{"id":"https://openalex.org/W1537317641","doi":null,"title":"Genetics of pancreatitis with a focus on the pancreatic ducts.","display_name":"Genetics of pancreatitis with a focus on the pancreatic ducts.","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W1537317641","mag":"1537317641","pmid":"https://pubmed.ncbi.nlm.nih.gov/23207607","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3684070"},"language":"en","primary_location":{"id":"pmid:23207607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23207607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva gastroenterologica e dietologica","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3684070","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012792887","display_name":"Jessica LaRusch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Larusch","raw_affiliation_strings":["Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021037951","display_name":"David Clement Whitcomb","orcid":"https://orcid.org/0000-0002-4462-1410","observed_orcids":["https://orcid.org/0000-0002-4462-1410"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D C Whitcomb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2554,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.22402921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"58","issue":"4","first_page":"299","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatitis","display_name":"pancreatitis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/acute-pancreatitis","display_name":"acute pancreatitis","score":0.859000027179718},{"id":"https://openalex.org/keywords/recurrent-acute-pancreatitis","display_name":"recurrent acute pancreatitis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-duct","display_name":"pancreatic duct","score":0.8510000109672546},{"id":"https://openalex.org/keywords/duct-cells","display_name":"duct cells","score":0.6209999918937683},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6549999713897705},{"id":"https://openalex.org/keywords/prss1","display_name":"PRSS1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.9800000190734863},{"id":"https://openalex.org/keywords/spink1","display_name":"SPINK1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cftr-mutations","display_name":"CFTR mutations","score":0.8080000281333923},{"id":"https://openalex.org/keywords/calcium-sensing-receptor","display_name":"calcium-sensing receptor","score":0.9229999780654907},{"id":"https://openalex.org/keywords/aquaporins","display_name":"aquaporins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/claudins","display_name":"claudins","score":1.0},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.7849528789520264},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6831548810005188},{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.5850890874862671},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5775740146636963},{"id":"https://openalex.org/C2779960720","wikidata":"https://www.wikidata.org/wiki/Q668063","display_name":"Pancreatic duct","level":3,"score":0.5681441426277161},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.5397475957870483},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5232381224632263},{"id":"https://openalex.org/C2780471426","wikidata":"https://www.wikidata.org/wiki/Q7130410","display_name":"Pancreatic injury","level":3,"score":0.5155291557312012},{"id":"https://openalex.org/C2776382852","wikidata":"https://www.wikidata.org/wiki/Q3361967","display_name":"Hereditary pancreatitis","level":5,"score":0.4324570596218109},{"id":"https://openalex.org/C2991930265","wikidata":"https://www.wikidata.org/wiki/Q5062943","display_name":"Acinar cell","level":3,"score":0.4247297942638397},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3386172950267792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33424049615859985},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28126853704452515},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23275384306907654},{"id":"https://openalex.org/C2781286802","wikidata":"https://www.wikidata.org/wiki/Q421373","display_name":"Trypsinogen","level":4,"score":0.2149694263935089},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20610198378562927},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014359","descriptor_name":"Trypsin Inhibitor, Kazal Pancreatic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020346","descriptor_name":"Aquaporins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044169","descriptor_name":"Receptors, Calcium-Sensing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050500","descriptor_name":"Pancreatitis, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057167","descriptor_name":"Claudins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:23207607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23207607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva gastroenterologica e dietologica","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2680184","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3684070","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3684070","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3684070/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Minerva Gastroenterol