{"id":"https://openalex.org/W1533711237","doi":"https://doi.org/10.1111/j.1742-4658.2011.08035.x","title":"Role of the cag \u2010pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis","display_name":"Role of the cag \u2010pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W1533711237","doi":"https://doi.org/10.1111/j.1742-4658.2011.08035.x","mag":"1533711237","pmid":"https://pubmed.ncbi.nlm.nih.gov/21352489","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3070773"},"language":"en","primary_location":{"id":"doi:10.1111/j.1742-4658.2011.08035.x","doi":"https://doi.org/10.1111/j.1742-4658.2011.08035.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1742-4658.2011.08035.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-4658.2011.08035.x","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-4658.2011.08035.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005740243","display_name":"Nicole Tegtmeyer","orcid":"https://orcid.org/0000-0002-6300-1831","observed_orcids":["https://orcid.org/0000-0002-6300-1831"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Nicole Tegtmeyer","raw_affiliation_strings":["School of Biomolecular and Biomedical Sciences, Science Center West, Belfield Campus, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomolecular and Biomedical Sciences, Science Center West, Belfield Campus, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073583894","display_name":"Silja We\u00dfler","orcid":"https://orcid.org/0000-0001-7011-6162","observed_orcids":["https://orcid.org/0000-0001-7011-6162"]},"institutions":[{"id":"https://openalex.org/I182212641","display_name":"University of Salzburg","ror":"https://ror.org/05gs8cd61","country_code":"AT","type":"education","lineage":["https://openalex.org/I182212641"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Silja Wessler","raw_affiliation_strings":["Department of Molecular Biology, Division of Microbiology, Paris-Lodron University of Salzburg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Division of Microbiology, Paris-Lodron University of Salzburg, Austria","institution_ids":["https://openalex.org/I182212641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056524563","display_name":"Steffen Backert","orcid":"https://orcid.org/0000-0002-8948-8254","observed_orcids":["https://orcid.org/0000-0002-8948-8254"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE","IE"],"is_corresponding":false,"raw_author_name":"Steffen Backert","raw_affiliation_strings":["Institute for Medical Microbiology, Otto von Guericke University Magdeburg, Germany","School of Biomolecular and Biomedical Sciences, Science Center West, Belfield Campus, University College Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology, Otto von Guericke University Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]},{"raw_affiliation_string":"School of Biomolecular and Biomedical Sciences, Science Center West, Belfield Campus, University College Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":5.1494,"has_fulltext":true,"cited_by_count":250,"citation_normalized_percentile":{"value":0.98486282,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"278","issue":"8","first_page":"1190","last_page":"1202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":1.0},{"id":"https://openalex.org/keywords/cag-pathogenicity-island","display_name":"cag pathogenicity island","score":0.9800000190734863},{"id":"https://openalex.org/keywords/type-iv-secretion-system","display_name":"type IV secretion system","score":0.9980000257492065},{"id":"https://openalex.org/keywords/caga","display_name":"CagA","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cagl","display_name":"CagL","score":0.8399999737739563},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.6050000190734863},{"id":"https://openalex.org/keywords/phosphatidylserine","display_name":"phosphatidylserine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/host-cell-signalling","display_name":"host cell signalling","score":0.652999997138977},{"id":"https://openalex.org/keywords/membrane-dynamics","display_name":"membrane dynamics","score":0.5429999828338623},{"id":"https://openalex.org/keywords/cell-cell-contact","display_name":"cell-cell contact","score":0.906000018119812},{"id":"https://openalex.org/keywords/actin-cytoskeleton-reorganization","display_name":"actin cytoskeleton remodeling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/proinflammatory-response","display_name":"pro-inflammatory response","score":0.6399999856948853},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.5920000076293945},{"id":"https://openalex.org/keywords/bacterial-virulence","display_name":"bacterial virulence","score":0.6449999809265137},{"id":"https://openalex.org/keywords/gastritis","display_name":"gastritis","score":0.5730000138282776},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.8169999718666077},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2778204961","wikidata":"https://www.wikidata.org/wiki/Q83146136","display_name":"CagA","level":4,"score":0.9646508693695068},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.8037970066070557},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.7165787816047668},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7060277462005615},{"id":"https://openalex.org/C62130838","wikidata":"https://www.wikidata.org/wiki/Q5196163","display_name":"Pathogenicity island","level":4,"score":0.6407350897789001},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.6064825057983398},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5874249935150146},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5029658675193787},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.4741976857185364},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4065343141555786},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.40147972106933594},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2232213020324707},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14651569724082947},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07419806718826294}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005849","descriptor_name":"Gerbillinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044404","descriptor_name":"Genomic Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1742-4658.2011.08035.x","doi":"https://doi.org/10.1111/j.1742-4658.2011.08035.