{"id":"https://openalex.org/W1529426752","doi":null,"title":"Structural modeling of regulation in alpha-actinin/F-actin interactions","display_name":"Structural modeling of regulation in alpha-actinin/F-actin interactions","publication_year":2014,"publication_date":"2014-08-22","ids":{"openalex":"https://openalex.org/W1529426752","mag":"1529426752"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:22819","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/22819/1/TraversTimothy_ETD2014.pdf","pdf_url":"https://d-scholarship.pitt.edu/22819/1/TraversTimothy_ETD2014.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109859135","display_name":"Timothy Nino S. Travers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Timothy Nino S. Travers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109859135"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.16699999570846558,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-actinin","display_name":"alpha-actinin","score":0.8640000224113464},{"id":"https://openalex.org/keywords/actn4","display_name":"ACTN4","score":0.9959999918937683},{"id":"https://openalex.org/keywords/actin-cross-linking","display_name":"actin cross-linking","score":0.8059999942779541},{"id":"https://openalex.org/keywords/actin-binding-domain","display_name":"actin-binding domain","score":0.7049999833106995},{"id":"https://openalex.org/keywords/calcium-binding","display_name":"calcium binding","score":0.6499999761581421},{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.7940000295639038},{"id":"https://openalex.org/keywords/phosphoinositides","display_name":"phosphoinositides","score":0.8679999709129333},{"id":"https://openalex.org/keywords/actin-filament-binding","display_name":"actin filament binding","score":0.6029999852180481},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.8379999995231628},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.5379999876022339},{"id":"https://openalex.org/keywords/network-models","display_name":"network models","score":0.3959999978542328},{"id":"https://openalex.org/keywords/actin-cytoskeleton-reorganization","display_name":"actin cytoskeleton remodeling","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6310684680938721},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.6303372383117676},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6259450912475586},{"id":"https://openalex.org/C20563397","wikidata":"https://www.wikidata.org/wiki/Q410803","display_name":"Filamin","level":4,"score":0.556715190410614},{"id":"https://openalex.org/C3620293","wikidata":"https://www.wikidata.org/wiki/Q14908027","display_name":"Actin remodeling","level":5,"score":0.5441620349884033},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5402429103851318},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.48332738876342773},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.47194427251815796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4415954053401947},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.44055765867233276},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41967281699180603},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2959707975387573},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2736225724220276}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:22819","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/22819/1/TraversTimothy_ETD2014.pdf","pdf_url":"https://d-scholarship.pitt.edu/22819/1/TraversTimothy_ETD2014.