{"id":"https://openalex.org/W1530859705","doi":null,"title":"Investigating the role of ion channels across the fetomaternal interface of the human placenta","display_name":"Investigating the role of ion channels across the fetomaternal interface of the human placenta","publication_year":2012,"publication_date":"2012-07-16","ids":{"openalex":"https://openalex.org/W1530859705","mag":"1530859705"},"language":"en","primary_location":{"id":"pmh:oai:eprints.nottingham.ac.uk:12478","doi":null,"is_oa":true,"landing_page_url":"https://eprints.nottingham.ac.uk/12478/1/Thesis_T_Ali.pdf","pdf_url":"http://eprints.nottingham.ac.uk/12478/1/Thesis_T_Ali.pdf","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis (University of Nottingham only)"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://eprints.nottingham.ac.uk/12478/1/Thesis_T_Ali.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057801157","display_name":"Tayyba Ali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tayyba Ali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057801157"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.8237000107765198,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.8237000107765198,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.16419999301433563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.6439999938011169},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.8220000267028809},{"id":"https://openalex.org/keywords/fetomaternal-interface","display_name":"fetomaternal interface","score":0.7820000052452087},{"id":"https://openalex.org/keywords/trek-1","display_name":"TREK-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/two-pore-domain-potassium-channels","display_name":"two-pore domain potassium channels","score":0.8379999995231628},{"id":"https://openalex.org/keywords/acid-sensing-ion-channels","display_name":"acid-sensing ion channels","score":0.6269999742507935},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.6520000100135803},{"id":"https://openalex.org/keywords/acidosis","display_name":"acidosis","score":0.6140000224113464},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"vascular smooth muscle","score":0.6579999923706055},{"id":"https://openalex.org/keywords/vasorelaxation","display_name":"vasorelaxation","score":0.4309999942779541},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.4129999876022339},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.6809999942779541},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.3179999887943268},{"id":"https://openalex.org/keywords/ion-channel-modulators","display_name":"ion channel modulators","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.6723073124885559},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6290663480758667},{"id":"https://openalex.org/C1918360","wikidata":"https://www.wikidata.org/wiki/Q5357720","display_name":"Electrical impedance myography","level":3,"score":0.5155906081199646},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.5074650645256042},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.484768807888031},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.4143942594528198},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3873146176338196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3786569833755493},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.36427080631256104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3458632826805115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29373735189437866},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.28054189682006836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2721201181411743},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.2313845157623291},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2197330892086029},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09420332312583923},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:eprints.nottingham.ac.uk:12478","doi":null,"is_oa":true,"landing_page_url":"https://eprints.nottingham.ac.uk/12478/1/Thesis_T_Ali.pdf","pdf_url":"http://eprints.nottingham.ac.uk/12478/1/Thesis_T_Ali.pdf","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis (University of Nottingham only)"},{"id":"pmh:oai:repository.nottingham.ac.uk:123456789/46648","doi":null,"is_oa":true,"landing_page_url":"https://repository.nottingham.ac.uk/handle/123456789/46648","pdf_url":"https://repository.nottingham.ac.uk/bitstreams/00f4e0cd-8425-479c-9e9c-3dbe724328cf/download","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ethesis"},{"id":"pmh:oai:uilis.unsyiah.ac.id:7091","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/7091","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/7091","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis (University of Nottingham only)"},{"id":"pmh:hdl:10068/996825","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/996825","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:1530859705","doi":null,"is_oa":false,"landing_page_url":"http://eprints.nottingham.ac.uk/12478/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:eprints.nottingham.ac.uk:12478","doi":null,"is_oa":true,"landing_page_url":"https://eprints.nottingham.ac.uk/12478/1/Thesis_T_Ali.pdf","pdf_url":"http://eprints.nottingham.ac.uk/12478/1/Thesis_T_Ali.pdf","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis (University of Nottingham only)"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1530859705.pdf","grobid_xml":"https://content.openalex.org/works/W1530859705.grobid-xml"},"referenced_works_count":305,"referenced_works":["https://openalex.org/W18997466","https://openalex.org/W34574262","https://openalex.org/W59088806","https://openalex.org/W67943641","https://openalex.org/W86858381","https://openalex.org/W108909600","https://openalex.org/W119779276","https://openalex.org/W120335510","https://openalex.org/W125605838","https://openalex.org/W125935861","https://openalex.org/W138906208","https://openalex.org/W140380104","https://openalex.org/W171819190","https://openalex.org/W1485300099","https://openalex.org/W1500060932","https://openalex.org/W1504796212","https://openalex.org/W1518080919","https://openalex.org/W1521516049","https://openalex.org/W1534508378","https://openalex.org/W1541419413","https://openalex.org/W1577197696","https://openalex.org/W1596952637","https://openalex.org/W1726784060","https://openalex.org/W1796580524","https://openalex.org/W1854945595","https://openalex.org/W1878890461","https://openalex.org/W1901441522","https://openalex.org/W1963631121","https://openalex.org/W1964396898","https://openalex.org/W1966143879","https://openalex.org/W1966284289","https://openalex.org/W1966420005","https://openalex.org/W1967863888","https://openalex.org/W1968001136","https://openalex.org/W1970445852","https://openalex.org/W1971022054","https://openalex.org/W1971656740","https://openalex.org/W1972319192","https://openalex.org/W1972617290","https://openalex.org/W1973272114","https://openalex.org/W1975195151","https://openalex.org/W1975755498","https://openalex.org/W1976535357","https://openalex.org/W1976827821","https://openalex.org/W1977017927","https://openalex.org/W1977321043","https://openalex.org/W1978513752","https://openalex.org/W1979071912","https://openalex.org/W1979417846","https://openalex.org/W1980952325","https://openalex.org/W1981964819","https://openalex.org/W1982213003","https://openalex.org/W1983186128","https://openalex.org/W1984810013","https://openalex.org/W1986439675","https://openalex.org/W1987245561","https://openalex.org/W1987258233","https://openalex.org/W1987431351","https://openalex.org/W1988418174","https://openalex.org/W1989074567","https://openalex.org/W1989756791","https://openalex.org/W1990285738","https://openalex.org/W1990323937","https://openalex.org/W1990445103","https://openalex.org/W1990866037","https://openalex.org/W1991451992","https://openalex.org/W1991624086","https://openalex.org/W1992900591","https://openalex.org/W1994642596","https://openalex.org/W1994919529","https://openalex.org/W1996166328","https://openalex.org/W1997080801","https://openalex.org/W1997125695","https://openalex.org/W1998332422","https://openalex.org/W1998719957","https://openalex.org/W1999723828","https://openalex.org/W2000961219","https://openalex.org/W2001475113","https://openalex.org/W2002597141","https://openalex.org/W2003263756","https://openalex.org/W2004055816","https://openalex.org/W2004569084","https://openalex.org/W2004651230","https://openalex.org/W2005791783","https://openalex.org/W2008066000","https://openalex.org/W2008311196","https://openalex.org/W2010110485","https://openalex.org/W2010371327","https://openalex.org/W2012986942","https://openalex.org/W2013187579","https://openalex.org/W2015720543","https://openalex.org/W2015865872","https://openalex.org/W2015950622","https://openalex.org/W2016294504","https://openalex.org/W2016326896","https://openalex.org/W2016511759","https://openalex.org/W2016817628","https://openalex.org/W2016915299","https://openalex.org/W2017358028","https://openalex.org/W2017590643