{"id":"https://openalex.org/W1524969005","doi":null,"title":"Mechanobiology of Stem Cells: Implications for Vascular Tissue Engineering","display_name":"Mechanobiology of Stem Cells: Implications for Vascular Tissue Engineering","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1524969005","mag":"1524969005"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9479","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9479/1/Maul_ETD_2007.pdf","pdf_url":"http://d-scholarship.pitt.edu/9479/1/Maul_ETD_2007.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/9479/1/Maul_ETD_2007.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076781763","display_name":"Timothy M. Maul","orcid":"https://orcid.org/0000-0003-2722-7523","observed_orcids":["https://orcid.org/0000-0003-2722-7523"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Timothy M. Maul","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2722-7523","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076781763"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0938,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.42789333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.33180001378059387,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanobiology","display_name":"mechanobiology","score":0.9169999957084656},{"id":"https://openalex.org/keywords/bone-marrow-derived-mesenchymal-stem-cells","display_name":"bone marrow-derived mesenchymal stem cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/vascular-tissue-engineering","display_name":"vascular tissue engineering","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cyclic-stretch","display_name":"cyclic strain","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cyclic-pressure","display_name":"cyclic pressure","score":0.9919999837875366},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.9950000047683716},{"id":"https://openalex.org/keywords/smooth-muscle-cell-differentiation","display_name":"smooth muscle differentiation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/endothelial-cell-differentiation","display_name":"endothelial differentiation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mechanical-stimulation","display_name":"mechanical stimulation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cellular-plasticity","display_name":"cellular plasticity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/alpha-actin","display_name":"alpha-actin","score":0.7269999980926514},{"id":"https://openalex.org/keywords/calponin","display_name":"calponin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/myosin-heavy-chain","display_name":"myosin heavy chain","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.49799999594688416},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.72381192445755},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6470160484313965},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.6262273192405701},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5873767137527466},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5534477829933167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5289815664291382},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.48086148500442505},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4192701280117035},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32283926010131836},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16760987043380737},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11967161297798157}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:9479","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9479/1/Maul_ETD_2007.pdf","pdf_url":"http://d-scholarship.pitt.edu/9479/1/Maul_ETD_2007.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:1524969005","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/9479/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9479","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9479/1/Maul_ETD_2007.pdf","pdf_url":"http://d-scholarship.pitt.edu/9479/1/Maul_ETD_2007.