{"id":"https://openalex.org/W1536738523","doi":null,"title":"Zinc Signaling in Neuronal Tolerance","display_name":"Zinc Signaling in Neuronal Tolerance","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W1536738523","mag":"1536738523"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9276","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/9276/1/Aras_2009_dissertation.pdf","pdf_url":"https://d-scholarship.pitt.edu/9276/1/Aras_2009_dissertation.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111065710","display_name":"Mandar A. Aras","orcid":"https://orcid.org/0000-0002-7528-4971","observed_orcids":["https://orcid.org/0000-0002-7528-4971"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mandar A. Aras","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111065710"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.7422000169754028,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.7422000169754028,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.11940000206232071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc-signaling","display_name":"zinc signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/zinc-accumulation","display_name":"zinc accumulation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/metallothionein","display_name":"metallothionein","score":0.7839999794960022},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9570000171661377},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.7760000228881836},{"id":"https://openalex.org/keywords/ischemia","display_name":"ischemia","score":0.8560000061988831},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cell-death-pathways","display_name":"cell death pathways","score":0.5680000185966492},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6127858757972717},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5952322483062744},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5218478441238403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4705299139022827},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.45733246207237244},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.4466278851032257},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.4392082095146179},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4387626647949219},{"id":"https://openalex.org/C20719415","wikidata":"https://www.wikidata.org/wiki/Q416896","display_name":"Metallothionein","level":3,"score":0.42221707105636597},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3953397870063782},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36372900009155273},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32096201181411743},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2557048797607422},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18773415684700012},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.16243308782577515}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:9276","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/9276/1/Aras_2009_dissertation.pdf","pdf_url":"https://d-scholarship.pitt.edu/9276/1/Aras_2009_dissertation.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:1536738523","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/9276/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":364,"referenced_works":["https://openalex.org/W36570623","https://openalex.org/W88594106","https://openalex.org/W127852528","https://openalex.org/W157666778","https://openalex.org/W182253977","https://openalex.org/W201456908","https://openalex.org/W204294393","https://openalex.org/W223798810","https://openalex.org/W1501091531","https://openalex.org/W1501492534","https://openalex.org/W1512307340","https://openalex.org/W1513218206","https://openalex.org/W1515063177","https://openalex.org/W1517355592","https://openalex.org/W1520819787","https://openalex.org/W1530104357","https://openalex.org/W1533559637","https://openalex.org/W1540707536","https://openalex.org/W1545362848","https://openalex.org/W1545889271","https://openalex.org/W1549264432","https://openalex.org/W1566271574","https://openalex.org/W1567272218","https://openalex.org/W1581040775","https://openalex.org/W1594286037","https://openalex.org/W1605897432","https://openalex.org/W1612987016","https://openalex.org/W1641731911","https://openalex.org/W1670939209","https://openalex.org/W1691996697","https://openalex.org/W1701555181","https://openalex.org/W1721669572","https://openalex.org/W1767847062","https://openalex.org/W1831164682","https://openalex.org/W1862030732","https://openalex.org/W1868155710","https://openalex.org/W1890098172","https://openalex.org/W1896045165","https://openalex.org/W1921754339","https://openalex.org/W1922083656","https://openalex.org/W1922443931","https://openalex.org/W1939692783","https://openalex.org/W1955702721","https://openalex.org/W1960815164","https://openalex.org/W1965486340","https://openalex.org/W1966