{"id":"https://openalex.org/W1536623713","doi":"https://doi.org/10.1186/cc2004","title":"Usefulness of double luminal drain with continuous high-pressure aspiration for draining mucinous discharge in abdominal sepsis: prevention of worsening of local inflammation until definitive surgery","display_name":"Usefulness of double luminal drain with continuous high-pressure aspiration for draining mucinous discharge in abdominal sepsis: prevention of worsening of local inflammation until definitive surgery","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1536623713","doi":"https://doi.org/10.1186/cc2004","mag":"1536623713","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3301560"},"language":"en","primary_location":{"id":"doi:10.1186/cc2004","doi":"https://doi.org/10.1186/cc2004","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc2004","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc2004","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc2004","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034025448","display_name":"Matsukuma Yoshihiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Yoshihiro","raw_affiliation_strings":["Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082227401","display_name":"Mikiko Sugiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Sugiyama","raw_affiliation_strings":["Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101588978","display_name":"Keiji Uchida","orcid":"https://orcid.org/0000-0002-8469-2870","observed_orcids":["https://orcid.org/0000-0002-8469-2870"]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Uchida","raw_affiliation_strings":["Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109282833","display_name":"Hiroshi Toyoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Toyoda","raw_affiliation_strings":["Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Tomita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Tomita","raw_affiliation_strings":["Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088363151","display_name":"Kouji Yoshida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Yoshida","raw_affiliation_strings":["Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112157157","display_name":"Shigeru Yamagishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Yamagishi","raw_affiliation_strings":["Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113464779","display_name":"Koji Kanaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Kanaya","raw_affiliation_strings":["Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110438426","display_name":"TATSUFUMI KOSUGE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Kosuge","raw_affiliation_strings":["Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003587073","display_name":"Toshiro Yamamoto","orcid":"https://orcid.org/0000-0001-9797-1556","observed_orcids":["https://orcid.org/0000-0001-9797-1556"]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Yamamoto","raw_affiliation_strings":["Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866"]}]},{"author_position":"last","author":{"id":null,"display_name":"N Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Suzuki","raw_affiliation_strings":["Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care and Emergency Centre, Yokohama City University Medical Centre, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802180866"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"Suppl 2","first_page":"P115","last_page":"P115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12333","display_name":"Abdominal Surgery and Complications","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12333","display_name":"Abdominal Surgery and Complications","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intra-abdominal-sepsis","display_name":"abdominal sepsis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/local-inflammation","display_name":"local inflammation","score":0.5070000290870667},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.6499999761581421},{"id":"https://openalex.org/keywords/pituitary-dysfunction","display_name":"pituitary dysfunction","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hypogonadism","display_name":"hypogonadism","score":0.8519999980926514},{"id":"https://openalex.org/keywords/growth-hormone-deficiency","display_name":"growth hormone deficiency","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.7699999809265137},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8806525468826294},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.33964836597442627}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/cc2004","doi":"https://doi.org/10.1186/cc2004","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc2004","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc2004","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3301560","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3301560/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crit Care","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/cc2004","doi":"https://doi.org/10.1186/cc2004","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc2004","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc2004","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1536623713.pdf","grobid_xml":"https://content.openalex.org/works/W1536623713.