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1742-4658.2011.08035.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-4658.2011.08035.x","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:21352489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21352489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3070773","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3070773","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FEBS J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/j.1742-4658.2011.08035.x","doi":"https://doi.org/10.1111/j.1742-4658.2011.08035.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1742-4658.2011.08035.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1742-4658.2011.08035.x","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1035922161","display_name":"Mechanisms of H. pylori-Induced Hypochlorhydria","funder_award_id":"R56DK064371","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2239569184","display_name":"Mechanisms of H pylori-Induced Hypochlorhydria","funder_award_id":"R01DK064371","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1533711237.pdf","grobid_xml":"https://content.openalex.org/works/W1533711237.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1511963303","https://openalex.org/W1550554578","https://openalex.org/W1965254865","https://openalex.org/W1974377924","https://openalex.org/W1986853519","https://openalex.org/W1987009735","https://openalex.org/W1988532871","https://openalex.org/W1989973014","https://openalex.org/W1991444764","https://openalex.org/W1993429107","https://openalex.org/W1998057417","https://openalex.org/W1999587546","https://openalex.org/W2000476027","https://openalex.org/W2003035812","https://openalex.org/W2008782135","https://openalex.org/W2018707425","https://openalex.org/W2020861520","https://openalex.org/W2034521161","https://openalex.org/W2038471507","https://openalex.org/W2040853949","https://openalex.org/W2055625865","https://openalex.org/W2058849414","https://openalex.org/W2059781799","https://openalex.org/W2078336838","https://openalex.org/W2097301400","https://openalex.org/W2131695415","https://openalex.org/W2151497108","https://openalex.org/W2155357810","https://openalex.org/W2160687212","https://openalex.org/W2166628251","https://openalex.org/W4248856047"],"related_works":["https://openalex.org/W1965254865","https://openalex.org/W2442397882","https://openalex.org/W2789369516","https://openalex.org/W1556992304","https://openalex.org/W2601318866","https://openalex.org/W2379583728","https://openalex.org/W2808760744","https://openalex.org/W4401752179","https://openalex.org/W2175134890","https://openalex.org/W1965323568"],"abstract_inverted_index":{"Helicobacter":[0],"pylori":[1,31,199],"is":[2,71,201],"a":[3,41,50,74,134],"very":[4],"successful":[5],"human-specific":[6],"bacterium":[7],"worldwide.":[8],"Infections":[9],"of":[10,57,76,98,107,143,162,169,173,191],"the":[11,34,55,62,89,101,120,139,156,163,167],"stomach":[12],"with":[13,110],"this":[14],"pathogen":[15],"can":[16],"induce":[17],"pathologies,":[18],"including":[19,79],"chronic":[20],"gastritis,":[21],"peptic":[22],"ulcers":[23],"and":[24,83,132,158,176,185],"even":[25],"gastric":[26],"cancer.":[27],"Highly":[28],"virulent":[29],"H.":[30,198],"strains":[32],"encode":[33],"cytotoxin-associated":[35],"gene":[36],"(cag)-pathogenicity":[37],"island,":[38],"which":[39,85,165],"expresses":[40],"type":[42],"IV":[43],"secretion":[44],"system":[45],"(T4SS).":[46],"This":[47,70],"T4SS":[48,77],"forms":[49],"syringe-like":[51],"pilus":[52],"structure":[53],"for":[54,119,138],"injection":[56,121],"virulence":[58],"factors":[59],"such":[60],"as":[61,179,181],"CagA":[63,99,108,125],"effector":[64],"protein":[65],"into":[66],"host":[67,90,102,135],"target":[68],"cells.":[69],"achieved":[72],"by":[73,86,96,128],"number":[75],"proteins,":[78],"CagI,":[80],"CagL,":[81],"CagY":[82],"CagA,":[84],"itself":[87],"binds":[88],"cell":[91,103,136,183],"integrin":[92],"member":[93],"\u03b2(1)":[94],"followed":[95],"delivery":[97],"across":[100],"membrane.":[104],"A":[105],"role":[106],"interaction":[109],"phosphatidylserine":[111],"has":[112],"also":[113],"been":[114],"shown":[115],"to":[116,154,195],"be":[117],"important":[118],"process.":[122],"After":[123],"delivery,":[124],"becomes":[126],"phosphorylated":[127],"oncogenic":[129],"tyrosine":[130],"kinases":[131],"mimics":[133],"factor":[137],"activation":[140],"or":[141],"inactivation":[142],"some":[144],"specific":[145],"intracellular":[146],"signalling":[147,160,193],"pathways.":[148],"We":[149],"review":[150],"recent":[151],"progress":[152],"aiming":[153],"characterize":[155],"CagA-dependent":[157],"CagA-independent":[159],"capabilities":[161],"T4SS,":[164],"include":[166],"induction":[168],"membrane":[170],"dynamics,":[171],"disruption":[172],"cell-cell":[174],"junctions":[175],"actin-cytoskeletal":[177],"rearrangements,":[178],"well":[180],"pro-inflammatory,":[182],"cycle-related":[184],"anti-apoptotic":[186],"transcriptional":[187],"responses.":[188],"The":[189],"contribution":[190],"these":[192],"pathways":[194],"pathogenesis":[196],"during":[197],"infections":[200],"discussed.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}