{"id":"https://openalex.org/W1528534342","doi":"https://doi.org/10.4049/jimmunol.133.4.1811","title":"Membrane and metabolic requirements for tolerance induction of neonatal B cells.","display_name":"Membrane and metabolic requirements for tolerance induction of neonatal B cells.","publication_year":1984,"publication_date":"1984-10-01","ids":{"openalex":"https://openalex.org/W1528534342","doi":"https://doi.org/10.4049/jimmunol.133.4.1811","mag":"1528534342","pmid":"https://pubmed.ncbi.nlm.nih.gov/6332134"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.133.4.1811","doi":"https://doi.org/10.4049/jimmunol.133.4.1811","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.133.4.1811","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064151448","display_name":"Judy M. Teale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Teale","raw_affiliation_strings":["University of Texas Health Science Center at San Antonio, Department of Microbiology , 7703 Floyd Curl Drive, San Antonio, TX 78284","South Texas Center for Emerging Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio, Department of Microbiology , 7703 Floyd Curl Drive, San Antonio, TX 78284","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"South Texas Center for Emerging Infectious Diseases","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113499725","display_name":"Norman R. Klinman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N R Klinman","raw_affiliation_strings":["Scripps Clinic and Research Foundation, Department of Immunology , 10666 North Torrey Pines Road, La Jolla, CA 92037","University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Clinic and Research Foundation, Department of Immunology , 10666 North Torrey Pines Road, La Jolla, CA 92037","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.6922,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.84289949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"133","issue":"4","first_page":"1811","last_page":"1817"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-tolerance","display_name":"B cell tolerance","score":0.8809999823570251},{"id":"https://openalex.org/keywords/neonatal-b-cells","display_name":"neonatal B cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/immature-b-cells","display_name":"immature B cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/metabolic-demand","display_name":"metabolic demand","score":0.5370000004768372},{"id":"https://openalex.org/keywords/rna-synthesis","display_name":"RNA synthesis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.996999979019165},{"id":"https://openalex.org/keywords/methyltransferase","display_name":"methyltransferase","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.718999981880188},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tolerogens","display_name":"tolerogens","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5849305391311646},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.5757935047149658},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5670256018638611},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5091139674186707},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5050714612007141},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4723576009273529},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.46195319294929504},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4146021008491516},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2320915162563324},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17884650826454163},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16713249683380127}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002746","descriptor_name":"Chlorpromazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003572","descriptor_name":"Cytochalasins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007152","descriptor_name":"Immunologic Capping","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008212","descriptor_name":"Lymphocyte Depletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014372","descriptor_name":"Tubercidin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.133.4.1811","doi":"https://doi.org/10.4049/jimmunol.133.4.1811","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.133.4.1811","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:6332134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6332134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.6800000071525574}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2413147060","https://openalex.org/W2012428299","https://openalex.org/W2031539156","https://openalex.org/W2101650690","https://openalex.org/W1562385747","https://openalex.org/W2052733766","https://openalex.org/W2100076275","https://openalex.org/W1922757901","https://openalex.org/W2030871047","https://openalex.org/W7095181911"],"abstract_inverted_index":{"The":[0,20],"metabolic":[1,97,124,197],"requirements":[2],"of":[3,6,16,31,39,51,69,76,80,99,151,186,199],"tolerance":[4,29,84,105,128,163,190],"induction":[5,30,106],"immature":[7,187],"B":[8,33,174,188],"cells":[9,34],"has":[10],"been":[11],"analyzed":[12],"through":[13],"the":[14,23,47,65,72,78,92,100,148,152,178,184,200],"use":[15],"various":[17],"putative":[18],"inhibitors.":[19],"study":[21],"utilizes":[22],"splenic":[24],"fragment":[25],"assay":[26],"in":[27,64],"which":[28,167],"individual":[32],"can":[35],"be":[36,86],"examined.":[37],"Concentrations":[38],"inhibitors":[40],"were":[41],"determined":[42],"which,":[43],"if":[44],"removed":[45],"after":[46],"first":[48,73],"18":[49,74],"hr":[50,75],"culture,":[52,77],"before":[53],"antigenic":[54],"stimulation,":[55],"had":[56],"no":[57],"inhibitory":[58],"effects.":[59],"Thus,":[60],"by":[61],"adding":[62],"tolerogen":[63],"presence":[66],"or":[67],"absence":[68],"inhibitor":[70,82],"during":[71],"effect":[79],"that":[81,95,120,134,145,183],"on":[83],"could":[85],"assessed.":[87],"By":[88],"using":[89],"this":[90],"protocol,":[91],"data":[93],"indicate":[94],"several":[96,196],"functions":[98],"cell":[101,153,169,175,189],"are":[102,140],"necessary":[103],"for":[104],"to":[107],"occur,":[108],"including":[109],"RNA":[110],"biosynthesis,":[111,113],"DNA":[112],"and":[114,137,154],"a":[115],"methyltransferase":[116],"reaction,":[117],"because":[118],"drugs":[119,144],"interfere":[121,161],"with":[122,147,162],"these":[123],"processes":[125],"also":[126,141],"prevent":[127],"induction.":[129,164],"Our":[130],"previous":[131],"studies":[132],"indicated":[133],"protein":[135],"biosynthesis":[136],"energy":[138],"generation":[139],"required.":[142],"However,":[143],"interact":[146],"cytoskeletal":[149],"structure":[150],"inhibit":[155,173],"surface":[156],"immunoglobulin":[157],"capping":[158],"do":[159],"not":[160,172],"Moreover,":[165],"colchicine,":[166],"inhibits":[168],"division,":[170],"does":[171],"tolerance.":[176],"Collectively,":[177],"results":[179],"provide":[180],"compelling":[181],"evidence":[182],"mechanism":[185],"involves":[191],"an":[192],"active":[193],"process":[194],"requiring":[195],"activities":[198],"cell.":[201]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
