{"id":"https://openalex.org/W1529782854","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1089.7","title":"cGMP amplification of pulmonary arterial myocyte Ca 2+ waves is preferentially impaired in high altitude\u2010induced hypoxic fetal sheep (1089.7)","display_name":"cGMP amplification of pulmonary arterial myocyte Ca 2+ waves is preferentially impaired in high altitude\u2010induced hypoxic fetal sheep (1089.7)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1529782854","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1089.7","mag":"1529782854"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.1089.7","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1089.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1089.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083905852","display_name":"Ricardo Paez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]},{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo Paez","raw_affiliation_strings":["Center for Health Disparities and Molecular Medicine LOMA LINDA University School of Medicine LOMA LINDA CA United States","2Center for Health Disparities and Molecular Medicine Loma Linda University School of Medicine Loma Linda CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Health Disparities and Molecular Medicine LOMA LINDA University School of Medicine LOMA LINDA CA United States","institution_ids":["https://openalex.org/I1293502524","https://openalex.org/I26347476"]},{"raw_affiliation_string":"2Center for Health Disparities and Molecular Medicine Loma Linda University School of Medicine Loma Linda CA United States","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074751581","display_name":"Monica Romero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293502524","display_name":"Loma Linda University Medical Center","ror":"https://ror.org/03et1qs84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293502524"]},{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Romero","raw_affiliation_strings":["Advanced Imaging Microscopy Facility LOMA LINDA University School of Medicine LOMA LINDA CA United States","1Advanced Imaging Microscopy Facility Loma Linda University School of Medicine Loma Linda CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Imaging Microscopy Facility LOMA LINDA University School of Medicine LOMA LINDA CA United States","institution_ids":["https://openalex.org/I1293502524","https://openalex.org/I26347476"]},{"raw_affiliation_string":"1Advanced Imaging Microscopy Facility Loma Linda University School of Medicine Loma Linda CA United States","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091116403","display_name":"Quintin Blood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quintin Blood","raw_affiliation_strings":["Center for Perinatal Biology LOMA LINDA University School of Medicine LOMA LINDA CA United States","3Center for Perinatal Biology Loma Linda University School of Medicine Loma Linda CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Perinatal Biology LOMA LINDA University School of Medicine LOMA LINDA CA United States","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"3Center for Perinatal Biology Loma Linda University School of Medicine Loma Linda CA United States","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014772614","display_name":"Noah J. Osman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noah Osman","raw_affiliation_strings":["Center for Perinatal Biology LOMA LINDA University School of Medicine LOMA LINDA CA United States","3Center for Perinatal Biology Loma Linda University School of Medicine Loma Linda CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Perinatal Biology LOMA LINDA University School of Medicine LOMA LINDA CA United States","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"3Center for Perinatal Biology Loma Linda University School of Medicine Loma Linda CA United States","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038909947","display_name":"Chetas Manjunath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chetas Manjunath","raw_affiliation_strings":["Center for Perinatal Biology LOMA LINDA University School of Medicine LOMA LINDA CA United States","3Center for Perinatal Biology Loma Linda University School of Medicine Loma Linda CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Perinatal Biology LOMA LINDA University School of Medicine LOMA LINDA CA United States","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"3Center for Perinatal Biology Loma Linda University School of Medicine Loma Linda CA United States","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053244871","display_name":"Shane Glasgow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shane Glasgow","raw_affiliation_strings":["Center for Perinatal Biology LOMA LINDA University School of Medicine LOMA LINDA CA United States","3Center for Perinatal Biology Loma Linda University School of Medicine Loma Linda CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Perinatal Biology LOMA LINDA University School of Medicine LOMA LINDA CA United