{"id":"https://openalex.org/W1534009784","doi":"https://doi.org/10.1001/jamaneurol.2015.0608","title":"Neuroelectronics and Biooptics","display_name":"Neuroelectronics and Biooptics","publication_year":2015,"publication_date":"2015-05-11","ids":{"openalex":"https://openalex.org/W1534009784","doi":"https://doi.org/10.1001/jamaneurol.2015.0608","mag":"1534009784","pmid":"https://pubmed.ncbi.nlm.nih.gov/25961887","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4501886"},"language":"en","primary_location":{"id":"doi:10.1001/jamaneurol.2015.0608","doi":"https://doi.org/10.1001/jamaneurol.2015.0608","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaneurol.2015.0608","pdf_url":"https://jamanetwork.com/journals/jamaneurology/articlepdf/2279876/nbs150002.pdf","source":{"id":"https://openalex.org/S164389565","display_name":"JAMA Neurology","issn_l":"2168-6149","issn":["2168-6149","2168-6157"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Neurology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jamanetwork.com/journals/jamaneurology/articlepdf/2279876/nbs150002.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011033594","display_name":"Esther I. Krook-Magnuson","orcid":"https://orcid.org/0000-0002-6119-0165","observed_orcids":["https://orcid.org/0000-0002-6119-0165"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther Krook-Magnuson","raw_affiliation_strings":["Department of Neuroscience, University of Minnesota, Minneapolis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of Minnesota, Minneapolis","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019062257","display_name":"Jennifer N. Gelinas","orcid":"https://orcid.org/0000-0002-1164-638X","observed_orcids":["https://orcid.org/0000-0002-1164-638X"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer N. Gelinas","raw_affiliation_strings":["New York University Neuroscience Institute, Langone Medical Center, New York3New York University Center for Neural Sciences, New York","New York University Center for Neural Sciences, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Neuroscience Institute, Langone Medical Center, New York3New York University Center for Neural Sciences, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"New York University Center for Neural Sciences, New York","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054420671","display_name":"Iv\u00e1n Solt\u00e9sz","orcid":"https://orcid.org/0000-0003-1493-3744","observed_orcids":["https://orcid.org/0000-0003-1493-3744"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Soltesz","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California, Irvine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California, Irvine","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043247282","display_name":"Gy\u00f6rgy Buzs\u00e1ki","orcid":"https://orcid.org/0000-0002-3100-4800","observed_orcids":["https://orcid.org/0000-0002-3100-4800"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gy\u00f6rgy Buzs\u00e1ki","raw_affiliation_strings":["New York University Neuroscience Institute, Langone Medical Center, New York3New York University Center for Neural Sciences, New York","New York University Center for Neural Sciences, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Neuroscience Institute, Langone Medical Center, New York3New York University Center for Neural Sciences, New York","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"New York University Center for Neural Sciences, New York","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043247282"],"corresponding_institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"],"apc_list":null,"apc_paid":null,"fwci":1.5618,"has_fulltext":true,"cited_by_count":98,"citation_normalized_percentile":{"value":0.83246073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"72","issue":"7","first_page":"823","last_page":"823"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/closed-loop-neurostimulation","display_name":"closed-loop neurostimulation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/neuroelectronics","display_name":"neuroelectronics","score":0.6480000019073486},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.6320000290870667},{"id":"https://openalex.org/keywords/movement-disorders","display_name":"movement disorders","score":0.996999979019165},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.734000027179718},{"id":"https://openalex.org/keywords/neurofeedback","display_name":"neurofeedback","score":0.5139999985694885},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.6650000214576721},{"id":"https://openalex.org/keywords/bioelectronics","display_name":"bioelectronics","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.5730196237564087},{"id":"https://openalex.org/C2778261627","wikidata":"https://www.wikidata.org/wiki/Q2608695","display_name":"Movement disorders","level":3,"score":0.5446419715881348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5215587615966797},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.4958110749721527},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48308733105659485},{"id":"https://openalex.org/C3019251811","wikidata":"https://www.wikidata.org/wiki/Q5135346","display_name":"Closed loop","level":2,"score":0.47573351860046387},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4516720473766327},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3920108675956726},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3153969645500183},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16911780834197998},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11840403079986572},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10122132301330566},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004567","descriptor_name":"Electrodes, Implanted","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1001/jamaneurol.2015.0608","doi":"https://doi.org/10.1001/jamaneurol.2015.0608","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaneurol.2015.0608","pdf_url":"https://jamanetwork.com/journals/jamaneurology/articlepdf/2279876/nbs150002.pdf","source":{"id":"https://openalex.org/S164389565","display_name":"JAMA Neurology","issn_l":"2168-6149","issn":["2168-6149","2168-6157"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Neurology","raw_type":"journal-article"},{"id":"pmid:25961887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25961887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA neurology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4501886","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4501886","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"JAMA Neurol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.706.1031","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.706.1031","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://buzsakilab.com/content/PDFs/KrookMagnuson2015JAMA.