{"id":"https://openalex.org/W153343040","doi":null,"title":"Intera\u00e7\u00f5es medicamentosas relevantes no tratamento de doen\u00e7as cardiovasculares","display_name":"Intera\u00e7\u00f5es medicamentosas relevantes no tratamento de doen\u00e7as cardiovasculares","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W153343040","mag":"153343040"},"language":"pt","primary_location":{"id":"pmh:oai:bdigital.ufp.pt:10284/4519","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10284/4519","pdf_url":"http://hdl.handle.net/10284/4519","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10284/4519","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052665457","display_name":"Marta Cruz Batista Pinto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marta Cruz Batista Pinto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052665457"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.5679000020027161,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.5679000020027161,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.26589998602867126,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.05249999836087227,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9390000104904175},{"id":"https://openalex.org/keywords/stroke-prevention","display_name":"stroke prevention","score":0.7850000262260437},{"id":"https://openalex.org/keywords/pharmacokinetic-interactions","display_name":"pharmacokinetic interactions","score":0.7829999923706055},{"id":"https://openalex.org/keywords/pharmacodynamic-interactions","display_name":"pharmacodynamic interactions","score":0.9919999837875366},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.8080000281333923},{"id":"https://openalex.org/keywords/drug-interaction-databases","display_name":"drug interaction databases","score":0.6330000162124634},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.703000009059906},{"id":"https://openalex.org/keywords/food-drug-interactions","display_name":"food-drug interactions","score":0.6620000004768372},{"id":"https://openalex.org/keywords/herbal-products","display_name":"herbal products","score":0.6060000061988831},{"id":"https://openalex.org/keywords/anticoagulants","display_name":"anticoagulants","score":0.6100000143051147},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.7670000195503235},{"id":"https://openalex.org/keywords/antithrombotic-agents","display_name":"antithrombotic agents","score":0.7170000076293945},{"id":"https://openalex.org/keywords/anticoagulation-monitoring","display_name":"anticoagulation monitoring","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3911009132862091},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3606069087982178},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3227279782295227}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:bdigital.ufp.pt:10284/4519","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10284/4519","pdf_url":"http://hdl.handle.net/10284/4519","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:153343040","doi":null,"is_oa":false,"landing_page_url":"https://bdigital.ufp.pt/bitstream/10284/4519/1/PPG_23855.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:bdigital.ufp.pt:10284/4519","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10284/4519","pdf_url":"http://hdl.handle.net/10284/4519","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W153343040.pdf","grobid_xml":"https://content.openalex.org/works/W153343040.