456749","https://openalex.org/W1966635399","https://openalex.org/W1966697245","https://openalex.org/W1967301498","https://openalex.org/W1967705818","https://openalex.org/W1969173610","https://openalex.org/W1969268163","https://openalex.org/W1970238670","https://openalex.org/W1970498090","https://openalex.org/W1970828358","https://openalex.org/W1971979491","https://openalex.org/W1972415953","https://openalex.org/W1972834856","https://openalex.org/W1973115255","https://openalex.org/W1974725853","https://openalex.org/W1975483893","https://openalex.org/W1975605964","https://openalex.org/W1977653137","https://openalex.org/W1978710583","https://openalex.org/W1979106875","https://openalex.org/W1979752940","https://openalex.org/W1980142584","https://openalex.org/W1980237518","https://openalex.org/W1980792888","https://openalex.org/W1980986613","https://openalex.org/W1982557954","https://openalex.org/W1982715379","https://openalex.org/W1984782455","https://openalex.org/W1984847320","https://openalex.org/W1986024151","https://openalex.org/W1986197357","https://openalex.org/W1986228861","https://openalex.org/W1986291674","https://openalex.org/W1986790448","https://openalex.org/W1987498682","https://openalex.org/W1987808124","https://openalex.org/W1988395593","https://openalex.org/W1988522729","https://openalex.org/W1989965028","https://openalex.org/W1990053315","https://openalex.org/W1990557260","https://openalex.org/W1990697514","https://openalex.org/W1990719784","https://openalex.org/W1990843666","https://openalex.org/W1992157491","https://openalex.org/W1992240624","https://openalex.org/W1992260035","https://openalex.org/W1992661805","https://openalex.org/W1993095840","https://openalex.org/W1993097538","https://openalex.org/W1994907534","https://openalex.org/W1995138033","https://openalex.org/W1995792679","https://openalex.org/W1997397901","https://openalex.org/W1997966386","https://openalex.org/W1998398302","https://openalex.org/W2002357878","https://openalex.org/W2002360249","https://openalex.org/W2002933697","https://openalex.org/W2002945872","https://openalex.org/W2004007082","https://openalex.org/W2004510097","https://openalex.org/W2004731363","https://openalex.org/W2004742141","https://openalex.org/W2005003771","https://openalex.org/W2005762905","https://openalex.org/W2008946188","https://openalex.org/W2009329006","https://openalex.org/W2009484284","https://openalex.org/W2009697737","https://openalex.org/W2009812062","https://openalex.org/W2010184804","https://openalex.org/W2010298858","https://openalex.org/W2010338437","https://openalex.org/W2010586937","https://openalex.org/W2013499155","https://openalex.org/W2013969512","https://openalex.org/W2013986174","https://openalex.org/W2014150894","https://openalex.org/W2014696835","https://openalex.org/W2014881508","https://openalex.org/W2016339654","https://openalex.org/W2016532781","https://openalex.org/W2016575029","https://openalex.org/W2016833067","https://openalex.org/W2016869607","https://openalex.org/W2016934775","https://openalex.org/W2017075380","https://openalex.org/W2017082833","https://openalex.org/W2017193677","https://openalex.org/W2018759588","https://openalex.org/W2019410704","https://openalex.org/W2019903373","https://openalex.org/W2020450325","https://openalex.org/W2020749822","https://openalex.org/W2021061739","https://openalex.org/W2021690131","https://openalex.org/W2021797855","https://openalex.org/W2022033428","https://openalex.org/W2022218526","https://openalex.org/W2022749897","https://openalex.org/W2026093245","https://openalex.org/W2027150047","https://openalex.org/W2027353535","https://openalex.org/W2027619123","https://openalex.org/W2027700486","https://openalex.org/W2027851046","https://openalex.org/W2029107363","https://openalex.org/W2029859548","https://openalex.org/W2031538927","https://openalex.org/W2032458072","https://openalex.org/W2034253733","https://openalex.org/W2034580062","https://openalex.org/W2034900642","https://openalex.org/W2035089473","https://openalex.org/W2035594105","https://openalex.org/W2036394095","https://openalex.org/W2036447879","https://openalex.org/W2036839645","https://openalex.org/W2037943457","https://openalex.org/W2038443140","https://openalex.org/W2038787225","https://openalex.org/W2039472414","https://openalex.org/W2039515131","https://openalex.org/W2040150290","https://openalex.org/W2040509902","https://openalex.org/W2041341129","https://openalex.org/W2041969644","https://openalex.org/W2042195518","https://openalex.org/W2042274919","https://openalex.org/W2042379312","https://openalex.org/W2042717034","https://openalex.org/W2043179564","https://openalex.org/W2043617798","https://openalex.org/W2044230889","https://openalex.org/W2044981704","https://openalex.org/W2045431166","https://openalex.org/W2045497115","https://openalex.org/W2046540215","https://openalex.org/W2048130120","https://openalex.org/W2048