{"id":"https://openalex.org/W1534367106","doi":"https://doi.org/10.57709/2113758","title":"Tuning Calcium Bindging Affinities with Related Biological Functions of Calmodulin and Designing Protein Based Contrast Agent","display_name":"Tuning Calcium Bindging Affinities with Related Biological Functions of Calmodulin and Designing Protein Based Contrast Agent","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1534367106","doi":"https://doi.org/10.57709/2113758","mag":"1534367106"},"language":"en","primary_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:3763","doi":null,"is_oa":true,"landing_page_url":"http://scholarworks.gsu.edu/chemistry_diss/60","pdf_url":"http://scholarworks.gsu.edu/chemistry_diss/60","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemistry Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://scholarworks.gsu.edu/chemistry_diss/60","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jiang, Jie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jiang, Jie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00075293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.4165000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.4165000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.2287999987602234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.12409999966621399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":1.0},{"id":"https://openalex.org/keywords/calcium-binding-affinity","display_name":"calcium affinity","score":0.9589999914169312},{"id":"https://openalex.org/keywords/ef-hand","display_name":"EF-hand","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"ryanodine receptor","score":0.7720000147819519},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"protein engineering","score":0.6470000147819519},{"id":"https://openalex.org/keywords/phosphodiesterase","display_name":"phosphodiesterase","score":0.625},{"id":"https://openalex.org/keywords/cgmp-hydrolysis","display_name":"cGMP hydrolysis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/gadolinium-based-mri-contrast-agents","display_name":"gadolinium-based MRI contrast agents","score":0.7739999890327454},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"molecular imaging","score":0.7379999756813049},{"id":"https://openalex.org/keywords/metal-binding-sites","display_name":"metal binding sites","score":0.5440000295639038},{"id":"https://openalex.org/keywords/single-channel-analysis","display_name":"single-channel analysis","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.8735330104827881},{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.7431790828704834},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5841581225395203},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.5449596047401428},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5228893160820007},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4342387318611145},{"id":"https://openalex.org/C122229402","wikidata":"https://www.wikidata.org/wiki/Q5018802","display_name":"Calcium-binding protein","level":3,"score":0.4301043450832367},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28243327140808105},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.28126659989356995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24945083260536194},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1674492061138153},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:uilis.unsyiah.ac.id:3763","doi":null,"is_oa":true,"landing_page_url":"http://scholarworks.gsu.edu/chemistry_diss/60","pdf_url":"http://scholarworks.gsu.edu/chemistry_diss/60","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemistry Dissertations","raw_type":"text"},{"id":"pmh:oai:scholarworks.gsu.edu:chemistry_diss-1056","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.gsu.edu/chemistry_diss/60","pdf_url":null,"source":{"id":"https://openalex.org/S4406922693","display_name":"Digital Archive @ GSU","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemistry Dissertations","raw_type":"text"},{"id":"pmh:oai:scholarworks.gsu.edu:20.500.14694/2811","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14694/2811","pdf_url":null,"source":{"id":"https://openalex.org/S4406922693","display_name":"Digital Archive @ GSU","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:1534367106","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.gsu.edu/cgi/viewcontent.cgi?article=1056&context=chemistry_diss","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.57709/2113758","doi":"https://doi.org/10.57709/2113758","is_oa":true,"landing_page_url":"https://doi.org/10.57709/2113758","pdf_url":null,"source":{"id":"https://openalex.org/S7407051460","display_name":"Georgia State University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"}],"best_oa_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:3763","doi":null,"is_oa":true,"landing_page_url":"http://scholarworks.gsu.edu/chemistry_diss/60","pdf_url":"http://scholarworks.gsu.edu/chemistry_diss/60","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemistry Dissertations","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1534367106.pdf","grobid_xml":"https://content.openalex.org/works/W1534367106.grobid-xml"},"referenced_works_count":183,"referenced_works":["https://openalex.org/W33516689","https://openalex.org/W53635167","https://openalex.org/W197699128","https://openalex.org/W1188688487","https://openalex.org/W1481302364","https://openalex.org/W1486466859","https://openalex.org/W1494998770","https://openalex.org/W1510814877","https://openalex.org/W1519525270","https://openalex.org/W1519540750","https://openalex.org/W1535121904","https://openalex.org/W1539182280","https://openalex.org/W1544824123","https://openalex.org/W1555399903","https://openalex.org/W1565248232","https://openalex.org/W1571243084","https://openalex.org/W1576403707","https://openalex.org/W1588015371","https://openalex.org/W1593235330","https://openalex.org/W1601691609","https://openalex.org/W1628979938","https://openalex.org/W1767701883","https://openalex.org/W1784820495","https://openalex.org/W1804875194","https://openalex.org/W1859509310","https://openalex.org/W1872107490","https://openalex.org/W1873199501","https://openalex.org/W1880612343","https://openalex.org/W1897633092","https://openalex.org/W1967118898","https://openalex.org/W1968127880","https://openalex.org/W1968785729","https://openalex.org/W1969971056","https://openalex.org/W1971501150","https://openalex.org/W1973648303","https://openalex.org/W1975356564","https://openalex.org/W1977722786","https://openalex.org/W1977874955","https://openalex.org/W1978283515","https://openalex.org/W1980430647","https://openalex.org/W1984904271","https://openalex.org/W1985308345","https://openalex.org/W1986902440","https://openalex.org/W1987309175","https://openalex.org/W1989847713","https://openalex.org/W1989847738","https://openalex.org/W1991753089","https://openalex.org/W1994138491","https://openalex.org/W1994607006","https://openalex.org/W1996316983","https://openalex.org/W1996981536","https://openalex.org/W1997297151","https://openalex.org/W2000249325","https://openalex.org/W2001535102","https://openalex.org/W2002152970","https://openalex.org/W2003382035","https://openalex.org/W2003414258","https://openalex.org/W2005722043","https://openalex.org/W2007889731","https://openalex.org/W2008386999","https://openalex.org/W2009473683","https://openalex.org/W2010455912","https://openalex.org/W2012544852","https://openalex.org/W2013260039","https://openalex.org/W2015792302","https://openalex.org/W2016443424","https://openalex.org/W2017052307","https://openalex.org/W2017865509","https://openalex.org/W2019869230","https://openalex.org/W2020623316","https://openalex.org/W2020687585","https://openalex.org/W2022234371","https://openalex.org/W2024142216","https://openalex.org/W2026296218","https://openalex.org/W2028421760","https://openalex.org/W2029817996","https://openalex.org/W2031811477","https://openalex.org/W2032217193","https://openalex.org/W2032752511","https://openalex.org/W2032842750","https://openalex.org/W2033370577","https://openalex.org/W2034406813","https://openalex.org/W2035380471","https://openalex.org/W2037360789","https://openalex.org/W2037744654","https://openalex.org/W2037825013","https://openalex.org/W2038071582","https://openalex.org/W2039805618","https://openalex.org/W2040209721","https://openalex.org/W2040415740","https://openalex.org/W2040695109","https://openalex.org/W2041903736","https://openalex.org/W2043638187","https://openalex.org/W2045440413","https://openalex.org/W2045586192","https://openalex.org/W2046993659","https://openalex.org/W2050140351","https://openalex.org/W2050552033","https://openalex.org/W2052677029","https://openalex.org/W2053989248","https://openalex.org/W2055923860","https://openalex.org/W2058970406","https://openalex.org/W2060571726","https://openalex.org/W2061095840","https://openalex.org/W2061373572","https://openalex.org/W2062804279","https://openalex.org/W2063593859","https://openalex.org/W2063823414","https://openalex.org/W2063963320","https://openalex.org/W2065571239","https://openalex.org/W2067093402","https://openalex.org/W2067686089","https://openalex.org/W2068518785","https://openalex.org/W2068650437","https://openalex.org/W2069187446","https://openalex.org/W2071130163","https://openalex.org/W2071362218","https://openalex.org/W2072271663","https://openalex.org/W2075989491","https://openalex.org/W2076674523","https://openalex.org/W2078511114","https://openalex.org/W2079118100","https://openalex.org/W2082763384","https://openalex.org/W2084712453","https://openalex.org/W2085139421","https://openalex.org/W2085326980","https://openalex.org/W2085701920","https://openalex.org/W2089778751","https://openalex.org/W2096887440","https://openalex.org/W2096942328","https://openalex.org/W2097085758","https://openalex.org/W2099666638","https://openalex.org/W2100239033","https://openalex.org/W2104683647","https