{"id":"https://openalex.org/W153053244","doi":null,"title":"Ibandronate: the first once-monthly oral bisphosphonate for treatment of postmenopausal osteoporosis.","display_name":"Ibandronate: the first once-monthly oral bisphosphonate for treatment of postmenopausal osteoporosis.","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W153053244","mag":"153053244","pmid":"https://pubmed.ncbi.nlm.nih.gov/18360577","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1661644"},"language":"en","primary_location":{"id":"pmid:18360577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18360577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutics and clinical risk management","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1661644/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021205472","display_name":"Frieder Bauss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Frieder Bauss","raw_affiliation_strings":["Hoffmann- La Roche"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hoffmann- La Roche","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079874524","display_name":"Ralph C. Schimmer","orcid":"https://orcid.org/0000-0002-9380-1784","observed_orcids":["https://orcid.org/0000-0002-9380-1784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph C Schimmer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2647,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.86532327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"1","first_page":"3","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ibandronate","display_name":"ibandronate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/once-monthly-dosing","display_name":"once-monthly dosing","score":0.8320000171661377},{"id":"https://openalex.org/keywords/oral-bisphosphonates","display_name":"oral bisphosphonates","score":0.8579999804496765},{"id":"https://openalex.org/keywords/nitrogen-containing-bisphosphonates","display_name":"nitrogen-containing bisphosphonates","score":0.9750000238418579},{"id":"https://openalex.org/keywords/intermittent-dosing","display_name":"intermittent dosing","score":0.6970000267028809},{"id":"https://openalex.org/keywords/antifracture-efficacy","display_name":"antifracture efficacy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/vertebral-fractures","display_name":"vertebral fractures","score":0.828000009059906},{"id":"https://openalex.org/keywords/non-vertebral-fractures","display_name":"non-vertebral fractures","score":0.8960000276565552},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9739999771118164},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7519999742507935},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.9089999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9599584341049194},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.842126727104187},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8020228147506714},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.8019629120826721},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.7350850105285645},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.489583820104599},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.47561079263687134},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4699319303035736},{"id":"https://openalex.org/C3018571302","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Postmenopausal osteoporosis","level":4,"score":0.4663761258125305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37092477083206177},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.24854329228401184}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:18360577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18360577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutics and clinical risk management","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1661644","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1661644/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Clin Risk Manag","raw_type":"Text"},{"id":"mag:153053244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18360577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1661644","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1661644/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Clin Risk