States","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"3Center for Perinatal Biology Loma Linda University School of Medicine Loma Linda CA United States","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Francis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Francis","raw_affiliation_strings":["Department of Physiology University of South Alabama College of Medicine Mobile AL United States","4Department of Physiology University of South Alabama College of Medicine Mobile AL United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology University of South Alabama College of Medicine Mobile AL United States","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"4Department of Physiology University of South Alabama College of Medicine Mobile AL United States","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101621208","display_name":"Mark Stephen Taylor","orcid":"https://orcid.org/0000-0002-8020-1712","observed_orcids":["https://orcid.org/0000-0002-8020-1712"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Taylor","raw_affiliation_strings":["Department of Physiology University of South Alabama College of Medicine Mobile AL United States","4Department of Physiology University of South Alabama College of Medicine Mobile AL United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology University of South Alabama College of Medicine Mobile AL United States","institution_ids":["https://openalex.org/I83809506"]},{"raw_affiliation_string":"4Department of Physiology University of South Alabama College of Medicine Mobile AL United States","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109048794","display_name":"L. D. Longo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawerence Longo","raw_affiliation_strings":["Center for Perinatal Biology LOMA LINDA University School of Medicine LOMA LINDA CA United States","3Center for Perinatal Biology Loma Linda University School of Medicine Loma Linda CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Perinatal Biology LOMA LINDA University School of Medicine LOMA LINDA CA United States","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"3Center for Perinatal Biology Loma Linda University School of Medicine Loma Linda CA United States","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003198184","display_name":"Sean M. Wilson","orcid":"https://orcid.org/0000-0003-4404-1173","observed_orcids":["https://orcid.org/0000-0003-4404-1173"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Wilson","raw_affiliation_strings":["Center for Perinatal Biology LOMA LINDA University School of Medicine LOMA LINDA CA United States","3Center for Perinatal Biology Loma Linda University School of Medicine Loma Linda CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Perinatal Biology LOMA LINDA University School of Medicine LOMA LINDA CA United States","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"3Center for Perinatal Biology Loma Linda University School of Medicine Loma Linda CA United States","institution_ids":["https://openalex.org/I26347476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07838067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia","score":0.11050000041723251,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.042500000447034836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cgmp-signaling","display_name":"cGMP signaling","score":0.843999981880188},{"id":"https://openalex.org/keywords/calcium-waves","display_name":"calcium waves","score":0.7620000243186951},{"id":"https://openalex.org/keywords/prolonged-hypoxia","display_name":"prolonged hypoxia","score":0.8479999899864197},{"id":"https://openalex.org/keywords/high-altitude","display_name":"high altitude","score":0.949999988079071},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.8349999785423279},{"id":"https://openalex.org/keywords/fetal-sheep","display_name":"fetal sheep","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cell-maturation","display_name":"cell maturation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"ryanodine receptor","score":0.8759999871253967},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-ca2-atpase","display_name":"sarcoplasmic reticulum Ca2+-ATPase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.6539999842643738},{"id":"https://openalex.org/keywords/phosphodiesterase-inhibitors","display_name":"phosphodiesterase