{"id":"https://openalex.org/W153113702","doi":null,"title":"Perioperative nutrition and insulin resistance","display_name":"Perioperative nutrition and insulin resistance","publication_year":2006,"publication_date":"2006-01-27","ids":{"openalex":"https://openalex.org/W153113702","mag":"153113702"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26923537","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Perioperative_nutrition_and_insulin_resistance/26923537","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/39307","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054315162","display_name":"Monika Svanfeldt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Monika Svanfeldt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5054315162"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12020","display_name":"Enhanced Recovery After Surgery","score":0.12489999830722809,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.04439999908208847,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perioperative-nutrition","display_name":"perioperative nutrition","score":0.9340000152587891},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9449999928474426},{"id":"https://openalex.org/keywords/postoperative-hyperglycaemia","display_name":"postoperative hyperglycaemia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/total-parenteral-nutrition","display_name":"total parenteral nutrition","score":0.7889999747276306},{"id":"https://openalex.org/keywords/bed-rest","display_name":"bed rest","score":0.8889999985694885},{"id":"https://openalex.org/keywords/epidural-anesthesia","display_name":"epidural anesthesia","score":0.777999997138977},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.7179999947547913},{"id":"https://openalex.org/keywords/glucose-kinetics","display_name":"glucose kinetics","score":0.7070000171661377},{"id":"https://openalex.org/keywords/substrate-utilization","display_name":"substrate utilization","score":0.9800000190734863},{"id":"https://openalex.org/keywords/nitrogen-balance","display_name":"nitrogen balance","score":0.8939999938011169},{"id":"https://openalex.org/keywords/colorectal-resection","display_name":"colorectal resection","score":0.8460000157356262},{"id":"https://openalex.org/keywords/glucose-disposal","display_name":"glucose disposal","score":0.4790000021457672},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.3709999918937683},{"id":"https://openalex.org/keywords/infectious-complications","display_name":"infectious complications","score":0.44999998807907104},{"id":"https://openalex.org/keywords/hyperinsulinemic-euglycemic-clamp","display_name":"hyperinsulinemic-euglycemic clamp","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7406415939331055},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7094814777374268},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7036562561988831},{"id":"https://openalex.org/C2777854218","wikidata":"https://www.wikidata.org/wiki/Q850197","display_name":"Bed rest","level":2,"score":0.6390724182128906},{"id":"https://openalex.org/C78722104","wikidata":"https://www.wikidata.org/wiki/Q21653202","display_name":"Parenteral nutrition","level":2,"score":0.5911296010017395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4994161128997803},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.47728481888771057},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4697112441062927},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.46264776587486267},{"id":"https://openalex.org/C190362976","wikidata":"https://www.wikidata.org/wiki/Q845261","display_name":"Caloric