/keywords/computer-simulation","display_name":"computer simulation","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8131007552146912},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7218709588050842},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6366860866546631},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6338043212890625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5854641199111938},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5578914284706116},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5358487367630005},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49951672554016113},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.47318434715270996},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.45263680815696716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.159968763589859},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15053993463516235},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0808398425579071},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/34135","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/34135","pdf_url":"https://dspace.library.uu.nl/handle/1874/34135","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:dspace.library.uu.nl:1874/34135","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/34135","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:1537824430","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/34135","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/34135","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/34135","pdf_url":"https://dspace.library.uu.nl/handle/1874/34135","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1537824430.pdf","grobid_xml":"https://content.openalex.org/works/W1537824430.grobid-xml"},"referenced_works_count":118,"referenced_works":["https://openalex.org/W49920453","https://openalex.org/W1482928030","https://openalex.org/W1489800389","https://openalex.org/W1507800008","https://openalex.org/W1558456135","https://openalex.org/W1560893038","https://openalex.org/W1603918837","https://openalex.org/W1606697907","https://openalex.org/W1633472206","https://openalex.org/W1674854702","https://openalex.org/W1964660012","https://openalex.org/W1966771136","https://openalex.org/W1967940959","https://openalex.org/W1968416705","https://openalex.org/W1970173303","https://openalex.org/W1970636319","https://openalex.org/W1974906492","https://openalex.org/W1977282539","https://openalex.org/W1980441640","https://openalex.org/W1984999783","https://openalex.org/W1986015062","https://openalex.org/W1986152436","https://openalex.org/W1990398742","https://openalex.org/W1992912761","https://openalex.org/W1994500037","https://openalex.org/W1999396723","https://openalex.org/W2002062046","https://openalex.org/W2004246558","https://openalex.org/W2006765654","https://openalex.org/W2007607803","https://openalex.org/W2008043760","https://openalex.org/W2010672055","https://openalex.org/W2011372623","https://openalex.org/W2011630381","https://openalex.org/W2012139740","https://openalex.org/W2015823673","https://openalex.org/W2017669223","https://openalex.org/W2019675656","https://openalex.org/W2019969899","https://openalex.org/W2020491131","https://openalex.org/W2020862462","https://openalex.org/W2022098233","https://openalex.org/W2022291864","https://openalex.org/W2030154869","https://openalex.org/W2031037912","https://openalex.org/W2032229307","https://openalex.org/W2034207391","https://openalex.org/W2035468000","https://openalex.org/W2035555649","https://openalex.org/W2037127778","https://openalex.org/W2043280201","https://openalex.org/W2044373215","https://openalex.org/W2048499136","https://openalex.org/W2051063688","https://openalex.org/W2051269276","https://openalex.org/W2052381091","https://openalex.org/W2057567758","https://openalex.org/W2059228919","https://openalex.org/W2060735144","https://openalex.org/W2062229947","https://openalex.org/W2063950143","https://openalex.org/W2064059889","https://openalex.org/W2064826754","https://openalex.org/W2065608903","https://openalex.org/W2067758651","https://openalex.org/W2069340283","https://openalex.org/W2073897604","https://openalex.org/W2078387120","https://openalex.org/W2080647790","https://openalex.org/W2080843536","https://openalex.org/W2081843353","https://openalex.org/W2085722235","https://openalex.org/W2090297178","https://openalex.org/W2097855813","https://openalex.org/W2099182602","https://openalex.org/W2099325940","https://openalex.org/W2099533369","https://openalex.org/W2101516953","https://openalex.org/W2107786521","https://openalex.org/W2109224736","https://openalex.org/W2109963121","https://openalex.org/W2110459643","https://openalex.org/W2110931762","https://openalex.org/W2111077677","https://openalex.org/W2112688502","https://openalex.org/W2113983720","https://openalex.org/W