inhibitors","score":0.828000009059906},{"id":"https://openalex.org/keywords/8-bromo-cgmp","display_name":"8-bromo-cGMP","score":0.6110000014305115},{"id":"https://openalex.org/keywords/8-bromo-camp","display_name":"8-bromo-cAMP","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7492684125900269},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6655547022819519},{"id":"https://openalex.org/C2781414619","wikidata":"https://www.wikidata.org/wiki/Q24785512","display_name":"SERCA","level":4,"score":0.582606315612793},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.5811046361923218},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5795656442642212},{"id":"https://openalex.org/C2781298581","wikidata":"https://www.wikidata.org/wiki/Q223093","display_name":"IBMX","level":4,"score":0.4681805670261383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46132057905197144},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.42659056186676025},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4114586412906647},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2990502119064331},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.2567349672317505},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.24940618872642517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2211577594280243},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2171398401260376},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.17284244298934937},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12121796607971191},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.1089.7","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.1089.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.1089.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1845078576","display_name":"Loma Linda University Center for Health Disparities Research","funder_award_id":"P20MD006988","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G6126536748","display_name":" (INTRODUCTION) MECHANISMS OF ACCLIMATIZATION:  FETUS AND ADULT","funder_award_id":"P01HD031226","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6381221989","display_name":"Intrauterine chronic hypoxia and ryanodine receptors in fetal pulmonary arteries","funder_award_id":"R03HD069746","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G874190830","display_name":"Cerebral Artery Alpha1 Adrenergic and PKC Regulatory Mechanisms","funder_award_id":"R01HD003807","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3174102816","https://openalex.org/W3167952658","https://openalex.org/W1466758037","https://openalex.org/W3172532591","https://openalex.org/W3177004588","https://openalex.org/W4253772679","https://openalex.org/W2048652290","https://openalex.org/W4206808252","https://openalex.org/W2137267977","https://openalex.org/W1238332815"],"abstract_inverted_index":{"High":[0],"altitude":[1,129],"is":[2],"a":[3,99],"risk":[4],"factor":[5],"in":[6,37,64,113,177,192,214],"the":[7,16,45,83,148,165],"development":[8],"of":[9,18,22,85,116,135,150,154,200],"pulmonary":[10,38],"hypertension":[11],"(PH).":[12],"Treatment":[13],"often":[14],"includes":[15],"use":[17],"phosphodiesterase":[19],"(PDE)":[20],"inhibitors":[21],"PDE3":[23],"(milrinone,":[24],"cAMP)":[25],"and":[26,34,49,55,80,87,106,118,142,162,184,207,218],"PDE5":[27],"(sildenafil,":[28],"cGMP),":[29],"which":[30,66],"increase":[31],"cyclic":[32],"nucleotides":[33],"promotes":[35],"vasodilation":[36],"arterial":[39],"(PA)":[40],"myocytes.":[41],"With":[42],"respect":[43],"to":[44,146,211],"current":[46],"studies,":[47],"c\u2010AMP":[48,86],"c\u2010GMP":[50,88,186,219],"enhance":[51],"ryanodine":[52],"receptor":[53],"(RyR)":[54],"Sarco/Endoplasmic":[56],"Reticulum":[57],"Ca":[58,69,91,111,201,215],"2+":[59,70,92,112,202,216],"\u2010ATPase":[60],"(SERCA)":[61],"pump":[62],"activity":[63],"myocytes,":[65],"regulate":[67],"intracellular":[68],".":[71],"To":[72],"test":[73],"whether":[74],"long":[75],"term":[76],"hypoxia":[77],"(LTH)":[78],"impairs,":[79],"maturity":[81],"enhances":[82],"effects":[84],"on":[89],"myocyte":[90],"waves,":[93],"we":[94],"selected":[95],"3\u2010isobutyl\u20101\u2010methyl":[96],"xanthine":[97],"(IBMX),":[98],"PDE":[100],"inhibitor,":[101],"as":[102,104],"well":[103],"8\u2010Br\u2010c\u2010AMP":[105],"8\u2010Br\u2010c\u2010GMP.":[107],"We":[108],"measured":[109],"cytosolic":[110],"PA":[114],"myocytes":[115],"fetal":[117],"adult":[119],"sheep":[120],"that":[121],"lived":[122],"at":[123],"low":[124],"(~353":[125],"m)":[126,131],"or":[127],"high":[128],"(~3801":[130],"via":[132],"confocal":[133],"imaging":[134],"fluo\u20104.":[136],"Maturation":[137],"increased":[138,187],"while":[139],"IBMX,":[140],"8\u2010Br\u2010c\u2010AMP,":[141],"8\u2010Br\u2010c\u2010GMP":[143],"each":[144],"failed":[145],"alter":[147],"percentage":[149],"responsive":[151],"cells":[152],"independent":[153],"altitude.":[155],"LTH":[156,178,212],"fetuses":[157],"had":[158],"reduced":[159],"wave":[160,169],"amplitude":[161],"area":[163],"under":[164],"curve":[166],"(AUC),":[167],"but":[168,180],"kinetics":[170],"were":[171,182],"unaltered.":[172],"The":[173],"AUC":[174,188],"was":[175],"maintained":[176],"adults,":[179],"waves":[181,191,217],"faster":[183],"larger.":[185],"by":[189,227],"lengthening":[190],"all":[193],"groups":[194],"except":[195],"for":[196],"hypoxic":[197],"fetuses.":[198],"Alterations":[199],"regulatory":[203],"pathways":[204],"including":[205],"SERCAs":[206],"RyRs":[208],"could":[209],"contribute":[210],"impairment":[213],"amplified":[220],"signals.":[221],"Grant":[222],"Funding":[223],"Source":[224],":":[225],"Supported":[226],"NSF":[228],"MRI":[229],"0923559,":[230],"NIH":[231],"HD\u2010069746,":[232],"P01HD031226,":[233],",":[234],"R01HD003807,":[235],"5P20":[236],"MD\u2010006988,LLUSOM":[237]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