theory","level":2,"score":0.4465760290622711},{"id":"https://openalex.org/C2780606744","wikidata":"https://www.wikidata.org/wiki/Q853930","display_name":"Starvation","level":2,"score":0.421160489320755},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.38677409291267395},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3505757451057434},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.22124353051185608}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26923537","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Perioperative_nutrition_and_insulin_resistance/26923537","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/39307","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39307","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:153113702","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/bitstream/handle/10616/39307/thesis.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/39307","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39307","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W1380689","https://openalex.org/W92645232","https://openalex.org/W100968474","https://openalex.org/W105244144","https://openalex.org/W114124658","https://openalex.org/W180575882","https://openalex.org/W577854292","https://openalex.org/W1588074949","https://openalex.org/W1594379317","https://openalex.org/W1608246244","https://openalex.org/W1917400540","https://openalex.org/W1939720700","https://openalex.org/W1966138998","https://openalex.org/W1966755400","https://openalex.org/W1969099200","https://openalex.org/W1970863229","https://openalex.org/W1971050397","https://openalex.org/W1975344770","https://openalex.org/W1977436003","https://openalex.org/W1980037770","https://openalex.org/W1980085988","https://openalex.org/W1980717583","https://openalex.org/W1988024297","https://openalex.org/W1988271520","https://openalex.org/W1989844324","https://openalex.org/W1993024401","https://openalex.org/W1995780597","https://openalex.org/W1996046593","https://openalex.org/W1996785297","https://openalex.org/W1997279776","https://openalex.org/W2004546786","https://openalex.org/W2007746238","https://openalex.org/W2008916567","https://openalex.org/W2008944235","https://openalex.org/W2011751065","https://openalex.org/W2014306439","https://openalex.org/W2019244812","https://openalex.org/W2021767274","https://openalex.org/W2024311973","https://openalex.org/W2025421578","https://openalex.org/W2026413826","https://openalex.org/W2029418107","https://openalex.org/W2032263586","https://openalex.org/W2036498916","https://openalex.org/W2036747686","https://openalex.org/W2039832247","https://openalex.org/W2040057688","https://openalex.org/W2040454056","https://openalex.org/W2041429573","https://openalex.org/W2043376328","https://openalex.org/W2047397124","https://openalex.org/W2049988272","https://openalex.org/W2050944145","https://openalex.org/W2053368806","https://openalex.org/W2055841167","https://openalex.org/W2063371084","https://openalex.org/W2066244030","https://openalex.org/W2068310051","https://openalex.org/W2068466771","https://openalex.org/W2075597440","https://openalex.org/W2080262569","https://openalex.org/W2083530901","https://openalex.org/W2084247271","https://openalex.org/W2084372106","https://openalex.org/W2084961392","https://openalex.org/W2086651817","https://openalex.org/W2092007264","https://openalex.org/W2094736071","https://openalex.org/W2094872479","https://openalex.org/W2098319359","https://openalex.org/W2099006036","https://openalex.org/W2099596814","https://openalex.org/W2102001134","https://openalex.org/W2105912552","https://openalex.org/W2106948376","https://openalex.org/W2108462699","https://openalex.org/W2111040033","https://openalex.org/W2113893959","https://openalex.org/W2114146921","https://openalex.org/W2114437130","https://openalex.org/W2133035546","https://openalex.org/W2133871414","https://openalex.org/W2135666165","https://openalex.org/W2136822555","https://openalex.org/W2139461849","https://openalex.org/W2140598688","https://openalex.org/W2140759276","https://openalex.org/W2142180065