{"id":"https://openalex.org/W1534409678","doi":"https://doi.org/10.4049/jimmunol.169.4.1837","title":"Thymocyte Apoptosis Induced by T Cell Activation Is Mediated by Glucocorticoids In Vivo","display_name":"Thymocyte Apoptosis Induced by T Cell Activation Is Mediated by Glucocorticoids In Vivo","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W1534409678","doi":"https://doi.org/10.4049/jimmunol.169.4.1837","mag":"1534409678","pmid":"https://pubmed.ncbi.nlm.nih.gov/12165507"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.169.4.1837","doi":"https://doi.org/10.4049/jimmunol.169.4.1837","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.169.4.1837","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/169/4/1837/1155678/1837.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/169/4/1837/1155678/1837.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056817403","display_name":"Judson A. Brewer","orcid":"https://orcid.org/0000-0001-8984-6704","observed_orcids":["https://orcid.org/0000-0001-8984-6704"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judson A Brewer","raw_affiliation_strings":["Department of Pediatrics, Molecular Biology, and Pharmacology, Washington University School of Medicine , St. Louis, MO 63110","*Pediatrics, Molecular Biology, and Pharmacology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Molecular Biology, and Pharmacology, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"*Pediatrics, Molecular Biology, and Pharmacology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004360797","display_name":"Osami Kanagawa","orcid":"https://orcid.org/0000-0001-6028-7742","observed_orcids":["https://orcid.org/0000-0001-6028-7742"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Osami Kanagawa","raw_affiliation_strings":["Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110","Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000388529","display_name":"Barry P. Sleckman","orcid":"https://orcid.org/0000-0001-8295-4462","observed_orcids":["https://orcid.org/0000-0001-8295-4462"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry P Sleckman","raw_affiliation_strings":["Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110","Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080833691","display_name":"Louis J. Muglia","orcid":"https://orcid.org/0000-0002-0301-8770","observed_orcids":["https://orcid.org/0000-0002-0301-8770"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis J Muglia","raw_affiliation_strings":["Department of Pediatrics, Molecular Biology, and Pharmacology, Washington University School of Medicine , St. Louis, MO 63110","*Pediatrics, Molecular Biology, and Pharmacology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Molecular Biology, and Pharmacology, Washington University School of Medicine , St. Louis, MO 63110","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"*Pediatrics, Molecular Biology, and Pharmacology, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.9,"has_fulltext":true,"cited_by_count":133,"citation_normalized_percentile":{"value":0.94129979,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"169","issue":"4","first_page":"1837","last_page":"1843"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymocyte-apoptosis","display_name":"thymocyte apoptosis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9879999756813049},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.859000027179718},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.7210000157356262},{"id":"https://openalex.org/keywords/negative-selection","display_name":"negative selection","score":0.8169999718666077},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.8830000162124634},{"id":"https://openalex.org/keywords/immune-reconstitution","display_name":"immune reconstitution","score":0.7200000286102295},{"id":"https://openalex.org/keywords/fetal-liver-transplantation","display_name":"fetal liver transplantation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/endogenous-glucocorticoids","display_name":"endogenous glucocorticoids","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2778954852","wikidata":"https://www.wikidata.org/wiki/Q7799635","display_name":"Thymocyte","level":4,"score":0.8994361758232117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.665604829788208},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.5982216596603394},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5890929698944092},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.5864402651786804},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.545046865940094},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.537721574306488},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5284411907196045},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.47380560636520386},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46440601348876953},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.44359973073005676},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.4345344305038452},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4195000231266022},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3273750841617584},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.321647047996521},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.169.4.1837","doi":"https://doi.org/10.4049/jimmunol.169.4.1837","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.169.4.1837","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/169/4/1837/1155678/1837.