{"id":"https://openalex.org/W152850406","doi":"https://doi.org/10.1016/0006-2952(79)90598-7","title":"Studies on methanol toxicity and formate metabolism in isolated hepatocytes","display_name":"Studies on methanol toxicity and formate metabolism in isolated hepatocytes","publication_year":1979,"publication_date":"1979-10-01","ids":{"openalex":"https://openalex.org/W152850406","doi":"https://doi.org/10.1016/0006-2952(79)90598-7","mag":"152850406","pmid":"https://pubmed.ncbi.nlm.nih.gov/518695"},"language":"en","primary_location":{"id":"doi:10.1016/0006-2952(79)90598-7","doi":"https://doi.org/10.1016/0006-2952(79)90598-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(79)90598-7","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017526683","display_name":"Ruth E. Billings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth E. Billings","raw_affiliation_strings":["The Toxicology Center, Department of Pharmacology, Iowa City, IA 52242, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Toxicology Center, Department of Pharmacology, Iowa City, IA 52242, U.S.A","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002630064","display_name":"Thomas R. Tephly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas R. Tephly","raw_affiliation_strings":["The Toxicology Center, Department of Pharmacology, Iowa City, IA 52242, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Toxicology Center, Department of Pharmacology, Iowa City, IA 52242, U.S.A","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":4.091,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.93128314,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"28","issue":"19","first_page":"2985","last_page":"2991"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.48170000314712524,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.48170000314712524,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.1298000067472458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.11079999804496765,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methanol-poisoning","display_name":"methanol poisoning","score":0.9990000128746033},{"id":"https://openalex.org/keywords/formate-metabolism","display_name":"formate metabolism","score":0.8740000128746033},{"id":"https://openalex.org/keywords/methanol-oxidation","display_name":"methanol oxidation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.7919999957084656},{"id":"https://openalex.org/keywords/methionine-deficiency","display_name":"methionine deficiency","score":0.8069999814033508},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":0.9290000200271606},{"id":"https://openalex.org/keywords/5-formyltetrahydrofolate","display_name":"5-formyltetrahydrofolate","score":0.9179999828338623},{"id":"https://openalex.org/keywords/metabolic-acidosis","display_name":"metabolic acidosis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/ocular-toxicity","display_name":"ocular toxicity","score":0.875},{"id":"https://openalex.org/keywords/formaldehyde","display_name":"formaldehyde","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2780178953","wikidata":"https://www.wikidata.org/wiki/Q2001841","display_name":"Formate","level":3,"score":0.8860906362533569},{"id":"https://openalex.org/C2779607525","wikidata":"https://www.wikidata.org/wiki/Q14982","display_name":"Methanol","level":2,"score":0.8086627721786499},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7427560687065125},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5925731062889099},{"id":"https://openalex.org/C2775930285","wikidata":"https://www.wikidata.org/wiki/Q161210","display_name":"Formaldehyde","level":2,"score":0.5908529758453369},{"id":"https://openalex.org/C530467964","wikidata":"https://www.wikidata.org/wiki/Q1997","display_name":"Carbon dioxide","level":2,"score":0.5158252120018005},{"id":"https://openalex.org/C2909879501","wikidata":"https://www.wikidata.org/wiki/Q3631225","display_name":"Methanol poisoning","level":3,"score":0.4994223117828369},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49304816126823425},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.44495123624801636},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4228825867176056},{"id":"https://openalex.org/C2779870537","wikidata":"https://www.wikidata.org/wiki/Q422779","display_name":"Methyl formate","level":3,"score":0.4124666154384613},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.22216951847076416},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2213945984840393},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15338316559791565},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.079220712184906}],"mesh":[{"descriptor_ui":"D000432","descriptor_name":"Methanol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005494","descriptor_name":"Folic Acid Deficiency","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005561","descriptor_name":"Formates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006016","descriptor_name":"Glycolates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010545","descriptor_name":"Peroxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-2952(79)90598-7","doi":"https://doi.org/10.1016/0006-2952(79)90598-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(79)90598-7","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:518695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/518695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W46996808","https://openalex.org/W130103429","https://openalex.org/W247698120","https://openalex.org/W938020732","https://openalex.org/W1514995876","https://openalex.org/W1523495581","https://openalex.org/W1542262792","https://openalex.org/W1587541605","https://openalex.org/W1590123859","https://openalex.org/W1618768312","https://openalex.org/W1982185507","https://openalex.org/W1982582725","https://openalex.org/W1989830281","https://openalex.org/W1995891215","https://openalex.org/W2003189563","https://openalex.org/W2004554235","https://openalex.org/W2005926878","https://openalex.org/W2011242734","https://openalex.org/W2017432284","https://openalex.org/W2018708925","https://openalex.org/W2019039571","https://openalex.org/W2032319980","https://openalex.org/W2036570557","https://openalex.org/W2053685377","https://openalex.org/W2056281227","https://openalex.org/W2076183022","https://openalex.org/W2082513483","https://openalex.org/W2090306342","https://openalex.org/W2093243558","https://openalex.org/W2139972268","https://openalex.org/W2140703352","https://openalex.org/W2141174000","https://openalex.org/W2169877348","https://openalex.org/W2197246437","https://openalex.org/W2215943057","https://openalex.org/W2261310899","https://openalex.org/W2290815490","https://openalex.org/W2334503167","https://openalex.org/W2395738650","https://openalex.org/W2715465520","https://openalex.org/W4256439374"],"related_works":["https://openalex.org/W144632747","https://openalex.org/W1839599377","https://openalex.org/W2291221078","https://openalex.org/W2080847007","https://openalex.org/W2217345325","https://openalex.org/W2011242734","https://openalex.org/W34618012","https://openalex.org/W2048312705","https://openalex.org/W7099325487","https://openalex.org/W2078781729"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
