{"id":"https://openalex.org/W1526645950","doi":null,"title":"Biosynthesis of RNA cytosine and RNA purines: differential inhibition by diazo-oxonorleucine.","display_name":"Biosynthesis of RNA cytosine and RNA purines: differential inhibition by diazo-oxonorleucine.","publication_year":1961,"publication_date":"1961-02-01","ids":{"openalex":"https://openalex.org/W1526645950","mag":"1526645950","pmid":"https://pubmed.ncbi.nlm.nih.gov/13772282"},"language":"en","primary_location":{"id":"pmid:13772282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13772282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109116363","display_name":"E. Colleen Moore","orcid":"https://orcid.org/0000-0002-3848-5416","observed_orcids":["https://orcid.org/0000-0002-3848-5416"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E C MOORE","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080646624","display_name":"Robert B. Hurlbert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R B HURLBERT","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4668,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.56219171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"21","issue":null,"first_page":"257","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/6-diazo-5-oxo-l-norleucine","display_name":"6-diazo-5-oxo-L-norleucine","score":0.9430000185966492},{"id":"https://openalex.org/keywords/orotic-acid","display_name":"orotic acid","score":0.5960000157356262},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":0.781000018119812},{"id":"https://openalex.org/keywords/cytidine-nucleotides","display_name":"cytidine nucleotides","score":0.8920000195503235},{"id":"https://openalex.org/keywords/purine-nucleotides","display_name":"purine nucleotides","score":0.9089999794960022},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.9259999990463257},{"id":"https://openalex.org/keywords/irreversible-inhibition","display_name":"irreversible inhibition","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2781184954","wikidata":"https://www.wikidata.org/wiki/Q422538","display_name":"Cytidine","level":3,"score":0.7845317125320435},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.7541024684906006},{"id":"https://openalex.org/C2775851010","wikidata":"https://www.wikidata.org/wiki/Q425536","display_name":"Orotic acid","level":2,"score":0.7045217752456665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6708563566207886},{"id":"https://openalex.org/C169586020","wikidata":"https://www.wikidata.org/wiki/Q3780159","display_name":"Purine metabolism","level":3,"score":0.6620180606842041},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.5576848983764648},{"id":"https://openalex.org/C2776023528","wikidata":"https://www.wikidata.org/wiki/Q178425","display_name":"Cytosine","level":3,"score":0.5373114347457886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5360842943191528},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5286534428596497},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.5238794684410095},{"id":"https://openalex.org/C194101687","wikidata":"https://www.wikidata.org/wiki/Q583813","display_name":"Nucleotide salvage","level":4,"score":0.4952518045902252},{"id":"https://openalex.org/C88742014","wikidata":"https://www.wikidata.org/wiki/Q1063702","display_name":"De novo synthesis","level":3,"score":0.4551349878311157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3709412217140198},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3240223228931427},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.28602761030197144},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10771685838699341},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08603817224502563}],"mesh":[{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:13772282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13772282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1526645950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13772282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W9686781","https://openalex.org/W105900778","https://openalex.org/W1600166291","https://openalex.org/W1847011500","https://openalex.org/W1980592056","https://openalex.org/W2160889646","https://openalex.org/W2345049479","https://openalex.org/W2399461665"],"related_works":["https://openalex.org/W1609362914","https://openalex.org/W1565621223","https://openalex.org/W2383364975","https://openalex.org/W1981779488","https://openalex.org/W2078363332","https://openalex.org/W2062965558","https://openalex.org/W3022081482","https://openalex.org/W1983697961","https://openalex.org/W2027951079","https://openalex.org/W7155287484"],"abstract_inverted_index":{"The":[0,63,96],"effects":[1],"of":[2,8,15,24,32,43,60,65,75,83,98,109,121,127,133],"6-diazo-5-oxo-l-norleucine":[3],"(DON)":[4],"on":[5],"the":[6,37,41,50,56,73,78,84,106,118,125],"conversions":[7],"orotic":[9],"acid-6-C14":[10],"to":[11,17,35,53,93,101,114],"RNA":[12,18],"pyrimidines":[13],"and":[14],"glycine-2-C14":[16],"purines":[19],"were":[20,46],"studied":[21],"in":[22,28,40,67,77,87,124],"suspensions":[23],"Novikoff":[25],"tumor":[26],"cells":[27],"vitro":[29],".\n\nThe":[30],"concentrations":[31,51],"DON":[33,82,122],"required":[34,52],"inhibit":[36,54],"amination":[38,85],"step":[39,86],"biosynthesis":[42,57],"cytidine":[44,88,110],"nucleotides":[45,111],"about":[47],"10":[48],"times":[49],"completely":[55],"de":[58],"novo":[59],"purine":[61,128],"nucleotides.":[62],"degree":[64],"inhibition":[66,80,126],"both":[68],"cases":[69],"was":[70,91,100,112],"diminished":[71],"by":[72,81,117],"presence":[74],"glutamine":[76,99],"medium.\n\nThe":[79],"nucleotide":[89,129],"formation":[90,108],"shown":[92],"be":[94,115],"irreversible.":[95],"effect":[97],"delay":[102],"or":[103],"partially":[104],"prevent":[105],"inhibition.\n\nThe":[107],"observed":[113],"stimulated":[116],"minimal":[119],"concentration":[120],"effective":[123],"formation;":[130],"an":[131],"explanation":[132],"this":[134],"anomaly":[135],"is":[136],"offered.":[137]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