://openalex.org/W2109130443","https://openalex.org/W2109805893","https://openalex.org/W2112119760","https://openalex.org/W2114632792","https://openalex.org/W2115612202","https://openalex.org/W2117621180","https://openalex.org/W2117971318","https://openalex.org/W2120385383","https://openalex.org/W2122745978","https://openalex.org/W2125068630","https://openalex.org/W2125312764","https://openalex.org/W2126551164","https://openalex.org/W2129483036","https://openalex.org/W2130151244","https://openalex.org/W2130291666","https://openalex.org/W2133380824","https://openalex.org/W2134269295","https://openalex.org/W2134689210","https://openalex.org/W2137283585","https://openalex.org/W2137852913","https://openalex.org/W2138131118","https://openalex.org/W2139996880","https://openalex.org/W2140974804","https://openalex.org/W2141378441","https://openalex.org/W2142203228","https://openalex.org/W2142759109","https://openalex.org/W2147343978","https://openalex.org/W2152791137","https://openalex.org/W2156282278","https://openalex.org/W2168106779","https://openalex.org/W2168398034","https://openalex.org/W2169091067","https://openalex.org/W2172712627","https://openalex.org/W2183993249","https://openalex.org/W2187616507","https://openalex.org/W2231884563","https://openalex.org/W2316337881","https://openalex.org/W2316453149","https://openalex.org/W2333645350","https://openalex.org/W2346564226","https://openalex.org/W2395381412","https://openalex.org/W2401164661","https://openalex.org/W2406747593","https://openalex.org/W2408703956","https://openalex.org/W2417751477","https://openalex.org/W2801365979","https://openalex.org/W2992162011","https://openalex.org/W3103727215","https://openalex.org/W4253345956"],"related_works":["https://openalex.org/W2306570200","https://openalex.org/W2306295729","https://openalex.org/W7095460079","https://openalex.org/W2295231906","https://openalex.org/W6973313694","https://openalex.org/W7097314341","https://openalex.org/W2730907615","https://openalex.org/W7100395577","https://openalex.org/W7099726330","https://openalex.org/W4391642231"],"abstract_inverted_index":{"Calmodulin":[0],"(CaM)":[1],"is":[2,76,95,180],"a":[3,43,96,183,214],"ubiquitous":[4],"intracellular":[5],"protein":[6,184,197],"that":[7,91],"regulates":[8],"biological":[9,138],"activities":[10],"of":[11,28,37,45,59,68,74,84,104,127,130,137,140,150,177,238],"numerous":[12],"enzymes":[13],"and":[14,32,114,135,146,156,171,227,234],"ion":[15,106],"channels.":[16,107],"Upon":[17],"responding":[18],"Ca2+":[19,33,52,81],"concentration":[20],"change,":[21],"Ca2+-":[22],"dependent":[23],"CaM":[24,46,85,113,131,191],"activates":[25],"the":[26,57,70,87,101,195,218],"hydrolyzation":[27],"cGMP":[29],"by":[30,55,79,160,205,245],"PDE":[31,172],"releasing":[34],"channel":[35,169],"activity":[36],"ryanodine":[38],"receptor.":[39],"In":[40],"this":[41],"dissertation,":[42],"series":[44],"variants":[47,152],"were":[48,158,165,243],"engineered":[49],"to":[50,99,119,153,181,221],"enhance":[51],"binding":[53,82,122,134,208],"affinities":[54,149],"increasing":[56],"number":[58],"negative":[60],"charged":[61],"residues":[62],"in":[63,132],"individual":[64],"EF-hand.":[65],"The":[66,230],"capability":[67],"shifting":[69],"biphasic":[71],"Ca2+-activation":[72],"profile":[73,103],"RyR1":[75],"significantly":[77],"altered":[78],"changing":[80],"affinity":[83,94],"at":[86],"C-terminal.":[88],"This":[89],"indicates":[90],"examining":[92],"Ca2+-CaM":[93],"valid":[97],"strategy":[98],"tune":[100],"activation":[102],"CaM-regulated":[105],"To":[108,124],"further":[109],"understand":[110],"interactions":[111],"between":[112],"RyR1,":[115],"NMR":[116],"was":[117,192],"used":[118],"determine":[120],"their":[121],"mode.":[123],"dissect":[125],"roles":[126],"structural":[128],"components":[129],"metal":[133,207],"regulation":[136],"functions":[139],"target":[141,223],"proteins,":[142],"we":[143],"created":[144],"half-CaMs":[145],"Del-CaM.":[147],"Binding":[148],"these":[151,239],"Ca2+,":[154],"Tb3+":[155],"Gd3+":[157,200],"determined":[159],"fluorescence":[161],"spectroscopy;":[162],"functional":[163],"studies":[164],"conducted":[166],"using":[167],"single":[168],"analysis":[170],"function":[173],"assay.":[174],"Another":[175],"objective":[176],"my":[178],"dissertation":[179],"design":[182],"based":[185,201],"contrast":[186,203,241],"agent":[187,204],"for":[188,198],"molecular":[189],"imaging.":[190],"selected":[193],"as":[194,210,212],"scaffold":[196],"designing":[199],"MRI":[202],"modifying":[206],"sites":[209],"well":[211],"grafting":[213],"biomarker":[215],"peptide":[216],"into":[217],"linker":[219],"region":[220],"specifically":[222],"cancers":[224],"with":[225],"efficient":[226],"optimized":[228],"modifications.":[229],"physical":[231],"kinetic":[232],"properties":[233],"animal":[235],"imaging":[236],"effects":[237],"designed":[240],"agents":[242],"investigated":[244],"various":[246],"methods.":[247]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}