{"id":"https://openalex.org/W1534865669","doi":"https://doi.org/10.1111/j.1528-1167.2011.03392.x","title":"Levetiracetam has an activity\u2010dependent effect on inhibitory transmission","display_name":"Levetiracetam has an activity\u2010dependent effect on inhibitory transmission","publication_year":2012,"publication_date":"2012-01-31","ids":{"openalex":"https://openalex.org/W1534865669","doi":"https://doi.org/10.1111/j.1528-1167.2011.03392.x","mag":"1534865669","pmid":"https://pubmed.ncbi.nlm.nih.gov/22292611"},"language":"en","primary_location":{"id":"doi:10.1111/j.1528-1167.2011.03392.x","doi":"https://doi.org/10.1111/j.1528-1167.2011.03392.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1528-1167.2011.03392.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1528-1167.2011.03392.x","source":{"id":"https://openalex.org/S203153751","display_name":"Epilepsia","issn_l":"0013-9580","issn":["0013-9580","1528-1157","1528-1167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1528-1167.2011.03392.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025263216","display_name":"Anna L. Meehan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna L. Meehan","raw_affiliation_strings":["Department of Neurology, University of Minnesota, Minneapolis, MN, USA","Department of Neurology","Graduate Program in Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Neurology","institution_ids":[]},{"raw_affiliation_string":"Graduate Program in Neuroscience","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011589908","display_name":"Xiaofeng Yang","orcid":"https://orcid.org/0000-0002-7847-0665","observed_orcids":["https://orcid.org/0000-0002-7847-0665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaofeng Yang","raw_affiliation_strings":["Department of Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028963541","display_name":"Li\u2010Lian Yuan","orcid":"https://orcid.org/0000-0001-7787-576X","observed_orcids":["https://orcid.org/0000-0001-7787-576X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li\u2010Lian Yuan","raw_affiliation_strings":["Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, U.S.A","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110346050","display_name":"Steven M. Rothman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Steven M. Rothman","raw_affiliation_strings":["Department of Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110346050"],"corresponding_institution_ids":[],"apc_list":{"value":4360,"currency":"USD","value_usd":4360},"apc_paid":null,"fwci":1.9084,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.83711328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"53","issue":"3","first_page":"469","last_page":"476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levetiracetam","display_name":"levetiracetam","score":1.0},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-currents","display_name":"inhibitory postsynaptic currents","score":0.8579999804496765},{"id":"https://openalex.org/keywords/gaba-release","display_name":"GABA release","score":0.7269999980926514},{"id":"https://openalex.org/keywords/synaptic-vesicle-glycoprotein-2a","display_name":"SV2A","score":0.6430000066757202},{"id":"https://openalex.org/keywords/vesicular-uptake","display_name":"vesicular uptake","score":0.8240000009536743},{"id":"https://openalex.org/keywords/ca1-neurons","display_name":"CA1 neurons","score":0.6899999976158142},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.828000009059906},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.9329767227172852},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.8556325435638428},{"id":"https://openalex.org/C2910581834","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Postsynaptic Current","level":4,"score":0.759547233581543},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.6415144801139832},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6155271530151367},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.505901038646698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4229188859462738},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37714362144470215},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11205834150314331},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07974830269813538}],"mesh":[{"descriptor_ui":"D000077287","descriptor_name":"Levetiracetam","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010889","descriptor_name":"Piracetam","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010889","descriptor_name":"Piracetam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1528-1167.2011.03392.x","doi":"https://doi.org/10.1111/j.1528-1167.2011.03392.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1528-1167.2011.03392.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1528-1167.2011.03392.x","source":{"id":"https://openalex.org/S203153751","display_name":"Epilepsia","issn_l":"0013-9580","issn":["0013-9580","1528-1157","1528-1167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsia","raw_type":"journal-article"},{"id":"pmid:22292611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22292611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1528-1167.2011.03392.x","doi":"https://doi.org/10.1111/j.1528-1167.2011.03392.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1528-1167.2011.03392.