{"id":"https://openalex.org/W1534128564","doi":"https://doi.org/10.1161/circ.129.suppl_1.mp58","title":"Abstract MP58: Association Between Plasma Low-Density Lipoprotein Cholesterol Level and Risk of Abdominal Aortic Aneurysm in ARIC: a Mendelian Randomization Study","display_name":"Abstract MP58: Association Between Plasma Low-Density Lipoprotein Cholesterol Level and Risk of Abdominal Aortic Aneurysm in ARIC: a Mendelian Randomization Study","publication_year":2014,"publication_date":"2014-03-25","ids":{"openalex":"https://openalex.org/W1534128564","doi":"https://doi.org/10.1161/circ.129.suppl_1.mp58","mag":"1534128564"},"language":"en","primary_location":{"id":"doi:10.1161/circ.129.suppl_1.mp58","doi":"https://doi.org/10.1161/circ.129.suppl_1.mp58","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.129.suppl_1.mp58","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005968538","display_name":"Lu-Chen C Weng","orcid":"https://orcid.org/0000-0003-1475-4930","observed_orcids":["https://orcid.org/0000-0003-1475-4930"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu-Chen Weng","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","University of Minnesota , Minneapolis, Mn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of Minnesota , Minneapolis, Mn","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082266331","display_name":"Pamela L. Lutsey","orcid":"https://orcid.org/0000-0002-1572-1340","observed_orcids":["https://orcid.org/0000-0002-1572-1340"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela L Lutsey","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","University of Minnesota , Minneapolis, Mn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of Minnesota , Minneapolis, Mn","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004776448","display_name":"\u00c1lvaro Alonso","orcid":"https://orcid.org/0000-0002-2225-8323","observed_orcids":["https://orcid.org/0000-0002-2225-8323"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alvaro Alonso","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","University of Minnesota , Minneapolis, Mn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of Minnesota , Minneapolis, Mn","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101877549","display_name":"Weihua Guan","orcid":"https://orcid.org/0000-0002-0956-9821","observed_orcids":["https://orcid.org/0000-0002-0956-9821"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weihua Guan","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","University of Minnesota , Minneapolis, Mn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of Minnesota , Minneapolis, Mn","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022683360","display_name":"James S. Pankow","orcid":"https://orcid.org/0000-0001-7076-483X","observed_orcids":["https://orcid.org/0000-0001-7076-483X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James S Pankow","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","University of Minnesota , Minneapolis, Mn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of Minnesota , Minneapolis, Mn","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075061959","display_name":"Aaron R. Folsom","orcid":"https://orcid.org/0000-0003-2635-2699","observed_orcids":["https://orcid.org/0000-0003-2635-2699"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron R Folsom","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","University of Minnesota , Minneapolis, Mn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of Minnesota , Minneapolis, Mn","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063972278","display_name":"Weihong Tang","orcid":"https://orcid.org/0000-0003-1200-0270","observed_orcids":["https://orcid.org/0000-0003-1200-0270"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weihong Tang","raw_affiliation_strings":["Univ of Minnesota, Minneapolis, MN","University of Minnesota , Minneapolis, Mn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Minnesota, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of Minnesota , Minneapolis, Mn","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"129","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abdominal-aortic-aneurysm","display_name":"abdominal aortic aneurysm","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9129999876022339},{"id":"https://openalex.org/keywords/causal-relationship","display_name":"causal relationship","score":0.6370000243186951},{"id":"https://openalex.org/keywords/lipid-lowering-drugs","display_name":"lipid-lowering drugs","score":0.5389999747276306},{"id":"https://openalex.org/keywords/atherosclerosis-risk-in-communities-study","display_name":"Atherosclerosis Risk in Communities Study","score":0.6899999976158142},{"id":"https://openalex.org/keywords/european-americans","display_name":"European Americans","score":0.5379999876022339},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.30300000309944153},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.3720000088214874},{"id":"https://openalex.org/keywords/cardiovascular-risk-stratification","display_name":"cardiovascular risk stratification","score":0.3059999942779541},{"id":"https://openalex.org/keywords/cardiovascular-risk-prediction-models","display_name":"cardiovascular risk prediction models","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9223461151123047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8646290302276611},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6347078084945679},{"id":"https://openalex.org/C2779993416","wikidata":"https://www.wikidata.org/wiki/Q2256736","display_name":"Abdominal