{"id":"https://openalex.org/W1532010591","doi":null,"title":"Antitumor drug adozelesin differentially affects active and silent origins of DNA replication in yeast checkpoint kinase mutants.","display_name":"Antitumor drug adozelesin differentially affects active and silent origins of DNA replication in yeast checkpoint kinase mutants.","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W1532010591","mag":"1532010591","pmid":"https://pubmed.ncbi.nlm.nih.gov/11325853"},"language":"en","primary_location":{"id":"pmid:11325853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11325853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100445097","display_name":"Yu Wang","orcid":"https://orcid.org/0000-0001-7935-9902","observed_orcids":["https://orcid.org/0000-0001-7935-9902"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Wang","raw_affiliation_strings":["Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080046324","display_name":"Terry A. Beerman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T A Beerman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109070972","display_name":"David Kowalski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Kowalski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6732,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.61878044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"61","issue":"9","first_page":"3787","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replication-origins","display_name":"origin of replication","score":0.8360000252723694},{"id":"https://openalex.org/keywords/replication-fork-stalling","display_name":"replication fork stalling","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dna-damage-checkpoint","display_name":"DNA damage checkpoint","score":0.8240000009536743},{"id":"https://openalex.org/keywords/rad53","display_name":"Rad53","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mec1","display_name":"Mec1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/replication-intermediates","display_name":"replication intermediates","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.796999990940094},{"id":"https://openalex.org/keywords/chromosome-integrity","display_name":"chromosome integrity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7110000252723694},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/intra-s-phase-checkpoint","display_name":"S-phase checkpoint","score":0.5920000076293945},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.7370057106018066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7158796787261963},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.6659865379333496},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6499310731887817},{"id":"https://openalex.org/C151158763","wikidata":"https://www.wikidata.org/wiki/Q1626856","display_name":"Origin recognition complex","level":5,"score":0.6490079164505005},{"id":"https://openalex.org/C175193931","wikidata":"https://www.wikidata.org/wiki/Q18047065","display_name":"DNA replication factor CDT1","level":5,"score":0.5572381019592285},{"id":"https://openalex.org/C67419583","wikidata":"https://www.wikidata.org/wiki/Q5205768","display_name":"DNA re-replication","level":5,"score":0.5061721205711365},{"id":"https://openalex.org/C188036394","wikidata":"https://www.wikidata.org/wiki/Q14902224","display_name":"Replication factor C","level":5,"score":0.493314653635025},{"id":"https://openalex.org/C41141232","wikidata":"https://www.wikidata.org/wiki/Q3685229","display_name":"Pre-replication complex","level":5,"score":0.4654698371887207},{"id":"https://openalex.org/C54266558","wikidata":"https://www.wikidata.org/wiki/Q6543075","display_name":"Licensing factor","level":5,"score":0.46413061022758484},{"id":"https://openalex.org/C35195891","wikidata":"https://www.wikidata.org/wiki/Q2289513","display_name":"S phase","level":5,"score":0.4620349705219269},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4522961378097534},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4372445046901703},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.42410776019096375},{"id":"https://openalex.org/C58337764","wikidata":"https://www.wikidata.org/wiki/Q976651","display_name":"Origin of replication","level":4,"score":0.4210547208786011},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39377039670944214},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36874818801879883},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3419038653373718},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.17098966240882874},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.15646931529045105}],"mesh":[{"descriptor_ui":"D000080890","descriptor_name":"Duocarmycins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053138","descriptor_name":"Cyclohexenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11325853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11325853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1532010591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11325853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1737961866","display_name":"Structure and Activity of DNA Replication Origins","funder_award_id":"R01GM030614","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000888465","display_name":"Roswell Park Cancer Center Support