{"id":"https://openalex.org/W1536865992","doi":null,"title":"Recent concepts for the roles of progenitor/stem cell niche in heart repair.","display_name":"Recent concepts for the roles of progenitor/stem cell niche in heart repair.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1536865992","mag":"1536865992","pmid":"https://pubmed.ncbi.nlm.nih.gov/22254217","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3257154"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2265345","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3257154","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3257154","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115589415","display_name":"Yuliang Feng","orcid":"https://orcid.org/0009-0002-9227-9717","observed_orcids":["https://orcid.org/0009-0002-9227-9717"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuliang Feng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100522344","display_name":"Xi\u2010Yong Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xi-Yong Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101961958","display_name":"Yigang Wang","orcid":"https://orcid.org/0000-0001-5315-4722","observed_orcids":["https://orcid.org/0000-0001-5315-4722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yigang Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.42,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.53909656,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"2","issue":"1","first_page":"75","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progenitor-cells","display_name":"progenitor cells","score":0.7609999775886536},{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cardiac-repair","display_name":"cardiac repair","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.9679999947547913},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.6209999918937683},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cell-fusion","display_name":"cell fusion","score":0.7839999794960022},{"id":"https://openalex.org/keywords/endogenous-repair","display_name":"endogenous repair","score":0.621999979019165},{"id":"https://openalex.org/keywords/cardiomyocyte-phenotype","display_name":"cardiomyocyte phenotype","score":0.7319999933242798},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.4699999988079071},{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.7274253368377686},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7184499502182007},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.7166818380355835},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6484422087669373},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.553682267665863},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.538653552532196},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5330793857574463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.522599995136261},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.49001947045326233},{"id":"https://openalex.org/C164794517","wikidata":"https://www.wikidata.org/wiki/Q16729831","display_name":"Stem cell niche","level":4,"score":0.4674910604953766},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4338434934616089},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3719494342803955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33867645263671875},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33719053864479065},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13035622239112854},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.12404924631118774},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.07390859723091125},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2265345","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3257154","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3257154","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3257154","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cardiovasc Dis","raw_type":"Text"},{"id":"pmid:22254217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22254217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cardiovascular disease","raw_type":"Journal Article"},{"id":"mag:1536865992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22254217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:2187949097","doi":null,"is_oa":false,"landing_page_url":"http://www.ajcd.us/files/AJCD1111004.