2117333383","https://openalex.org/W2124969212","https://openalex.org/W2130719514","https://openalex.org/W2132504853","https://openalex.org/W2141205048","https://openalex.org/W2141329963","https://openalex.org/W2141522875","https://openalex.org/W2144882745","https://openalex.org/W2145464880","https://openalex.org/W2147954548","https://openalex.org/W2150492554","https://openalex.org/W2155418451","https://openalex.org/W2155786171","https://openalex.org/W2163001100","https://openalex.org/W2163921097","https://openalex.org/W2164213171","https://openalex.org/W2168278523","https://openalex.org/W2168736565","https://openalex.org/W2168776079","https://openalex.org/W2169629503","https://openalex.org/W2170271908","https://openalex.org/W2171228793","https://openalex.org/W2172042588","https://openalex.org/W2172493364","https://openalex.org/W2177381833","https://openalex.org/W2258524519","https://openalex.org/W2318146960","https://openalex.org/W2320114104","https://openalex.org/W2321412851","https://openalex.org/W2331625639","https://openalex.org/W2412909330","https://openalex.org/W3044574244"],"related_works":["https://openalex.org/W1972845439","https://openalex.org/W7098791775","https://openalex.org/W3047549142","https://openalex.org/W4388364621","https://openalex.org/W2965881293","https://openalex.org/W6964610492","https://openalex.org/W2902752876","https://openalex.org/W6927008123","https://openalex.org/W2973779029","https://openalex.org/W2770592410"],"abstract_inverted_index":{"Infections":[0],"can":[1,37,228,261,303,312],"be":[2,304,313],"caused":[3],"by":[4,235,342],"viruses,":[5],"which":[6],"attack":[7],"certain":[8],"cells":[9,101,142,169],"within":[10,66],"an":[11,29,67],"infected":[12,41,68,100],"host.":[13,69,347],"However,":[14],"the":[15,19,55,62,79,85,89,124,129,138,164,182,200,203,208,211,214,217,226,236,244,251,259,263,267,290,293,296,300,310,316,320,332,335,343],"immune":[16,64,191,204,237,264,297],"system":[17],"of":[18,47,57,73,81,126,184,188,202,210,216,246,295,319,337,345],"host":[20,275,321],"has":[21,112,135],"evolved":[22],"remarkable":[23],"defense":[24],"mechanisms":[25],"that":[26,115,140,147,167,180],"counter":[27],"against":[28],"infection.":[30],"In":[31,84,213],"particular,":[32],"so-called":[33],"cytotoxic":[34],"T":[35],"lymphocytes":[36],"recognize":[38],"and":[39,50,61,106,146,230,233,253,281],"eliminate":[40],"cells.":[42],"This":[43,133,239],"thesis":[44,165,268],"makes":[45],"use":[46],"mathematical":[48],"models":[49,179],"computer":[51],"simulations":[52],"to":[53,76,137,151,198,206,243,249,288,315,327],"describe":[54,181],"dynamics":[56,183],"a":[58,161,189],"virus":[59,104,127,227,260],"population":[60],"cellular":[63,190],"response":[65,192,205,298],"Such":[70],"research":[71,324],"is":[72,96,223,241,255,285,325,340],"critical":[74],"importance":[75],"better":[77],"understand":[78],"nature":[80,336],"viral":[82,271,301,338],"infections.":[83],"beginning,":[86],"questions":[87],"on":[88,160,292,299,331],"HIV":[90],"replication":[91,209,302],"rate":[92],"are":[93,143,193,196],"addressed.":[94],"It":[95,111],"investigated":[97],"how":[98,107,225,257],"rapid":[99,108,258],"produce":[102],"new":[103,162],"particles":[105],"they":[109,148,155],"die.":[110],"been":[113,157],"known":[114],"after":[116,154],"HIV-infected":[117,141,168,247],"patients":[118,248],"start":[119],"with":[120,220,270],"antiretroviral":[121],"drug":[122],"treatment,":[123],"concentration":[125],"in":[128,186,273,309],"blood":[130],"decreases":[131],"rapidly.":[132],"observation":[134],"led":[136],"conclusion":[139],"short":[144],"lived":[145],"die":[149],"one":[150],"two":[152],"days":[153],"have":[156],"infected.":[158],"Based":[159],"analysis,":[163],"shows":[166],"might":[170],"even":[171],"live":[172],"shorter":[173],"than":[174],"previously":[175],"anticipated.":[176],"Further,":[177],"several":[178],"viruses":[185],"presence":[187],"presented.":[194],"They":[195],"used":[197],"investigate":[199],"ability":[201],"suppress":[207],"virus.":[212],"case":[215],"chronic":[218],"infection":[219,252],"HIV,":[221],"it":[222,254,284],"shown":[224,256],"mutate":[229],"avoid":[231],"recognition":[232],"elimination":[234],"response.":[238,265],"process":[240],"attributed":[242,314],"failing":[245],"control":[250],"escape":[262],"Finally,":[266],"deals":[269],"infections":[272,339],"different":[274],"species,":[276,322],"such":[277],"as":[278,287],"mice,":[279],"macaques":[280],"humans.":[282],"Therefore,":[283],"discussed":[286],"whether":[289,334],"findings":[291],"influence":[294],"generalized.":[305],"Although":[306],"some":[307],"differences":[308],"results":[311],"body":[317],"weight":[318],"additional":[323],"needed":[326],"shed":[328],"more":[329],"light":[330],"question":[333],"affected":[341],"size":[344],"their":[346]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}