{"id":"https://openalex.org/W1536630937","doi":null,"title":"Evaluation of the effects of galbanic acid from Ferula szowitsiana and conferol from F. badrakema, as modulators of multi-drug resistance in clinical isolates of Escherichia coli and Staphylococcus aureus.","display_name":"Evaluation of the effects of galbanic acid from Ferula szowitsiana and conferol from F. badrakema, as modulators of multi-drug resistance in clinical isolates of Escherichia coli and Staphylococcus aureus.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1536630937","mag":"1536630937","pmid":"https://pubmed.ncbi.nlm.nih.gov/21589765","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3093094"},"language":"en","primary_location":{"id":"pmid:21589765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21589765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in pharmaceutical sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3093094/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020639473","display_name":"Bibi Sedigheh Fazly Bazzaz","orcid":"https://orcid.org/0000-0001-7857-1493","observed_orcids":["https://orcid.org/0000-0001-7857-1493"]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"B S Fazly Bazzaz","raw_affiliation_strings":["Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I.R.Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I.R.Iran","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032595344","display_name":"Mehrdad Iranshahi","orcid":"https://orcid.org/0000-0002-3018-5750","observed_orcids":["https://orcid.org/0000-0002-3018-5750"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Iranshahi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111576154","display_name":"M Naderinasab","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Naderinasab","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084183408","display_name":"Sobhan Hajian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Hajian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113491867","display_name":"Zahra Sabeti","orcid":"https://orcid.org/0000-0003-3079-1088","observed_orcids":["https://orcid.org/0000-0003-3079-1088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z Sabeti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086005133","display_name":"E Masumi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Masumi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3607,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.62584898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"1","first_page":"21","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.4424000084400177,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.4424000084400177,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.32499998807907104,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.16990000009536743,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galbanic-acid","display_name":"galbanic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ferula-szowitsiana","display_name":"Ferula szowitsiana","score":0.9800000190734863},{"id":"https://openalex.org/keywords/sesquiterpene-coumarins","display_name":"sesquiterpene coumarins","score":0.9800000190734863},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7829999923706055},{"id":"https://openalex.org/keywords/efflux-pump-inhibition","display_name":"efflux pump inhibition","score":0.7739999890327454},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9620000123977661},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ciprofloxacin","display_name":"ciprofloxacin","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":1.0},{"id":"https://openalex.org/keywords/ethidium-bromide","display_name":"ethidium bromide","score":0.8600000143051147},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":0.7860000133514404},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.8180000185966492},{"id":"https://openalex.org/keywords/subinhibitory-concentrations","display_name":"subinhibitory concentrations","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.955322802066803},{"id":"https://openalex.org/C2776907736","wikidata":"https://www.wikidata.org/wiki/Q408634","display_name":"Ethidium bromide","level":3,"score":0.8547788858413696},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6571105122566223},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.6558728218078613},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6437375545501709},{"id":"https://openalex.org/C2780923616","wikidata":"https://www.wikidata.org/wiki/Q193045","display_name":"Tetracycline","level":3,"score":0.5259369015693665},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.5045908689498901},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4970681965351105},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.4885185956954956},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.48313042521476746},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4446811079978943},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.4119483232498169},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4111328125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34727466106414795},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:21589765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21589765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in pharmaceutical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3093094","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3093094/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Res Pharm Sci","raw_type":"Text"},{"id":"mag:1536630937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21589765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3093094","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3093094/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Res Pharm Sci","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1974741835","https://openalex.org/W1993279122","https://openalex.org/W2008798208","https://openalex.org/W2010033479","https://openalex.org/W2015884448","https://openalex.org/W2063328772","https://openalex.org/W2067096136","https://openalex.org/W2091498869","https://openalex.org/W2100406929","https://openalex.org/W2101021971","https://openalex.org/W2112586763","https://openalex.org/W2121319673","https://openalex.org/W2122848035","https://openalex.org/W2127533658","https://openalex.org/W2128834033","https://openalex.org/W2132963724","https://openalex.org/W2142123742","https://openalex.org/W2142826460","https://openalex.org/W2159355055","https://openalex.org/W2165615238","https://openalex.org/W2165861026","https://openalex.org/W2951739923"],"related_works":["https://openalex.org/W2122848035","https://openalex.org/W7095840240","https://openalex.org/W2100406929","https://openalex.org/W7097704895","https://openalex.org/W2063328772","https://openalex.org/W4304890542","https://openalex.org/W2279691529","https://openalex.org/W7216733094","https://openalex.org/W2014547584","https://openalex.org/W2087601544"],"abstract_inverted_index":{"Galbanic":[0,100],"acid,":[1],"a":[2,158],"sesquiterpene":[3,11],"coumarin":[4,12],"from":[5,13],"Ferula":[6],"szowitsiana,":[7],"and":[8,33,66,76,176],"conferol,":[9],"another":[10,132],"F.":[14],"badrakema,":[15],"were":[16,68],"evaluated":[17],"for":[18,138],"their":[19],"effects":[20],"on":[21,108,150],"the":[22,74,98,119,151,164,191,204],"reversal":[23],"of":[24,30,64,78,81,97,111,122,148,168,180,190],"multi-drug":[25],"resistance":[26,139,169,192],"in":[27,73,95,140,194,212],"clinical":[28],"isolates":[29],"Staphylococcus":[31],"aureus":[32,197],"Escherichia":[34],"coli,":[35],"respectively.":[36],"Neither":[37],"galbanic":[38,82],"acid":[39,83,101],"(up":[40,46],"to":[41,47,118,128,170],"1000":[42],"\u03bcg/ml)":[43,49,85],"nor":[44],"conferol":[45,87,149],"400":[48],"by":[50,208],"itself":[51],"shows":[52],"any":[53,105],"antibacterial":[54],"activities":[55],"against":[56],"tested":[57,141,195],"strains.":[58,144,198],"The":[59],"minimum":[60],"inhibitory":[61,106,146],"concentrations":[62,80],"(MICs)":[63],"ciprofloxacin":[65],"tetracycline":[67],"determined":[69],"using":[70],"macrodilution":[71],"technique":[72],"presence":[75],"absence":[77],"sub-inhibitory":[79],"(31.25-1000":[84],"or":[86,131],"(50-400":[88],"\u03bcg/ml),":[89],"however":[90],"they":[91],"caused":[92],"no":[93],"change":[94],"MICs":[96],"antibiotics.":[99],"did":[102,201],"not":[103,202],"show":[104],"effect":[107,147],"efflux":[109,136,152,162,174,183,210],"phenomenon":[110],"E.":[112,142],"coli.":[113],"This":[114],"can":[115,185],"be":[116,186],"related":[117],"outer":[120],"membrane":[121],"gram-negative":[123],"bacteria":[124],"which":[125],"is":[126,163],"impermeable":[127],"lipophilic":[129],"compounds":[130],"mechanism":[133,167,184],"rather":[134],"than":[135],"responsible":[137],"coli":[143],"An":[145],"was":[153],"compared":[154],"with":[155],"verapamil":[156,177],"as":[157,188],"positive":[159],"control.":[160],"Because":[161],"only":[165],"known":[166],"ethidium":[171,181],"bromide":[172],"(model":[173],"substrate)":[175],"reduced":[178],"MIC":[179],"bromide,":[182],"considered":[187],"one":[189],"mechanisms":[193],"S.":[196],"Conferol,":[199],"however,":[200],"enhance":[203],"antibiotic":[205],"efficacy":[206],"mediated":[207],"inhibiting":[209],"pumps":[211],"bacteria.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}