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:1529426752","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/22819/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":126,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W343086395","https://openalex.org/W1498358597","https://openalex.org/W1500148089","https://openalex.org/W1508178505","https://openalex.org/W1521650410","https://openalex.org/W1522437515","https://openalex.org/W1607701774","https://openalex.org/W1968815565","https://openalex.org/W1968968494","https://openalex.org/W1969723894","https://openalex.org/W1969765360","https://openalex.org/W1970804746","https://openalex.org/W1971532437","https://openalex.org/W1971572370","https://openalex.org/W1972399880","https://openalex.org/W1973858832","https://openalex.org/W1974454557","https://openalex.org/W1975203189","https://openalex.org/W1980819423","https://openalex.org/W1983377384","https://openalex.org/W1985497018","https://openalex.org/W1988077177","https://openalex.org/W1990894658","https://openalex.org/W1992899488","https://openalex.org/W1993944415","https://openalex.org/W1996423252","https://openalex.org/W1996614690","https://openalex.org/W2001339111","https://openalex.org/W2003186950","https://openalex.org/W2004798786","https://openalex.org/W2006924926","https://openalex.org/W2007719816","https://openalex.org/W2013570410","https://openalex.org/W2013843427","https://openalex.org/W2017370697","https://openalex.org/W2018554691","https://openalex.org/W2018837494","https://openalex.org/W2023472866","https://openalex.org/W2024570610","https://openalex.org/W2026582002","https://openalex.org/W2027408247","https://openalex.org/W2028629022","https://openalex.org/W2029667189","https://openalex.org/W2029862878","https://openalex.org/W2032652036","https://openalex.org/W2034541989","https://openalex.org/W2034880643","https://openalex.org/W2040617316","https://openalex.org/W2040980668","https://openalex.org/W2041603328","https://openalex.org/W2041791898","https://openalex.org/W2042160897","https://openalex.org/W2044177027","https://openalex.org/W2044529288","https://openalex.org/W2046392615","https://openalex.org/W2049430206","https://openalex.org/W2051238023","https://openalex.org/W2053733974","https://openalex.org/W2056462932","https://openalex.org/W2057246411","https://openalex.org/W2059943461","https://openalex.org/W2062114704","https://openalex.org/W2067174909","https://openalex.org/W2069941324","https://openalex.org/W2072089764","https://openalex.org/W2075093176","https://openalex.org/W2076742999","https://openalex.org/W2079149769","https://openalex.org/W2079587994","https://openalex.org/W2081685693","https://openalex.org/W2082798563","https://openalex.org/W2083539472","https://openalex.org/W2084001805","https://openalex.org/W2085725940","https://openalex.org/W2085767196","https://openalex.org/W2089537140","https://openalex.org/W2093428806","https://openalex.org/W2095252377","https://openalex.org/W2102025585","https://openalex.org/W2106140689","https://openalex.org/W2110007427","https://openalex.org/W2111211467","https://openalex.org/W2111966042","https://openalex.org/W2112743424","https://openalex.org/W2114239896","https://openalex.org/W2120881407","https://openalex.org/W2121400889","https://openalex.org/W2121853844","https://openalex.org/W2123298030","https://openalex.org/W2126551164","https://openalex.org/W2127322768","https://openalex.org/W2127929745","https://openalex.org/W2129037338","https://openalex.org/W2130581715","https://openalex.org/W2131458456","https://openalex.org/W2132629607","https://openalex.org/W2132926880","https://openalex.org/W2134967712","https://openalex.org/W2137568584","https://openalex.org/W2138766779","https://openalex.org/W2139229287","https://openalex.org/W2139796802","https://openalex.org/W2142436130","https://openalex.org/W2142520482","https://openalex.org/W2144571979","https://openalex.org/W2147421370","https://openalex.org/W2148220372","https://openalex.org/W2152964937","https://openalex.org/W2153731681","https://openalex.org/W2154465669","https://openalex.org/W2154535641","https://openalex.org/W2156016724","https://openalex.org/W2158044026","https://openalex.org/W2162075759","https://openalex.org/W2165620713","https://openalex.org/W2166114438","https://openalex.org/W2166776794","https://openalex.org/W2169150541","https://openalex.org/W2169436026","https://openalex.org/W2170421654","https://openalex.org/W2217682155","https://openalex.org/W2313116527","https://openalex.org/W2605068739","https://openalex.org/W2885056221","https://openalex.org/W3096977082"],"related_works":["https://openalex.org/W6996822205","https://openalex.org/W2056796765","https://openalex.org/W1996614690