","https://openalex.org/W2017695960","https://openalex.org/W2018201418","https://openalex.org/W2019129862","https://openalex.org/W2019741032","https://openalex.org/W2020268012","https://openalex.org/W2026441070","https://openalex.org/W2027564114","https://openalex.org/W2027617326","https://openalex.org/W2028055213","https://openalex.org/W2035992288","https://openalex.org/W2036578336","https://openalex.org/W2036597685","https://openalex.org/W2037464698","https://openalex.org/W2037800265","https://openalex.org/W2038602542","https://openalex.org/W2039458448","https://openalex.org/W2039741690","https://openalex.org/W2040119916","https://openalex.org/W2040173574","https://openalex.org/W2041050846","https://openalex.org/W2041307526","https://openalex.org/W2042264430","https://openalex.org/W2042921800","https://openalex.org/W2042923562","https://openalex.org/W2043182261","https://openalex.org/W2043469580","https://openalex.org/W2043897518","https://openalex.org/W2043930136","https://openalex.org/W2044227570","https://openalex.org/W2044995040","https://openalex.org/W2046003026","https://openalex.org/W2051649715","https://openalex.org/W2051777630","https://openalex.org/W2052269083","https://openalex.org/W2053056001","https://openalex.org/W2053263924","https://openalex.org/W2053754035","https://openalex.org/W2054076134","https://openalex.org/W2055551778","https://openalex.org/W2058752988","https://openalex.org/W2058912845","https://openalex.org/W2059555535","https://openalex.org/W2059674903","https://openalex.org/W2059745013","https://openalex.org/W2060285089","https://openalex.org/W2060937867","https://openalex.org/W2060974177","https://openalex.org/W2063945321","https://openalex.org/W2064391449","https://openalex.org/W2064540829","https://openalex.org/W2064686740","https://openalex.org/W2064796645","https://openalex.org/W2064974004","https://openalex.org/W2065216772","https://openalex.org/W2065342543","https://openalex.org/W2065986052","https://openalex.org/W2066190048","https://openalex.org/W2066192232","https://openalex.org/W2067202339","https://openalex.org/W2068577158","https://openalex.org/W2069296756","https://openalex.org/W2069898130","https://openalex.org/W2070112963","https://openalex.org/W2071338376","https://openalex.org/W2071860803","https://openalex.org/W2075273934","https://openalex.org/W2076156388","https://openalex.org/W2076181757","https://openalex.org/W2076651312","https://openalex.org/W2077365895","https://openalex.org/W2077921059","https://openalex.org/W2078417738","https://openalex.org/W2078554664","https://openalex.org/W2078971375","https://openalex.org/W2079512981","https://openalex.org/W2080323803","https://openalex.org/W2081087975","https://openalex.org/W2081604258","https://openalex.org/W2081701711","https://openalex.org/W2082059445","https://openalex.org/W2082406934","https://openalex.org/W2082534894","https://openalex.org/W2082548564","https://openalex.org/W2082710058","https://openalex.org/W2083547969","https://openalex.org/W2083818620","https://openalex.org/W2083839003","https://openalex.org/W2084586130","https://openalex.org/W2085385120","https://openalex.org/W2086844966","https://openalex.org/W2087278720","https://openalex.org/W2087787002","https://openalex.org/W2087815276","https://openalex.org/W2088106988","https://openalex.org/W2088766126","https://openalex.org/W2089753154","https://openalex.org/W2089806567","https://openalex.org/W2089846768","https://openalex.org/W2089848535","https://openalex.org/W2091003012","https://openalex.org/W2091520623","https://openalex.org/W2092840409","https://openalex.org/W2092913031","https://openalex.org/W2093769893","https://openalex.org/W2095398301","https://openalex.org/W2095731799","https://openalex.org/W2096377596","https://openalex.org/W2096601431","https://openalex.org/W2098714915","https://openalex.org/W2098880799","https://openalex.org/W2099258590","https://openalex.org/W2099437428","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2102115309","https://openalex.org/W2106607972","https://openalex.org/W2106849785","https://openalex.org/W2109431719","https://openalex.org/W2110782817","https://openalex.org/W2113316512","https://openalex.org/W2113318363","https://openalex.org/W2113565576","https://openalex.org/W2113994428","https://openalex.org/W2115741133","https://openalex.org/W2116039819","https://openalex.org/W2116616972","https://openalex.org/W2117919325","https://openalex.org/W2119334033","https://openalex.org/W2119856586","https://openalex.org/W2121074075","https://openalex.org