Grant","funder_award_id":"P30CA016056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1488535384","https://openalex.org/W1559338898","https://openalex.org/W1566625041","https://openalex.org/W1597133026","https://openalex.org/W1618976685","https://openalex.org/W1669659061","https://openalex.org/W1680979333","https://openalex.org/W1968863900","https://openalex.org/W1970190452","https://openalex.org/W1970898019","https://openalex.org/W1979923851","https://openalex.org/W1988876917","https://openalex.org/W1989971670","https://openalex.org/W1994751550","https://openalex.org/W1998875155","https://openalex.org/W2001231830","https://openalex.org/W2003279154","https://openalex.org/W2008754067","https://openalex.org/W2010234900","https://openalex.org/W2013648875","https://openalex.org/W2017928245","https://openalex.org/W2018741051","https://openalex.org/W2019027893","https://openalex.org/W2025011614","https://openalex.org/W2025378139","https://openalex.org/W2027095809","https://openalex.org/W2028044172","https://openalex.org/W2028263332","https://openalex.org/W2028886686","https://openalex.org/W2033950216","https://openalex.org/W2037174303","https://openalex.org/W2037728125","https://openalex.org/W2043136696","https://openalex.org/W2046865715","https://openalex.org/W2052540561","https://openalex.org/W2060787001","https://openalex.org/W2061537158","https://openalex.org/W2062630273","https://openalex.org/W2063169293","https://openalex.org/W2074468648","https://openalex.org/W2078242581","https://openalex.org/W2084712319","https://openalex.org/W2085061139","https://openalex.org/W2090601888","https://openalex.org/W2096954920","https://openalex.org/W2101013700","https://openalex.org/W2102056802","https://openalex.org/W2102433010","https://openalex.org/W2103646786","https://openalex.org/W2110513450","https://openalex.org/W2113439921","https://openalex.org/W2120365943","https://openalex.org/W2123273708","https://openalex.org/W2124156743","https://openalex.org/W2128994729","https://openalex.org/W2135754931","https://openalex.org/W2138034994","https://openalex.org/W2139425035","https://openalex.org/W2145252755","https://openalex.org/W2150688223","https://openalex.org/W2152054208","https://openalex.org/W2154747133","https://openalex.org/W2157677911","https://openalex.org/W2159040452","https://openalex.org/W2163827697","https://openalex.org/W2165155144","https://openalex.org/W2165158667","https://openalex.org/W2166548889","https://openalex.org/W2170861064","https://openalex.org/W2214602901","https://openalex.org/W2414626044"],"related_works":["https://openalex.org/W2085061139","https://openalex.org/W2019027893","https://openalex.org/W6990192128","https://openalex.org/W7100933553","https://openalex.org/W1521972387","https://openalex.org/W1566625041","https://openalex.org/W7100383274","https://openalex.org/W2011396983","https://openalex.org/W2151898531","https://openalex.org/W2130115977"],"abstract_inverted_index":{"The":[0],"antitumor":[1,187],"drug":[2,188],"adozelesin":[3,14,55,178],"is":[4],"a":[5,20,24,60,139,199],"potent":[6],"cytotoxic":[7],"DNA-damaging":[8],"agent.":[9],"Here":[10],"we":[11],"determined":[12],"how":[13],"affects":[15],"chromosomal":[16,69],"DNA":[17,70,90,101,129,191],"replication":[18,47,61,65,98,121,125,163,196,225],"at":[19,71,119],"molecular":[21],"level":[22],"in":[23,43,102,105,134,145,149,171,179,198,208,219],"yeast":[25,209],"model":[26],"system":[27],"and":[28,63,75,84,116,181],"examined":[29],"the":[30,36,57,72,120,135,142,150,153,158,161,172,213,228],"influence":[31],"of":[32,39,46,59,81,99,113,128,152,160,215,222,231],"checkpoint":[33,92,210],"kinase":[34,78,211],"genes,":[35,79,212],"human":[37,82],"homologues":[38,80,214],"which":[40,216],"are":[41,217,234],"mutated":[42,218],"cancer.":[44,220],"Analysis":[45],"intermediates":[48,126],"using":[49],"two-dimensional":[50],"gel":[51],"electrophoresis":[52],"showed":[53],"that":[54,189],"inhibited":[56],"activity":[58,115],"origin":[62,114,164],"stalled":[64],"fork":[66,117],"progression":[67,118],"through":[68],"origin.":[73,122],"RAD53":[74],"MEC1":[76],"protein":[77],"CHK2":[83],"ATM,":[85],"respectively,":[86],"regulate":[87],"an":[88,186,194,223],"intra-S-phase":[89],"damage":[91],"and,":[93],"when":[94],"mutated,":[95],"permit":[96],"unchecked":[97],"damaged":[100],"S-phase.":[103],"Mutations":[104],"these":[106],"genes":[107],"did":[108],"not":[109],"abrogate":[110],"adozelesin-induced":[111],"inhibition":[112,159],"However,":[123],"novel":[124],"indicative":[127],"breaks":[130],"were":[131,175],"detected":[132],"only":[133],"rad53":[136,180],"mutant,":[137],"suggesting":[138],"role":[140],"for":[141,227],"wild-type":[143],"gene":[144,232],"maintaining":[146],"chromosome":[147,174,200],"integrity":[148],"presence":[151],"drug.":[154],"In":[155],"contrast":[156],"to":[157],"active":[162],"by":[165,177,201],"adozelesin,":[166],"normally":[167],"silent":[168,203],"origins":[169],"present":[170],"same":[173],"activated":[176],"mec1":[182],"mutant":[183],"cells.":[184],"Thus,":[185],"damages":[190],"can":[192],"induce":[193],"abnormal":[195,224],"pattern":[197,226],"activating":[202],"origins,":[204],"depending":[205],"upon":[206],"defects":[207],"Implications":[221],"epigenetic":[229],"regulation":[230],"expression":[233],"discussed.":[235]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