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W62556515","https://openalex.org/W1594910725","https://openalex.org/W1916373817","https://openalex.org/W1968063155","https://openalex.org/W1973225510","https://openalex.org/W1975897275","https://openalex.org/W1986823509","https://openalex.org/W1989438928","https://openalex.org/W1994465725","https://openalex.org/W2007840482","https://openalex.org/W2008294930","https://openalex.org/W2012395882","https://openalex.org/W2015222024","https://openalex.org/W2015854890","https://openalex.org/W2023036969","https://openalex.org/W2023636483","https://openalex.org/W2026224501","https://openalex.org/W2030978880","https://openalex.org/W2031055244","https://openalex.org/W2035822708","https://openalex.org/W2043384854","https://openalex.org/W2065965076","https://openalex.org/W2073546757","https://openalex.org/W2077205688","https://openalex.org/W2079953715","https://openalex.org/W2091582819","https://openalex.org/W2098344528","https://openalex.org/W2099065264","https://openalex.org/W2121404852","https://openalex.org/W2139290108","https://openalex.org/W2151268696","https://openalex.org/W2154639143","https://openalex.org/W2158891997","https://openalex.org/W2163576316","https://openalex.org/W2172147566","https://openalex.org/W2182775535","https://openalex.org/W2238922708","https://openalex.org/W2253369231","https://openalex.org/W2299360681","https://openalex.org/W3163053144","https://openalex.org/W3204374530"],"related_works":["https://openalex.org/W2946228427","https://openalex.org/W7143566413","https://openalex.org/W2036934332","https://openalex.org/W2417032878","https://openalex.org/W4380091440","https://openalex.org/W4327575097","https://openalex.org/W2399864040","https://openalex.org/W4327575117","https://openalex.org/W2418940738","https://openalex.org/W4327575144"],"abstract_inverted_index":{"Os":[0],"doentes":[1],"cardiovasculares":[2],"constituem":[3],"um":[4,53],"dos":[5,182],"principais":[6],"grupos":[7],"de":[8,15,22,32,37,52,61,88,137,200,212,219,224],"risco":[9],"no":[10,25,114,154],"que":[11,40,97,201],"respeita":[12],"\u00e0":[13],"ocorr\u00eancia":[14],"intera\u00e7\u00f5es":[16,79,107,126,150,187,204],"medicamentosas,":[17],"n\u00e3o":[18],"s\u00f3":[19],"pela":[20,56],"combina\u00e7\u00e3o":[21],"f\u00e1rmacos":[23,152],"usada":[24],"tratamento":[26,155,163],"destas":[27],"doen\u00e7as":[28],"como":[29,216],"pelo":[30],"facto":[31],"muitos":[33],"indiv\u00edduos":[34],"sofrerem":[35],"igualmente":[36,173],"outras":[38],"patologias":[39],"requerem":[41],"medica\u00e7\u00e3o.":[42],"A":[43],"intera\u00e7\u00e3o":[44],"medicamentosa":[45],"consiste":[46],"na":[47,120,160,169],"altera\u00e7\u00e3o":[48],"da":[49,69,106,116,156],"atividade":[50],"farmacol\u00f3gica":[51,67],"f\u00e1rmaco":[54,74],"provocada":[55],"administra\u00e7\u00e3o":[57],"anterior":[58],"ou":[59,92,102],"concomitante":[60],"outro":[62],"e":[63,94,139,159,180,188],"traduz-se":[64],"numa":[65],"resposta":[66],"diferente":[68],"prevista":[70],"quando":[71],"o":[72,86],"mesmo":[73],"\u00e9":[75],"administrado":[76],"isoladamente.":[77],"As":[78],"medicamentosas":[80,127,205],"s\u00e3o":[81,108],"classificadas":[82],"tendo":[83],"em":[84],"conta":[85],"mecanismo":[87],"a\u00e7\u00e3o":[89],"envolvido":[90],"(farmacocin\u00e9ticas":[91],"farmacodin\u00e2micas)":[93],"as":[95,125,148,189,203,217,434,436],"subst\u00e2ncias":[96],"nelas":[98],"interv\u00eam":[99],"(f\u00e1rmacos,":[100],"alimentos":[101],"produtos":[103],"naturais).":[104],"Algumas":[105],"ben\u00e9ficas,":[109],"podendo":[110],"resultar,":[111],"por":[112],"exemplo,":[113],"aumento":[115],"efic\u00e1cia":[117],"terap\u00eautica.":[118],"Contudo,":[119],"maior":[121],"parte":[122],"das":[123],"vezes,":[124],"culminam":[128],"num":[129],"efeito":[130],"indesejado,":[131],"designado":[132],"rea\u00e7\u00e3o":[133],"adversa,":[134],"importante":[135],"causa":[136],"morbilidade":[138],"mortalidade.":[140],"O":[141],"presente":[142,176],"trabalho":[143,177],"monogr\u00e1fico":[144],"visa":[145],"compilar":[146],"todas":[147],"poss\u00edveis":[149],"com":[151],"usados":[153],"hipertens\u00e3o":[157],"arterial":[158],"preven\u00e7\u00e3o":[161],"e/ou":[162],"do":[164,175,195],"acidente":[165],"vascular":[166],"cerebral":[167],"descritas":[168],"literatura":[170],"cient\u00edfica.":[171],"\u00c9":[172],"objetivo":[174],"a":[178,193,230,277,291],"discuss\u00e3o":[179],"compreens\u00e3o":[181],"mecanismos":[183],"envolvidos":[184],"nas":[185],"referidas":[186],"suas":[190],"consequ\u00eancias":[191],"para":[192],"sa\u00fade":[194],"indiv\u00edduo.":[196],"Adicionalmente,":[197],"pretende-se":[198],"referir":[199],"forma":[202],"podem":[206],"ser":[207],"evitadas,":[208],"abordando":[209],"os":[210],"sistemas":[211],"farmacovigil\u00e2ncia":[213],"implementados":[214],"assim":[215],"bases":[218],"dados":[220],"disponibilizadas":[221],"aos":[222],"profissionais":[223],"sa\u00fade.":[225],"The":[226,361],"cardiovascular":[227],"patients":[228],"are":[229,309,333],"major":[231],"risk":[232],"group":[233],"with":[234],"regard":[235],"of":[236,247,252,272,276,285,316,363,378,386,400,413,431],"drugs":[237,248,373],"interaction.":[238],"This":[239],"is":[240,269,366,395,418],"not":[241],"only":[242],"due":[243],"to":[244,313,357,367,410,420,440],"the":[245,270,273,296,300,314,337,376,382,390,396,401,411,414,429,437],"combination":[246],"used":[249,374],"in":[250,311,342,348,375,381,389,404],"treatment":[251,377,385],"these":[253,405],"diseases":[254],"but":[255],"also":[256,260],"ause":[257],"many":[258],"individuals":[259],"suffer":[261],"from":[262],"other":[263],"disorders":[264],"requiring":[265],"medication.":[266],"Drug":[267],"interaction":[268,308],"modification":[271],"pharmacological":[274,293],"activity":[275],"drug":[278,287,302,423],"caused":[279],"by":[280,428],"prior":[281],"or":[282,320,328,384],"concomitant":[283],"administration":[284],"another":[286],"and":[288,322,359,380,398,407],"results":[289],"into":[290],"different":[292],"response":[294],"that":[295,354],"one":[297],"expected":[298],"if":[299],"same":[301],"had":[303],"been":[304],"administered":[305],"alone.":[306],"Drugs":[307],"classified":[310],"relation":[312],"mechanism":[315],"action":[317],"involved":[318,403],"(pharmacokinetic":[319],"pharmacodynamic)":[321],"substances":[323],"taking":[324],"part":[325],"(drugs,":[326],"food":[327],"natural":[329],"products).":[330],"Some":[331],"interactions":[332,371,406,424],"beneficial,":[334],"for":[335],"example,":[336],"increase":[338],"therapeutic":[339],"efficacy.":[340],"However,":[341],"most":[343],"cases,":[344],"they":[345],"will":[346,355],"culminate":[347],"unexpected":[349],"effects,":[350],"designated":[351],"adverse":[352],"reactions,":[353],"lead":[356],"morbidity":[358],"mortality.":[360],"aim":[362],"this":[364],"monograph":[365],"compile":[368],"all":[369],"possible":[370],"between":[372],"hypertension":[379],"prevention":[383],"stroke,":[387],"described":[388],"scientific":[391],"literature.":[392],"Another":[393],"objective":[394],"discussion":[397],"understanding":[399],"mechanisms":[402],"their":[408],"consequences":[409],"health":[412,441],"individual.":[415],"Additionally,":[416],"it":[417],"intended":[419],"approach":[421],"how":[422],"can":[425],"be":[426],"avoided":[427],"use":[430],"pharmacovigilance":[432],"systems":[433],"well":[435],"databases":[438],"available":[439],"professionals.":[442]},"counts_by_year":[],"updated_date":"2026-08-29T07:29:34.045763","created_date":"2016-06-24T00:00:00"}