/W2122119818","https://openalex.org/W2123150738","https://openalex.org/W2124631967","https://openalex.org/W2124735494","https://openalex.org/W2125269141","https://openalex.org/W2126087368","https://openalex.org/W2127279692","https://openalex.org/W2127461430","https://openalex.org/W2128764672","https://openalex.org/W2130379248","https://openalex.org/W2134991186","https://openalex.org/W2135122106","https://openalex.org/W2136682322","https://openalex.org/W2137212044","https://openalex.org/W2137248860","https://openalex.org/W2137262465","https://openalex.org/W2138033933","https://openalex.org/W2139163475","https://openalex.org/W2139553271","https://openalex.org/W2139775312","https://openalex.org/W2139785932","https://openalex.org/W2140742458","https://openalex.org/W2140865853","https://openalex.org/W2142551707","https://openalex.org/W2142940631","https://openalex.org/W2143180984","https://openalex.org/W2143495069","https://openalex.org/W2144010503","https://openalex.org/W2144437938","https://openalex.org/W2145241122","https://openalex.org/W2145830262","https://openalex.org/W2146217294","https://openalex.org/W2146582067","https://openalex.org/W2149635665","https://openalex.org/W2152156058","https://openalex.org/W2152622855","https://openalex.org/W2155285827","https://openalex.org/W2157194890","https://openalex.org/W2157624459","https://openalex.org/W2159003098","https://openalex.org/W2160369484","https://openalex.org/W2160836414","https://openalex.org/W2163085971","https://openalex.org/W2164965367","https://openalex.org/W2169038382","https://openalex.org/W2170016330","https://openalex.org/W2171061164","https://openalex.org/W2174566149","https://openalex.org/W2217917207","https://openalex.org/W2222944310","https://openalex.org/W2226815533","https://openalex.org/W2256724151","https://openalex.org/W2257957146","https://openalex.org/W2262873829","https://openalex.org/W2263515345","https://openalex.org/W2277335307","https://openalex.org/W2314622789","https://openalex.org/W2321875764","https://openalex.org/W2322229785","https://openalex.org/W2336547101","https://openalex.org/W2394755261","https://openalex.org/W2401996977","https://openalex.org/W2407692670","https://openalex.org/W2410526287","https://openalex.org/W2412892448","https://openalex.org/W2413844347","https://openalex.org/W2415142924","https://openalex.org/W2415161995","https://openalex.org/W2416162087","https://openalex.org/W2416686379","https://openalex.org/W2424377934","https://openalex.org/W2439460377","https://openalex.org/W2444048239","https://openalex.org/W2474128270","https://openalex.org/W2476827169"],"related_works":["https://openalex.org/W1978673498","https://openalex.org/W2127461430","https://openalex.org/W61323080","https://openalex.org/W765614227","https://openalex.org/W2325467822","https://openalex.org/W2098714915","https://openalex.org/W1992792350","https://openalex.org/W2145849863","https://openalex.org/W2021225492","https://openalex.org/W1996873411"],"abstract_inverted_index":{"Chorionic":[0],"plate":[1],"(CPA)":[2],"and":[3,12,23,82,99,109,153,166,206,218,228,242,263,269,278,289,413,480,496,521,541,556,570,596],"stem":[4],"villous":[5],"(SVA)":[6],"arteries":[7,146],"located":[8],"at":[9,136,282,358,381,392,419,442],"the":[10,16,29,40,59,67,83,151,154,167,213,261,283,303,359,369,403,427,434,446,500,511,518,529,561,572,603],"fetal":[11],"maternal":[13],"interface":[14],"of":[15,31,58,69,111,143,169,181,188,193,196,216,240,247,350,362,371,388,456,526,575,605],"placenta":[17,41],"respond":[18,95],"to":[19,48,94,96,178,237,354,400,436,565,601],"stimuli":[20,50],"including":[21,528],"hypoxia":[22],"acidic":[24,323],"pH":[25,171,183,189,324,336,341,361,370,382,393,420,443,498,567,576,593],"which":[26,352,432],"can":[27,522,587],"be":[28,52,588,612],"result":[30],"an":[32,298,504],"intermittent":[33],"blood":[34],"supply.":[35],"Unlike":[36],"other":[37,592,606],"vascular":[38,214,578],"tissue":[39,202,230,494],"lacks":[42],"nervous":[43],"control":[44],"so":[45],"any":[46],"response":[47,215,405,562],"such":[49],"will":[51],"autoregulated":[53],"by":[54,234,265,534,563,591],"ion":[55,114,197,249,608],"channels.":[56,531],"Members":[57],"two":[60],"pore":[61],"domain":[62],"potassium":[63,79],"channel":[64,80,89,198,250,585],"family":[65],"(K2P)":[66],"Tandem":[68],"P":[70],"domains":[71],"in":[72,116,364,462,486,507,510,548,614],"a":[73,186,194,311,327,344,375,385,453,470,524,543],"weak":[74],"inward":[75],"rectifying":[76],"(TWIK)":[77],"related":[78],"(TREK-1)":[81],"TWIK":[84],"Related