{"id":"https://openalex.org/W1528944640","doi":"https://doi.org/10.11606/t.5.2014.tde-14082014-151107","title":"Estudo da Beta-catenina em tumores adrenocorticais humanos","display_name":"Estudo da Beta-catenina em tumores adrenocorticais humanos","publication_year":2014,"publication_date":"2014-04-14","ids":{"openalex":"https://openalex.org/W1528944640","doi":"https://doi.org/10.11606/t.5.2014.tde-14082014-151107","mag":"1528944640"},"language":"pt","primary_location":{"id":"doi:10.11606/t.5.2014.tde-14082014-151107","doi":"https://doi.org/10.11606/t.5.2014.tde-14082014-151107","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.5.2014.tde-14082014-151107","pdf_url":"http://www.teses.usp.br/teses/disponiveis/5/5135/tde-14082014-151107/publico/LorenadeOliveiraeLima.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.teses.usp.br/teses/disponiveis/5/5135/tde-14082014-151107/publico/LorenadeOliveiraeLima.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044622003","display_name":"Lorena de Oliveira Lima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lorena de Oliveira e Lima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044622003"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ctnnb1-mutation","display_name":"CTNNB1 mutation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/adrenocortical-tumors","display_name":"adrenocortical tumors","score":0.8579999804496765},{"id":"https://openalex.org/keywords/adrenocortical-carcinoma","display_name":"adrenocortical carcinoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/adrenal-adenoma","display_name":"adrenal adenoma","score":0.902999997138977},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8240000009536743},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7699999809265137},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.824999988079071},{"id":"https://openalex.org/keywords/exon-3","display_name":"exon 3","score":0.765999972820282},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pediatric-adrenal-tumors","display_name":"pediatric adrenal tumors","score":0.6759999990463257},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.546999990940094},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.4066953659057617},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15554401278495789},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.04449373483657837}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.11606/t.5.2014.tde-14082014-151107","doi":"https://doi.org/10.11606/t.5.2014.tde-14082014-151107","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.5.2014.tde-14082014-151107","pdf_url":"http://www.teses.usp.br/teses/disponiveis/5/5135/tde-14082014-151107/publico/LorenadeOliveiraeLima.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},{"id":"pmh:oai:americanae.aecid.es:2207136","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2207136","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da USP","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:teses.usp.br:tde-14082014-151107","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.11606/T.5.2014.tde-14082014-151107","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"doi:10.11606/t.5.2014.tde-14082014-151107","doi":"https://doi.org/10.11606/t.5.2014.tde-14082014-151107","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.5.2014.tde-14082014-151107","pdf_url":"http://www.teses.usp.br/teses/disponiveis/5/5135/tde-14082014-151107/publico/LorenadeOliveiraeLima.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1528944640.pdf","grobid_xml":"https://content.openalex.org/works/W1528944640.