","https://openalex.org/W2143031634","https://openalex.org/W2146877877","https://openalex.org/W2153868160","https://openalex.org/W2153988832","https://openalex.org/W2154490896","https://openalex.org/W2160117767","https://openalex.org/W2160978530","https://openalex.org/W2162268531","https://openalex.org/W2163405222","https://openalex.org/W2163567504","https://openalex.org/W2167697543","https://openalex.org/W2169968309","https://openalex.org/W2172252111","https://openalex.org/W2282585473","https://openalex.org/W2320086683","https://openalex.org/W2325670516","https://openalex.org/W2325918023","https://openalex.org/W2326554808","https://openalex.org/W2330433230","https://openalex.org/W2334014332","https://openalex.org/W2395347800","https://openalex.org/W2407611453","https://openalex.org/W2411192367","https://openalex.org/W2416397790","https://openalex.org/W2426019711","https://openalex.org/W2464771298"],"related_works":["https://openalex.org/W1989385934","https://openalex.org/W102654699","https://openalex.org/W105244144","https://openalex.org/W1990893369","https://openalex.org/W97905739","https://openalex.org/W180575882","https://openalex.org/W1038969938","https://openalex.org/W2320086683","https://openalex.org/W2510304529","https://openalex.org/W2171730819"],"abstract_inverted_index":{"Surgical":[0],"trauma":[1],"induces":[2],"a":[3,12,124,143,162,365,410,547,659],"catabolic":[4],"response":[5],"with":[6,61,146,178,598],"development":[7,211,260],"of":[8,23,33,65,70,94,131,139,157,186,208,212,218,248,261,321,372,391,393,449,451,474,485,498,562,574,590,593,650,689],"insulin":[9,18,24,34,75,86,104,165,214,263,386,440,462,469,491,563,604,630,656],"resistance":[10],"as":[11,354],"central":[13],"and":[14,29,52,68,79,100,113,127,135,171,179,190,238,270,277,304,308,337,364,397,428,516,520,527,546,698],"well-characterised":[15],"feature.":[16],"In":[17,88,493],"resistance,":[19],"the":[20,30,47,89,92,140,199,240,246,279,358,381,389,414,419,424,437,447,464,472,482,496,529],"stimulating":[21],"effect":[22,32,93,185,497,561],"on":[25,35,103,278,406,489,503,528,564,603,655,694],"peripheral":[26],"glucose":[27,37,267,295,312,517,699],"uptake":[28],"suppressing":[31],"endogenous":[36],"release":[38],"are":[39,82],"decreased,":[40],"resulting":[41],"in":[42,120,123,164,174,198,223,227,254,283,332,334,402,409,436,479,533,606,664],"hyperglycaemia.":[43],"It":[44],"is":[45],"marked":[46],"first":[48,90,530],"day":[49,282,359,532],"after":[50,128,309,418,423,429,571],"surgery":[51,226,276,361,475,526],"normalises":[53],"within":[54],"two":[55,382],"to":[56,84,196,229,235,257,292,376,378,446],"three":[57,129,442],"weeks.":[58],"Preoperative":[59,347,552],"treatment":[60,303,350,434,502,545,554,654,693],"oral":[62,301,348,500,543,652,691],"carbohydrates":[63],"instead":[64],"traditional":[66,95],"fasting":[67],"use":[69,217],"epidural":[71,305],"anaesthesia":[72,306],"reduce":[73,230],"postoperative":[74,213,262,281,293,490,504,531,556,695],"resistance.":[76,87,215,264,631],"Both":[77],"starvation":[78],"bed":[80,101,136,153,181,191,601],"rest":[81,102,192,602],"known":[83],"induce":[85,236],"study,":[91],"post-surgical":[96],"low":[97,132,148,158,187,203,595],"caloric":[98,133,149,159,188,204,329,596],"feeding":[99,134,150,160,189,205,330,597],"sensitivity":[105,166,387,396,441,463,470,605],"(hyperinsulinaemic":[106],"(0.8":[107],"mU/kg/min)":[108],"normoglycaemic":[109],"(4.5":[110],"mM)":[111],"clamps)":[112],"substrate":[114,175,271,335,398,521],"utilisation":[115,176,272,336,399,522],"(indirect":[116],"calorimetry)":[117],"were":[118,273,290,400,523,540],"studied":[119,274,524],"healthy":[121,404,607,665],"volunteers":[122,141,405],"control":[125],"situation":[126],"days":[130,156,592],"rest.":[137,154,182],"Half":[138],"underwent":[142],"second":[144],"protocol":[145],"identical":[147],"but":[151],"without