{"id":"https://openalex.org/W1536137342","doi":null,"title":"Preclinical evaluation of \"whole\" cell vaccines for prophylaxis and therapy using a disabled infectious single cycle-herpes simplex virus vector to transduce cytokine genes.","display_name":"Preclinical evaluation of \"whole\" cell vaccines for prophylaxis and therapy using a disabled infectious single cycle-herpes simplex virus vector to transduce cytokine genes.","publication_year":2000,"publication_date":"2000-03-15","ids":{"openalex":"https://openalex.org/W1536137342","mag":"1536137342","pmid":"https://pubmed.ncbi.nlm.nih.gov/10749137"},"language":"en","primary_location":{"id":"pmid:10749137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10749137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026424262","display_name":"Samim Ali","orcid":"https://orcid.org/0009-0004-0070-526X","observed_orcids":["https://orcid.org/0009-0004-0070-526X"]},"institutions":[{"id":"https://openalex.org/I52590639","display_name":"Nottingham Trent University","ror":"https://ror.org/04xyxjd90","country_code":"GB","type":"education","lineage":["https://openalex.org/I52590639"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S A Ali","raw_affiliation_strings":["Department of Life Sciences, Nottingham Trent University, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Nottingham Trent University, United Kingdom","institution_ids":["https://openalex.org/I52590639"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090756469","display_name":"Cornelia S. McLean","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C S McLean","raw_affiliation_strings":["Cantab Pharmaceuticals Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cantab Pharmaceuticals Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039098987","display_name":"M. E. G. Boursnell","orcid":"https://orcid.org/0000-0002-2554-8190","observed_orcids":["https://orcid.org/0000-0002-2554-8190"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Boursnell","raw_affiliation_strings":["Cantab Pharmaceuticals Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cantab Pharmaceuticals Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109625999","display_name":"G Mart\u00edn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Martin","raw_affiliation_strings":["Cantab Pharmaceuticals Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cantab Pharmaceuticals Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113491789","display_name":"Chole Holmes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C L Holmes","raw_affiliation_strings":["Cantab Pharmaceuticals Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cantab Pharmaceuticals Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070586395","display_name":"Stephen Reeder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52590639","display_name":"Nottingham Trent University","ror":"https://ror.org/04xyxjd90","country_code":"GB","type":"education","lineage":["https://openalex.org/I52590639"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Reeder","raw_affiliation_strings":["Nottingham Trent University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nottingham Trent University","institution_ids":["https://openalex.org/I52590639"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040151708","display_name":"Claire Entwisle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Entwisle","raw_affiliation_strings":["Cantab Pharmaceuticals Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cantab Pharmaceuticals Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111757736","display_name":"Diane M. Blakeley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D M Blakeley","raw_affiliation_strings":["Cantab Pharmaceuticals Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cantab Pharmaceuticals Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061332920","display_name":"John G. Shields","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J G Shields","raw_affiliation_strings":["Cantab Pharmaceuticals Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cantab Pharmaceuticals Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051618862","display_name":"Stephen M. Todryk","orcid":"https://orcid.org/0000-0003-4566-0793","observed_orcids":["https://orcid.org/0000-0003-4566-0793"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Todryk","raw_affiliation_strings":["IMPERIAL COLLEGE HEALTHCARE NHS TRUST"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMPERIAL COLLEGE HEALTHCARE NHS TRUST","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070554485","display_name":"Richard G. Vile","orcid":"https://orcid.org/0000-0003-2192-9372","observed_orcids":["https://orcid.org/0000-0003-2192-9372"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Vile","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108089910","display_name":"R. A. Robins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137227","display_name":"Queen's Medical Centre","ror":"https://ror.org/03ap6wx93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I4210137227"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R A Robins","raw_affiliation_strings":["Queen's Medical Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen's Medical Centre","institution_ids":["https://openalex.org/I4210137227"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111659155","display_name":"Robert C. Rees","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52590639","display_name":"Nottingham Trent University","ror":"https://ror.org/04xyxjd90","country_code":"GB","type":"education","lineage":["https://openalex.org/I52590639"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R C Rees","raw_affiliation_strings":["Nottingham Trent University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nottingham Trent University","institution_ids":["https://openalex.org/I52590639"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5559,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.81412282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"60","issue":"6","first_page":"1663","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.36550000309944153,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.6380000114440918},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7459999918937683},{"id":"https://openalex.org/keywords/prophylactic-vaccination","display_name":"prophylactic vaccination","score":0.7110000252723694},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.7850000262260437},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9430000185966492},{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/t-cell-dependent-immune-response","display_name":"T cell-dependent immunity","score":0.7149999737739563},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.5460000038146973},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tumor-rejection","display_name":"tumor