{"id":"https://openalex.org/W1525751970","doi":"https://doi.org/10.5090/kjtcs.2010.43.6.576","title":"Study on Effective Preservation of Bovine Pericardium Using Decellularization and \u03b1-galactosidase for Eliminating Xenoreactive Antigen","display_name":"Study on Effective Preservation of Bovine Pericardium Using Decellularization and \u03b1-galactosidase for Eliminating Xenoreactive Antigen","publication_year":2010,"publication_date":"2010-12-05","ids":{"openalex":"https://openalex.org/W1525751970","doi":"https://doi.org/10.5090/kjtcs.2010.43.6.576","mag":"1525751970"},"language":"en","primary_location":{"id":"doi:10.5090/kjtcs.2010.43.6.576","doi":"https://doi.org/10.5090/kjtcs.2010.43.6.576","is_oa":true,"landing_page_url":"https://doi.org/10.5090/kjtcs.2010.43.6.576","pdf_url":null,"source":{"id":"https://openalex.org/S13555218","display_name":"The Korean Journal of Thoracic and Cardiovascular Surgery","issn_l":"0301-2859","issn":["0301-2859","2093-6516","2233-601X","2765-1606","2765-1614"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","poland-20","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319423","host_organization_name":"Korean Society for Thoracic and Cardiovascular Surgery","host_organization_lineage":["https://openalex.org/P4310319423"],"host_organization_lineage_names":["Korean Society for Thoracic and Cardiovascular Surgery"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korean Journal of Thoracic and Cardiovascular Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.5090/kjtcs.2010.43.6.576","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100680042","display_name":"Min\u2010Seok Kim","orcid":"https://orcid.org/0000-0003-3425-882X","observed_orcids":["https://orcid.org/0000-0003-3425-882X","https://orcid.org/0009-0001-0567-3875"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Seok Kim","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103345334","display_name":"Cham Jin Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Cham Jin Park","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049263804","display_name":"Soo Hwan Kim","orcid":"https://orcid.org/0000-0001-5213-9213","observed_orcids":["https://orcid.org/0000-0001-5213-9213"]},"institutions":[{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo Hwan Kim","raw_affiliation_strings":["Seoul National University Hospital, Clinical Research Institute, Xenotransplantation Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National University Hospital, Clinical Research Institute, Xenotransplantation Research Center","institution_ids":["https://openalex.org/I2802835388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006100314","display_name":"Hong\u2010Gook Lim","orcid":"https://orcid.org/0000-0001-9247-6775","observed_orcids":["https://orcid.org/0000-0001-9247-6775"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hong-Gook Lim","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100613942","display_name":"Yong Jin Kim","orcid":"https://orcid.org/0000-0002-3763-8265","observed_orcids":["https://orcid.org/0000-0002-3763-8265"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I2802835388","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong Jin Kim","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I2802835388"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"6","first_page":"576","last_page":"587"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-pericardium","display_name":"bovine pericardium","score":0.9760000109672546},{"id":"https://openalex.org/keywords/alpha-galactosidase","display_name":"alpha-galactosidase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tissue-preservation","display_name":"tissue preservation","score":0.5189999938011169},{"id":"https://openalex.org/keywords/glutaraldehyde-fixation","display_name":"glutaraldehyde fixation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/edc-nhs-coupling","display_name":"EDC/NHS coupling","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sodium-dodecyl-sulfate","display_name":"sodium dodecyl sulfate","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tensile-strength","display_name":"tensile strength","score":0.7080000042915344},{"id":"https://openalex.org/keywords/thermal-stability","display_name":"thermal stability","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tissue-calcification","display_name":"tissue calcification","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.6385214328765869},{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.5057029724121094},{"id":"https://openalex.org/C59061564","wikidata":"https://www.wikidata.org/wiki/Q7783071","display_name":"Thermal stability","level":2,"score":0.49994564056396484},{"id":"https://openalex.org/C2776708817","wikidata":"https://www.wikidata.org/wiki/Q4380751","display_name":"Pronase","level":4,"score":0.4716312885284424},{"id":"https://openalex.org/C2778944976","wikidata":"https://www.wikidata.org/wiki/Q421098","display_name":"Ninhydrin","level":3,"score":0.44691452383995056},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39655211567878723},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.32939571142196655},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3061527609825134},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.27778875827789307},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23358049988746643},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16712069511413574},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1393357217311859},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.10844454169273376},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09182241559028625},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5090/kjtcs.2010.43.6.576","doi":"https://doi.org/10.5090/kjtcs.2010.43.6.576","is_oa":true,"landing_page_url":"https://doi.org/10.5090/kjtcs.2010.43.6.576","pdf_url":null,"source":{"id":"https://openalex.org/S13555218","display_name":"The