{"id":"https://openalex.org/W1536623641","doi":null,"title":"Studies on the induction and expression of T cell-mediated immunity. II. Antiserum blocking of cell-mediated cytolysis.","display_name":"Studies on the induction and expression of T cell-mediated immunity. II. Antiserum blocking of cell-mediated cytolysis.","publication_year":1974,"publication_date":"1974-04-01","ids":{"openalex":"https://openalex.org/W1536623641","mag":"1536623641","pmid":"https://pubmed.ncbi.nlm.nih.gov/4592598"},"language":"en","primary_location":{"id":"pmid:4592598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4592598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055490703","display_name":"Benjamin Bonavida","orcid":"https://orcid.org/0000-0001-5594-2060","observed_orcids":["https://orcid.org/0000-0001-5594-2060"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"B Bonavida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055490703"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8423,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.83011218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"112","issue":"4","first_page":"1308","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-mediated-cytotoxicity","display_name":"T cell cytotoxicity","score":0.9020000100135803},{"id":"https://openalex.org/keywords/alloantiserum","display_name":"alloantiserum","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8080000281333923},{"id":"https://openalex.org/keywords/h-2-antigens","display_name":"H-2 antigens","score":0.6499999761581421},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.7739999890327454},{"id":"https://openalex.org/keywords/complement-mediated-cell-lysis","display_name":"complement-mediated lysis","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.8061577677726746},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.7839521169662476},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7413935661315918},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5798481702804565},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5009753704071045},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.4876762628555298},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45527026057243347},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.4325270354747772},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.42483651638031006},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39069807529449463},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.31351765990257263},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28427654504776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15286681056022644}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000961","descriptor_name":"Antilymphocyte Serum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002860","descriptor_name":"Chromium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003601","descriptor_name":"Cytotoxicity Tests, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007158","descriptor_name":"Immunologic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011828","descriptor_name":"Radiation Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4592598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4592598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Comparative Study"},{"id":"mag:1536623641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4592598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5799999833106995}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4321829472","https://openalex.org/W1928628906","https://openalex.org/W2099908616","https://openalex.org/W1892787361","https://openalex.org/W2143344455","https://openalex.org/W1535500846","https://openalex.org/W1997631092","https://openalex.org/W1498099821","https://openalex.org/W1988562153","https://openalex.org/W2094228017"],"abstract_inverted_index":{"Purified":[0],"thymus-derived":[1],"(T)":[2],"cytotoxic":[3,197],"lymphocytes":[4,45,91],"were":[5,65,77,92,230],"inhibited":[6],"from":[7,171],"mediating":[8],"cytolysis":[9],"of":[10,24,111,150,162,165,218,227,249,259,270],"51":[12],"Cr-labeled":[13],"target":[14,21,68,84,101,118,153,173,187,271],"cells":[15,64,85,154,167,174,188,272],"by":[16,140,182],"alloantiserum":[17],"directed":[18],"against":[19,37],"the":[20,74,90,95,100,109,163,179,192,196,242,247,250,257,281],"cell.":[22],"Sensitization":[23],"BALB/c":[25],"(H-2":[26,41,60],"d":[27],")":[28,43,62],"thymocytes":[29],"was":[30,80,87,106,114,129,135,145,157,199,213,222,239,244],"obtained":[31,81,170,223,240],"in":[32,47,126,233],"one":[33],"way-mixed":[34],"lymphocyte":[35],"cultures":[36],"mitomycin":[38],"C-treated":[39],"C57BL/6":[40,54],"b":[42,61],"spleen":[44],"and":[46,156,215],"vivo":[48],"after":[49,275],"injection":[50],"into":[51],"lethally":[52],"irradiated":[53],"mice":[55],"(educated":[56],"T":[57],"cells).":[58],"EL-4":[59],"tumor":[63],"used":[66],"as":[67],"cells.":[69,102,194],"Several":[70],"criteria":[71],"for":[72,201],"optimizing":[73],"blocking":[75,104,133,143,211,238,263],"effect":[76,144],"investigated.":[78],"Blocking":[79],"with":[82,94,99,147,185,191,224],"antibody-coated":[83,172],"but":[86,189],"absent":[88],"when":[89,241],"pretreated":[93],"antiserum":[96,181,228,243,260],"before":[97,280],"admixing":[98],"The":[103,142],"activity":[105,212],"dependent":[107],"on":[108,116],"concentration":[110,128,164],"antiserum.":[112],"It":[113],"estimated":[115],"a":[117],"cell":[119,277],"basis":[120],"that":[121,268],"50-":[122],"to":[123,131,137,152,159],"200-fold":[124],"increase":[125],"antibody":[127],"required":[130],"mediate":[132],"than":[134],"necessary":[136],"induce":[138],"lysis":[139],"complement.":[141],"observed":[146],"different":[148],"ratios":[149],"effector":[151,166,193],"(E:T)":[155],"found":[158],"be":[160],"independent":[161],"present.":[168],"Eluates":[169],"behaved":[175],"very":[176],"much":[177],"like":[178],"original":[180],"reacting":[183],"again":[184],"fresh":[186],"not":[190,231],"When":[195],"assay":[198],"run":[200],"shorter":[202],"incubation":[203,235],"periods":[204],"(90":[205],"min":[206,254],"vs":[207],"180":[208],"min),":[209],"more":[210],"detected,":[214],"significant":[216],"inhibition":[217],"cell-mediated":[219],"cytotoxicity":[220],"(CMC)":[221],"high":[225],"dilutions":[226],"which":[229],"inhibitory":[232],"longer":[234],"periods.":[236],"Maximum":[237],"present":[245],"at":[246,252],"beginning":[248],"assay;":[251],"30":[253],"or":[255],"after,":[256],"addition":[258],"had":[261],"no":[262],"effect.":[264],"These":[265],"results":[266],"demonstrated":[267],"damage":[269],"occurs":[273],"rapidly":[274],"effector-target":[276],"interaction":[278],"long":[279],"radioactive":[282],"chromium":[283],"marker":[284],"is":[285],"released.":[286]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}