{"id":"https://openalex.org/W1535454853","doi":"https://doi.org/10.1128/iai.58.9.2972-2976.1990","title":"N-linked oligosaccharides of human transferrin are not required for binding to bacterial transferrin receptors","display_name":"N-linked oligosaccharides of human transferrin are not required for binding to bacterial transferrin receptors","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W1535454853","doi":"https://doi.org/10.1128/iai.58.9.2972-2976.1990","mag":"1535454853","pmid":"https://pubmed.ncbi.nlm.nih.gov/2117577","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/313597"},"language":"en","primary_location":{"id":"doi:10.1128/iai.58.9.2972-2976.1990","doi":"https://doi.org/10.1128/iai.58.9.2972-2976.1990","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.58.9.2972-2976.1990","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC313597","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061310142","display_name":"J. S. Padda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J S Padda","raw_affiliation_strings":["Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048328229","display_name":"Anthony Bernard Schryvers","orcid":"https://orcid.org/0000-0002-4029-3296","observed_orcids":["https://orcid.org/0000-0002-4029-3296"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A B Schryvers","raw_affiliation_strings":["Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I168635309"],"apc_list":null,"apc_paid":null,"fwci":2.1381,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.87342832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"58","issue":"9","first_page":"2972","last_page":"2976"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-transferrin","display_name":"human transferrin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/n-glycans","display_name":"N-glycans","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neisseria-meningitidis","display_name":"Neisseria meningitidis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/neisseria-gonorrhoeae","display_name":"Neisseria gonorrhoeae","score":0.9959999918937683},{"id":"https://openalex.org/keywords/haemophilus-influenzae","display_name":"Haemophilus influenzae","score":1.0},{"id":"https://openalex.org/keywords/deglycosylation","display_name":"deglycosylation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/periodate-oxidation","display_name":"periodate oxidation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/iron-acquisition","display_name":"iron acquisition","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.8123679161071777},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6008474826812744},{"id":"https://openalex.org/C2778458888","wikidata":"https://www.wikidata.org/wiki/Q154625","display_name":"Neisseria meningitidis","level":3,"score":0.5918324589729309},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.5540470480918884},{"id":"https://openalex.org/C32264632","wikidata":"https://www.wikidata.org/wiki/Q1134983","display_name":"Transferrin receptor","level":3,"score":0.548109233379364},{"id":"https://openalex.org/C2777726330","wikidata":"https://www.wikidata.org/wiki/Q320607","display_name":"Oligosaccharide","level":2,"score":0.5410856008529663},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5186914205551147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46268144249916077},{"id":"https://openalex.org/C179247698","wikidata":"https://www.wikidata.org/wiki/Q382799","display_name":"Affinity chromatography","level":3,"score":0.453222393989563},{"id":"https://openalex.org/C2779166590","wikidata":"https://www.wikidata.org/wiki/Q131129","display_name":"Neisseria gonorrhoeae","level":2,"score":0.43169015645980835},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4279903471469879},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.4257453680038452},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3581162691116333},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3445754647254944},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.20826837420463562},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009344","descriptor_name":"Neisseria gonorrhoeae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009345","descriptor_name":"Neisseria meningitidis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011990","descriptor_name":"Receptors, Transferrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043524","descriptor_name":"Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.58.9.2972-2976.1990","doi":"https://doi.org/10.1128/iai.58.9.2972-2976.1990","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.58.9.2972-2976.1990","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:221588","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC313597","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:313597","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/313597","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:2117577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2117577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:221588","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC313597","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1575133603","https://openalex.org/W1701141768","https://openalex.org/W1775749144","https://openalex.org/W1895178838","https://openalex.org/W1909643721","https://openalex.org/W1923005546","https://openalex.org/W1999550122","https://openalex.org/W2011757750","https://openalex.org/W2018909260","https://openalex.org/W2022961230","https://openalex.org/W2031119708","https://openalex.org/W2036430011","https://openalex.org/W2043970797","https://openalex.org/W2051593862","https://openalex.org/W2054587928","https://openalex.org/W2066485735","https://openalex.org/W2068939314","https://openalex.org/W2083580139","https://openalex.org/W2094293981","https://openalex.org/W2100837269","https://openalex.org/W2122934351","https://openalex.org/W2150139767","https://openalex.org/W2154294860","https://openalex.org/W2169032126","https://openalex.org/W2280101559"],"related_works":["https://openalex.org/W1967685613","https://openalex.org/W35895212","https://openalex.org/W2069865974","https://openalex.org/W1988734637","https://openalex.org/W1568487852","https://openalex.org/W2129681064","https://openalex.org/W1558551598","https://openalex.org/W2055643046","https://openalex.org/W1853583946","https://openalex.org/W2037505980"],"abstract_inverted_index":{"Derivatives":[0],"of":[1],"human":[2],"transferrin":[3],"(hTf)":[4],"with":[5,13,16,43,66],"removed":[6],"or":[7],"modified":[8],"N-linked":[9],"oligosaccharides":[10,74],"were":[11,38],"compared":[12],"native":[14],"hTf":[15,23,37,54,68,73,83],"respect":[17],"to":[18,21,80],"their":[19],"binding":[20,64,79],"bacterial":[22,82],"receptors":[24],"from":[25],"Neisseria":[26],"meningitidis,":[27],"N.":[28],"gonorrhoeae,":[29],"and":[30,34,46,62],"Haemophilus":[31],"influenzae.":[32],"Partially":[33],"fully":[35],"deglycosylated":[36],"prepared":[39,56],"by":[40,48],"enzymatic":[41],"deglycosylation":[42],"glycopeptidase":[44],"F":[45],"isolated":[47],"concanavalin":[49],"A-Sepharose":[50],"affinity":[51],"chromatography.":[52],"Oligosaccharide-modified":[53],"was":[55],"via":[57],"mild":[58],"periodate":[59],"oxidation.":[60],"Competition":[61],"direct":[63],"experiments":[65],"the":[67,72,81],"derivatives":[69],"demonstrated":[70],"that":[71],"are":[75],"not":[76],"essential":[77],"for":[78],"receptors.":[84]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}