{"id":"https://openalex.org/W152590526","doi":null,"title":"Chronic obstructive pulmonary disease \u2013 multisistemic disease","display_name":"Chronic obstructive pulmonary disease \u2013 multisistemic disease","publication_year":2009,"publication_date":"2009-03-02","ids":{"openalex":"https://openalex.org/W152590526","mag":"152590526"},"language":"en","primary_location":{"id":"pmh:oai:hrcak.srce.hr:34697","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/34697","pdf_url":"http://hrcak.srce.hr/34697","source":{"id":"https://openalex.org/S4306400071","display_name":"University of Zagreb University Computing Centre (SRCE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181343428","host_organization_name":"University of Zagreb","host_organization_lineage":["https://openalex.org/I181343428"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina Fluminensis : Medicina Fluminensis","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hrcak.srce.hr/34697","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070987424","display_name":"Dubravka Matani\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122486","display_name":"Klini\u010dki Bolni\u010dki Centar Rijeka","ror":"https://ror.org/027wyhf03","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210122486"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Dubravka Matani\u0107","raw_affiliation_strings":["Zavod za pulmologiju, Klinika za internu medicinu, KBC Rijeka, Rijeka, Hrvatska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zavod za pulmologiju, Klinika za internu medicinu, KBC Rijeka, Rijeka, Hrvatska","institution_ids":["https://openalex.org/I4210122486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108574039","display_name":"Veljko Flego","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122486","display_name":"Klini\u010dki Bolni\u010dki Centar Rijeka","ror":"https://ror.org/027wyhf03","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210122486"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Veljko Flego","raw_affiliation_strings":["Zavod za pulmologiju, Klinika za internu medicinu, KBC Rijeka, Rijeka, Hrvatska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zavod za pulmologiju, Klinika za internu medicinu, KBC Rijeka, Rijeka, Hrvatska","institution_ids":["https://openalex.org/I4210122486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072816510","display_name":"Igor Barkovi\u0107","orcid":"https://orcid.org/0000-0001-7911-3769","observed_orcids":["https://orcid.org/0000-0001-7911-3769","https://orcid.org/0000-0002-4794-7926"]},"institutions":[{"id":"https://openalex.org/I4210122486","display_name":"Klini\u010dki Bolni\u010dki Centar Rijeka","ror":"https://ror.org/027wyhf03","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210122486"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Igor Barkovi\u0107","raw_affiliation_strings":["Zavod za pulmologiju, Klinika za internu medicinu, KBC Rijeka, Rijeka, Hrvatska"],"raw_orcid":"https://orcid.org/0000-0001-7911-3769","affiliations":[{"raw_affiliation_string":"Zavod za pulmologiju, Klinika za internu medicinu, KBC Rijeka, Rijeka, Hrvatska","institution_ids":["https://openalex.org/I4210122486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026963094","display_name":"Ivica Zeba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122486","display_name":"Klini\u010dki Bolni\u010dki Centar Rijeka","ror":"https://ror.org/027wyhf03","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210122486"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Ivica Zeba","raw_affiliation_strings":["Zavod za pulmologiju, Klinika za internu medicinu, KBC Rijeka, Rijeka, Hrvatska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zavod za pulmologiju, Klinika za internu medicinu, KBC Rijeka, Rijeka, Hrvatska","institution_ids":["https://openalex.org/I4210122486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053661093","display_name":"\u017deljko Kupanovac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122486","display_name":"Klini\u010dki Bolni\u010dki Centar Rijeka","ror":"https://ror.org/027wyhf03","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210122486"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"\u017deljko Kupanovac","raw_affiliation_strings":["Zavod za pulmologiju, Klinika za internu medicinu, KBC Rijeka, Rijeka, Hrvatska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zavod za pulmologiju, Klinika za internu medicinu, KBC Rijeka, Rijeka, Hrvatska","institution_ids":["https://openalex.org/I4210122486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045272157","display_name":"Ljiljana Bulat-Kardum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122486","display_name":"Klini\u010dki Bolni\u010dki Centar Rijeka","ror":"https://ror.org/027wyhf03","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210122486"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Ljiljana Bulat-Kardum","raw_affiliation_strings":["Zavod za pulmologiju, Klinika za internu medicinu, KBC Rijeka, Rijeka, Hrvatska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zavod za pulmologiju, Klinika za internu medicinu, KBC Rijeka, Rijeka, Hrvatska","institution_ids":["https://openalex.org/I4210122486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210122486"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"1","first_page":"60","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":1.0},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/extrapulmonary-manifestations","display_name":"extrapulmonary manifestations","score":0.8629999756813049},{"id":"https://openalex.org/keywords/airway-obstruction","display_name":"airway obstruction","score":0.6179999709129333},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.9200000166893005},{"id":"https://openalex.org/keywords/chronic-airway-inflammation","display_name":"chronic airway inflammation","score":0.5339999794960022},{"id":"https://openalex.org/keywords/pathobiology","display_name":"pathobiology","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8549997210502625},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8030620813369751},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5874282121658325},{"id":"https://openalex.org/C2778333281","wikidata":"https://www.wikidata.org/wiki/Q4330029","display_name":"Airway