{"id":"https://openalex.org/W1528297898","doi":"https://doi.org/10.1002/9780470048672.wecb516","title":"Locked Nucleic Acids","display_name":"Locked Nucleic Acids","publication_year":2008,"publication_date":"2008-05-15","ids":{"openalex":"https://openalex.org/W1528297898","doi":"https://doi.org/10.1002/9780470048672.wecb516","mag":"1528297898"},"language":"en","primary_location":{"id":"doi:10.1002/9780470048672.wecb516","doi":"https://doi.org/10.1002/9780470048672.wecb516","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470048672.wecb516","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiley Encyclopedia of Chemical Biology","raw_type":"other"},"volume":{"id":"https://openalex.org/W605885627","display_name":"Wiley Encyclopedia of Chemical Biology"},"type":"reference-entry","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062861779","display_name":"Zenia Marian St\u00f8rling","orcid":"https://orcid.org/0000-0003-4704-3051","observed_orcids":["https://orcid.org/0000-0003-4704-3051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zenia M. St\u00f8rling","raw_affiliation_strings":["Santaris Pharma A/S, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santaris Pharma A/S, H\u00f8rsholm, Denmark","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042696215","display_name":"Troels Koch","orcid":"https://orcid.org/0000-0001-9224-9353","observed_orcids":["https://orcid.org/0000-0001-9224-9353"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Troels Koch","raw_affiliation_strings":["Santaris Pharma A/S, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santaris Pharma A/S, H\u00f8rsholm, Denmark","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.5464000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.5464000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.44040000438690186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locked-nucleic-acid","display_name":"locked nucleic acid","score":0.984000027179718},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.9739999771118164},{"id":"https://openalex.org/keywords/preclinical-toxicology","display_name":"preclinical toxicology","score":0.8740000128746033},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.7590000033378601},{"id":"https://openalex.org/keywords/drug-candidates","display_name":"drug candidates","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.7201154232025146},{"id":"https://openalex.org/C14363569","wikidata":"https://www.wikidata.org/wiki/Q418639","display_name":"Locked nucleic acid","level":4,"score":0.7092400193214417},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.6491252183914185},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6144486665725708},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4372968375682831},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33568572998046875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3068397641181946},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16307327151298523}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9780470048672.wecb516","doi":"https://doi.org/10.1002/9780470048672.wecb516","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470048672.wecb516","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiley Encyclopedia of Chemical Biology","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1493046933","https://openalex.org/W1495409864","https://openalex.org/W1496645167","https://openalex.org/W1505652529","https://openalex.org/W1564730852","https://openalex.org/W1593893811","https://openalex.org/W1624382596","https://openalex.org/W1676072584","https://openalex.org/W1906502852","https://openalex.org/W1942185956","https://openalex.org/W1976306943","https://openalex.org/W1981186391","https://openalex.org/W1981430299","https://openalex.org/W1983305810","https://openalex.org/W1990548509","https://openalex.org/W1992696785","https://openalex.org/W2001911979","https://openalex.org/W2002703021","https://openalex.org/W2012222863","https://openalex.org/W2016696388","https://openalex.org/W2018841002","https://openalex.org/W2020326055","https://openalex.org/W2020678086","https://openalex.org/W2020713872","https://openalex.org/W2024244702","https://openalex.org/W2026050954","https://openalex.org/W2028767896","https://openalex.org/W2034180036","https://openalex.org/W2036915037","https://openalex.org/W2038332844","https://openalex.org/W2044005056","https://openalex.org/W2045397431","https://openalex.org/W2053999548","https://openalex.org/W2063024922","https://openalex.org/W2072034558","https://openalex.org/W2074030375","https://openalex.org/W2075881778","https://openalex.org/W2080853945","https://openalex.org/W2082998873","https://openalex.org/W2083843089","https://openalex.org/W2091559790","https://openalex.org/W2094851638","https://openalex.org/W2104610341","https://openalex.org/W2107705149","https://openalex.org/W2108185026","https://openalex.org/W2120439078","https://openalex.org/W2125673458","https://openalex.org/W2129932149","https://openalex.org/W2135314242","https://openalex.org/W2137665434","https://openalex.org/W2141128504","https://openalex.org/W2150536104","https://openalex.org/W2152374411","https://openalex.org/W2152558372","https://openalex.org/W2155225853","https://openalex.org/W2161576295","https://openalex.org/W2161975833","https://openalex.org/W2163914444","https://openalex.org/W2168639664","https://openalex.org/W2172186946","https://openalex.org/W2174837190","https://openalex.org/W2174841548","https://openalex.org/W4240935799"],"related_works":["https://openalex.org/W1989350280","https://openalex.org/W7094800448","https://openalex.org/W66102147","https://openalex.org/W2763910338","https://openalex.org/W2042578211","https://openalex.org/W2005880821","https://openalex.org/W1998666145","https://openalex.org/W2169788363","https://openalex.org/W30481062","https://openalex.org/W4240206368"],"abstract_inverted_index":{"Abstract":[0],"The":[1,82,119],"intensive":[2],"research":[3],"and":[4,22,33,62,74,91,95,112],"development":[5],"of":[6,17,20,53,77,84,100,121,132],"antisense":[7],"oligonucleotides":[8,86,107],"in":[9,57,116],"the":[10,51,70,130,133],"past":[11],"decades":[12],"has":[13,64],"refined":[14],"our":[15],"knowledge":[16],"this":[18,37,68],"class":[19,42],"molecules,":[21],"they":[23],"are":[24,113],"now":[25,114],"recognized":[26],"as":[27],"potent":[28],"reagents":[29],"for":[30,55],"gene\u2010target":[31],"validation":[32],"therapeutic":[34],"uses.":[35],"Within":[36],"field,":[38],"a":[39],"very":[40],"promising":[41],"is":[43],"locked":[44],"nucleic":[45],"acid":[46],"(LNA).":[47],"In":[48,67],"recent":[49],"years,":[50],"number":[52],"applications":[54],"LNA":[56,78,85,106],"basic":[58],"research,":[59],"molecular":[60],"diagnostics,":[61],"therapeutics":[63],"expanded":[65],"continuously.":[66],"article,":[69],"general":[71],"biophysical,":[72],"biochemical,":[73],"pharmacological":[75],"properties":[76],"will":[79,102,125],"be":[80,103,126],"summarised.":[81],"ability":[83],"to":[87],"target":[88],"both":[89],"coding":[90],"noncoding":[92],"RNAs":[93],"effectively":[94],"specifically":[96],"via":[97],"different":[98],"modes":[99],"action":[101],"discussed.":[104],"Several":[105],"have":[108],"completed":[109],"preclinical":[110],"toxicology":[111],"tested":[115],"clinical":[117],"trials.":[118],"status":[120],"one":[122],"drug":[123],"candidate":[124],"presented":[127],"briefly":[128],"at":[129],"end":[131],"article.":[134]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