766756","https://openalex.org/W2048814892","https://openalex.org/W2049420248","https://openalex.org/W2050443213","https://openalex.org/W2050551315","https://openalex.org/W2051084778","https://openalex.org/W2051395367","https://openalex.org/W2051432193","https://openalex.org/W2052069766","https://openalex.org/W2052217916","https://openalex.org/W2052853635","https://openalex.org/W2053487364","https://openalex.org/W2054526986","https://openalex.org/W2054566340","https://openalex.org/W2055121607","https://openalex.org/W2055667796","https://openalex.org/W2056025481","https://openalex.org/W2056063805","https://openalex.org/W2056313547","https://openalex.org/W2056374170","https://openalex.org/W2056857556","https://openalex.org/W2057487100","https://openalex.org/W2057520074","https://openalex.org/W2057628589","https://openalex.org/W2058109041","https://openalex.org/W2059309243","https://openalex.org/W2059965406","https://openalex.org/W2060699509","https://openalex.org/W2061264676","https://openalex.org/W2061298493","https://openalex.org/W2061342234","https://openalex.org/W2063175209","https://openalex.org/W2064338289","https://openalex.org/W2066168019","https://openalex.org/W2066932409","https://openalex.org/W2068482929","https://openalex.org/W2068976530","https://openalex.org/W2069400645","https://openalex.org/W2070584671","https://openalex.org/W2071213192","https://openalex.org/W2072926617","https://openalex.org/W2073174042","https://openalex.org/W2075361934","https://openalex.org/W2075876062","https://openalex.org/W2077122729","https://openalex.org/W2077435537","https://openalex.org/W2077471914","https://openalex.org/W2077776173","https://openalex.org/W2079762354","https://openalex.org/W2079793974","https://openalex.org/W2080155677","https://openalex.org/W2080313800","https://openalex.org/W2080633827","https://openalex.org/W2080934825","https://openalex.org/W2081047481","https://openalex.org/W2082469108","https://openalex.org/W2082470605","https://openalex.org/W2082490296","https://openalex.org/W2083695657","https://openalex.org/W2084060660","https://openalex.org/W2084096897","https://openalex.org/W2085037886","https://openalex.org/W2085273994","https://openalex.org/W2085530783","https://openalex.org/W2086684841","https://openalex.org/W2088161712","https://openalex.org/W2088262395","https://openalex.org/W2088793021","https://openalex.org/W2088912287","https://openalex.org/W2088985332","https://openalex.org/W2091343209","https://openalex.org/W2091908180","https://openalex.org/W2093022545","https://openalex.org/W2093477633","https://openalex.org/W2093658250","https://openalex.org/W2094164804","https://openalex.org/W2096396515","https://openalex.org/W2096592089","https://openalex.org/W2096613113","https://openalex.org/W2096741239","https://openalex.org/W2097045992","https://openalex.org/W2097459689","https://openalex.org/W2098407672","https://openalex.org/W2099018685","https://openalex.org/W2099816146","https://openalex.org/W2099949778","https://openalex.org/W2100013751","https://openalex.org/W2100438302","https://openalex.org/W2101013409","https://openalex.org/W2102200664","https://openalex.org/W2102323685","https://openalex.org/W2103839002","https://openalex.org/W2105202319","https://openalex.org/W2105280572","https://openalex.org/W2105452080","https://openalex.org/W2105528812","https://openalex.org/W2110358620","https://openalex.org/W2110534885","https://openalex.org/W2111116475","https://openalex.org/W2111580310","https://openalex.org/W2113594370","https://openalex.org/W2114918609","https://openalex.org/W2115205812","https://openalex.org/W2116404635","https://openalex.org/W2116951446","https://openalex.org/W2116954627","https://openalex.org/W2117029515","https://openalex.org/W2117449859","https://openalex.org/W2118185015","https://openalex.org/W2118740391","https://openalex.org/W2118808586","https://openalex.org/W2121039111","https://openalex.org/W2122535871","https://openalex.org/W2124027170","https://openalex.org/W2124998768","https://openalex.org/W2127394252","https://openalex.org/W2129803440","https://openalex.org/W2129843256","https://openalex.org/W2130191536","https://openalex.org/W2131097801","https://openalex.org/W2131437696","https://openalex.org/W2131499646","https://openalex.org/W2132480056","https://openalex.org/W2132703716","https://openalex.org/W2132929868","https://openalex.org/W2133107935","https://openalex.org/W2133319949","https://openalex.org/W2133569747","https://openalex.org/W2136008443","https://openalex.org/W2136781825","https://openalex.org/W2137122673","https://openalex.org/W2137241623","https://openalex.org/W2138009367","https://openalex.org/W2138127178","https://openalex.org/W2138136105","https://openalex.org/W2138149556","https://openalex.org/W2138861499","https://openalex.org/W2143546229","https://openalex.org/W2143843694","https://openalex.org/W2146217294","https://openalex.org/W2147