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2265345","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3257154","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1106347365","display_name":"iPS cells-derived progenitor cells for angiomyogenesis","funder_award_id":"R01HL110740","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5006288209","display_name":"Lineage Specific Stem Cell Mobilization for Heart Repair","funder_award_id":"R01HL081859","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8101657261","display_name":"Stem Cell Therapy","funder_award_id":"R01HL089824","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1504660023","https://openalex.org/W1810772665","https://openalex.org/W1872140826","https://openalex.org/W1968663723","https://openalex.org/W1972782503","https://openalex.org/W1973994763","https://openalex.org/W1978172109","https://openalex.org/W1979608640","https://openalex.org/W1985164695","https://openalex.org/W1991037959","https://openalex.org/W1995701551","https://openalex.org/W1997576345","https://openalex.org/W2003502792","https://openalex.org/W2007982994","https://openalex.org/W2009545124","https://openalex.org/W2010486643","https://openalex.org/W2010653927","https://openalex.org/W2015609204","https://openalex.org/W2017610560","https://openalex.org/W2022056325","https://openalex.org/W2026749151","https://openalex.org/W2032570745","https://openalex.org/W2036632122","https://openalex.org/W2039707890","https://openalex.org/W2039748263","https://openalex.org/W2040446110","https://openalex.org/W2043457504","https://openalex.org/W2046587551","https://openalex.org/W2048507807","https://openalex.org/W2050689355","https://openalex.org/W2051945150","https://openalex.org/W2067067950","https://openalex.org/W2069019884","https://openalex.org/W2069417165","https://openalex.org/W2069500991","https://openalex.org/W2072239613","https://openalex.org/W2080185076","https://openalex.org/W2094986197","https://openalex.org/W2097675424","https://openalex.org/W2099474957","https://openalex.org/W2103540918","https://openalex.org/W2105925116","https://openalex.org/W2105988341","https://openalex.org/W2106485710","https://openalex.org/W2122616632","https://openalex.org/W2123963701","https://openalex.org/W2125914414","https://openalex.org/W2125987139","https://openalex.org/W2127114313","https://openalex.org/W2128085444","https://openalex.org/W2138977668","https://openalex.org/W2141248581","https://openalex.org/W2141376975","https://openalex.org/W2142267227","https://openalex.org/W2142721799","https://openalex.org/W2149487482","https://openalex.org/W2149792859","https://openalex.org/W2152483372","https://openalex.org/W2156712000","https://openalex.org/W2157806433","https://openalex.org/W2158626287","https://openalex.org/W2158979552","https://openalex.org/W2161304727","https://openalex.org/W2166941736","https://openalex.org/W2171998177","https://openalex.org/W2740048833","https://openalex.org/W3147645180"],"related_works":["https://openalex.org/W2187949097","https://openalex.org/W143445751","https://openalex.org/W2603814441","https://openalex.org/W2015609204","https://openalex.org/W7081707861","https://openalex.org/W2567466572","https://openalex.org/W2035149291","https://openalex.org/W2001391660","https://openalex.org/W2023754730","https://openalex.org/W2053361380"],"abstract_inverted_index":{"Progenitor/stem":[0],"cell":[1],"(PSC)":[2],"has":[3],"shown":[4],"great":[5,66],"promise":[6],"for":[7,167],"generation":[8],"in":[9,13,39,58,68,75,158],"failing":[10],"heart.":[11],"Advances":[12],"PSC":[14,23,43,52,60,73,78,102,125,141,145,159,178],"biology":[15],"have":[16,64,154,164],"greatly":[17],"enhanced":[18],"our":[19,69],"understanding":[20,70],"of":[21,27,36,71,92,100,105,109,114,123,130,136,140,177],"how":[22],"self-renewal,":[24],"migration,":[25],"maintenance":[26],"stemness,":[28],"and":[29,47,133,150,171],"cell-fate":[30],"commitment":[31],"depend":[32],"on":[33,97],"the":[34,72,90,101,106,110,119,124,127,131,181],"balance":[35],"complex":[37],"signals":[38],"their":[40],"microenvironment.":[41],"Endogenous":[42],"exists":[44],"within":[45,180],"structural":[46],"functional":[48],"units":[49],"known":[50],"as":[51],"niches,":[53],"which":[54],"play":[55],"important":[56,165],"roles":[57,157],"directing":[59],"behavior.":[61],"Recent":[62],"years":[63],"witnessed":[65],"progress":[67],"niche":[74,182],"cardiovascular":[76],"biology.":[77],"based":[79,96,160],"therapy":[80],"could":[81],"lead":[82],"to":[83],"successful":[84],"cardiac":[85,144],"regeneration":[86],"or":[87],"repair.":[88],"Realizing":[89],"potential":[91],"therapeutic":[93],"strategies":[94],"is":[95],"1)":[98],"differentiation":[99],"into":[103],"all":[104],"cellular":[107],"constituents":[108,129],"heart;":[111,132],"2)":[112],"release":[113],"paracrine/":[115],"autocrine":[116],"factors":[117],"from":[118],"PSC;":[120],"3)":[121],"fusion":[122],"with":[126],"existing":[128],"4)":[134],"stimulation":[135],"endogenous":[137],"repair":[138],"(regeneration":[139],"niches).":[142],"Importantly,":[143],"niches":[146],"contain":[147],"supporting":[148],"cells":[149],"these":[151],"cell-cell":[152],"interactions":[153],"crucial":[155],"regulatory":[156],"therapy.":[161],"These":[162],"findings":[163],"implications":[166],"heart":[168],"development,":[169],"bioengineering,":[170],"furthermore":[172],"elucidate":[173],"a":[174],"broader":[175],"dimension":[176],"control":[179],"toward":[183],"cardiomyocyte":[184],"phenotype.":[185]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