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1524969005.pdf","grobid_xml":"https://content.openalex.org/works/W1524969005.grobid-xml"},"referenced_works_count":665,"referenced_works":["https://openalex.org/W6561443","https://openalex.org/W36342825","https://openalex.org/W37545008","https://openalex.org/W62872458","https://openalex.org/W72464374","https://openalex.org/W89219456","https://openalex.org/W112845012","https://openalex.org/W153768115","https://openalex.org/W163741303","https://openalex.org/W179463710","https://openalex.org/W182527492","https://openalex.org/W184509831","https://openalex.org/W192738711","https://openalex.org/W195235204","https://openalex.org/W224172490","https://openalex.org/W263695075","https://openalex.org/W291015836","https://openalex.org/W341993295","https://openalex.org/W426067948","https://openalex.org/W587182826","https://openalex.org/W934277892","https://openalex.org/W1432640003","https://openalex.org/W1453493201","https://openalex.org/W1481127812","https://openalex.org/W1482652685","https://openalex.org/W1495677064","https://openalex.org/W1495712810","https://openalex.org/W1508246447","https://openalex.org/W1511388020","https://openalex.org/W1512987131","https://openalex.org/W1514012453","https://openalex.org/W1516075858","https://openalex.org/W1523556909","https://openalex.org/W1524114372","https://openalex.org/W1530383702","https://openalex.org/W1543752796","https://openalex.org/W1555330200","https://openalex.org/W1560566818","https://openalex.org/W1576487484","https://openalex.org/W1577577364","https://openalex.org/W1578564433","https://openalex.org/W1582207864","https://openalex.org/W1585792064","https://openalex.org/W1586474677","https://openalex.org/W1596170938","https://openalex.org/W1606473945","https://openalex.org/W1746540096","https://openalex.org/W1837633367","https://openalex.org/W1845564232","https://openalex.org/W1851722589","https://openalex.org/W1854803455","https://openalex.org/W1857298428","https://openalex.org/W1865553888","https://openalex.org/W1872922514","https://openalex.org/W1879535988","https://openalex.org/W1893070603","https://openalex.org/W1908983746","https://openalex.org/W1912592877","https://openalex.org/W1921428702","https://openalex.org/W1921434079","https://openalex.org/W1924909341","https://openalex.org/W1942611570","https://openalex.org/W1943962033","https://openalex.org/W1945199177","https://openalex.org/W1949173079","https://openalex.org/W1952078600","https://openalex.org/W1963528166","https://openalex.org/W1963643013","https://openalex.org/W1963711373","https://openalex.org/W1964513396","https://openalex.org/W1964570763","https://openalex.org/W1965123892","https://openalex.org/W1965178804","https://openalex.org/W1965415256","https://openalex.org/W1965588557","https://openalex.org/W1965772617","https://openalex.org/W1965953554","https://openalex.org/W1966908049","https://openalex.org/W1967082353","https://openalex.org/W1967365012","https://openalex.org/W1967460493","https://openalex.org/W1967679731","https://openalex.org/W1967846152","https://openalex.org/W1968021701","https://openalex.org/W1968051022","https://openalex.org/W1968442155","https://openalex.org/W1968642584","https://openalex.org/W1968830328","https://openalex.org/W1969084423","https://openalex.org/W1969250799","https://openalex.org/W1969336957","https://openalex.org/W1969361725","https://openalex.org/W1969812283","https://openalex.org/W1970007383","https://openalex.org/W1970214811","https://openalex.org/W1971105386","https://openalex.org/W1971222830","https://openalex.org/W1971845276","https://openalex.org/W1972320565","https://openalex.org/W1972324682","https://openalex.org/W1973483839","https://openalex.org/W1973696220","https://openalex.org/W1973838542","https://openalex.org/W1974203601","https://openalex.org/W1974463416","https://openalex.org/W1974956893","https://openalex.org/W1975216002","https://openalex.org/W1975250411","https://openalex.org/W1975256041","https://openalex.org/W1975522586","https://openalex.org/W1975651989","https://openalex.org/W1975792001","https://openalex.org/W1976275689","https://openalex.org/W1976491768","https://openalex.org/W1976536011","https://openalex.org/W1976805189","https://openalex.org/W1976938135","https://openalex.org/W1976943496","https://openalex.org/W1977950302","https://openalex.org/W1977980079","https://openalex.org/W1978485557","https://openalex.org/W1978996505","https://openalex.org/W1979356105","https://openalex.org/W1979935374","https://openalex.org/W1980127068","https://openalex.org/W1980165544","https://openalex.org/W1980767386","https://openalex.org/W1980864081","https://openalex.org/W1981157406","https://openalex.org/W1981727007","https://openalex.org/W1982035434","https://openalex.org/W1982912692","https://openalex.org/W1984197852","https://openalex.org/W1984812357","https://openalex.org/W1984877522","https://openalex.org/W1984946459","https://openalex.org/W1985125414","https://openalex.org/W1985712533","https://openalex.org/W1985850927","https://openalex.org/W1985867932","https://openalex.org/W1985905343","https://openalex.org/W1986052708","https://openalex.org/W1986143942","https://openalex.org/W1986276800","https://openalex.org/W1986382117","https://openalex.org/W1986620288","https://openalex.org/W1986912541","https://openalex.org/W1987913622","https://openalex.org/W1989016641","https://openalex.org/W1989053944","https://openalex.org/W1989485116","https://openalex.org/W1989704675","https://openalex.org/W1989813335","https://openalex.org/W1989995366","https://openalex.org/W1991050551","https://openalex.org/W1991237283","https://openalex.org/W1991300666","https://openalex.org/W1991353944","https://openalex.org/W1991384147","https://openalex.org/W1991937939","https://openalex.org/W1991965398","https://openalex.org/W1992676375","https://openalex.org/W1993212911","https://openalex.org/W1993415261","https://openalex.org/W1993487598","https://openalex.org/W1993925802","https://openalex.org/W1994481920","https://openalex.org/W1994488138","https://openalex.org/W1994776728","https://openalex.org/W1994810375","https://openalex.org/W1995039844","https://openalex.org/W1995527685","https://openalex.org/W1996565603","https://openalex.org/W1996735025","https://openalex.org/W1996803044","https://openalex.org/W1997507706","https://openalex.org/W1997689655","https://openalex.org/W1998008462","https://openalex.org/W1999083451","https://openalex.org/W1999091296","https://openalex.org/W1999340769","https://openalex.org/W2000292756","https://openalex.org/W2000509898","https://openalex.org/W2001132215","https://openalex.org/W2001561950","https://openalex.org/W2001671166","https://openalex.org/W2001881013","https://openalex.org/W2002204510","https://openalex.org/W2002292414","https://openalex.org/W2002324407","https://openalex.org/W2002903502","https://openalex.org/W2003218637","https://openalex.org/W2004095802","https://openalex.org/W2004181539","https://openalex.org/W2004186357","https://openalex.org/W2005152193","https://openalex.org/W2005165360","https://openalex.org/W2005381611","https://openalex.org/W2005962739","https://openalex.org/W2006758883","https://openalex.org/W2006986081","https://openalex.org/W2007516825","https://openalex.org/W2008018400","https://openalex.org/W2008191749","https://openalex.org/W2008498256","https://openalex.org/W2008632796","https://openalex.org/W2008691173","https://openalex.org/W2009197347","https://openalex.org/W2009251691","https://openalex.org/W2010614795","https://openalex.org/W2011160007","https://openalex.org/W2011285940","https://openalex.org/W2011403734","https://openalex.org/W2011628763","https://openalex.org/W2011913681","https://openalex.org/W2012390831","https://openalex.org/W2012821794","https://openalex.org/W2013012232","https://openalex.org/W2013164206","https://openalex.org/W2013970253","https://openalex.org/W2014096386","https