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1001/jamaneurol.2015.0608","doi":"https://doi.org/10.1001/jamaneurol.2015.0608","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaneurol.2015.0608","pdf_url":"https://jamanetwork.com/journals/jamaneurology/articlepdf/2279876/nbs150002.pdf","source":{"id":"https://openalex.org/S164389565","display_name":"JAMA Neurology","issn_l":"2168-6149","issn":["2168-6149","2168-6157"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1111111293","display_name":"HIPPOCAMPAL INTERNEURONAL NETWORK","funder_award_id":"R01MH054671","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1111246736","display_name":"Towards a Complete Description of the Circuitry Underlying Memory replay.","funder_award_id":"U01NS090583","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1872289060","display_name":null,"funder_award_id":"NS074015","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3646197309","display_name":"GABAergic regulation of entorhino-hippocampal excitability in epilepsy","funder_award_id":"R01NS074432","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4496423624","display_name":"The Temporal Dynamics of Learning","funder_award_id":"0542013","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5318893862","display_name":null,"funder_award_id":"SBE-0542013","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6172037519","display_name":null,"funder_award_id":"NS74432","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6731844918","display_name":null,"funder_award_id":"NS 090583","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7286171303","display_name":"Deducing the origin and effect of extracellular electric fields in hippocampus","funder_award_id":"R01NS074015","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8365320023","display_name":"On-demand optogenetic cerebellar intervention for temporal lobe epilepsy","funder_award_id":"K99NS087110","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000894640","display_name":"Pediatric Scientist Development Program","funder_award_id":"K12HD000850","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G977327898","display_name":null,"funder_award_id":"MH54671","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306182","display_name":"March of Dimes Foundation","ror":"https://ror.org/04bd5p711"},{"id":"https://openalex.org/F4320307214","display_name":"Citizens United for Research in Epilepsy","ror":"https://ror.org/01awnfh35"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1534009784.pdf","grobid_xml":"https://content.openalex.org/works/W1534009784.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1779780961","https://openalex.org/W1834763371","https://openalex.org/W1944155217","https://openalex.org/W1963837902","https://openalex.org/W1967456522","https://openalex.org/W1970604942","https://openalex.org/W1971797700","https://openalex.org/W1972879677","https://openalex.org/W1978574256","https://openalex.org/W1981992221","https://openalex.org/W1984414718","https://openalex.org/W1986592610","https://openalex.org/W1986855353","https://openalex.org/W1989189053","https://openalex.org/W1997654862","https://openalex.org/W2000092788","https://openalex.org/W2008017799","https://openalex.org/W2008113252","https://openalex.org/W2008325510","https://openalex.org/W2009578021","https://openalex.org/W2014514161","https://openalex.org/W2018376333","https://openalex.org/W2019664149","https://openalex.org/W2022001004","https://openalex.org/W2029609355","https://openalex.org/W2034129279","https://openalex.org/W2038606869","https://openalex.org/W2046999866","https://openalex.org/W2059009040","https://openalex.org/W2060589548","https://openalex.org/W2061124896","https://openalex.org/W2062642893","https://openalex.org/W2063592395","https://openalex.org/W2072296702","https://openalex.org/W2074069661","https://openalex.org/W2078098979","https://openalex.org/W2083233554","https://openalex.org/W2083932518","https://openalex.org/W2107635023","https://openalex.org/W2110736328","https://openalex.org/W2111937020","https://openalex.org/W2112002552","https://openalex.org/W2112830076","https://openalex.org/W2113981430","https://openalex.org/W2118398549","https://openalex.org/W2120968628","https://openalex.org/W2125112186","https://openalex.org/W2133082272","https://openalex.org/W2140186468","https://openalex.org/W2143685192","https://openalex.org/W2149681593","https://openalex.org/W2151033573","https://openalex.org/W2154214065","https://openalex.org/W2156108573","https://openalex.org/W2158048307","https://openalex.org/W2158256695","https://openalex.org/W2167237768","https://openalex.org/W2295048429","https://openalex.org/W2325996598","https://openalex.org/W2329970637","https://openalex.org/W2340243459","https://openalex.org/W2410564133"],"related_works":["https://openalex.org/W2607603038","https://openalex.org/W4388739124","https://openalex.org/W1485775","https://openalex.org/W7117946134","https://openalex.org/W4210287031","https://openalex.org/W2219712765","https://openalex.org/W4388638776","https://openalex.org/W6980613601","https://openalex.org/W2965768781","https://openalex.org/W7132863646"],"abstract_inverted_index":{"Brain-implanted":[0],"devices":[1],"are":[2,14,30],"no":[3],"longer":[4],"a":[5],"futuristic":[6],"idea.":[7],"Traditionally,":[8],"therapies":[9,29],"for":[10,110],"most":[11],"neurological":[12,66,81,117],"disorders":[13],"adjusted":[15],"based":[16],"on":[17],"changes":[18],"in":[19,104,114],"clinical":[20,112],"symptoms":[21,48],"and":[22,68,86,96],"diagnostic":[23],"measures":[24],"observed":[25],"over":[26],"time.":[27],"These":[28],"commonly":[31],"pharmacological":[32],"or":[33,37,49],"surgical,":[34],"requiring":[35],"continuous":[36],"irreversible":[38],"treatment":[39],"regimens":[40],"that":[41],"cannot":[42],"respond":[43],"rapidly":[44],"to":[45,79],"fluctuations":[46],"of":[47,52],"isolated":[50],"episodes":[51],"dysfunction.":[53],"In":[54],"contrast,":[55],"closed-loop":[56,106],"systems":[57,75,107],"provide":[58],"intervention":[59],"only":[60],"when":[61],"needed":[62],"by":[63,94],"detecting":[64],"abnormal":[65],"signals":[67],"modulating":[69],"them":[70],"with":[71,116],"instantaneous":[72],"feedback.":[73],"Closed-loop":[74],"have":[76],"been":[77],"applied":[78],"several":[80],"conditions":[82],"(most":[83],"notably":[84],"epilepsy":[85],"movement":[87],"disorders),":[88],"but":[89],"widespread":[90],"use":[91],"is":[92],"limited":[93],"conceptual":[95],"technical":[97],"challenges.":[98],"Herein,":[99],"we":[100],"discuss":[101],"how":[102],"advances":[103],"experimental":[105],"hold":[108],"promise":[109],"improved":[111],"benefit":[113],"patients":[115],"disorders.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