obstruction","level":3,"score":0.5757867097854614},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5522225499153137},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.5505688786506653},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5477773547172546},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5384243726730347},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.505450963973999},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.49666649103164673},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.48724403977394104},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.46058031916618347},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27814608812332153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20679360628128052},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.08549097180366516}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:hrcak.srce.hr:34697","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/34697","pdf_url":"http://hrcak.srce.hr/34697","source":{"id":"https://openalex.org/S4306400071","display_name":"University of Zagreb University Computing Centre (SRCE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181343428","host_organization_name":"University of Zagreb","host_organization_lineage":["https://openalex.org/I181343428"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina Fluminensis : Medicina Fluminensis","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:cria:bioline:me:me09008","doi":null,"is_oa":false,"landing_page_url":"http://www.bioline.org.br/abstract?id=me09008","pdf_url":null,"source":{"id":"https://openalex.org/S4306402188","display_name":"Bioline International (Bioline International)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina (ISSN: 0025-7729) Vol 45 Num 1","raw_type":"RA"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/54415","doi":null,"is_oa":false,"landing_page_url":"http://www.bioline.org.br/abstract?id=me09008","pdf_url":null,"source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"mag:152590526","doi":null,"is_oa":false,"landing_page_url":"http://www.bioline.org.br/pdf?me09008","pdf_url":null,"source":{"id":"https://openalex.org/S4210173356","display_name":"Medicina Fluminensis","issn_l":"1847-6864","issn":["1847-6864","1848-820X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310314755","host_organization_name":"University of Rijeka","host_organization_lineage":["https://openalex.org/P4310314755"],"host_organization_lineage_names":["University of Rijeka"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Medicina Fluminensis : Medicina Fluminensis","raw_type":null},{"id":"mag:1547216814","doi":null,"is_oa":false,"landing_page_url":"http://hrcak.srce.hr/34697","pdf_url":null,"source":{"id":"https://openalex.org/S1032365090","display_name":"Medicina-buenos Aires","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4320800550","host_organization_name":"Fundaci\u00f3n Revista Medicina","host_organization_lineage":["https://openalex.org/P4320800550"],"host_organization_lineage_names":["Fundaci\u00f3n Revista Medicina"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Medicina-buenos Aires","raw_type":null}],"best_oa_location":{"id":"pmh:oai:hrcak.srce.hr:34697","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/34697","pdf_url":"http://hrcak.srce.hr/34697","source":{"id":"https://openalex.org/S4306400071","display_name":"University of Zagreb University Computing Centre (SRCE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181343428","host_organization_name":"University of Zagreb","host_organization_lineage":["https://openalex.org/I181343428"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina Fluminensis : Medicina Fluminensis","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W152590526.pdf","grobid_xml":"https://content.openalex.org/works/W152590526.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1494816904","https://openalex.org/W1689405614","https://openalex.org/W1987102995","https://openalex.org/W1991360334","https://openalex.org/W2011876371","https://openalex.org/W2019358153","https://openalex.org/W2026192447","https://openalex.org/W2040476667","https://openalex.org/W2049479384","https://openalex.org/W2053337621","https://openalex.org/W2056880490","https://openalex.org/W2058169534","https://openalex.org/W2073468412","https://openalex.org/W2088593313","https://openalex.org/W2091146487","https://openalex.org/W2093843016","https://openalex.org/W2099548121","https://openalex.org/W2104168490","https://openalex.org/W2108426443","https://openalex.org/W2110378267","https://openalex.org/W2114423036","https://openalex.org/W2118228748","https://openalex.org/W2119166127","https://openalex.org/W2122630923","https://openalex.org/W2125968371","https://openalex.org/W2127748163","https://openalex.org/W2138695842","https://openalex.org/W2147607947","https://openalex.org/W2147875779","https://openalex.org/W2150285844","https://openalex.org/W2165340553","https://openalex.org/W2191391362"],"related_works":["https://openalex.org/W2332998216","https://openalex.org/W1547216814","https://openalex.org/W2133358886","https://openalex.org/W2415595102","https://openalex.org/W4282929253","https://openalex.org/W7095958866","https://openalex.org/W2067200721","https://openalex.org/W2060405242","https://openalex.org/W3160240297","https://openalex.org/W2009370032"],"abstract_inverted_index":{"Chronic":[0],"obstructive":[1],"pulmonary":[2,29,73],"disease":[3,7],"(COPD)":[4],"is":[5,44],"a":[6],"of":[8,20,24,33,55,69,95,99,104,114],"the":[9,18,25,28,34,45,52,84,93,100,109],"lungs":[10],"characterized":[11],"by":[12,51],"chronic":[13,53],"airflow":[14],"obstruction,":[15],"secondary":[16],"to":[17,92],"presence":[19],"specific":[21],"structural":[22,61],"abnormalities":[23,62],"airways":[26],"and":[27,37,58,72,111],"parenchima.":[30],"The":[31,87,106],"etiology":[32],"airway":[35,42],"obstruction":[36],"emphysematous":[38],"destruction":[39],"that":[40],"cause":[41],"limitation":[43],"persistent":[46],"lung":[47],"tissue":[48],"injury":[49],"produced":[50],"inhalation":[54],"toxic":[56],"particles":[57],"gases.":[59],"These":[60],"are":[63],"associated":[64],"with":[65],"an":[66],"inflammatory":[67,77],"reaction":[68,78],"airways,":[70],"alveoli":[71],"vessels.":[74],"This":[75],"abnormal":[76],"can":[79],"also":[80],"be":[81],"detected":[82],"in":[83],"systemic":[85,88,102],"circulation.":[86],"inflammation":[89],"contributes":[90],"significantly":[91],"pathobiology":[94],"numerous":[96],"extrapulmonary":[97,112],"effects":[98,103,113],"disease,":[101],"COPD.":[105],"interplay":[107],"between":[108],"intrapulmonary":[110],"COPD":[115],"has":[116],"important":[117],"clinical":[118],"outcomes.":[119]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