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W43208304","https://openalex.org/W96839666","https://openalex.org/W205939220","https://openalex.org/W251366448","https://openalex.org/W316710720","https://openalex.org/W1493706936","https://openalex.org/W1526805624","https://openalex.org/W1548200273","https://openalex.org/W1559115431","https://openalex.org/W1572931240","https://openalex.org/W1576908618","https://openalex.org/W1576966672","https://openalex.org/W1592625810","https://openalex.org/W1596054581","https://openalex.org/W1596253636","https://openalex.org/W1596785397","https://openalex.org/W1602885769","https://openalex.org/W1605327504","https://openalex.org/W1608840548","https://openalex.org/W1660168429","https://openalex.org/W1967069359","https://openalex.org/W1968590837","https://openalex.org/W1986475921","https://openalex.org/W1994143830","https://openalex.org/W1996702729","https://openalex.org/W1997605256","https://openalex.org/W1998797443","https://openalex.org/W2008157912","https://openalex.org/W2008261942","https://openalex.org/W2010904472","https://openalex.org/W2018022364","https://openalex.org/W2020446261","https://openalex.org/W2020492980","https://openalex.org/W2025801705","https://openalex.org/W2027586945","https://openalex.org/W2034727456","https://openalex.org/W2035917666","https://openalex.org/W2039313192","https://openalex.org/W2041279543","https://openalex.org/W2042785780","https://openalex.org/W2044595431","https://openalex.org/W2048249523","https://openalex.org/W2057567574","https://openalex.org/W2058166338","https://openalex.org/W2058582189","https://openalex.org/W2066446873","https://openalex.org/W2068977670","https://openalex.org/W2070247267","https://openalex.org/W2070441271","https://openalex.org/W2082513868","https://openalex.org/W2086549762","https://openalex.org/W2089023472","https://openalex.org/W2091277295","https://openalex.org/W2091326259","https://openalex.org/W2092640719","https://openalex.org/W2093134398","https://openalex.org/W2093890705","https://openalex.org/W2093970188","https://openalex.org/W2097035185","https://openalex.org/W2097431335","https://openalex.org/W2100322726","https://openalex.org/W2101879890","https://openalex.org/W2101950940","https://openalex.org/W2102372841","https://openalex.org/W2110561675","https://openalex.org/W2115058538","https://openalex.org/W2116612251","https://openalex.org/W2139167898","https://openalex.org/W2143872077","https://openalex.org/W2157385670","https://openalex.org/W2166281097","https://openalex.org/W2169250915","https://openalex.org/W2253598100","https://openalex.org/W2322121630","https://openalex.org/W2419291948","https://openalex.org/W2535832570","https://openalex.org/W2599527603","https://openalex.org/W2737680193","https://openalex.org/W2939634163","https://openalex.org/W4232042530","https://openalex.org/W4242838047"],"related_works":["https://openalex.org/W1481229842","https://openalex.org/W1586710125","https://openalex.org/W1681625358","https://openalex.org/W1603711701","https://openalex.org/W1492915449","https://openalex.org/W1850715318","https://openalex.org/W1536872489","https://openalex.org/W1524990505","https://openalex.org/W1590878151","https://openalex.org/W1535490505"],"abstract_inverted_index":{"Studies":[0],"on":[1],"head":[2,35,254],"injury-induced":[3],"pituitary":[4],"dysfunction":[5],"are":[6,270],"limited":[7],"in":[8,48,64,88,92,170,205,244,256],"number":[9],"and":[10,61,96,100,116,193,226,264,279],"conflicting":[11],"results":[12,235],"have":[13],"been":[14],"reported.To":[15],"further":[16],"clarify":[17],"this":[18],"issue,":[19],"29":[20,209],"consecutive":[21],"patients":[22,53,210,228,249],"(24":[23],"males),":[24],"with":[25,108,150,199,250,261],"severe":[26,253],"(n":[27,32],"=":[28,33],"21)":[29],"or":[30,153,161,177,190,252],"moderate":[31,251],"8)":[34],"trauma,":[36],"having":[37],"a":[38,68,143,151,184,238],"mean":[39],"age":[40],"of":[41,78,173,207,241,248,276],"37":[42],"\u00b1":[43],"17":[44],"years":[45],"were":[46,62,103,164,181,203],"investigated":[47],"the":[49,65,166,171,208,257,274],"immediate":[50,258],"post-trauma":[51,259],"period.All":[52],"required":[54,271],"mechanical":[55],"ventilatory":[56],"support":[57],"for":[58],"8-55":[59],"days":[60,70],"enrolled":[63],"study":[66],"within":[67],"few":[69],"before":[71],"ICU":[72],"discharge.Basal":[73],"hormonal":[74],"assessment":[75],"included":[76],"measurement":[77],"cortisol,":[79],"corticotropin,":[80],"free":[81],"thyroxine":[82],"(fT4),":[83],"thyrotropin":[84],"(TSH),":[85],"testosterone":[86],"(T)":[87],"men,":[89],"estradiol":[90],"(E2)":[91],"women,":[93],"prolactin":[94],"(PRL),":[95],"growth":[97,119],"hormone":[98,114,120,122],"(GH).Cortisol":[99],"GH":[101,179,186,232],"levels":[102],"measured":[104],"also":[105],"after":[106,197],"stimulation":[107,198],"100":[109,117],"\u00b5g":[110,118],"human":[111],"corticotropin":[112],"releasing":[113,121],"(hCRH)":[115],"(GHRH),":[123],"respectively.Cortisol":[124],"hyporesponsiveness":[125,263],"was":[126,132,140,148,156],"considered":[127,157],"when":[128,142,158],"peak":[129,185],"cortisol":[130,220,262],"concentration":[131],"less":[133],"than":[134,246],"20":[135],"\u00b5g/dl":[136],"following":[137],"hCRH.TSH":[138],"deficiency":[139],"diagnosed":[141],"subnormal":[144,201],"serum":[145],"fT4":[146],"level":[147],"associated":[149],"normal":[152,174],"low":[154],"TSH.Hypogonadism":[155],"T":[159],"(males)":[160],"E2":[162],"(women)":[163],"below":[165,187],"local":[167],"reference":[168],"ranges,":[169],"presence":[172],"PRL":[175],"levels.Severe":[176],"partial":[178,231],"deficiencies":[180],"defined":[182],"as":[183],"3":[188,192],"\u00b5g/l":[189],"between":[191],"5":[194],"\u00b5g/l,":[195],"respectively,":[196],"GHRH.Twenty-one":[200],"responses":[202],"found":[204],"15":[206],"(52%)":[211],"tested;":[212],"seven":[213,217],"(24%)":[214,218],"had":[215,219,224,230],"hypogonadism,":[216],"hyporesponsiveness,":[221],"five":[222],"(17%)":[223],"hypothyroidism,":[225],"two":[227],"(7%)":[229],"deficiency.These":[233],"preliminary":[234],"suggest":[236],"that":[237],"certain":[239],"degree":[240],"hypopituitarism":[242],"occurs":[243],"more":[245],"50%":[247],"injury":[255],"period,":[260],"hypogonadism":[265],"being":[266],"most":[267],"common.Further":[268],"studies":[269],"to":[272,280],"elucidate":[273],"pathogenesis":[275],"these":[277],"abnormalities":[278],"investigate":[281],"whether":[282],"they":[283],"affect":[284],"long-term":[285],"morbidity.":[286]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}