{"id":"https://openalex.org/W1528658656","doi":"https://doi.org/10.4081/hmr.v2i5.733","title":"New agents for the treatment of acute myeloid leukemia: gemtuzumab ozogamicin","display_name":"New agents for the treatment of acute myeloid leukemia: gemtuzumab ozogamicin","publication_year":2009,"publication_date":"2009-06-23","ids":{"openalex":"https://openalex.org/W1528658656","doi":"https://doi.org/10.4081/hmr.v2i5.733","mag":"1528658656"},"language":"en","primary_location":{"id":"mag:1528658656","doi":"https://doi.org/10.4081/hmr.v2i5.733","is_oa":false,"landing_page_url":"https://www.pagepress.org/journals/index.php/hmr/article/view/733","pdf_url":null,"source":{"id":"https://openalex.org/S4306512029","display_name":"Hematology Meeting Reports (formerly Haematologica Reports)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Hematology Meeting Reports (formerly Haematologica Reports)","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080855457","display_name":"Sergio Amadori","orcid":"https://orcid.org/0000-0002-2356-8681","observed_orcids":["https://orcid.org/0000-0002-2356-8681"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sergio Amadori","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2356-8681","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080855457"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0601667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gemtuzumab-ozogamicin","display_name":"gemtuzumab ozogamicin","score":0.996999979019165},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anti-cd33-monoclonal-antibody","display_name":"anti-CD33 monoclonal antibody","score":0.902999997138977},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.8769999742507935},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5149999856948853},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4620000123977661},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2778245361","wikidata":"https://www.wikidata.org/wiki/Q409744","display_name":"Calicheamicin","level":3,"score":0.9587796926498413},{"id":"https://openalex.org/C2778623314","wikidata":"https://www.wikidata.org/wiki/Q412685","display_name":"Gemtuzumab ozogamicin","level":5,"score":0.9266033172607422},{"id":"https://openalex.org/C176290653","wikidata":"https://www.wikidata.org/wiki/Q21114013","display_name":"CD33","level":4,"score":0.7816776037216187},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.59992516040802},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5846415162086487},{"id":"https://openalex.org/C115085202","wikidata":"https://www.wikidata.org/wiki/Q425665","display_name":"Immunotoxin","level":4,"score":0.5100598931312561},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4845649302005768},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48311448097229004},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47831228375434875},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4719385802745819},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.46945303678512573},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38468119502067566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3741145133972168},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3579229414463043},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3451322317123413},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2980843484401703},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.2715355157852173},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25411489605903625},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2349621057510376},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1648915410041809}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1528658656","doi":"https://doi.org/10.4081/hmr.v2i5.733","is_oa":false,"landing_page_url":"https://www.pagepress.org/journals/index.php/hmr/article/view/733","pdf_url":null,"source":{"id":"https://openalex.org/S4306512029","display_name":"Hematology Meeting Reports (formerly Haematologica Reports)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Hematology Meeting Reports (formerly Haematologica Reports)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2335862939","https://openalex.org/W1992291725","https://openalex.org/W2521706876","https://openalex.org/W2970756680","https://openalex.org/W2320121145","https://openalex.org/W2006420057","https://openalex.org/W2625583949","https://openalex.org/W1998409697","https://openalex.org/W2080001974","https://openalex.org/W2007433984"],"abstract_inverted_index":{"The":[0,75,115],"CD33":[1,16,91],"antigen":[2,32],"is":[3,11,17,78,95,103],"a":[4,57,62,68],"67-kD":[5],"sialic":[6],"acid-dependent":[7],"adhesion":[8],"protein":[9],"that":[10,86],"specific":[12],"for":[13],"myeloid":[14,110],"cells.":[15],"expressed":[18],"on":[19,33,43],"approximately":[20],"90%":[21],"of":[22,30,37,56,60,108],"AML":[23],"cases,":[24],"as":[25],"defined":[26],"by":[27,80,112,135],"the":[28,31,38,90,93,100,106,109,123],"presence":[29],"greater":[34],"than":[35],"20%":[36],"leukemic":[39],"blasts,":[40],"but":[41],"not":[42],"normal":[44],"CD34+":[45],"pluripotent":[46],"hematopoietic":[47],"stem":[48],"cells":[49],"or":[50],"nonhematopoietic":[51],"tissues.1":[52],"Gemtuzumab":[53],"ozogamicin":[54],"consists":[55],"semisynthetic":[58],"derivative":[59,102,118],"calicheamicin,":[61],"potent":[63],"cytotoxic":[64],"antibiotic,":[65],"linked":[66],"to":[67,120],"humanized":[69],"IgG4":[70],"anti-CD33":[71],"monoclonal":[72],"antibody":[73,77],"(hP67.6).":[74],"hP67.6":[76],"non-cytotoxic":[79],"itself.2":[81],"In":[82],"vitro":[83],"data":[84],"indicate":[85],"when":[87],"GO":[88],"binds":[89,119],"antigen,":[92],"complex":[94],"rapidly":[96],"internalized.3,4":[97],"Upon":[98],"internalization,":[99],"calicheamicin":[101,117],"released":[104,116],"inside":[105],"lysosomes":[107],"cell":[111,133],"acid":[113],"hydrolysis.":[114],"DNA":[121,128],"in":[122,127],"minor":[124],"groove":[125],"resulting":[126],"double":[129],"strand":[130],"breaks":[131],"and":[132],"death":[134],"apoptosis.":[136]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