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1528-1167.2011.03392.x","source":{"id":"https://openalex.org/S203153751","display_name":"Epilepsia","issn_l":"0013-9580","issn":["0013-9580","1528-1157","1528-1167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epilepsia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337846","display_name":"UCB Pharma","ror":"https://ror.org/01n029866"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1534865669.pdf"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1504181864","https://openalex.org/W1679634005","https://openalex.org/W1758735213","https://openalex.org/W1970167469","https://openalex.org/W1990636181","https://openalex.org/W1993009709","https://openalex.org/W1996382884","https://openalex.org/W2001243727","https://openalex.org/W2003338471","https://openalex.org/W2010990414","https://openalex.org/W2012541464","https://openalex.org/W2013185877","https://openalex.org/W2032794571","https://openalex.org/W2033500343","https://openalex.org/W2039108005","https://openalex.org/W2049757067","https://openalex.org/W2054324876","https://openalex.org/W2063091823","https://openalex.org/W2076802398","https://openalex.org/W2077288868","https://openalex.org/W2080196512","https://openalex.org/W2083547018","https://openalex.org/W2088296164","https://openalex.org/W2101604610","https://openalex.org/W2112375525","https://openalex.org/W2127801604","https://openalex.org/W2129993967","https://openalex.org/W2150116014","https://openalex.org/W4211013093"],"related_works":["https://openalex.org/W2080196512","https://openalex.org/W2010990414","https://openalex.org/W4293276588","https://openalex.org/W2055866540","https://openalex.org/W1993009709","https://openalex.org/W2118869247","https://openalex.org/W7047081747","https://openalex.org/W2090928900","https://openalex.org/W2973124392","https://openalex.org/W2094967280"],"abstract_inverted_index":{"PURPOSE:":[0],"Previous":[1],"work":[2],"has":[3],"shown":[4],"that":[5,52,118,269,322],"levetiracetam":[6],"(LEV)":[7],"binds":[8],"the":[9,82,128,133,137,193,212,257,267,275,287,304],"vesicular":[10,31,270,282],"protein":[11],"SV2A":[12,57],"and":[13,43,48,106,245,293],"reduces":[14,65,120],"excitatory":[15,34,42,108,145,169,208],"neurotransmitter":[16],"release":[17,46,328],"during":[18,162],"trains":[19,152,219,228,308],"of":[20,84,168,220,260,277,284,306,324],"high-frequency":[21],"activity,":[22],"most":[23],"likely":[24],"by":[25,98,205,309],"accessing":[26],"its":[27],"binding":[28],"site":[29],"through":[30],"endocytosis":[32],"into":[33,279],"synaptic":[35,201],"terminals.":[36,280],"Because":[37],"there":[38,49,318],"are":[39,50,319],"differences":[40],"in":[41,55,76,123,136,142,263],"inhibitory":[44,66,87,100,121],"transmitter":[45,209],"mechanisms,":[47],"suggestions":[51],"neurons":[53,75],"differ":[54],"their":[56],"expression,":[58],"we":[59],"were":[60,92,178],"curious":[61],"whether":[62],"LEV":[63,85,119,149,171,187,214,216,235,285,310],"also":[64],"transmission.":[67],"METHODS:":[68],"We":[69,91,116],"used":[70],"patch-clamp":[71],"recording":[72],"from":[73],"CA1":[74],"rat":[77],"brain":[78,264],"slices":[79,177],"to":[80,94,103,144,180,191,197,225],"quantify":[81],"effects":[83],"on":[86,132,242],"postsynaptic":[88,109,146],"currents":[89,110,122,147],"(IPSCs).":[90],"able":[93],"elicit":[95],"pure":[96],"IPSCs":[97,135,244],"stimulating":[99],"terminals":[101],"close":[102],"neuronal":[104],"soma":[105],"blocking":[107],"with":[111,127,166,207,256],"specific":[112],"antagonists.":[113],"KEY":[114],"FINDINGS:":[115],"found":[117],"a":[124,154,237],"frequency-dependent":[125,240],"manner,":[126],"largest":[129],"relative":[130],"effect":[131,241],"later":[134],"highest":[138],"frequency":[139],"trains.":[140],"However,":[141,199],"contrast":[143],"(EPSCs),":[148],"reduced":[150,174],"IPSC":[151,194,227,252,307],"after":[153,186,211],"briefer,":[155],"30":[156],"min":[157],"incubation.":[158],"When":[159],"spontaneous":[160,261],"activity":[161,202],"incubation":[163],"was":[164,203,229],"blocked":[165],"antagonists":[167],"transmission,":[170],"no":[172],"longer":[173],"IPSCs.":[175],"If":[176],"returned":[179],"LEV-free":[181],"artificial":[182],"cerebrospinal":[183],"fluid":[184],"(ACSF)":[185],"incubation,":[188],"but":[189,296],"prior":[190],"recording,":[192],"reduction":[195,253,305],"failed":[196],"appear.":[198],"if":[200],"limited":[204],"treating":[206],"antagonists,":[210],"initial":[213],"exposure,":[215],"still":[217],"diminished":[218],"IPSC.":[221],"The":[222,247,281],"concentration":[223],"required":[224],"diminish":[226],"lower":[230],"than":[231],"for":[232,251,274,291,299,314],"EPSCs.":[233,246],"SIGNIFICANCE:":[234],"exerts":[236],"qualitatively":[238],"similar,":[239],"both":[243],"much":[248],"shorter":[249],"latency":[250],"is":[254,272,297],"consistent":[255],"greater":[258],"levels":[259],"inhibition":[262],"slices,":[265],"supporting":[266],"hypothesis":[268],"uptake":[271],"necessary":[273],"entry":[276,283,289],"LEVs":[278],"resembles":[286],"cell":[288],"pathways":[290],"tetanus":[292],"botulinum":[294],"neurotoxins,":[295],"unique":[298],"small,":[300],"neuroactive":[301],"drugs.":[302],"Although":[303],"initially":[311],"seems":[312],"counterintuitive":[313],"an":[315],"antiepileptic":[316],"drug,":[317],"multiple":[320],"reasons":[321],"disruption":[323],"\u03b3-aminobutyric":[325],"acid":[326],"(GABA)":[327],"could":[329],"ultimately":[330],"attenuate":[331],"pathologic":[332],"discharges.":[333]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}