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W99169869","https://openalex.org/W104694997","https://openalex.org/W1495683248","https://openalex.org/W1571062015","https://openalex.org/W1965069888","https://openalex.org/W1969237887","https://openalex.org/W1970258636","https://openalex.org/W1970399383","https://openalex.org/W1974253337","https://openalex.org/W1975503072","https://openalex.org/W1977936925","https://openalex.org/W1978219906","https://openalex.org/W1986341242","https://openalex.org/W1990671646","https://openalex.org/W1990938697","https://openalex.org/W1991690093","https://openalex.org/W1992127683","https://openalex.org/W1993058544","https://openalex.org/W1998000101","https://openalex.org/W2000464147","https://openalex.org/W2003238497","https://openalex.org/W2008257691","https://openalex.org/W2013170178","https://openalex.org/W2017507479","https://openalex.org/W2023370041","https://openalex.org/W2025974572","https://openalex.org/W2026435298","https://openalex.org/W2026906603","https://openalex.org/W2028862042","https://openalex.org/W2029987737","https://openalex.org/W2033737920","https://openalex.org/W2034018110","https://openalex.org/W2039634774","https://openalex.org/W2039836243","https://openalex.org/W2044828697","https://openalex.org/W2056320368","https://openalex.org/W2057726003","https://openalex.org/W2057805027","https://openalex.org/W2059773232","https://openalex.org/W2059783931","https://openalex.org/W2059880490","https://openalex.org/W2060854675","https://openalex.org/W2061913524","https://openalex.org/W2062291407","https://openalex.org/W2063635264","https://openalex.org/W2068845486","https://openalex.org/W2070089477","https://openalex.org/W2071364196","https://openalex.org/W2072799858","https://openalex.org/W2075318195","https://openalex.org/W2075490648","https://openalex.org/W2076335441","https://openalex.org/W2077858999","https://openalex.org/W2079316739","https://openalex.org/W2084654797","https://openalex.org/W2085558559","https://openalex.org/W2085761470","https://openalex.org/W2092112503","https://openalex.org/W2092675326","https://openalex.org/W2095417135","https://openalex.org/W2095699011","https://openalex.org/W2097689792","https://openalex.org/W2098165008","https://openalex.org/W2098232585","https://openalex.org/W2105268776","https://openalex.org/W2105635119","https://openalex.org/W2106396959","https://openalex.org/W2107790330","https://openalex.org/W2109134289","https://openalex.org/W2114965121","https://openalex.org/W2117828965","https://openalex.org/W2120218419","https://openalex.org/W2122095127","https://openalex.org/W2129110988","https://openalex.org/W2129142610","https://openalex.org/W2132781906","https://openalex.org/W2138551378","https://openalex.org/W2140991656","https://openalex.org/W2148501348","https://openalex.org/W2148626383","https://openalex.org/W2153828013","https://openalex.org/W2157179385","https://openalex.org/W2161568796","https://openalex.org/W2162539090","https://openalex.org/W2163679869","https://openalex.org/W2170729108","https://openalex.org/W2330736154","https://openalex.org/W2415630917","https://openalex.org/W2604195884","https://openalex.org/W3021616971","https://openalex.org/W4231669744","https://openalex.org/W4241049756","https://openalex.org/W4251059890","https://openalex.org/W7095779489","https://openalex.org/W7096465494"],"related_works":["https://openalex.org/W7037766665","https://openalex.org/W7120306685","https://openalex.org/W2570327079","https://openalex.org/W7126124155","https://openalex.org/W7119403001","https://openalex.org/W358286178","https://openalex.org/W2915468641","https://openalex.org/W6946394490","https://openalex.org/W2089356922","https://openalex.org/W2153838960"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o:":[0],"A":[1,70,93,269,359,389,424,509],"incid\u00eancia":[2,46],"de":[3,48,72,79,81,97,103,185,188,196,205,211,231,240,271,299,308,311,352,365,378,383,394,398,406,415,420,465,475,506,511,524,538,556,568,571,576,581,584,587,604,610,614,617,626,636,644,647,663,666,672,684,691,696,698,703,715],"tumores":[4,191,229,250,286,303,335,372,436,492,588,615,627,718],"adrenocorticais":[5,192,230,251,304,351,373,408,437,616,628,719],"em":[6,40,83,117,135,138,190,248,265,284,293,325,385,432,434,717],"crian\u00e7as":[7,197,232,256,309,386,439,582,664,676],"\u00e9":[8,34,59,75,99,687],"particularmente":[9],"elevada":[10],"nas":[11,558],"regi\u00f5es":[12],"sudeste":[13],"e":[14,68,86,106,137,169,187,194,198,208,225,233,244,253,257,306,310,314,338,346,349,387,396,440,573,583,641,665,677,712],"sul":[15],"do":[16,26,178,220,276,426,451,477,486,521,550,694,730],"Brasil,":[17],"correlacionandose":[18],"com":[19,44,213,374,493,504,606],"a":[20,158,167,170,183,217,226,238,289,463,472,566,607,634,642,655],"ocorr\u00eancia":[21,168],"da":[22,101,112,162,203,481,547,657,732],"muta\u00e7\u00e3o":[23,218,548],"germinativa":[24,549],"p.R337H":[25,219],"supressor":[27],"tumoral":[28],"p53,":[29,221,577],"entretanto,":[30],"o":[31,42,222,624],"carcinoma":[32,695],"adrenocortical":[33,662,697],"uma":[35,45,60,76,418,473,670,704,722],"neoplasia":[36],"end\u00f3crina":[37,361],"maligna":[38],"rara":[39],"todo":[41],"mundo":[43],"aproximada":[47],"0,5":[49],"-":[50],"2":[51],"casos":[52],"por":[53,55,281],"milh\u00e3o":[54],"ano.":[56],"Esta":[57],"condi\u00e7\u00e3o":[58],"doen\u00e7a":[61],"heterog\u00eanea,":[62],"apresentando":[63],"frequentemente":[64,133],"comportamento":[65],"cl\u00ednico":[66],"agressivo":[67],"letal.":[69],"cascata":[71],"sinaliza\u00e7\u00e3o":[73,98],"Wnt":[74,659],"via":[77,96,658],"importante":[78],"transdu\u00e7\u00e3o":[80],"sinal":[82],"c\u00e2nceres":[84],"humanos":[85],"tem":[87],"sido":[88],"implicada":[89],"na":[90,413,660,728],"tumorig\u00eanese":[91,661,729],"adrenocortical.":[92],"atividade":[94],"desta":[95],"dependente":[100],"quantidade":[102],"beta-catenina":[104,113,186,243,292,324,384,395,572,685],"citoplasm\u00e1tica":[105],"nuclear.":[107],"Muta\u00e7\u00f5es":[108],"ativadoras":[109],"no":[110,125,149,175,273,446,496,513,530,536,597,612,638,709],"gene":[111,126,150,179,277,427,447,497,514,551,598,639,710],"(CTNNB1)":[114],"foram":[115],"relatadas":[116],"diversas":[118],"neoplasias":[119],"humanas.":[120],"Estudos":[121],"demonstraram":[122],"que":[123,146,156,668],"muta\u00e7\u00f5es":[124,144,173,206,272,430,444,460,494,596,637,708],"CTNNB1":[127,151,278,428,448,498,515,640,711],"s\u00e3o":[128],"os":[129,201,209,334,371,491,544,579],"defeitos":[130],"gen\u00e9ticos":[131],"mais":[132],"encontrados":[134],"adenomas":[136,348],"carcinomas":[139,350,407],"adrenocorticais.":[140,287,589],"O":[141,317,679],"estudo":[142],"destas":[143,725],"demonstrou":[145],"as":[147,214,261],"altera\u00e7\u00f5es":[148,512],"localizam-se":[152],"principalmente":[153],"exon":[154,176,274,478],"3,":[155],"codifica":[157],"por\u00e7\u00e3o":[159],"amino":[160],"terminal":[161],"beta-":[163],"catenina.":[164],"Objetivos:":[165],"determinar":[166,182],"frequ\u00eancia":[171],"das":[172,319],"som\u00e1ticas":[174,431,495],"3":[177,275],"CTNNB1.":[180],"Adicionalmente,":[181,590,700],"imunorreatividade":[184,212,290,554,574,608],"p53":[189,245,557,611,648,716],"benignos":[193,252,305,337],"malignos":[195,254,307,339],"adultos.":[199,234,388,678,699],"Correlacionar":[200],"resultados":[202],"an\u00e1lise":[204,239,425],"g\u00eanicas":[207],"dados":[210,653],"caracter\u00edsticas":[215],"hormonais,":[216],"diagn\u00f3stico":[223],"histol\u00f3gico":[224],"evolu\u00e7\u00e3o":[227],"dos":[228,483],"M\u00e9todos:":[235