Dietol","raw_type":"Text"},{"id":"mag:1537317641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23207607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2680184","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3684070","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1894322783","display_name":"NAPS2 Continuation - Genome-Wide Association Study of Pancreatitis","funder_award_id":"R01DK061451","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4425087846","display_name":"Digestive Diseases Training Program","funder_award_id":"T32DK063922","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5726324370","display_name":"Molecular Genetics of Hereditary Pancreatitis","funder_award_id":"R01DK054709","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W80318783","https://openalex.org/W1563800735","https://openalex.org/W1822551178","https://openalex.org/W1870094350","https://openalex.org/W1966776937","https://openalex.org/W1972147587","https://openalex.org/W1986682462","https://openalex.org/W1990814447","https://openalex.org/W1990956835","https://openalex.org/W1991395851","https://openalex.org/W1992072808","https://openalex.org/W1992500371","https://openalex.org/W1995478495","https://openalex.org/W1997718215","https://openalex.org/W2004148998","https://openalex.org/W2004416274","https://openalex.org/W2005585762","https://openalex.org/W2009467716","https://openalex.org/W2011407823","https://openalex.org/W2014318914","https://openalex.org/W2016221014","https://openalex.org/W2016400633","https://openalex.org/W2016847093","https://openalex.org/W2023076580","https://openalex.org/W2024005495","https://openalex.org/W2039474311","https://openalex.org/W2043935974","https://openalex.org/W2045887134","https://openalex.org/W2049127413","https://openalex.org/W2049351211","https://openalex.org/W2062137132","https://openalex.org/W2067454290","https://openalex.org/W2071407356","https://openalex.org/W2072778751","https://openalex.org/W2077024045","https://openalex.org/W2083214486","https://openalex.org/W2083449603","https://openalex.org/W2085404502","https://openalex.org/W2085803061","https://openalex.org/W2090299518","https://openalex.org/W2092918003","https://openalex.org/W2113193681","https://openalex.org/W2119745826","https://openalex.org/W2119848779","https://openalex.org/W2121576595","https://openalex.org/W2122484880","https://openalex.org/W2124318163","https://openalex.org/W2127892856","https://openalex.org/W2132210046","https://openalex.org/W2138362876","https://openalex.org/W2139648891","https://openalex.org/W2141217885","https://openalex.org/W2143520831","https://openalex.org/W2143738663","https://openalex.org/W2148602450","https://openalex.org/W2150902124","https://openalex.org/W2153311369","https://openalex.org/W2155759872","https://openalex.org/W2158010208","https://openalex.org/W2160674655","https://openalex.org/W2161006505","https://openalex.org/W2166336576","https://openalex.org/W2166863205","https://openalex.org/W2273171223","https://openalex.org/W2313829157","https://openalex.org/W2315062805","https://openalex.org/W2330410882","https://openalex.org/W2436433118"],"related_works":["https://openalex.org/W3042714550","https://openalex.org/W2016400633","https://openalex.org/W2126164686","https://openalex.org/W4402021113","https://openalex.org/W1995243958","https://openalex.org/W1974089819","https://openalex.org/W2143738663","https://openalex.org/W2087266225","https://openalex.org/W2569717916","https://openalex.org/W2109594412"],"abstract_inverted_index":{"Genetic":[0],"risk":[1],"for":[2],"acute":[3,7],"pancreatitis":[4,8,12,49],"(AP),":[5],"recurrent":[6],"(RAP)":[9],"and":[10,26,36,106,140,160,162],"chronic":[11],"(CP)":[13],"are":[14,67,109],"increasingly":[15],"recognized.":[16],"The":[17,166],"exocrine":[18],"pancreas":[19,59],"is":[20,149,174],"composed":[21],"of":[22,104,121,126,168],"both":[23],"acinar":[24],"cells":[25],"duct":[27,146],"cells,":[28],"with":[29,33],"genetic":[30,105,118],"factors":[31,108,128],"associated":[32],"AP,":[34],"RAP":[35],"CP":[37],"linked":[38],"to":[39,48,60,62,94,133,151],"one":[40],"cell":[41,147],"type":[42],"or":[43,65,113,135],"the":[44,52,58,131,153],"other.":[45],"Increased":[46],"susceptibility":[47],"occurs":[50],"when":[51],"normal":[53],"physiological":[54],"mechanisms":[55],"that":[56,79,90,100,130],"allow":[57],"respond":[61],"common":[63],"stresses":[64,134],"injury":[66,136],"altered.":[68],"Currently,":[69],"most":[70],"our":[71],"knowledge":[72],"about":[73],"genetics":[74],"focuses":[75],"on":[76],"three":[77],"genes":[78],"play":[80],"critical":[81,141],"roles":[82],"in":[83,171],"pancreatic":[84,172],"function":[85],"(PRSS1,":[86],"CFTR,":[87,156],"SPINK1)":[88],"such":[89],"isolated":[91],"defects":[92],"lead":[93],"disease.":[95],"However,":[96],"recent":[97],"data":[98],"suggest":[99],"more":[101,114],"complex":[102,122],"combination":[103],"environmental":[107],"also":[110],"as":[111],"important,":[112],"important":[115],"than":[116],"Mendelian":[117],"risk.":[119],"Understanding":[120],"interactions":[123,142],"requires":[124],"modeling":[125],"these":[127],"so":[129],"response":[132],"can":[137],"be":[138],"simulated":[139],"understood.":[143],"A":[144],"simple":[145],"model":[148],"given":[150],"illustration":[152],"relationship":[154],"between":[155],"CASR,":[157],"aquaporins,":[158],"claudins,":[159],"SPINK1,":[161],"how":[163],"they":[164],"interact.":[165],"role":[167],"CFTR":[169],"variants":[170],"diseases":[173],"then":[175],"discussed.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}