rejection","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7029432058334351},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.5805037021636963},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.532545268535614},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.49755480885505676},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4902696907520294},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4755420684814453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46365886926651},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.44324925541877747},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43848907947540283},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.43384912610054016},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4331413507461548},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.42838984727859497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42528191208839417},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.40279948711395264},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20699766278266907},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018258","descriptor_name":"Herpesvirus 2, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018258","descriptor_name":"Herpesvirus 2, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10749137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10749137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:irep.ntu.ac.uk:4264","doi":null,"is_oa":false,"landing_page_url":"http://irep.ntu.ac.uk/id/eprint/4264/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400559","display_name":"Nottingham Trent University's Institutional Repository (Nottingham Trent Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52590639","host_organization_name":"Nottingham Trent University","host_organization_lineage":["https://openalex.org/I52590639"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:1536137342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10749137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W232053191","https://openalex.org/W1488558875","https://openalex.org/W1491759514","https://openalex.org/W1598900039","https://openalex.org/W1604517259","https://openalex.org/W1610624614","https://openalex.org/W1646920382","https://openalex.org/W1928896893","https://openalex.org/W1970212185","https://openalex.org/W1989775015","https://openalex.org/W1990668606","https://openalex.org/W1991148746","https://openalex.org/W2002323372","https://openalex.org/W2021612058","https://openalex.org/W2024451340","https://openalex.org/W2041020348","https://openalex.org/W2041534129","https://openalex.org/W2056828274","https://openalex.org/W2059483129","https://openalex.org/W2067375651","https://openalex.org/W2068032204","https://openalex.org/W2075621682","https://openalex.org/W2079439306","https://openalex.org/W2091691801","https://openalex.org/W2092768308","https://openalex.org/W2106047760","https://openalex.org/W2117027356","https://openalex.org/W2136683349","https://openalex.org/W2147701669","https://openalex.org/W2158500407","https://openalex.org/W2164251380","https://openalex.org/W2167965989","https://openalex.org/W2169388007","https://openalex.org/W2261215219","https://openalex.org/W2417625253","https://openalex.org/W4313343489"],"related_works":["https://openalex.org/W65872052","https://openalex.org/W2316646072","https://openalex.org/W2020051788","https://openalex.org/W1936786554","https://openalex.org/W2051204315","https://openalex.org/W2021612058","https://openalex.org/W2001396113","https://openalex.org/W2073147475","https://openalex.org/W2261215219","https://openalex.org/W1970368422"],"abstract_inverted_index":{"The":[0,164],"development":[1],"of":[2,19,57,80,86,88,149,169,214,225,238],"genetically":[3,264],"modified":[4,265],"\"whole\"":[5,204],"tumor":[6,58,81,110,118,123,140,157,192,215,246],"cell":[7,179,205],"vaccines":[8,206,267],"for":[9,268],"cancer":[10],"therapy":[11],"relies":[12],"on":[13],"the":[14,24,63,84,89,144,156,184,194,210,239],"efficient":[15],"transduction":[16],"and":[17,60,83,146,166,183,197,234],"expression":[18,75],"genes":[20,46],"by":[21],"vectors.":[22],"In":[23],"present":[25],"study,":[26],"we":[27],"have":[28],"used":[29,130],"a":[30,54,176],"disabled":[31],"infectious":[32],"single":[33],"cycle-herpes":[34],"simplex":[35],"virus":[36],"2":[37],"(DISC-HSV-2)":[38],"vector":[39,256],"constructed":[40],"to":[41,52,98,117,132,155,161,208,244,259],"express":[42,62],"cytokine":[43],"or":[44,71,94,107,212,222],"marker":[45],"upon":[47],"infection.":[48],"DISC-HSV-2":[49],"is":[50],"able":[51],"infect":[53],"wide":[55],"range":[56],"cells":[59,111,124,141,171],"efficiently":[61],"beta-galactosidase":[64],"reporter":[65],"gene,":[66],"granulocyte-macrophage":[67],"colony-stimulating":[68],"factor":[69],"(GM-CSF),":[70],"IL-2":[72],"genes.":[73],"Gene":[74],"occurred":[76],"rapidly":[77],"after":[78],"infection":[79],"cells,":[82],"level":[85],"production":[87],"gene":[90],"product":[91],"(beta-galactosidase,":[92],"GM-CSF,":[93],"IL-2)":[95],"was":[96,172],"shown":[97,173],"be":[99,260],"both":[100,232],"time-and":[101],"dose-dependent.":[102],"Vaccination":[103],"with":[104,120,126,137,201],"irradiated":[105,138],"DISC-mGM-CSF":[106],"DISC-hIL-2-infected":[108],"murine":[109,177,191],"resulted":[112],"in":[113,188,216,262],"greatly":[114],"enhanced":[115],"immunity":[116],"challenge":[119],"live":[121],"parental":[122],"compared":[125],"control":[127],"vaccines.":[128],"When":[129],"therapeutically":[131],"treat":[133],"existing":[134],"tumors,":[135],"vaccination":[136],"DISC-mGM-CSF-infected":[139,170],"significantly":[142],"reduced":[143],"incidence":[145,211],"growth":[147,213],"rates":[148],"tumors":[150],"when":[151],"administered":[152],"locally":[153],"adjacent":[154],"site,":[158],"providing":[159],"up":[160],"90%":[162],"protection.":[163],"prophylactic":[165],"therapeutic":[167],"efficacy":[168],"initially":[174],"using":[175],"renal":[178],"carcinoma":[180],"model":[181],"(RENCA),":[182],"results":[185,250],"were":[186],"confirmed":[187],"two":[189],"additional":[190],"models:":[193],"M3":[195],"melanoma":[196],"302R":[198],"sarcoma.":[199],"Therapy":[200],"DISC-infected":[202],"RENCA":[203],"failed":[207],"reduce":[209],"congenitally":[217],"T-cell":[218],"deficient":[219],"(Nu+/Nu+)":[220],"mice":[221,223],"depleted":[224],"CD4+":[226],"and/or":[227],"CD8+":[228],"T-lymphocytes,":[229],"confirming":[230],"that":[231,252],"T-helper":[233],"T-cytotoxic":[235],"effector":[236],"arms":[237],"immune":[240],"response":[241],"are":[242],"required":[243],"promote":[245],"rejection.":[247],"These":[248],"preclinical":[249],"suggest":[251],"this":[253],"\"novel\"":[254],"DISC-HSV":[255],"may":[257],"prove":[258],"efficacious":[261],"developing":[263],"whole-cell":[266],"clinical":[269],"use.":[270]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