":[85],"acid":[86,177],"sensitive":[87,594],"K+":[88],"(TASK-1/3)":[90],"have":[91],"been":[92,538],"shown":[93,492],"both":[97,474],"intracellular":[98],"extracellular":[100,170,497],"pH.":[101],"The":[102,140,191,244,322,465,532],"hypothesis":[103],"that":[104,314,330,493,583,610],"there":[105],"is":[106,598],"differential":[107],"expression":[108,239,292,309],"modulation":[110],"these":[112],"candidate":[113],"channels":[115,558,595,609],"normal":[117],"pregnancy":[118],"was":[119,172,223,251,331,568],"tested.":[120],"Placentae":[121],"(N)":[122],"were":[123,156,162,209,271,423,559],"collected":[124],"with":[125,164,201,232,254,297,317,333,384,407,426,473],"written":[126],"informed":[127],"consent":[128],"from":[129,150,260,287,340,398],"healthy":[130],"patients":[131],"undergoing":[132],"elective":[133],"Caesarean":[134],"section":[135],"term":[137],"(\u226537":[138],"weeks).":[139],"functional":[141],"responses":[142],"resistance":[144],"sized":[145],"(\u2264500\u00b5m)":[147],"(n)":[148],"taken":[149],"SVA":[152,229,264,270,290,373,414,481],"CPA":[155,217,227,262,268,288,351,408,422,475,564],"characterised":[157],"using":[158,174],"wire":[159],"myography.":[160],"Vessels":[161],"pre-contracted":[163],"U46619":[165],"effect":[168],"studied":[173],"1M":[175],"lactic":[176],"produce":[179],"falls":[180],"0.2":[182],"units":[184],"over":[185],"range":[187,502,525],"7.4-6.4.":[190],"effects":[192],"variety":[195],"modulators":[199],"along":[200],"oxygenation":[203,495],"(20%,":[204],"5%":[205,401,459],"2%":[207,378,391],"O2)":[208],"also":[210,252,424,581],"investigated":[211],"on":[212,225,577],"SVA.":[219],"Western":[220],"blot":[221],"analysis":[222],"performed":[224],"crude":[226],"homogenates":[231],"separation":[233],"12%":[235],"SDS-PAGE":[236],"quantify":[238],"TASK-1/3":[241],"TREK-1.":[243],"subcellular":[245],"localisation":[246],"each":[248,334],"examined":[253],"smooth":[255],"muscle":[256],"cells":[257],"(SMC)":[258],"cultured":[259],"confocal":[266],"immunofluorescence.":[267],"equally":[272],"positive":[273],"for":[274,293,546,590],"TASK":[275,294,447],"1/3":[276,295,448],"(N=31)":[277],"TREK":[279],"1":[280],"(N=40)":[281],"protein":[284],"level.":[285],"SMC":[286],"showed":[291,310],"(N=8)":[296],"increased":[299,353,433],"fluorescence":[300],"stain":[301],"around":[302],"peri":[304],"nuclear":[305],"region.":[306],"TREK-1":[307,428,466,547,555],"(N=12)":[308],"linear":[312],"organisation":[313],"closely":[315],"overlapped":[316],"\u03b1":[318],"actin":[319],"IF":[320],"stain.":[321],"stimulation":[325],"triggered":[326],"biphasic":[328],"relaxation":[329,349,387,404,435,455,472,533],"repeated":[332],"subsequent":[335],"insult.":[337],"A":[338],"change":[339],"7.4-7.2":[342],"produced":[343],"29":[345],"\u00b1":[346,356,377,390,410,416,438,458,477,483],"3%":[347],"(n=9)":[348],"61":[355],"4%":[357],"lowest":[360],"6.4":[363,394],"20%":[365,399,463,487],"pO2.":[366,464,488],"Similarly,":[367],"altering":[368],"pre-constricted":[372],"caused":[374],"21":[376],"(n=6)":[379],"fall":[380],"7.2":[383],"maximum":[386,454],"69":[389],"(p<0.01).":[395],"Lowering":[396],"pO2":[397],"inhibited":[402],"seen":[406],"(45":[409],"3%,":[411,417],"n=8)":[412],"(34":[415],"n=6)":[418,479,485],"6.4.":[421,444],"treated":[425],"blocker":[429,449],"L-methionine":[430],"(1mM)":[431,451],"67":[437],"7%":[439],"(n=6":[440],"p<0.001)":[441],"Similarly":[445],"ZnCl2":[450],"gave":[452],"72":[457],"(n=8":[460],"p<0.01)":[461],"opener":[467],"riluzole":[468,535],"demonstrated":[469],"potent":[471],"(75":[476],"5%,":[478,484],"(78":[482],"Our":[489],"data":[490],"has":[491,503,536],"within":[499],"physiological":[501],"important":[505],"role":[506,545,604],"controlling":[508,549],"vasodilatation":[509],"placenta.":[512],"Protons":[513],"are":[514],"readily":[515],"transported":[516],"across":[517],"cell":[519],"membrane":[520],"activate":[523],"targets":[527],"K2P":[530,584],"not":[537],"previously":[539],"reported":[540],"implicates":[542],"direct":[544],"placental":[550],"vessel":[551],"function.":[552,579],"However,":[553],"when":[554],"TASK-3":[557],"blocked,":[560],"lower":[566],"exaggerated,":[569],"reflects":[571],"complex":[573],"pharmacology":[574],"This":[580],"suggests":[582],"activity":[586],"compensated":[589],"work":[597],"currently":[599],"underway":[600],"identify":[602],"potential":[607],"may":[611],"involved":[613],"this":[615],"pathway.":[616]},"counts_by_year":[],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2016-06-24T00:00:00"}
