{"id":"https://openalex.org/W153746867","doi":"https://doi.org/10.1096/fasebj.21.5.a629-c","title":"Molecular targeting of alpha\u20102\u2010macroglobulin by homocysteine: stoichiometry and possible implications in inflammatory diseases","display_name":"Molecular targeting of alpha\u20102\u2010macroglobulin by homocysteine: stoichiometry and possible implications in inflammatory diseases","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W153746867","doi":"https://doi.org/10.1096/fasebj.21.5.a629-c","mag":"153746867"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a629-c","doi":"https://doi.org/10.1096/fasebj.21.5.a629-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a629-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039414431","display_name":"Carmen Otilia Catanescu","orcid":"https://orcid.org/0000-0002-9392-4784","observed_orcids":["https://orcid.org/0000-0002-9392-4784"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmen Otilia Catanescu","raw_affiliation_strings":["Cell Biology, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031346240","display_name":"John C. Barbato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C Barbato","raw_affiliation_strings":["Cell Biology, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068871080","display_name":"Patricia M. DiBello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia M DiBello","raw_affiliation_strings":["Cell Biology, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013491797","display_name":"Belinda B. Willard","orcid":"https://orcid.org/0000-0001-6884-6369","observed_orcids":["https://orcid.org/0000-0001-6884-6369"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Belinda Willard","raw_affiliation_strings":["Cell Biology, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mike T Kinter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike T Kinter","raw_affiliation_strings":["Cell Biology, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195","Molecular Medicine, Cleveland Clinic Lerner College of Medicine, CWRU, 9500 Euclid Avenue NA24, Cleveland, OH, 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"Molecular Medicine, Cleveland Clinic Lerner College of Medicine, CWRU, 9500 Euclid Avenue NA24, Cleveland, OH, 44106","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026025245","display_name":"\u0410. \u0410. \u0416\u043b\u043e\u0431\u0430","orcid":"https://orcid.org/0000-0003-0605-7617","observed_orcids":["https://orcid.org/0000-0003-0605-7617"]},"institutions":[{"id":"https://openalex.org/I2799540354","display_name":"First Pavlov State Medical University of St. Petersburg","ror":"https://ror.org/04g525b43","country_code":"RU","type":"education","lineage":["https://openalex.org/I2799540354"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander A Zhloba","raw_affiliation_strings":["Biochemistry, State I.P. Pavlov Medical University, L. Tolstoy Street 619, St. Petersburg, 197089 Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry, State I.P. Pavlov Medical University, L. Tolstoy Street 619, St. Petersburg, 197089 Russian Federation","institution_ids":["https://openalex.org/I2799540354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108384236","display_name":"Donald W. Jacobsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald W Jacobsen","raw_affiliation_strings":["Cell Biology, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195","Molecular Medicine, Cleveland Clinic Lerner College of Medicine, CWRU, 9500 Euclid Avenue NA24, Cleveland, OH, 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology, Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, NC10, Cleveland, OH, 44195","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"Molecular Medicine, Cleveland Clinic Lerner College of Medicine, CWRU, 9500 Euclid Avenue NA24, Cleveland, OH, 44106","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0141051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-2-macroglobulin","display_name":"alpha2-macroglobulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":1.0},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.8410000205039978},{"id":"https://openalex.org/keywords/thiol-exchange","display_name":"thiol exchange","score":0.8289999961853027},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.5929999947547913},{"id":"https://openalex.org/keywords/binding-stoichiometry","display_name":"binding stoichiometry","score":0.7160000205039978},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9810000061988831}],"concepts":[{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.7518213391304016},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.6587440967559814},{"id":"https://openalex.org/C2781054842","wikidata":"https://www.wikidata.org/wiki/Q6725283","display_name":"Macroglobulin","level":2,"score":0.6471349000930786},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.618850588798523},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5850763916969299},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5425660014152527},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.49316638708114624},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.4905661940574646},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.44789206981658936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3005821704864502},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2005022168159485},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1595982015132904}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a629-c","doi":"https://doi.org/10.1096/fasebj.21.5.a629-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a629-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2273438810","https://openalex.org/W995791940","https://openalex.org/W1926150511","https://openalex.org/W2031510175","https://openalex.org/W2085859382","https://openalex.org/W3039909536","https://openalex.org/W1945834820","https://openalex.org/W1966919944","https://openalex.org/W2921351490","https://openalex.org/W2052335753"],"abstract_inverted_index":{"Alpha\u20102\u2010macroglobulin":[0],"(a2M),":[1],"a":[2],"720\u2010kDa":[3],"plasma":[4],"protein,":[5],"functions":[6],"as":[7],"an":[8],"extracellular":[9],"proteinase":[10],"inhibitor":[11],"and":[12,18,38,65,79,87,92,108,113,115,166,169,187],"carrier":[13],"of":[14,32,44,74,85,106,123,142,152,185],"cytokines,":[15],"growth":[16,170],"factors":[17,171],"hormones.":[19],"Disulfide":[20],"bonds":[21],"are":[22],"susceptible":[23],"for":[24,99,110,117],"thiol\u2010exchange":[25],"reactions":[26],"with":[27,50,90],"homocysteine":[28],"(Hcy).":[29],"The":[30,72],"structure":[31],"a2M":[33,58,81,89,124,176],"contains":[34],"96":[35],"cysteine":[36],"residues":[37],"one":[39],"can":[40],"assume":[41],"that":[42,57,139,172],"some":[43],"these":[45],"disulfide":[46],"bridges":[47],"might":[48,155],"interact":[49],"Hcy.":[51],"Using":[52],"35":[53,95],"S\u2010D,L\u2010homocysteine,":[54],"we":[55],"show":[56],"is":[59,82],"homocysteinylated":[60],"in":[61,66,132,144,162,182],"both":[62],"its":[63],"native":[64,78,86,111],"the":[67,145,149,183],"protein\u2010proteinase":[68],"complex":[69],"(\u201cactivated\u201d":[70],"a2M).":[71],"stoichiometry":[73],"Hcy":[75,143],"binding":[76],"to":[77,127,135,175,178],"activated":[80,88,118],"dose\u2010dependent:":[83],"treatment":[84],"25":[91],"50":[93],"\u03bcM":[94],"S\u2010D,L\u2010Hcy":[96],"at":[97],"37\u00b0C":[98],"4":[100],"h":[101],"yielded":[102],"approximate":[103],"Hcy:a2M":[104],"ratios":[105],"2:1":[107],"4:1":[109],"a2M,":[112,137],"3:1":[114],"6:1":[116],"a2M.":[119,153],"Trypsin\u2010protein":[120],"esterase":[121],"activity":[122,159],"was":[125],"shown":[126],"be":[128],"decreased":[129],"by":[130],"12\u201335%":[131],"homocysteinylated\u2010a2M":[133],"compared":[134],"untreated":[136],"suggesting":[138],"high":[140,161],"levels":[141],"blood":[146],"may":[147],"affect":[148],"proteinase\u2010binding":[150],"function":[151],"This":[154],"explain":[156],"why":[157,167],"proteolytic":[158],"remains":[160],"inflammatory":[163],"tissue":[164],"fluids":[165],"cytokines":[168],"usually":[173],"bind":[174],"continue":[177],"play":[179],"important":[180],"roles":[181],"progression":[184],"inflammation":[186],"atherosclerosis.":[188]},"counts_by_year":[{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}