{"id":"https://openalex.org/W153456554","doi":null,"title":"Ethanol and central nicotinic acetylcholine receptors : a behavioral and neurochemical study in rodents","display_name":"Ethanol and central nicotinic acetylcholine receptors : a behavioral and neurochemical study in rodents","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W153456554","mag":"153456554"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/15843","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/15843","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042746052","display_name":"Ola Blomqvist","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ola Blomqvist","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042746052"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.11190000176429749,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.9739999771118164},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.6570000052452087},{"id":"https://openalex.org/keywords/mesolimbic-dopamine-system","display_name":"mesolimbic dopamine system","score":0.8709999918937683},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.968999981880188},{"id":"https://openalex.org/keywords/mecamylamine","display_name":"mecamylamine","score":0.8529999852180481},{"id":"https://openalex.org/keywords/hexamethonium","display_name":"hexamethonium","score":0.9079999923706055},{"id":"https://openalex.org/keywords/dopamine-turnover","display_name":"dopamine turnover","score":0.7670000195503235},{"id":"https://openalex.org/keywords/catecholamine-biosynthesis","display_name":"catecholamine synthesis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/dopamine-overflow","display_name":"dopamine overflow","score":0.5820000171661377},{"id":"https://openalex.org/keywords/ethanol-preference","display_name":"ethanol preference","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cross-sensitization","display_name":"cross-sensitization","score":0.8989999890327454},{"id":"https://openalex.org/keywords/nicotine-sensitization","display_name":"nicotine sensitization","score":0.5989999771118164},{"id":"https://openalex.org/keywords/limbic-forebrain","display_name":"limbic forebrain","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.9030568599700928},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.6673879623413086},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.6607904434204102},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6135092973709106},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.4743199050426483},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42293819785118103},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3387695550918579},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32708030939102173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3118290901184082},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2739325761795044},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22467485070228577}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/15843","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/15843","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:153456554","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/handle/2077/15843","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1981963493","https://openalex.org/W61468495","https://openalex.org/W2095191590","https://openalex.org/W2007188824","https://openalex.org/W2088227377","https://openalex.org/W2099342322","https://openalex.org/W1971837409","https://openalex.org/W7055336307","https://openalex.org/W1970168883","https://openalex.org/W1965725321"],"abstract_inverted_index":{"ETHANOL":[0],"AND":[1],"CENTRAL":[2],"NICOTINIC":[3],"ACETYLCHOLINE":[4],"RECEPTORS.":[5],"A":[6],"behavioral":[7,257],"and":[8,18,32,40,45,65,72,92,181,264,268,292,296,306,314,335],"neurochemical":[9],"study":[10],"in":[11,59,113,118,142,176,185,194,222,230,243,266,281,290,299,328,362],"rodents.":[12],"pp.":[13],"1-61.,":[14],"Institute":[15],"of":[16,21,50,81,97,278,318,347,365],"Physiology":[17],"Pharmacology,":[19],"Department":[20],"Phannacology,":[22],"G\u00f6teborg":[23],"University,":[24],"Medieinaregatan":[25],"7,":[26],"S-413":[27],"90":[28],"G\u00f6teborg,":[29],"Sweden.":[30],"Smoking":[31],"alcoholism":[33],"cause":[34],"severe":[35],"health":[36],"problems.":[37],"Furthermore,":[38,331],"smoking":[39],"drinking":[41],"covary":[42],"positively.":[43],"Ethanol":[44,190],"nicotine,":[46,260],"like":[47],"other":[48],"drugs":[49],"abuse,":[51],"activate":[52],"the":[53,60,69,73,90,93,103,114,119,133,146,165,186,195,223,231,282,310,315,329,345,363],"iiiesocortieolimbic":[54],"dopamine":[55,105,179,192,212,297,312],"system,":[56],"that":[57,161,341,354],"originates":[58],"ventral":[61],"segmental":[62],"area":[63],"(VTA)":[64],"projects":[66],"mainly":[67],"to":[68,85,259,321,344],"nucleus":[70,120,197,232],"accumbens":[71],"frontal":[74],"cortex.":[75],"In":[76,132,308],"experimental":[77],"animals,":[78],"drug-induced":[79],"activation":[80],"this":[82,130],"system":[83,106],"appears":[84,320],"be":[86,360],"associated":[87],"both":[88],"with":[89],"reinforcing":[91,316],"locomotor":[94],"stimulatory":[95],"properties":[96,317],"dependence":[98],"producing":[99],"drugs.":[100],"Nicotine":[101],"activates":[102,129],"mesocortieolimbic":[104],"by":[107,203,207],"stimulating":[108],"nicotinie":[109],"acetylcholine":[110],"receptors":[111],"(nAChR)":[112],"VTA":[115,224],"and/or":[116],"presynaptically":[117],"accumbens.":[121,198,233],"It":[122,350],"is,":[123],"however,":[124],"not":[125,156,163,206,226,237,247,248,270],"clear":[126],"how":[127],"ethanol":[128,147,241,244,262,289,319,336],"system.":[131],"present":[134],"study,":[135],"nicotine":[136,253,287,305,334],"increased":[137,191,261],"or":[138,220,288],"antagonized":[139],"ethanol-induced":[140,169,174,210,294],"hyper-locomotion":[141],"mice,":[143,300],"depending":[144],"on":[145],"dose.":[148],"Mecamylarnine,":[149],"a":[150,158,302],"centrally":[151],"acting":[152],"nAChR":[153,159,358],"antagonist,":[154],"but":[155,205,225,236,246],"hexamethonium,":[157,238],"antagonist":[160],"does":[162],"enter":[164],"brain,":[166],"partially":[167],"counteracted":[168,173],"hyperlocomotion.":[170],"Mecamylamine":[171],"also":[172,275,352],"increases":[175],"mouse":[177],"brain":[178],"turnover":[180,298],"catecholamine":[182],"synthesis":[183],"rate":[184],"rat":[187,196],"limbie":[188],"forebrain.":[189],"overflow":[193,213],"This":[199,273],"effect":[200,340],"was":[201,214],"blocked":[202],"mecamylamine":[204,219,228],"hexamethonium.":[208],"Furtherinore,":[209],"accumbal":[211],"abolished":[215],"after":[216,227,285],"local":[217],"perfusion":[218,229],"hexamethonium":[221],"Systemic":[234],"mecamylan-iine,":[235],"reduced":[239],"voluntary":[240],"intake":[242,263],"high-":[245],"low-":[249],"preferring":[250],"rats.":[251,272],"Subchronic":[252],"treatment,":[254],"which":[255],"produced":[256],"sensitization":[258],"preference":[265],"medium-":[267],"low-but":[269],"high-preferring":[271],"treatment":[274,364],"inereased":[276],"measures":[277],"doparnine":[279],"release":[280],"limbic":[283],"forebrain":[284],"acute":[286],"rats":[291],"enhanced":[293],"hyperlocomotion":[295],"suggesting":[301],"cross-sensitization":[303,332],"between":[304,333],"ethanol.":[307],"summary,":[309],"mesolimbic":[311],"activating":[313],"involve":[322],"central":[323,357],"nAChR,":[324],"preferrably":[325],"those":[326],"located":[327],"VTA.":[330],"may":[337,359],"develop,":[338],"an":[339],"could":[342],"contribute":[343],"co-abuse":[346],"these":[348],"compounds.":[349],"is":[351],"suggested":[353],"antagonists":[355],"at":[356],"useful":[361],"alcoholism.":[366]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}