","https://openalex.org/W2085725940","https://openalex.org/W2461393143","https://openalex.org/W2089537140","https://openalex.org/W1944220006","https://openalex.org/W7080531879","https://openalex.org/W7221814008","https://openalex.org/W2385658184"],"abstract_inverted_index":{"The":[0,61],"\u03b1-actinins":[1],"(ACTNs)":[2],"are":[3,12,75],"a":[4,143,181,200,324,332],"highly":[5],"conserved":[6],"family":[7],"of":[8,32,49,58,72,100,140,169,193,210,214,228,234,246,260,282,301,340,345],"actin-crosslinking":[9],"proteins":[10],"that":[11,89,95,146,173,199,328],"critical":[13],"to":[14,28,34,115,123,149,249,303,307,322],"various":[15],"fundamental":[16],"biological":[17],"processes":[18],"in":[19,156,205,231,241,342],"eukaryotes,":[20],"ranging":[21],"from":[22,295],"cell":[23,112,150,262],"motility":[24,151],"and":[25,56,120,152,159,164,188,257,298],"surface":[26],"remodeling":[27,119],"muscle":[29],"contraction.":[30],"Binding":[31],"ACTNs":[33],"actin":[35,117,309],"filaments":[36,310],"is":[37,83,113,147,223],"regulated":[38],"by":[39,53,64],"several":[40],"mechanisms:":[41],"epidermal":[42],"growth":[43],"factor":[44],"(EGF)-induced":[45],"tyrosine":[46],"phosphorylation,":[47],"binding":[48,57,281,300],"calcium,":[50],"limited":[51],"proteolysis":[52],"calpain":[54],"enzymes,":[55],"phosphoinositide":[59],"moieties.":[60],"molecular":[62,102],"mechanisms":[63,103],"which":[65],"these":[66,101,133,319],"external":[67,134,347],"cues":[68,135],"drive":[69],"the":[70,92,111,137,170,176,191,206,215,226,232,247,255,261,286,292,312,337,343],"regulation":[71,227],"ACTN":[73],"function":[74,139,230],"still":[76],"not":[77],"understood,":[78],"however,":[79],"largely":[80],"because":[81],"there":[82],"currently":[84],"no":[85],"high-resolution":[86],"experimental":[87],"structure":[88],"brings":[90],"together":[91,318],"multiple":[93,346],"domains":[94],"comprise":[96],"ACTNs.":[97],"An":[98],"understanding":[99],"should":[104],"provide":[105],"us":[106],"with":[107,180,243],"insights":[108,321],"into":[109],"how":[110,132],"able":[114],"modulate":[116],"cytoskeletal":[118],"give":[121],"rise":[122],"complex":[124,184],"cellular":[125],"phenomena.":[126],"In":[127],"this":[128,194],"thesis,":[129],"we":[130,162,197,270,316],"investigate":[131],"regulate":[136],"actin-binding":[138,252,338],"human":[141],"ACTN4,":[142,211],"non-muscle":[144],"isoform":[145],"essential":[148],"has":[153],"been":[154],"implicated":[155],"cancer":[157],"invasion":[158],"metastasis.":[160],"First,":[161],"develop":[163,323],"validate":[165],"an":[166],"atomic":[167],"model":[168,327],"multi-domain":[171],"assembly":[172],"makes":[174],"up":[175],"full":[177,267],"ACTN4":[178,229,306,341],"homodimer,":[179],"novel":[182,201],"ternary":[183],"between":[185],"CH2,":[186],"neck,":[187],"CaM2":[189,290],"comprising":[190],"core":[192],"assembly.":[195],"Next,":[196],"show":[198,272],"tandem":[202,237],"phosphorylation":[203,213,220,276],"mechanism":[204,238],"disordered":[207],"N-terminal":[208,248],"region":[209,294],"where":[212],"functional":[216],"Y31":[217],"requires":[218],"prior":[219],"at":[221,254,311],"Y4,":[222],"responsible":[224],"for":[225,335],"presence":[233,344],"EGF.":[235],"This":[236],"can":[239,329],"work":[240],"conjunction":[242],"m-calpain":[244,296],"cleavage":[245],"generate":[250],"varied":[251],"responses":[253],"front":[256],"rear":[258],"ends":[259],"during":[263],"motility.":[264],"Using":[265],"our":[266],"structural":[268,320],"model,":[269],"also":[271],"that:":[273],"(i)":[274],"Y265":[275],"eases":[277],"ABD":[278],"opening:":[279],"(ii)":[280],"calcium":[283],"may":[284],"break":[285],"CaM2/neck":[287],"complex;":[288],"(iii)":[289],"protects":[291],"neck":[293],"cleavage;":[297],"(iv)":[299],"phosphoinositides":[302],"CH2":[304],"allows":[305],"crosslink":[308],"inner":[313],"membrane.":[314],"Finally,":[315],"bring":[317],"preliminary":[325],"network-level":[326],"serve":[330],"as":[331],"computational":[333],"tool":[334],"predicting":[336],"response":[339],"cues.":[348]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}