://openalex.org/W2014171174","https://openalex.org/W2014890004","https://openalex.org/W2015192989","https://openalex.org/W2015219342","https://openalex.org/W2015230474","https://openalex.org/W2015344488","https://openalex.org/W2015353751","https://openalex.org/W2015875177","https://openalex.org/W2015989195","https://openalex.org/W2017556825","https://openalex.org/W2018379453","https://openalex.org/W2019101681","https://openalex.org/W2019222060","https://openalex.org/W2019724225","https://openalex.org/W2020095634","https://openalex.org/W2020108005","https://openalex.org/W2020250111","https://openalex.org/W2020331803","https://openalex.org/W2020913592","https://openalex.org/W2020966571","https://openalex.org/W2021126566","https://openalex.org/W2021202906","https://openalex.org/W2021218223","https://openalex.org/W2021270289","https://openalex.org/W2022963237","https://openalex.org/W2024131229","https://openalex.org/W2024317870","https://openalex.org/W2024450698","https://openalex.org/W2025412540","https://openalex.org/W2026130860","https://openalex.org/W2027135709","https://openalex.org/W2027736364","https://openalex.org/W2028018397","https://openalex.org/W2028436401","https://openalex.org/W2029018878","https://openalex.org/W2029020090","https://openalex.org/W2030194874","https://openalex.org/W2030662016","https://openalex.org/W2030876656","https://openalex.org/W2030955128","https://openalex.org/W2031014037","https://openalex.org/W2031131334","https://openalex.org/W2031480185","https://openalex.org/W2031499319","https://openalex.org/W2031585313","https://openalex.org/W2031856001","https://openalex.org/W2032481416","https://openalex.org/W2032610571","https://openalex.org/W2032812024","https://openalex.org/W2034091561","https://openalex.org/W2034351871","https://openalex.org/W2035582618","https://openalex.org/W2035704867","https://openalex.org/W2035790993","https://openalex.org/W2035819392","https://openalex.org/W2035970448","https://openalex.org/W2036393564","https://openalex.org/W2036452348","https://openalex.org/W2036924431","https://openalex.org/W2036925553","https://openalex.org/W2037051896","https://openalex.org/W2037084333","https://openalex.org/W2037150903","https://openalex.org/W2037360849","https://openalex.org/W2037904160","https://openalex.org/W2038936463","https://openalex.org/W2038963002","https://openalex.org/W2039229665","https://openalex.org/W2039787319","https://openalex.org/W2039971229","https://openalex.org/W2040074755","https://openalex.org/W2041708400","https://openalex.org/W2042066999","https://openalex.org/W2042954599","https://openalex.org/W2042991080","https://openalex.org/W2043134608","https://openalex.org/W2043238627","https://openalex.org/W2043320249","https://openalex.org/W2043438898","https://openalex.org/W2044173810","https://openalex.org/W2044323676","https://openalex.org/W2044725419","https://openalex.org/W2045285578","https://openalex.org/W2045360522","https://openalex.org/W2045497567","https://openalex.org/W2045784174","https://openalex.org/W2046327350","https://openalex.org/W2046516822","https://openalex.org/W2047431499","https://openalex.org/W2047530687","https://openalex.org/W2048058951","https://openalex.org/W2048258133","https://openalex.org/W2048919565","https://openalex.org/W2049493324","https://openalex.org/W2050054761","https://openalex.org/W2050093300","https://openalex.org/W2050154697","https://openalex.org/W2050725087","https://openalex.org/W2050982071","https://openalex.org/W2051292594","https://openalex.org/W2051308343","https://openalex.org/W2051487747","https://openalex.org/W2051669235","https://openalex.org/W2051864488","https://openalex.org/W2052364512","https://openalex.org/W2053121568","https://openalex.org/W2053704719","https://openalex.org/W2054045818","https://openalex.org/W2054061477","https://openalex.org/W2054114699","https://openalex.org/W2054117078","https://openalex.org/W2054271984","https://openalex.org/W2055004388","https://openalex.org/W2055188910","https://openalex.org/W2055299311","https://openalex.org/W2055365552","https://openalex.org/W2055583156","https://openalex.org/W2055755227","https://openalex.org/W2055919889","https://openalex.org/W2056045426","https://openalex.org/W2056242981","https://openalex.org/W2056384897","https://openalex.org/W2056466914","https://openalex.org/W2057046543","https://openalex.org/W2057307695","https://openalex.org/W2057447151","https://openalex.org/W2057464020","https://openalex.org/W2058187245","https://openalex.org/W2058504739","https://openalex.org/W2058528119","https://openalex.org/W2058799403","https://openalex.org/W2058868183","https://openalex.org/W2059105624","https://openalex.org/W2059360769","https://openalex.org/W2059484412","https://openalex.org/W2059634664","https://openalex.org/W2060043401","https://openalex.org/W2060952558","https://openalex.org/W2061142495","https://openalex.org/W2061892936","https://openalex.org/W2062237782","https://openalex.org/W2062457533","https://openalex.org/W2062594120","https://openalex.org/W2063207344","https://openalex.org/W2064090125","https://openalex.org/W2064150552","https://openalex.org/W2064323791","https://openalex.org/W2064810465","https://openalex.org/W2065427776","https://openalex.org/W2065901291","https://openalex.org/W2066198185","https://openalex.org/W2066274999","https://openalex.org/W2066402175","https://openalex.org/W2066875325","https://openalex.org/W2067561562","https://openalex.org/W2069370313","https://openalex.org/W2069568986","https://openalex.org/W2070323211","https://openalex.org/W2070727024","https://openalex.org/W2070781736","https://openalex.org/W2071404882","https://openalex.org/W2072212761","https://openalex.org/W2072386632","https://openalex.org/W2072674109","https://openalex.org/W2072737643","https://openalex.org/W2072752297","https://openalex.org/W2072941419","https://openalex.org/W2073705349","https://openalex.org/W2073903637","https://openalex.org/W2074054404","https://openalex.org/W2074499846","https://openalex.org/W2074629755","https://openalex.org/W2075181613","https://openalex.org/W2075359556","https://openalex.org/W2075416346","https://openalex.org/W2075520655","https://openalex.org/W2075547493","https://openalex.org/W2075618050","https://openalex.org/W2075889255","https://openalex.org/W2076009567","https://openalex.org/W2076033729","https://openalex.org/W2076546994","https://openalex.org/W2078023703","https://openalex.org/W2078179318","https://openalex.org/W2078212435","https://openalex.org/W2078702741","https://openalex.org/W2078789063","https://openalex.org/W2079117111","https://openalex.org/W2079386210","https://openalex.org/W2079405800","https://openalex.org/W2080431580","https://openalex.org/W2080667675","https://openalex.org/W2080731079","https://openalex.org/W2080798849","https://openalex.org/W2081791895","https://openalex.org/W2082005845","https://openalex.org/W2082092391","https://openalex.org/W2082494120","https://openalex.org/W2082549842","https://openalex.org/W2083428565","https://openalex.org/W2083494361","https://openalex.org/W2083585958","https://openalex.org/W2084084342","https://openalex.org/W2084286711","https://openalex.org/W2084293556","https://openalex.org/W2084567069","https://openalex.org/W2084687998","https://openalex.org/W2085234576","https://openalex.org/W2086069154","https://openalex.org/W2086145217","https://openalex.org/W2086555107","https://openalex.org/W2087863947","https://openalex.org/W2089439159","https://openalex.org/W2089833323","https://openalex.org/W2090073018","https://openalex.org/W2090875242","https://openalex.org/W2091464648","https://openalex.org/W2091526175","https://openalex.org/W2091630371","https://openalex.org/W2091784906","https://openalex.org/W2092177299","https://openalex.org/W2092268844","https://openalex.org/W2092815019","https://openalex.org/W2093630746","https://openalex.org/W2094199657","https://openalex.org/W2094670158","https://openalex.org/W2094890383","https://openalex.