{"id":"https://openalex.org/W1536617201","doi":"https://doi.org/10.33588/rn.4201.2005322","title":"Enfermedad de Alzheimer y evoluci\u00f3n cerebral: \u00bfes la enfermedad de Alzheimer un ejemplo de pleiotrop\u00eda antag\u00f3nica?","display_name":"Enfermedad de Alzheimer y evoluci\u00f3n cerebral: \u00bfes la enfermedad de Alzheimer un ejemplo de pleiotrop\u00eda antag\u00f3nica?","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W1536617201","doi":"https://doi.org/10.33588/rn.4201.2005322","mag":"1536617201","pmid":"https://pubmed.ncbi.nlm.nih.gov/16402323"},"language":"es","primary_location":{"id":"doi:10.33588/rn.4201.2005322","doi":"https://doi.org/10.33588/rn.4201.2005322","is_oa":false,"landing_page_url":"https://doi.org/10.33588/rn.4201.2005322","pdf_url":null,"source":{"id":"https://openalex.org/S184263677","display_name":"Revista de Neurolog\u00eda","issn_l":"0210-0010","issn":["0210-0010","1576-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4322632785","host_organization_name":"Viguera Publishers","host_organization_lineage":["https://openalex.org/P4322632785"],"host_organization_lineage_names":["Viguera Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de Neurolog\u00eda","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016065339","display_name":"Enric Bufill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enric Bufill Soler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101610180","display_name":"Rafael Blesa","orcid":"https://orcid.org/0000-0003-4026-2884","observed_orcids":["https://orcid.org/0000-0003-4026-2884"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rafael Blesa Gonz\u00e1lez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2323,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.45355362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"42","issue":"01","first_page":"25","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/antagonistic-pleiotropy","display_name":"antagonistic pleiotropy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/human-brain-evolution","display_name":"human brain evolution","score":0.9269999861717224},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/axonal-transport","display_name":"axonal transport","score":0.9399999976158142},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8169999718666077},{"id":"https://openalex.org/keywords/electron-transport-chain","display_name":"electron transport chain","score":0.7580000162124634},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.9350000023841858},{"id":"https://openalex.org/keywords/animal-fat-intake","display_name":"animal fat intake","score":0.8370000123977661},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6320000290870667},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.4580000042915344},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.7798324823379517},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37788721919059753},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.3162074089050293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24199289083480835}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.33588/rn.4201.2005322","doi":"https://doi.org/10.33588/rn.4201.2005322","is_oa":false,"landing_page_url":"https://doi.org/10.33588/rn.4201.2005322","pdf_url":null,"source":{"id":"https://openalex.org/S184263677","display_name":"Revista de Neurolog\u00eda","issn_l":"0210-0010","issn":["0210-0010","1576-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4322632785","host_organization_name":"Viguera Publishers","host_organization_lineage":["https://openalex.org/P4322632785"],"host_organization_lineage_names":["Viguera Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de Neurolog\u00eda","raw_type":"journal-article"},{"id":"pmid:16402323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16402323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de neurologia","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2573326435","https://openalex.org/W169833192","https://openalex.org/W1554922261","https://openalex.org/W7026926704","https://openalex.org/W6981725154","https://openalex.org/W7220677550","https://openalex.org/W7162639157","https://openalex.org/W3192648521","https://openalex.org/W4294896193","https://openalex.org/W7028768903"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Alzheimer's":[1],"disease":[2,17],"(AD)":[3],"appears":[4],"to":[5,8,41,51,80,96,103,106,183,208],"be":[6,209],"exclusive":[7],"our":[9],"species.":[10],"This":[11],"suggests":[12],"a":[13,70,125,180],"relationship":[14],"between":[15],"the":[16,29,32,55,85,134,152,168,175,195],"and":[18,21,48,59,132,178],"genetic,":[19],"functional":[20],"structural":[22],"changes":[23],"that":[24,64,87,139],"have":[25,52],"taken":[26],"place":[27],"throughout":[28,69],"evolution":[30],"of":[31,38,75,83,115,124,127,137,142,147,151,163,170,192,198],"human":[33,56],"brain.":[34],"DEVELOPMENT:":[35],"The":[36],"expression":[37,197],"genes":[39,94,119,149,200],"linked":[40],"neurotransmission,":[42],"neuroplasticity,":[43],"axonal":[44,130],"transport,":[45],"aerobic":[46],"metabolism":[47],"neuroprotection":[49],"seems":[50],"increased":[53,97,196],"within":[54],"cerebral":[57],"cortex":[58],"such":[60,109,118],"phenomena":[61],"represent":[62],"adaptations":[63],"induce":[65],"greater":[66],"neuronal":[67,78,98,176],"activity":[68,99],"long":[71],"lifespan.":[72],"High":[73],"levels":[74],"neuroplasticity":[76],"increase":[77],"vulnerability":[79],"factors":[81,104],"capable":[82],"triggering":[84],"lesions":[86],"are":[88,100],"typically":[89],"found":[90],"in":[91,117,174],"AD.":[92,143,160],"Several":[93],"related":[95,105],"extremely":[101],"vulnerable":[102],"old":[107],"age,":[108],"as":[110],"oxidative":[111,184],"stress.":[112,185],"Some":[113],"kind":[114],"dysfunction":[116],"can":[120],"disrupt":[121],"proper":[122],"regulation":[123],"number":[126],"pathways":[128],"(neuroplasticity,":[129],"transport)":[131],"promote":[133],"abnormal":[135],"accumulation":[136],"peptides":[138],"is":[140],"characteristic":[141],"Possessing":[144],"certain":[145],"polymorphisms":[146],"neuroprotective":[148],"or":[150],"electron":[153],"transport":[154],"chain":[155],"could":[156,166,188,205],"afford":[157],"protection":[158],"against":[159],"Increased":[161],"intake":[162],"animal":[164],"fats":[165],"alter":[167],"balance":[169],"polyunsaturated":[171],"fatty":[172],"acids":[173],"membrane":[177],"favour":[179],"higher":[181],"susceptibility":[182],"CONCLUSIONS:":[186],"AD":[187],"constitute":[189],"an":[190,202,212],"example":[191],"antagonistic":[193],"pleiotropy:":[194],"advantageous":[199],"at":[201,211],"early":[203],"age":[204],"turn":[206],"out":[207],"harmful":[210],"advanced":[213],"age.":[214]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}