Manag","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W132416067","https://openalex.org/W1526826623","https://openalex.org/W1964315400","https://openalex.org/W1965511198","https://openalex.org/W1966391931","https://openalex.org/W1966703501","https://openalex.org/W1966722256","https://openalex.org/W1967591628","https://openalex.org/W1970071306","https://openalex.org/W1970155252","https://openalex.org/W1971046106","https://openalex.org/W1987169166","https://openalex.org/W1989637027","https://openalex.org/W1990173735","https://openalex.org/W1992428758","https://openalex.org/W2004424725","https://openalex.org/W2006671424","https://openalex.org/W2006825597","https://openalex.org/W2009558420","https://openalex.org/W2009678900","https://openalex.org/W2011470894","https://openalex.org/W2011716536","https://openalex.org/W2012291531","https://openalex.org/W2012831893","https://openalex.org/W2022641698","https://openalex.org/W2024412436","https://openalex.org/W2027093084","https://openalex.org/W2029588254","https://openalex.org/W2031575345","https://openalex.org/W2035190861","https://openalex.org/W2039548369","https://openalex.org/W2044178924","https://openalex.org/W2054738028","https://openalex.org/W2065916720","https://openalex.org/W2067177940","https://openalex.org/W2072797307","https://openalex.org/W2076807367","https://openalex.org/W2078267056","https://openalex.org/W2089272876","https://openalex.org/W2090642025","https://openalex.org/W2092721372","https://openalex.org/W2099054178","https://openalex.org/W2099606865","https://openalex.org/W2099955896","https://openalex.org/W2102123887","https://openalex.org/W2112629831","https://openalex.org/W2124527463","https://openalex.org/W2126070576","https://openalex.org/W2126162095","https://openalex.org/W2134664830","https://openalex.org/W2137575981","https://openalex.org/W2147874800","https://openalex.org/W2150410663","https://openalex.org/W2153009489","https://openalex.org/W2156015681","https://openalex.org/W2161837912","https://openalex.org/W2162150486","https://openalex.org/W2162255898","https://openalex.org/W2164933519","https://openalex.org/W2321227665","https://openalex.org/W2336969031","https://openalex.org/W2341257405","https://openalex.org/W2411171679","https://openalex.org/W2471984307","https://openalex.org/W2783103906"],"related_works":["https://openalex.org/W2110246484","https://openalex.org/W2064152097","https://openalex.org/W333911000","https://openalex.org/W2031097687","https://openalex.org/W2047163853","https://openalex.org/W2465649486","https://openalex.org/W7100864374","https://openalex.org/W2168386840","https://openalex.org/W2118859574","https://openalex.org/W2167560032"],"abstract_inverted_index":{"Osteoporosis":[0],"is":[1,47,64,79,176],"a":[2,80],"major":[3],"healthcare":[4,27],"problem":[5],"that":[6,50,66],"continues":[7],"growing":[8],"as":[9,120],"the":[10,31,37,60,115,161],"population":[11],"ages.":[12],"Sufferers":[13],"become":[14],"increasingly":[15],"susceptible":[16],"to":[17,135,142,170,186,191],"fractures,":[18,155],"which":[19,146],"compromise":[20],"physical":[21],"and":[22,25,39,74,107,139,153,163,165,182,184],"emotional":[23],"health":[24],"increase":[26],"costs.":[28],"Bisphosphonates":[29],"are":[30,56],"most":[32],"widely":[33],"used":[34],"medicines":[35],"for":[36,86,151],"treatment":[38],"prevention":[40],"of":[41,104,111],"postmenopausal":[42,127],"osteoporosis.":[43],"However,":[44],"therapeutic":[45,189,196],"adherence":[46,190],"suboptimal,":[48],"meaning":[49],"outcomes":[51],"demonstrated":[52,99,148],"in":[53,59,167],"clinical":[54],"trials":[55],"not":[57],"realized":[58],"real":[61],"world.":[62],"It":[63],"anticipated":[65],"reducing":[67],"dosing":[68,113,122],"frequency":[69],"may":[70],"facilitate":[71],"medication":[72],"intake":[73],"thereby":[75,194],"improve":[76,188],"adherence.":[77],"Ibandronate":[78],"potent":[81],"nitrogen-containing":[82],"bisphosphonate":[83,192],"specifically":[84],"developed":[85],"administration":[87],"with":[88,179],"long":[89],"dose-free":[90],"intervals.":[91],"The":[92,109],"comprehensive":[93],"ibandronate":[94,131,175],"preclinical":[95],"development":[96],"program":[97],"has":[98,132,147],"dose-dependent":[100],"improvements":[101],"or":[102],"preservation":[103],"bone":[105,156,168],"quality":[106],"strength.":[108],"feasibility":[110],"intermittent":[112],"using":[114],"same":[116],"total":[117],"dose":[118],"level":[119],"continuous":[121],"was":[123],"also":[124,177],"confirmed.":[125],"In":[126],"osteoporosis,":[128],"once-monthly":[129],"oral":[130,144,174],"been":[133],"shown":[134],"be":[136],"therapeutically":[137],"equivalent":[138],"even":[140],"superior":[141],"daily":[143],"ibandronate,":[145],"antifracture":[149],"efficacy":[150],"vertebral":[152],"nonvertebral":[154],"mineral":[157],"density":[158],"gains":[159],"at":[160],"spine":[162],"hip,":[164],"reduction":[166],"resorption":[169],"premenopausal":[171],"levels.":[172],"Once-monthly":[173],"associated":[178],"excellent":[180],"safety":[181],"tolerability,":[183],"promises":[185],"further":[187],"treatment,":[193],"enhancing":[195],"outcomes.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}