org/W2096280264","https://openalex.org/W2096384326","https://openalex.org/W2096448056","https://openalex.org/W2096628719","https://openalex.org/W2097146615","https://openalex.org/W2097405401","https://openalex.org/W2097425865","https://openalex.org/W2097792029","https://openalex.org/W2098364808","https://openalex.org/W2098444281","https://openalex.org/W2098573363","https://openalex.org/W2098630467","https://openalex.org/W2098728140","https://openalex.org/W2099543104","https://openalex.org/W2099583647","https://openalex.org/W2099890567","https://openalex.org/W2100124039","https://openalex.org/W2100281765","https://openalex.org/W2100932027","https://openalex.org/W2101154639","https://openalex.org/W2101290420","https://openalex.org/W2102105402","https://openalex.org/W2102878034","https://openalex.org/W2102968559","https://openalex.org/W2103031848","https://openalex.org/W2103386241","https://openalex.org/W2104225093","https://openalex.org/W2104898886","https://openalex.org/W2105534871","https://openalex.org/W2106122256","https://openalex.org/W2106441070","https://openalex.org/W2107277218","https://openalex.org/W2109623522","https://openalex.org/W2110121929","https://openalex.org/W2110372792","https://openalex.org/W2110610344","https://openalex.org/W2110743056","https://openalex.org/W2111128336","https://openalex.org/W2112541717","https://openalex.org/W2112647085","https://openalex.org/W2112951853","https://openalex.org/W2113357422","https://openalex.org/W2115078186","https://openalex.org/W2115390024","https://openalex.org/W2115393735","https://openalex.org/W2115444861","https://openalex.org/W2118199431","https://openalex.org/W2118651896","https://openalex.org/W2118814154","https://openalex.org/W2119472989","https://openalex.org/W2119882428","https://openalex.org/W2120188930","https://openalex.org/W2120909504","https://openalex.org/W2121556945","https://openalex.org/W2121700889","https://openalex.org/W2121822802","https://openalex.org/W2122238986","https://openalex.org/W2122318374","https://openalex.org/W2122611427","https://openalex.org/W2122818217","https://openalex.org/W2122892477","https://openalex.org/W2123994053","https://openalex.org/W2124056447","https://openalex.org/W2124450086","https://openalex.org/W2124897569","https://openalex.org/W2125155374","https://openalex.org/W2125764762","https://openalex.org/W2126725396","https://openalex.org/W2126804384","https://openalex.org/W2127588346","https://openalex.org/W2127963035","https://openalex.org/W2128150118","https://openalex.org/W2128462536","https://openalex.org/W2128502634","https://openalex.org/W2128539657","https://openalex.org/W2128781299","https://openalex.org/W2129479929","https://openalex.org/W2129926109","https://openalex.org/W2129963242","https://openalex.org/W2130086807","https://openalex.org/W2131388270","https://openalex.org/W2131655610","https://openalex.org/W2133006437","https://openalex.org/W2133184968","https://openalex.org/W2134812217","https://openalex.org/W2134941807","https://openalex.org/W2135036955","https://openalex.org/W2137186141","https://openalex.org/W2137281565","https://openalex.org/W2137685764","https://openalex.org/W2138146853","https://openalex.org/W2138582489","https://openalex.org/W2138860685","https://openalex.org/W2138900954","https://openalex.org/W2139274621","https://openalex.org/W2139524845","https://openalex.org/W2139716418","https://openalex.org/W2139961479","https://openalex.org/W2142943611","https://openalex.org/W2143631034","https://openalex.org/W2144268541","https://openalex.org/W2144712422","https://openalex.org/W2144756700","https://openalex.org/W2144789700","https://openalex.org/W2145345825","https://openalex.org/W2145884701","https://openalex.org/W2146478997","https://openalex.org/W2146534751","https://openalex.org/W2146635117","https://openalex.org/W2147176626","https://openalex.org/W2147276889","https://openalex.org/W2147976122","https://openalex.org/W2148346685","https://openalex.org/W2148371225","https://