{"id":"https://openalex.org/W153759746","doi":null,"title":"Cell-mediated and humoral immune responses in mice. III. Dynamic balance between delayed-type hypersensitivity and antibody response.","display_name":"Cell-mediated and humoral immune responses in mice. III. Dynamic balance between delayed-type hypersensitivity and antibody response.","publication_year":1977,"publication_date":"1977-03-01","ids":{"openalex":"https://openalex.org/W153759746","mag":"153759746","pmid":"https://pubmed.ncbi.nlm.nih.gov/66195","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1445299"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1445299","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1445299","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1445299","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001657741","display_name":"Y Katsura","orcid":"https://orcid.org/0000-0003-4759-4267","observed_orcids":["https://orcid.org/0000-0003-4759-4267"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Y Katsura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001657741"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3495,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.5105364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"32","issue":"3","first_page":"227","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.9679999947547913},{"id":"https://openalex.org/keywords/bovine-serum-albumin","display_name":"bovine serum albumin","score":0.8920000195503235},{"id":"https://openalex.org/keywords/complete-freund-s-adjuvant","display_name":"complete Freund's adjuvant","score":0.9290000200271606},{"id":"https://openalex.org/keywords/bacterial-endotoxin","display_name":"bacterial endotoxin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/suppressor-cells","display_name":"suppressor cells","score":0.6029999852180481},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.6990000009536743},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.9610000252723694},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.4740000069141388},{"id":"https://openalex.org/keywords/subcutaneous-vaccination","display_name":"subcutaneous immunization","score":0.675000011920929},{"id":"https://openalex.org/keywords/irradiated-recipients","display_name":"irradiated recipients","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.9014840126037598},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.7607709169387817},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6674917340278625},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.6550076603889465},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6488227844238281},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6393418312072754},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5341120958328247},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.4887049198150635},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.46342623233795166},{"id":"https://openalex.org/C3017924640","wikidata":"https://www.wikidata.org/wiki/Q7860879","display_name":"Delayed hypersensitivity","level":3,"score":0.4414594769477844},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.42650237679481506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3598330616950989},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.347289115190506}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006462","descriptor_name":"Hemolytic Plaque Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1445299","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1445299","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:66195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/66195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1977-3075","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1977/2076","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1977","raw_type":"text"},{"id":"mag:153759746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/66195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1445299","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1445299","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W41389100","https://openalex.org/W90081773","https://openalex.org/W214812796","https://openalex.org/W579357192","https://openalex.org/W1523570416","https://openalex.org/W1542804872","https://openalex.org/W1935295184","https://openalex.org/W1967717169","https://openalex.org/W2012272820","https://openalex.org/W2018218318","https://openalex.org/W2024151692","https://openalex.org/W2031447041","https://openalex.org/W2035809424","https://openalex.org/W2067242472","https://openalex.org/W2135267016","https://openalex.org/W2155364730","https://openalex.org/W2187691537","https://openalex.org/W4313310036"],"related_works":["https://openalex.org/W2613691390","https://openalex.org/W2406995057","https://openalex.org/W579357192","https://openalex.org/W2416529625","https://openalex.org/W1574061444","https://openalex.org/W2394692040","https://openalex.org/W2010287552","https://openalex.org/W1640954481","https://openalex.org/W1507029529","https://openalex.org/W2413995428"],"abstract_inverted_index":{"Delayed-type":[0],"hypersensitivity":[1],"in":[2,19,48,69,79,88,106,142,159],"mice":[3,53,129,147],"to":[4,85,112,115,182],"bovine":[5],"serum":[6],"albumin":[7],"(BSA)":[8],"which":[9],"would":[10],"be":[11,113,163],"induced":[12],"by":[13,25,94,165],"a":[14],"s.c.":[15,40,96,149,184],"injection":[16,28,41,59,97],"of":[17,29,42,51,60,98,102,127,132,135,146,168,171],"BSA":[18,31,43],"Freund's":[20],"complete":[21],"adjuvant":[22,63,71],"was":[23,91,139],"interrupted":[24],"an":[26,66],"i.v.":[27],"alum-precipitated":[30],"plus":[32,36,56],"bacterial":[33],"endotoxin":[34],"(AP-BSA":[35],"ET).":[37],"In":[38],"contrast,":[39],"restrained":[44],"the":[45,49,52,62,70,75,80,89,95,103,107,119,124,143,155,160,166,172,180,183],"antibody":[46,77,83,104,125,157],"response":[47,78,84,105,126,158],"spleen":[50,90,108,137,144,161,181],"receiving":[54],"AP-BSA":[55],"ET.":[57],"Subcutaneous":[58],"either":[61],"alone":[64],"or":[65,176],"unrelated":[67],"antigen":[68,173],"did":[72],"not":[73,92,110,140],"affect":[74],"anti-BSA":[76],"spleen.":[81],"The":[82,100,151],"other":[86],"antigens":[87],"affected":[93],"BSA.":[99],"reduction":[101],"does":[109],"seem":[111],"attributable":[114],"suppressor":[116,120],"cells,":[117],"since":[118],"cell":[121],"activity":[122],"against":[123],"normal":[128],"and":[130],"that":[131,154],"irradiated":[133],"recipients":[134],"primed":[136],"cells":[138,145,175],"observed":[141],"given":[148],"immunization.":[150],"results":[152],"indicated":[153],"reduced":[156],"may":[162],"caused":[164],"migration":[167],"some":[169],"part":[170],"reactive":[174],"their":[177],"precursors":[178],"from":[179],"region.":[185]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}