309521","https://openalex.org/W2148291059","https://openalex.org/W2149684302","https://openalex.org/W2151104149","https://openalex.org/W2151126528","https://openalex.org/W2151404647","https://openalex.org/W2151625241","https://openalex.org/W2151942667","https://openalex.org/W2154718824","https://openalex.org/W2156945415","https://openalex.org/W2158009878","https://openalex.org/W2159389717","https://openalex.org/W2160154880","https://openalex.org/W2160582900","https://openalex.org/W2160606731","https://openalex.org/W2161361673","https://openalex.org/W2162171562","https://openalex.org/W2162184782","https://openalex.org/W2162478231","https://openalex.org/W2162690000","https://openalex.org/W2162778581","https://openalex.org/W2164229282","https://openalex.org/W2164258188","https://openalex.org/W2166660871","https://openalex.org/W2167558147","https://openalex.org/W2169063473","https://openalex.org/W2170901098","https://openalex.org/W2171757104","https://openalex.org/W2189144032","https://openalex.org/W2231807690","https://openalex.org/W2294709860","https://openalex.org/W2321914176","https://openalex.org/W2322029934","https://openalex.org/W2346429022","https://openalex.org/W2460971768","https://openalex.org/W2792583460","https://openalex.org/W3216995939","https://openalex.org/W4252073970","https://openalex.org/W4406059073"],"related_works":["https://openalex.org/W2073174042","https://openalex.org/W2055036461","https://openalex.org/W1998758194","https://openalex.org/W2290277395","https://openalex.org/W2021690131","https://openalex.org/W2156730370","https://openalex.org/W7008546306","https://openalex.org/W134270384","https://openalex.org/W2039962464","https://openalex.org/W2049420248"],"abstract_inverted_index":{"Sub-lethal":[0],"preconditioning":[1,68,110,140],"stimuli":[2],"can":[3],"confer":[4],"neuronal":[5,47,56,75,118,122,204,259,269],"tolerance":[6,57,270],"by":[7],"triggering":[8],"the":[9,31,53,87,109,113,153,171,187,220,233,291],"activation":[10,33],"of":[11,34,86,152,174,186,293],"endogenous":[12],"survival":[13,294],"pathways":[14,295],"that":[15,25,55,67,127,254],"limit":[16],"or":[17],"resist":[18],"subsequent":[19,100,135],"injury.":[20],"Recent":[21],"evidence":[22],"has":[23,42],"demonstrated":[24],"neuroprotection":[26],"is":[27,58,262,282],"paradoxically":[28],"dependent":[29,60],"on":[30,61],"sub-lethal":[32,62,90],"cell":[35,48,137],"death":[36,49],"mediators.":[37],"As":[38],"intracellular":[39,172],"Zn2+":[40,63,93,107,119,129,197,212,235,261,281],"accumulation":[41,85,116],"been":[43],"closely":[44],"associated":[45],"with":[46],"pathways,":[50],"I":[51,65,227],"tested":[52],"hypothesis":[54],"also":[59,215],"signals.":[64],"found":[66,228],"triggered":[69,141],"an":[70,263],"immediate":[71],"transient":[72,234,256],"rise":[73,91,236,257],"in":[74,92,98,103,117,149,156,168,195,218,237,240,258,267,272,290,296],"free":[76,260],"Zn2+,":[77],"while":[78],"lethal":[79,114],"excitotoxicity":[80],"led":[81],"to":[82,208,224,278],"a":[83,162,229,255,283],"delayed":[84],"metal.":[88],"The":[89],"was":[94,181,193],"necessary":[95],"and":[96,120,201,245,271],"sufficient":[97],"attenuating":[99],"Zn2+-dependent":[101,136],"toxicity":[102],"preconditioned":[104],"neurons.":[105,150,297],"Chelating":[106],"during":[108],"stimulus":[111],"restored":[112],"excitotoxic":[115],"abolished":[121],"tolerance.":[123,205],"These":[124],"data":[125,251],"suggested":[126],"preconditioning-induced":[128],"could":[130],"trigger":[131],"mechanisms":[132],"for":[133,166,232],"preventing":[134],"death.":[138],"Indeed,":[139],"protein":[142,190],"kinase":[143],"C":[144],"(PKC)-dependent":[145],"Zn2+-regulated":[146,158],"gene":[147,159,199,210],"expression":[148,160,200],"Examination":[151],"mechanism":[154],"involved":[155],"modulating":[157,196,209,238],"revealed":[161],"surprisingly":[163],"early":[164,265],"role":[165,231],"PKC":[167,178],"directly":[169],"modifying":[170],"source":[173],"Zn2+.":[175],"A":[176],"conserved":[177],"phosphorylation":[179],"site":[180],"identified":[182],"at":[183],"serine":[184],"32":[185],"metal":[188],"binding":[189],"metallothionein,":[191],"which":[192],"important":[194,217,264],"regulated":[198,287],"ultimately":[202],"conferring":[203,268],"In":[206],"addition":[207],"expression,":[211],"signals":[213],"may":[214],"be":[216],"mediating":[219,273],"acute":[221,274],"cellular":[222,275],"response":[223],"stress.":[225,279],"Here,":[226],"critical":[230],"changes":[239],"voltage-gated":[241],"potassium":[242],"channel":[243],"activity":[244],"localization":[246],"following":[247],"ischemia.":[248],"Together,":[249],"these":[250],"strongly":[252],"suggest":[253],"signal":[266],"adaptive":[276],"responses":[277],"Thus,":[280],"previously":[284],"unrecognized,":[285],"highly":[286],"signaling":[288],"component":[289],"initiation":[292]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