openalex.org/W2148636992","https://openalex.org/W2148711016","https://openalex.org/W2148802097","https://openalex.org/W2148841677","https://openalex.org/W2149854502","https://openalex.org/W2149907763","https://openalex.org/W2150258518","https://openalex.org/W2150472293","https://openalex.org/W2151045797","https://openalex.org/W2151165961","https://openalex.org/W2152198035","https://openalex.org/W2152542845","https://openalex.org/W2152717709","https://openalex.org/W2152924176","https://openalex.org/W2153608588","https://openalex.org/W2154383810","https://openalex.org/W2154514319","https://openalex.org/W2156051913","https://openalex.org/W2156286892","https://openalex.org/W2156606731","https://openalex.org/W2157145576","https://openalex.org/W2157439567","https://openalex.org/W2157757288","https://openalex.org/W2157862070","https://openalex.org/W2158048826","https://openalex.org/W2158201763","https://openalex.org/W2159265736","https://openalex.org/W2159809260","https://openalex.org/W2159999899","https://openalex.org/W2160301642","https://openalex.org/W2160424655","https://openalex.org/W2160501358","https://openalex.org/W2162011599","https://openalex.org/W2162031629","https://openalex.org/W2162184056","https://openalex.org/W2162238950","https://openalex.org/W2162507144","https://openalex.org/W2162669740","https://openalex.org/W2162927790","https://openalex.org/W2163139958","https://openalex.org/W2163220652","https://openalex.org/W2163424852","https://openalex.org/W2163504684","https://openalex.org/W2164228805","https://openalex.org/W2164726223","https://openalex.org/W2166171562","https://openalex.org/W2168736535","https://openalex.org/W2168856219","https://openalex.org/W2169199162","https://openalex.org/W2169234200","https://openalex.org/W2169334227","https://openalex.org/W2169608796","https://openalex.org/W2169873503","https://openalex.org/W2172233079","https://openalex.org/W2172253185","https://openalex.org/W2173497140","https://openalex.org/W2175263209","https://openalex.org/W2176300883","https://openalex.org/W2181276474","https://openalex.org/W2183737922","https://openalex.org/W2184679592","https://openalex.org/W2225425591","https://openalex.org/W2231149392","https://openalex.org/W2244445046","https://openalex.org/W2260668538","https://openalex.org/W2262423141","https://openalex.org/W2267056057","https://openalex.org/W2284274452","https://openalex.org/W2285309728","https://openalex.org/W2307290500","https://openalex.org/W2313374973","https://openalex.org/W2315503839","https://openalex.org/W2321439462","https://openalex.org/W2326189631","https://openalex.org/W2329426994","https://openalex.org/W2338923297","https://openalex.org/W2340662762","https://openalex.org/W2346196421","https://openalex.org/W2397107898","https://openalex.org/W2399805922","https://openalex.org/W2404277287","https://openalex.org/W2409656149","https://openalex.org/W2410864420","https://openalex.org/W2410877085","https://openalex.org/W2413662286","https://openalex.org/W2415149934","https://openalex.org/W2416053928","https://openalex.org/W2417003994","https://openalex.org/W2417504343","https://openalex.org/W2417840485","https://openalex.org/W2418307193","https://openalex.org/W2418810100","https://openalex.org/W2419537006","https://openalex.org/W2427380975","https://openalex.org/W2470568359","https://openalex.org/W2484779185","https://openalex.org/W2506095365","https://openalex.org/W2615043561","https://openalex.org/W2801747336","https://openalex.org/W3149209040","https://openalex.org/W4231980237","https://openalex.org/W4255951408","https://openalex.org/W4292330637"],"related_works":["https://openalex.org/W2040788343","https://openalex.org/W2126563871","https://openalex.org/W2013164206","https://openalex.org/W1877596152","https://openalex.org/W2759970371","https://openalex.org/W3175116762","https://openalex.org/W85762671","https://openalex.org/W2284274452","https://openalex.org/W2277755700","https://openalex.org/W2283318613"],"abstract_inverted