aortic aneurysm","level":3,"score":0.6339561939239502},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5085476636886597},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41167202591896057},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19148308038711548},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.12259635329246521},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11144214868545532},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.10315811634063721},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.075837641954422},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.06809026002883911},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.129.suppl_1.mp58","doi":"https://doi.org/10.1161/circ.129.suppl_1.mp58","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.129.suppl_1.mp58","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2901309888","https://openalex.org/W2169283889","https://openalex.org/W4210703904","https://openalex.org/W3111647380","https://openalex.org/W2052821216","https://openalex.org/W1136751063","https://openalex.org/W4294125588","https://openalex.org/W2416849719","https://openalex.org/W2036527494","https://openalex.org/W2610080820"],"abstract_inverted_index":{"Introduction:":[0],"Abdominal":[1],"aortic":[2],"aneurysm":[3],"(AAA)":[4],"is":[5,27,43,48],"one":[6],"of":[7,11,24,41,57,94,98,143,146,149,172,194,198,215,226,301,321,329,333,402,437,454],"the":[8,14,89,105,141,144,150,155,163,169,192,267,275,280,298,311,327,334,378,387,400,435],"leading":[9,463],"causes":[10],"death":[12,210],"in":[13,100,104,113,307,326,384,399,408],"United":[15],"States.":[16],"Observational":[17],"epidemiological":[18],"studies":[19],"demonstrated":[20,62],"that":[21,110],"circulating":[22],"level":[23,93,391,453,462],"LDL":[25,38,54,75,95,120,135,160,187,227,270,281,296,308,312,335,379,390,409,455,461],"cholesterol":[26,129],"positively":[28],"associated":[29,123,316],"with":[30,124,317,386,431,459],"AAA":[31,42,99,201,221,272,393,403,457,467],"risk.":[32,468],"However,":[33],"a":[34,49,64,71,83,114,180,289,416,448,465],"causal":[35,50,449],"link":[36],"between":[37,52,91,269,294,389,451],"and":[39,55,96,121,165,241,259,271,297,346,392,433,456],"risk":[40,56,97,147,219,257,273,300,328,354,401],"still":[44],"unclear.":[45],"Hypothesis:":[46],"There":[47],"relationship":[51,450],"plasma":[53,92,186,295,452],"AAA,":[58,357],"which":[59],"can":[60],"be":[61],"by":[63,154,168,310,419],"Mendelian":[65],"randomization":[66],"(MR)":[67],"approach.":[68],"Methods:":[69],"Using":[70,279],"gene":[72,136,282,313,336,380,395],"score":[73,137,283,337,348,381,396,427],"for":[74,119,191,220,236,247,255,287,356],"as":[76,140,284,338],"an":[77,231,285,318,339],"instrumental":[78],"variable":[79],"(IV),":[80],"we":[81,366],"conducted":[82,415],"large":[84],"MR":[85,438],"study":[86,118],"to":[87,184,189,245,265,352,423,440,464],"investigate":[88],"association":[90,117,268,291,375,388],"8,967":[101],"European":[102],"Americans":[103],"ARIC":[106],"Study.":[107],"Twelve":[108],"SNPs":[109,152,421],"were":[111,131,203,363],"reported":[112],"published":[115],"genome-wide":[116],"not":[122,350],"other":[125,260,353,359],"lipids":[126,261],"or":[127,209],"total":[128,170,197],"(TC)":[130],"selected.":[132],"A":[133,196,250],"weighted":[134],"was":[138,182,228,262,292,315,341,349,382,428],"created":[139],"sum":[142],"number":[145,171],"alleles":[148],"selected":[151],"multiplied":[153],"SNP-specific":[156],"effect":[157,193],"size":[158],"on":[159,377],"obtained":[161],"from":[162],"literature":[164],"then":[166],"divided":[167],"SNPs.":[173],"For":[174],"participants":[175,368],"who":[176,369],"took":[177,370],"antihyperlipidemic":[178,371],"medication,":[179],"constant":[181],"added":[183],"their":[185],"value":[188],"account":[190,246],"medication.":[195],"262":[199],"clinical":[200],"cases":[202],"ascertained":[204],"through":[205],"hospital":[206],"discharge":[207],"diagnoses":[208],"certificates":[211],"during":[212],"23":[213],"years":[214],"follow-up.":[216],"The":[217,331,373],"IV-predicted":[218],"per":[222,404],"1":[223,304,405],"SD":[224,305,406],"increment":[225,407],"assessed":[229],"using":[230],"IV":[232,286,340],"probit":[233,251],"model":[234,253,439],"adjusted":[235,254],"age,":[237],"sex,":[238],"field":[239],"center,":[240],"10":[242],"principal":[243],"components":[244],"population":[248],"stratification.":[249],"regression":[252],"known":[256],"factors":[258,355],"also":[263],"performed":[264],"confirm":[266],"at":[274],"phenotype":[276],"level.":[277],"Results:":[278],"LDL,":[288],"positive":[290,374],"observed":[293,364],"predicted":[299],"AAA.":[302,330],"Each":[303],"increase":[306,320,398],"(instrumented":[309],"score)":[314],"average":[319],"10%":[322],"(95%":[323],"CI=0.1%-":[324],"20%)":[325],"strength":[332],"adequate":[342],"(F-statistic":[343],"=":[344,410],"20),":[345],"this":[347],"related":[351,422],"including":[358],"lipids.":[360],"Similar":[361],"results":[362],"after":[365],"removed":[367],"medications.":[372],"based":[376],"concordant":[383],"direction":[385],"without":[394],"(average":[397],"0.6%,":[411],"95%CI=0.3":[412],"%-1%).":[413],"We":[414],"sensitivity":[417],"analysis":[418],"adding":[420],"TC.":[424],"This":[425],"new":[426],"marginally":[429],"correlated":[430],"triglycerides":[432],"reduced":[434],"adequacy":[436],"below":[441],"statistical":[442],"significance.":[443],"Conclusion:":[444],"Our":[445],"finding":[446],"supports":[447],"risk,":[458],"higher":[460,466]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}