],"Neste":[236],"estudo,":[237],"imunohistoqu\u00edmica":[241],"para":[242,291,323,502],"foi":[246,279,297,330,368,400,562,592,630],"realizada":[247],"103":[249],"(40":[255],"63":[258],"adultos),":[259],"estando":[260],"amostras":[262],"histol\u00f3gicas":[263],"alocadas":[264],"micromatriz":[266],"tecidual":[267],"(TMA).":[268],"pesquisa":[270],"determinada":[280],"seq\u00fcenciamento":[282],"autom\u00e1tico":[283],"64":[285],"Resultados:":[288],"citoplasma":[294,326],"e/ou":[295,327,381,682],"n\u00facleo":[296,328],"evidenciada":[298],"maneira":[300],"similar":[301,369],"nos":[302,402],"adultos":[312,353,404,540,585],"(15%":[313],"23,8%,":[315],"respectivamente).":[316],"percentual":[318],"c\u00e9lulas":[320,559],"neopl\u00e1sicas":[321],"imunorreativas":[322],"n\u00e3o":[329,516,591],"significativamente":[331],"diferente":[332],"entre":[333,347,370,391,565,595,633,675,707],"clinicamente":[336],"pedi\u00e1tricos":[340],"(15,6%":[341],"vs.":[342,355],"12,5%,":[343],"respectivamente;":[344,357],"p=0,93)":[345],"(28,5%":[354],"17,8%,":[356],"p=0,38).":[358],"s\u00edndrome":[360],"causada":[362],"pelo":[363],"perfil":[364],"secre\u00e7\u00e3o":[366],"hormonal":[367],"presen\u00e7a":[375,510,567,635,643],"ou":[376],"aus\u00eancia":[377],"ac\u00famulo":[379,392,500,569,602,645,680,713],"citoplasm\u00e1tico":[380,681],"nuclear":[382,555,575,609,646,683,714],"associa\u00e7\u00e3o":[390],"anormal":[393,501,570,603],"diminui\u00e7\u00e3o":[397],"sobrevida":[399],"avaliada":[401],"pacientes":[403,539,545,618],"portadores":[405,546,586],"isoladamente":[409,623],"(n=25),":[410],"sendo":[411],"observada":[412,593,631],"curva":[414],"Kaplan-":[416],"Meier":[417],"tend\u00eancia":[419],"signific\u00e2ncia":[421],"(log-rank":[422,533,541],"p=0,07).":[423],"revelou":[429],"heterozigose":[433],"10":[435],"(4":[438],"6":[441],"adultos).":[442],"As":[443],"encontradas":[445,461],"foram,":[449],"sobretudo":[450],"tipo":[452],"missense":[453],"(p.Ser45Pro,":[454],"p.Ser45Phe,":[455],"p.Asp32Asn,":[456],"p.Pro44Ala_Ser45Pro;":[457],"p.His36Gln_Ser37Lys).":[458],"Outras":[459],"compreenderam:":[462],"inser\u00e7\u00e3o":[464],"um":[466,507,688],"\u00fanico":[467],"nucleot\u00eddeo":[468],"(p.E9GfsX14),":[469],"dando":[470],"origem":[471],"desvio":[474],"leitura":[476],"3;":[479],"al\u00e9m":[480],"dele\u00e7\u00e3o":[482],"tr\u00eas":[484],"nucleot\u00eddeos":[485],"c\u00f3don":[487],"45":[488],"(p.Ser45del).":[489],"Todos":[490,543],"mostraram":[499],"?-catenina,":[503],"exce\u00e7\u00e3o":[505],"caso.":[508],"se":[517],"associou":[518],"ao":[519],"tamanho":[520],"tumor":[522],"(Teste":[523],"Mann-Whitney:":[525],"p=0,75),":[526],"desfecho":[527],"desfavor\u00e1vel":[528],"tanto":[529],"grupo":[531,537,613,625],"pedi\u00e1trico":[532],"p=0,29)":[534],"como":[535,601],"p=0,77).":[542],"TP53":[552],"apresentaram":[553],"tumorais.":[560],"N\u00e3o":[561],"encontrada":[563],"correla\u00e7\u00e3o":[564,594,705],"considerando":[578],"grupos":[580],"CTNNB1,":[599],"bem":[600],"beta-catenina,":[605],"adultos,":[619,667],"por\u00e9m,":[620],"interessantemente,":[621],"avaliando":[622],"pedi\u00e1tricos,":[629,720],"rela\u00e7\u00e3o":[632,724],"(X2:":[649],"p=0,009).":[650],"Conclus\u00f5es:":[651],"Estes":[652],"confirmam":[654],"participa\u00e7\u00e3o":[656],"apresenta":[669],"preval\u00eancia":[671],"ativa\u00e7\u00e3o":[673],"semelhante":[674],"provavelmente":[686],"marcador":[689],"biol\u00f3gico":[690],"mau":[692],"progn\u00f3stico":[693],"observamos":[701],"evid\u00eancias":[702],"positiva":[706],"confirmando":[721],"poss\u00edvel":[723],"duas":[726],"vias":[727],"c\u00f3rtex":[731],"gl\u00e2ndula":[733],"suprarrenal":[734]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}