":[152,180,600],"Three":[155],"induced":[161],"decrease":[163],"by":[167,315,453],"nearly":[168],"60":[169],"%":[170,319],"caused":[172],"alterations":[173],"both":[177,430],"The":[183,216,370,456,560],"metabolic":[184],"was":[193,326,375,508,568],"not":[194,251,324,460,569],"related":[195],"age":[197],"present":[200],"study.":[201],"Thus,":[202,467],"might":[206],"be":[207],"importance":[209],"for":[210],"total":[219],"parenteral":[220,625],"nutrition":[221,626],"(TPN)":[222],"patients":[224,255,285,535],"undergoing":[225,286,536],"order":[228,412],"catabolism":[231],"has":[232,351],"been":[233,252,352],"shown":[234],"hyperglycaemia":[237],"increase":[239],"complication":[241],"rate,":[242],"mainly":[243],"infectious.":[244],"However,":[245],"effects":[247,484],"TPN":[249,325,343],"have":[250],"investigated":[253],"treated":[256],"proactively":[258,628],"minimise":[259],"Insulin":[265,395,510],"sensitivity,":[266,511],"kinetics":[268,507,519,567],"(6,62H2-D-glucose)":[269,518],"before":[275,360,525,550],"third":[280],"13":[284],"colorectal":[287,537],"resections.":[288,538],"Patients":[289,539],"randomised":[291,411,541,660],"hypocaloric":[294],"or":[296,323,599],"TPN.":[297],"All":[298],"received":[299],"preoperative":[300,499,690],"carbohydrate":[302,349,433,486,501,544,553,653,692],"during":[307],"surgery.":[310,394,551,572],"Whole-body":[311],"disposal":[313],"decreased":[314],"only":[316],"approximately":[317,454],"25":[318],"irrespective":[320],"whether":[322],"given.":[327],"Low":[328],"resulted":[331],"changes":[333],"nitrogen":[338],"balance":[339],"resembling":[340],"starvation,":[341],"while":[342,627],"attenuated":[344],"these":[345],"changes.":[346],"used":[353],"an":[355],"evening":[356,420,457],"dose":[357,367,421,426,458],"(100":[362],"g)":[363],"morning":[366,425,438],"(50":[368],"g).":[369],"aim":[371],"study":[373,663],"III":[374],"investigate":[377],"what":[379],"extent":[380],"doses,":[383],"respectively,":[384],"affected":[385],"at":[388,471,477],"time":[390,448],"onset":[392,450,473],"measured":[401],"six":[403],"four":[407],"occasions":[408],"(in":[413],"overnight":[415],"fasted":[416],"state,":[417],"only,":[422,427],"doses).":[431],"Oral":[432],"given":[435],"increased":[439,468],"hours":[443],"later":[444],"(corresponding":[445],"surgery)":[452],"50%.":[455],"did":[459],"affect":[461],"following":[465],"day.":[466],"might,":[476],"least":[478],"part,":[480],"explain":[481],"positive":[483],"loading":[487],"seen":[488],"sensitivity.":[492],"paper":[494],"IV,":[495],"whole-body":[505,557,565,696],"protein":[506,512,558,566,697],"evaluated.":[509],"(2H5-phenylalanine,":[513],"2H2-tyrosine,":[514],"2H4-tyrosine)":[515],"12":[534],"between":[542],"placebo":[548],"drink":[549],"improved":[555],"balance.":[559],"altered":[570],"List":[573],"scientific":[575],"papers":[576],"I.":[577],"Svanfeldt":[578,615,636,673],"M,":[579,616,637,643,674,680],"Thorell":[580,617,638,675],"A,":[581,618,639,676],"Brismar":[582],"K,":[583],"Nygren":[584,619,644,683],"J,":[585,620,641,645,678,684],"Ljungqvist":[586,621,646,685],"O":[587,622,647,686],"(2003).":[588],"Effects":[589],"3":[591],"\"postoperative\"":[594],"subjects.":[608,666],"Clin":[609,667],"Nutr.":[610,668],"22(1):":[611],"31-8.":[612],"https://doi.org/10.1054/clnu.2002.0589":[613],"II.":[614],"(2006).":[623,687],"Postoperative":[624],"minimizing":[629],"Nutrition.":[632],"[Accepted]":[633],"https://doi.org/10.1016/j.nut.2005.06.013":[634],"III.":[635],"Hausel":[640,677],"Soop":[642,679],"(2005).":[648],"Effect":[649,688],"\"preoperative\"":[651],"action":[657],"-":[658],"cross-over":[661],"unblinded":[662],"24(5):":[669],"815-21.":[670],"https://doi.org/10.1016/j.clnu.2005.05.002":[671],"IV.":[672],"Rooyackers":[681],"O,":[682],"kinetics.":[700],"[Manuscript]":[701]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}
