{"id":"https://openalex.org/W1529198736","doi":"https://doi.org/10.1016/s0021-9258(19)44397-4","title":"An Early Effect of Prolactin on the Formation of \u03b1-Lactalbumin by Mouse Mammary Epithelial Cells","display_name":"An Early Effect of Prolactin on the Formation of \u03b1-Lactalbumin by Mouse Mammary Epithelial Cells","publication_year":1973,"publication_date":"1973-01-01","ids":{"openalex":"https://openalex.org/W1529198736","doi":"https://doi.org/10.1016/s0021-9258(19)44397-4","mag":"1529198736","pmid":"https://pubmed.ncbi.nlm.nih.gov/4630846"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)44397-4","doi":"https://doi.org/10.1016/s0021-9258(19)44397-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)44397-4","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)44397-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072058527","display_name":"Barbara K. Vonderhaar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara K. Vonderhaar","raw_affiliation_strings":["From the National Institute of Arthritis, Metabolism am1 Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Institute of Arthritis, Metabolism am1 Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111431825","display_name":"Ida S. Owens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ida S. Owens","raw_affiliation_strings":["From the National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109984128","display_name":"Yale J. Topper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yale J. Topper","raw_affiliation_strings":["From the National Institute of Arthritis, Metabolism am1 Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the National Institute of Arthritis, Metabolism am1 Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":11.5887,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.98824837,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"248","issue":"2","first_page":"467","last_page":"471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.14399999380111694,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alpha-lactalbumin","display_name":"alpha-lactalbumin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/casein-synthesis","display_name":"casein synthesis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/lactose-synthase","display_name":"lactose synthase","score":0.7820000052452087},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/milk-protein-synthesis","display_name":"milk protein synthesis","score":0.5870000123977661},{"id":"https://openalex.org/keywords/hormone-priming","display_name":"hormone priming","score":0.5149999856948853},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.906000018119812},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.8309999704360962},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9480000138282776},{"id":"https://openalex.org/keywords/mammary-explants","display_name":"mammary explants","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.9188908338546753},{"id":"https://openalex.org/C68863886","wikidata":"https://www.wikidata.org/wiki/Q1799818","display_name":"Lactalbumin","level":2,"score":0.8272271156311035},{"id":"https://openalex.org/C2776142715","wikidata":"https://www.wikidata.org/wiki/Q193970","display_name":"Casein","level":2,"score":0.7096133232116699},{"id":"https://openalex.org/C2778724459","wikidata":"https://www.wikidata.org/wiki/Q127900","display_name":"Lactose","level":2,"score":0.6016004085540771},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5656359195709229},{"id":"https://openalex.org/C178617795","wikidata":"https://www.wikidata.org/wiki/Q14897677","display_name":"Alpha-lactalbumin","level":3,"score":0.5190423130989075},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5125800967216492},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5094252228736877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49807167053222656},{"id":"https://openalex.org/C2780895608","wikidata":"https://www.wikidata.org/wiki/Q5517847","display_name":"Galactosyltransferase","level":3,"score":0.49572479724884033},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.48219290375709534},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.41693180799484253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33684492111206055},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3331245183944702},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2875886559486389},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07032808661460876},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.06283977627754211},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002364","descriptor_name":"Caseins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007768","descriptor_name":"Lactalbumin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007788","descriptor_name":"Lactose Synthase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)44397-4","doi":"https://doi.org/10.1016/s0021-9258(19)44397-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)44397-4","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:4630846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4630846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)44397-4","doi":"https://doi.org/10.1016/s0021-9258(19)44397-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)44397-4","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1592350172","https://openalex.org/W1598101055","https://openalex.org/W1716826009","https://openalex.org/W1906197854","https://openalex.org/W1977241593","https://openalex.org/W1979854241","https://openalex.org/W1984422644","https://openalex.org/W2018495851","https://openalex.org/W2022869592","https://openalex.org/W2025192630","https://openalex.org/W2032858388","https://openalex.org/W2038228648","https://openalex.org/W2044163321","https://openalex.org/W2056260959","https://openalex.org/W2056755246","https://openalex.org/W2074754198","https://openalex.org/W2091678274","https://openalex.org/W2091729696","https://openalex.org/W2094187023","https://openalex.org/W2135138190","https://openalex.org/W2345902112","https://openalex.org/W2587724197"],"related_works":["https://openalex.org/W2025192630","https://openalex.org/W1716826009","https://openalex.org/W1991279507","https://openalex.org/W2091678274","https://openalex.org/W1977171276","https://openalex.org/W2051818509","https://openalex.org/W2161553185","https://openalex.org/W2153624193","https://openalex.org/W2063878099","https://openalex.org/W2004651360"],"abstract_inverted_index":{"Abstract":[0],"Epithelial":[1],"cells":[2],"from":[3,49],"freshly":[4],"isolated":[5],"mammary":[6,47,107],"glands":[7],"of":[8,15,21,42,73,84,91,102,113,118,142,145],"mature":[9,50,92],"virgin":[10,51,93],"mice":[11,52,94],"make":[12],"minute":[13],"amounts":[14],"casein":[16,114,131],"and":[17,45,64,78,116,132],"exhibit":[18],"low":[19],"levels":[20],"lactose":[22,32],"synthetase":[23,33],"A-protein":[24,65,119],"(a":[25],"UDP-galactosyltransferase)":[26],"activity.":[27,36,86],"They":[28],"have":[29],"barely":[30],"detectable":[31],"B-protein":[34,85,103],"(\u03b1-lactalbumin)":[35],"When":[37],"cultured":[38],"in":[39,105,147],"the":[40,54,76,82,96,100,106,110,128,143],"presence":[41],"insulin,":[43],"hydrocortisone,":[44],"prolactin,":[46,89],"explants":[48],"develop":[53,134],"capacity":[55],"to":[56,75],"synthesize":[57],"these":[58],"milk":[59],"proteins":[60],"asynchronously.":[61],"Casein":[62],"synthesis":[63,115],"activity":[66,104,120],"reach":[67],"their":[68],"maxima":[69],"after":[70],"72":[71],"hours":[72,80],"exposure":[74],"hormones":[77],"24":[79],"before":[81],"emergence":[83],"Estradiol-17\u03b2,":[87],"or":[88],"priming":[90],"reduces":[95],"time":[97,111],"required":[98],"for":[99],"development":[101],"explants,":[108],"while":[109],"course":[112],"appearance":[117],"is":[121],"not":[122],"appreciably":[123],"affected.":[124],"As":[125],"a":[126,138],"result,":[127],"secretory":[129],"proteins,":[130],"\u03b1-lactalbumin,":[133],"synchronously.":[135],"This":[136],"represents":[137],"heretofore":[139],"undiscovered":[140],"manifestation":[141],"influence":[144],"prolactin":[146],"this":[148],"system.":[149]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}