_index":{"Current":[0],"challenges":[1],"in":[2,90,156,164,182,323,342],"vascular":[3,16,37],"medicine":[4,39],"(e.g.,":[5],"bypass":[6],"grafting,":[7],"stenting,":[8],"and":[9,66,71,124,138,151,167,169,185,223,225,241,255,263,273,315,339],"angioplasty.)":[10],"have":[11,55,73],"driven":[12],"the":[13,75,78,116,176,191,194,229,258,336],"field":[14],"of":[15,77,81,97,140,146,160,179,193,196,257],"regenerative":[17,38,365],"medicine.":[18,366],"Bone":[19],"marrow-derived":[20],"mesenchymal":[21],"stem":[22,27],"cells":[23,28,64,68],"(BMMSCs)":[24],"are":[25,285],"adult":[26],"which":[29,144,250],"may":[30],"be":[31,349,359],"a":[32,93,141,183,294,362],"suitable":[33],"cell":[34,208],"source":[35],"for":[36,58,235,247,364],"applications.":[40],"While":[41,290],"it":[42],"is":[43,101,110,308,316],"well":[44,203],"known":[45],"that":[46,106,111,215,270,304,332],"BMMSCs":[47,131,343],"readily":[48,310],"differentiate":[49],"into":[50,61,334],"musculoskeletal":[51],"cells,":[52],"recent":[53],"studies":[54],"provided":[56],"evidence":[57],"their":[59],"differentiation":[60,87,121,201],"smooth":[62],"muscle":[63],"(SMCs)":[65],"endothelial":[67,279],"(ECs).":[69],"We":[70],"others":[72],"demonstrated":[74],"ability":[76],"mechanical":[79,112,211,216,313,346,356],"stimulus":[80,181],"cyclic":[82,147,149,248,271],"stretch":[83],"to":[84,115,134,158,174,199,277,287,297,351],"drive":[85],"BMMSC":[86,120,200,220],"towards":[88,122,228],"SMCs":[89,123],"vitro,":[91],"but":[92],"rigorous,":[94],"systematic":[95],"analysis":[96],"other":[98,236],"relevant":[99,114,136],"forces":[100],"lacking.":[102],"The":[103],"working":[104],"hypothesis":[105],"this":[107,128],"work":[108,327],"addressed":[109],"stimuli":[113,284,347],"vasculature":[117],"will":[118,348],"guide":[119],"ECs.":[125],"To":[126],"test":[127],"hypothesis,":[129,300],"rat":[130],"were":[132,172],"exposed":[133],"physiologically":[135],"magnitudes":[137],"frequencies":[139],"Mechanical":[142],"Panel,":[143],"consisted":[145],"stretch,":[148,249],"pressure,":[150],"shear":[152,274],"stress,":[153],"each":[154,180],"applied":[155,197,286],"parallel":[157],"subcultures":[159],"BMMSCs.":[161,289],"Quantitative":[162],"changes":[163,322,341],"morphology,":[165,221],"proliferation,":[166,222],"gene":[168,224,280,324],"protein":[170,226,306],"expression":[171,227,234,256,281,307],"assessed":[173],"determine":[175],"differential":[177],"effect":[178],"dose-":[184],"frequency-dependant":[186],"manner.":[187],"Next,":[188],"we":[189,268],"investigated":[190],"importance":[192],"duration":[195],"stimulation":[198,217,357],"as":[202,204,293,361],"tissue":[205],"commitment":[206],"(i.e.,":[207],"plasticity)":[209],"following":[210],"stimulation.Our":[212],"results":[213],"demonstrate":[214],"differentially":[218],"altered":[219],"cardiovascular":[230],"lineage":[231],"while":[232],"limiting":[233],"lineages":[237],"including":[238],"bone,":[239],"fat,":[240],"chondrocyte.":[242],"This":[243],"was":[244],"particularly":[245],"evident":[246],"caused":[251],"an":[252],"elongated,":[253],"spindle-shape":[254],"SMC":[259,305],"proteins":[260],"alpha-actin,":[261],"calponin,":[262],"myosin":[264],"heavy":[265],"chain.":[266],"Furthermore,":[267],"found":[269],"pressure":[272],"stress":[275],"tended":[276,296],"increase":[278],"when":[282],"these":[283,345],"confluent":[288],"our":[291,299,301],"findings":[292],"whole":[295],"support":[298],"data":[302],"indicate":[303],"more":[309,352],"increased":[311],"by":[312],"stimulation,":[314],"highly":[317],"variable,":[318],"even":[319],"without":[320],"associated":[321],"expression.":[325],"Future":[326],"employing":[328],"systems":[329],"biology":[330],"approaches":[331],"take":[333],"consideration":[335],"resulting":[337],"transcriptional":[338],"proteomic":[340],"from":[344],"necessary":[350],"accurately":[353],"identify":[354],"how":[355],"can":[358],"used":[360],"tool":[363]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}