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:12165507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12165507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.169.4.1837","doi":"https://doi.org/10.4049/jimmunol.169.4.1837","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.169.4.1837","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/169/4/1837/1155678/1837.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1534409678.pdf","grobid_xml":"https://content.openalex.org/works/W1534409678.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1522773084","https://openalex.org/W1537130778","https://openalex.org/W1552751328","https://openalex.org/W1975737859","https://openalex.org/W1991102055","https://openalex.org/W2000011436","https://openalex.org/W2004502371","https://openalex.org/W2013930926","https://openalex.org/W2025126559","https://openalex.org/W2027306447","https://openalex.org/W2031965453","https://openalex.org/W2035513032","https://openalex.org/W2050219792","https://openalex.org/W2057437717","https://openalex.org/W2067190664","https://openalex.org/W2068246413","https://openalex.org/W2082690640","https://openalex.org/W2109408308","https://openalex.org/W2112522175","https://openalex.org/W2112740572","https://openalex.org/W2127618101","https://openalex.org/W2128915263","https://openalex.org/W2134539194","https://openalex.org/W2143305123","https://openalex.org/W2153745738","https://openalex.org/W2154746915","https://openalex.org/W2156629452","https://openalex.org/W2160419609","https://openalex.org/W2410907818"],"related_works":["https://openalex.org/W2056503140","https://openalex.org/W1825379854","https://openalex.org/W2031965453","https://openalex.org/W2136182146","https://openalex.org/W1994618983","https://openalex.org/W2155670671","https://openalex.org/W2112522175","https://openalex.org/W4238293937","https://openalex.org/W208148829","https://openalex.org/W2003668639"],"abstract_inverted_index":{"Glucocorticoids,":[0],"administered":[1],"in":[2,28,63,112,128,134,151,199],"pharmacological":[3],"doses,":[4],"potently":[5],"modulate":[6],"immune":[7,32],"system":[8],"function":[9],"and":[10,36,45,90],"are":[11,117,173],"a":[12,26,168],"mainstay":[13],"therapy":[14],"for":[15,77,175],"many":[16],"common":[17],"human":[18],"diseases.":[19],"Physiologic":[20],"production":[21],"of":[22,30,42,47,80,93,143,160,167,170,177,180],"glucocorticoids":[23,61,144,172],"may":[24,164,188],"play":[25,62],"role":[27],"optimization":[29],"the":[31,57,73,161,178],"repertoire":[33],"both":[34],"centrally":[35],"peripherally.":[37],"Possible":[38],"effects":[39],"include":[40],"alteration":[41],"lymphocyte":[43],"development":[44],"down-regulation":[46],"cytokine":[48],"responses,":[49],"but":[50],"essential":[51],"roles":[52],"remain":[53],"unclear.":[54],"To":[55],"determine":[56],"part":[58],"that":[59,145,156],"endogenous":[60],"thymocyte":[64,126,149],"development,":[65],"we":[66],"used":[67],"fetal":[68],"liver":[69],"from":[70],"mice":[71],"lacking":[72],"glucocorticoid":[74],"receptor":[75],"GRko":[76,94,96,115],"immunological":[78],"reconstitution":[79],"lethally":[81],"irradiated":[82],"wild-type":[83],"(WT)":[84],"mice.":[85,153],"We":[86,154],"find":[87,155],"normal":[88],"numbers":[89],"subset":[91,169],"distribution":[92],"thymocytes.":[95,181],"thymocytes":[97,111,116,123],"also":[98],"exhibit":[99],"similar":[100],"sensitivity":[101],"to":[102,124],"apoptosis":[103,127,150],"induced":[104],"by":[105,185],"activating":[106],"anti-CD3epsilon":[107],"Ab":[108,186],"as":[109],"WT":[110,122,152],"vitro.":[113],"Surprisingly,":[114],"significantly":[118],"more":[119,189],"resistant":[120],"than":[121,196],"anti-CD3epsilon-mediated":[125],"vivo.":[129,200],"Consistent":[130],"with":[131,148],"this":[132],"finding,":[133],"vivo":[135],"TCR":[136,162,183],"complex":[137,163],"activation":[138,195],"induces":[139],"sustained":[140],"high":[141],"levels":[142],"correlate":[146],"strongly":[147],"while":[157],"direct":[158],"engagement":[159],"cause":[165],"death":[166],"thymocytes,":[171],"required":[174],"deletion":[176],"majority":[179],"Thus,":[182],"stimulation":[184],"administration":[187],"accurately":[190],"reflect":[191],"polyclonal":[192],"T":[193],"cell":[194],"negative":[197],"selection":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