Korean Journal of Thoracic and Cardiovascular Surgery","issn_l":"0301-2859","issn":["0301-2859","2093-6516","2233-601X","2765-1606","2765-1614"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","poland-20","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319423","host_organization_name":"Korean Society for Thoracic and Cardiovascular Surgery","host_organization_lineage":["https://openalex.org/P4310319423"],"host_organization_lineage_names":["Korean Society for Thoracic and Cardiovascular Surgery"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korean Journal of Thoracic and Cardiovascular Surgery","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5090/kjtcs.2010.43.6.576","doi":"https://doi.org/10.5090/kjtcs.2010.43.6.576","is_oa":true,"landing_page_url":"https://doi.org/10.5090/kjtcs.2010.43.6.576","pdf_url":null,"source":{"id":"https://openalex.org/S13555218","display_name":"The Korean Journal of Thoracic and Cardiovascular Surgery","issn_l":"0301-2859","issn":["0301-2859","2093-6516","2233-601X","2765-1606","2765-1614"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","poland-20","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319423","host_organization_name":"Korean Society for Thoracic and Cardiovascular Surgery","host_organization_lineage":["https://openalex.org/P4310319423"],"host_organization_lineage_names":["Korean Society for Thoracic and Cardiovascular Surgery"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Korean Journal of Thoracic and Cardiovascular Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W75078444","https://openalex.org/W170827143","https://openalex.org/W1528379065","https://openalex.org/W1833771797","https://openalex.org/W1966069745","https://openalex.org/W1974538559","https://openalex.org/W2034837878","https://openalex.org/W2035442517","https://openalex.org/W2054211588","https://openalex.org/W2074165893","https://openalex.org/W2090303367","https://openalex.org/W2118877693","https://openalex.org/W2138431756","https://openalex.org/W2158729728","https://openalex.org/W2165617122","https://openalex.org/W2166186747","https://openalex.org/W2210065642","https://openalex.org/W2244240422","https://openalex.org/W2409410419","https://openalex.org/W2414181771","https://openalex.org/W2414719672","https://openalex.org/W2988593198","https://openalex.org/W4237305863"],"related_works":["https://openalex.org/W1583812871","https://openalex.org/W2016165328","https://openalex.org/W2157510726","https://openalex.org/W2783314649","https://openalex.org/W4386379303","https://openalex.org/W3215164678","https://openalex.org/W4398232553","https://openalex.org/W3119204206","https://openalex.org/W407076532","https://openalex.org/W2054992789"],"abstract_inverted_index":{"Background:":[0],"Effective":[1],"decellularization":[2],"and":[3,28,34,52,60,63,108,125,140,147,159,165,177,201,220],"fixation":[4,49,215,234],"process":[5],"is":[6],"critical,":[7],"in":[8,37,182,241],"order":[9],"to":[10,40,114,180,188],"use":[11],"xenogenic":[12],"valves":[13],"clinically.":[14],"In":[15,156],"the":[16,43,222],"present":[17],"study,":[18],"we":[19,228],"decellularized":[20,57],"bovine":[21],"pericardium":[22,55],"using":[23],"sodium":[24],"dodecyl":[25],"sulfate":[26],"(SDS)":[27],"N-lauroyl":[29,61],"sarcosinate,":[30,62],"treated":[31,64],"with":[32,58,65],"\u03b1-galactosidase,":[33],"then":[35],"fixed":[36,70,119,130,134,145,154,163,168,185,190,195,206],"various":[38],"manners,":[39],"find":[41],"out":[42,113],"most":[44],"effective":[45,218],"tissue":[46,239],"preservation":[47],"&":[48,238],"procedure.":[50],"Material":[51],"Method:":[53],"Bovine":[54],"was":[56],"SDS":[59],"\u03b1-galactosidase.":[66],"Both":[67],"groups":[68,120,135,164,169,196],"were":[69,111],"differently,":[71],"by":[72],"varying":[73],"glutaraldehyde":[74],"(GA)":[75],"or":[76],"EDC":[77],"(1-ethyl-3-(3-dimethyl":[78],"aminopropyl)-carbodiimide)/N-hydroxysuccinamide":[79],"(NHS)":[80],"treatment":[81],"conditions.":[82],"Thereafter,":[83],"physical":[84,123,138],"examination,":[85],"tensile":[86,199],"strength":[87,200],"test,":[88,91,93,95,97,99,101,103,161],"thermal":[89,126,141,150],"stability":[90,127,142,151],"cytotoxicity":[92,203],"pronase":[94,157],"pronase-ninhydrin":[96,160],"purpald":[98],"permeability":[100],"compliance":[102,178],"H&E":[104],"staining,":[105],"DNA":[106],"quantification,":[107],"\u03b1-galactose":[109],"staining":[110],"carried":[112],"each":[115],"groups.":[116,131,155,175,191,207],"Result:":[117],"GA":[118,153,162,189,205,225],"showed":[121,136,148,170],"better":[122,137,149],"properties":[124,139],"than":[128,143,152,173,204],"EDC/NHS":[129,144,174],"EDC/NHS-GA":[132,166,183,193,213,232],"dual":[133,167,184,194,214,233],"groups,":[146,186],"test":[158],"stronger":[171,198],"crosslinks":[172,219],"Permeability":[176],"tended":[179],"increase":[181],"compared":[187],"But,":[192],"had":[197],"lower":[202,221,236],"Conclusion:":[208],"We":[209],"have":[210],"verified":[211],"that":[212],"can":[216,235],"make":[217],"toxicity":[223],"of":[224],"fixation.":[226],"Henceforth,":[227],"will":[229],"verify":[230],"if":[231],"calcifications":[237],"failure":[240],"vivo":[242],"experiment.":[243]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}