{"id":"https://openalex.org/W153372069","doi":null,"title":"Effects of Manipulating Dietary Carbohydrate and Fat on Circulating Saturated Fatty Acid Composition","display_name":"Effects of Manipulating Dietary Carbohydrate and Fat on Circulating Saturated Fatty Acid Composition","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W153372069","mag":"153372069"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-6489","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/291","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089194376","display_name":"Brittanie M. Volk","orcid":"https://orcid.org/0000-0003-3530-519X","observed_orcids":["https://orcid.org/0000-0003-3530-519X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Brittanie M. Volk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5089194376"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.5205000042915344,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.5205000042915344,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.2996000051498413,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.11649999767541885,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-saturated-fat","display_name":"dietary saturated fat","score":0.7749999761581421},{"id":"https://openalex.org/keywords/dietary-carbohydrates","display_name":"dietary carbohydrates","score":0.9520000219345093},{"id":"https://openalex.org/keywords/plasma-fatty-acid-composition","display_name":"plasma fatty acid composition","score":0.7089999914169312},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.8370000123977661},{"id":"https://openalex.org/keywords/de-novo-lipogenesis","display_name":"de novo lipogenesis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6119999885559082},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.718999981880188},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7350000143051147},{"id":"https://openalex.org/keywords/low-carbohydrate-diet","display_name":"low-carbohydrate diet","score":0.8090000152587891},{"id":"https://openalex.org/keywords/lipoproteins","display_name":"lipoproteins","score":0.6899999976158142},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.4009999930858612},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9070000052452087},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6870048642158508},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.6005938053131104},{"id":"https://openalex.org/C2778977261","wikidata":"https://www.wikidata.org/wiki/Q11358","display_name":"Carbohydrate","level":2,"score":0.5931016206741333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5440813899040222},{"id":"https://openalex.org/C2991897288","wikidata":"https://www.wikidata.org/wiki/Q970537","display_name":"Saturated fatty acid","level":3,"score":0.5151668787002563},{"id":"https://openalex.org/C3020261727","wikidata":"https://www.wikidata.org/wiki/Q970537","display_name":"Saturated fat","level":3,"score":0.44672074913978577},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.38877415657043457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3396601378917694},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.15136376023292542},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-6489","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/291","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"pmh:oai:opencommons.uconn.edu:dissertations-6489","doi":null,"is_oa":false,"landing_page_url":"https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=6489&context=dissertations","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"mag:153372069","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.uconn.edu/dissertations/291/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2981990520","https://openalex.org/W7096770196","https://openalex.org/W2016109681","https://openalex.org/W7099678612","https://openalex.org/W2038244575","https://openalex.org/W2142698946","https://openalex.org/W200151976","https://openalex.org/W7010368717","https://openalex.org/W4315865116","https://openalex.org/W98663949"],"abstract_inverted_index":{"Dietary":[0],"recommendations":[1],"by":[2],"public":[3],"health":[4],"organizations":[5],"promote":[6],"intakes":[7,60,306],"high":[8,58],"in":[9,13,63,100,152,187,246,251,254],"carbohydrates":[10,202,239,289],"and":[11,39,61,69,112,126,154,161,175,205,229,236,249,271,315,328,345],"low":[12,140],"saturated":[14],"fat":[15,248],"(SFA)":[16],"largely":[17],"based":[18],"on":[19,109],"the":[20,33,42,67,94,101,197,212],"belief":[21],"that":[22,96,149],"dietary":[23,45,77,107,188,247,295,326],"SFA":[24,30,46,108,111,178,189,206,210,305,314,327],"raises":[25],"plasma":[26,29,64],"cholesterol.":[27],"While":[28],"contributes":[31],"to":[32,47,75,81,92,119,196,285,310],"risk":[34,114,318],"of":[35,72,98,165,224,256,298,312,340],"metabolic":[36,129],"syndrome,":[37],"diabetes,":[38],"cardiovascular":[40,166],"disease,":[41],"evidence":[43],"linking":[44],"these":[48],"diseases":[49],"is":[50,322,331],"substantially":[51],"weak.":[52],"An":[53],"association":[54],"does":[55],"exist":[56],"between":[57,219],"carbohydrate":[59,78,99,141,153,199,233,252,280,320,330],"elevations":[62],"SFA,":[65],"but":[66,261,282],"amount":[68],"individual":[70,121],"variability":[71,218],"one\u2019s":[73],"ability":[74],"process":[76],"has":[79],"yet":[80],"be":[82],"explored":[83],"under":[84],"highly":[85],"controlled":[86],"conditions.":[87],"The":[88],"primary":[89],"purpose":[90],"was":[91],"investigate":[93],"hypothesis":[95],"levels":[97,287],"diet":[102],"are":[103],"more":[104,338],"influential":[105],"than":[106],"circulating":[110,209],"cardio-metabolic":[113],"with":[115,128,216,279,333],"an":[116],"additional":[117],"aim":[118],"explore":[120],"variability.":[122],"Fourteen":[123],"overweight":[124],"men":[125],"women":[127],"syndrome":[130],"were":[131,144,168,290],"monitored":[132],"for":[133],"21":[134],"weeks.":[135],"After":[136],"a":[137,184,222,334],"3-week":[138,147],"run-in":[139],"diet,":[142],"subjects":[143,191],"fed":[145],"six":[146],"diets":[148,195],"incrementally":[150],"increased":[151,204,272,341,346],"decreased":[155,179,235],"fat.":[156],"Plasma":[157,173],"fatty":[158,335],"acids,":[159],"lipoproteins,":[160],"traditional":[162],"clinical":[163],"markers":[164],"disease":[167,317,347],"evaluated":[169],"after":[170,273],"each":[171],"phase.":[172],"triglyceride":[174],"cholesteryl":[176],"ester":[177],"or":[180,214],"remained":[181,211],"unchanged":[182],"despite":[183],"two-fold":[185],"increase":[186],"as":[190,232,238,288],"transitioned":[192],"from":[193,265],"habitual":[194],"lowest":[198],"diet.":[200],"As":[201],"progressively":[203],"decreased,":[207],"total":[208,257],"same":[213],"increased,":[215],"significant":[217],"participants.":[220,303],"16:1n-7,":[221],"marker":[223],"de":[225,342],"novo":[226,343],"lipogenesis,":[227],"dramatically":[228],"uniformly":[230],"reduced":[231,268],"intake":[234,321],"rose":[237],"increased.":[240],"Despite":[241,292],"continued":[242],"weight":[243,299],"loss,":[244],"reductions":[245],"increases":[250],"resulted":[253],"fluctuations":[255],"cholesterol,":[258],"LDL-C,":[259],"HDL-C":[260],"all":[262],"maintained":[263],"improvements":[264],"baseline.":[266],"TAG":[267],"during":[269],"ChoI":[270],"subsequent":[274],"phases.":[275],"Insulin":[276],"sensitivity":[277],"improved":[278],"restriction":[281],"gradually":[283],"returned":[284],"near-baseline":[286],"reintroduced.":[291],"similar":[293],"relative":[294],"input,":[296],"degrees":[297],"loss":[300],"varied":[301],"among":[302],"High":[304],"do":[307],"not":[308],"contribute":[309],"accumulation":[311],"blood":[313],"chronic":[316],"when":[319],"limited.":[323],"However,":[324],"decreasing":[325],"increasing":[329],"associated":[332],"acid":[336],"profile":[337],"indicative":[339],"lipogenesis":[344],"risk.":[348]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}