{"id":"https://openalex.org/W152397849","doi":"https://doi.org/10.1007/s11745-004-1291-6","title":"A mutation in sphingolipid synthesis suppresses defects in yeast ergosterol metabolism","display_name":"A mutation in sphingolipid synthesis suppresses defects in yeast ergosterol metabolism","publication_year":2004,"publication_date":"2004-08-01","ids":{"openalex":"https://openalex.org/W152397849","doi":"https://doi.org/10.1007/s11745-004-1291-6","mag":"152397849","pmid":"https://pubmed.ncbi.nlm.nih.gov/15638242"},"language":"en","primary_location":{"id":"doi:10.1007/s11745-004-1291-6","doi":"https://doi.org/10.1007/s11745-004-1291-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11745-004-1291-6","pdf_url":null,"source":{"id":"https://openalex.org/S115623499","display_name":"Lipids","issn_l":"0024-4201","issn":["0024-4201","1558-9307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068401396","display_name":"Martin Valachovi\u010d","orcid":"https://orcid.org/0000-0001-7096-9325","observed_orcids":["https://orcid.org/0000-0001-7096-9325"]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Valachovic","raw_affiliation_strings":["Biology Department, Indiana University-Purdue University Indianapolis, 723 W. Michigan St., Indianapolis, Indiana, 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Indiana University-Purdue University Indianapolis, 723 W. Michigan St., Indianapolis, Indiana, 46202","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067932540","display_name":"Lisa J. Wilcox","orcid":"https://orcid.org/0009-0001-2642-4827","observed_orcids":["https://orcid.org/0009-0001-2642-4827"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa J. Wilcox","raw_affiliation_strings":["Institute of Human Nutrition, Columbia University Medical Center, New York, New York, 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Nutrition, Columbia University Medical Center, New York, New York, 10032","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023841024","display_name":"Stephen L. Sturley","orcid":"https://orcid.org/0000-0001-6805-3270","observed_orcids":["https://orcid.org/0000-0001-6805-3270"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen L. Sturley","raw_affiliation_strings":["Department of Pediatrics, Columbia University Medical Center, New York, New York, 10032","Institute of Human Nutrition, Columbia University Medical Center, New York, New York, 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Columbia University Medical Center, New York, New York, 10032","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Institute of Human Nutrition, Columbia University Medical Center, New York, New York, 10032","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027241044","display_name":"Martin Bard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martin Bard","raw_affiliation_strings":["Biology Department, Indiana University-Purdue University Indianapolis, 723 W. Michigan St., Indianapolis, Indiana, 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Indiana University-Purdue University Indianapolis, 723 W. Michigan St., Indianapolis, Indiana, 46202","institution_ids":["https://openalex.org/I55769427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027241044"],"corresponding_institution_ids":["https://openalex.org/I55769427"],"apc_list":{"value":3589,"currency":"USD","value_usd":3589},"apc_paid":null,"fwci":0.5918,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.60741286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"39","issue":"8","first_page":"747","last_page":"752"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.7231000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.7231000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.1639000028371811,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.08340000361204147,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingolipid-biosynthesis","display_name":"sphingolipid biosynthesis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/erg2","display_name":"ERG2","score":0.7739999890327454},{"id":"https://openalex.org/keywords/upc2","display_name":"UPC2","score":0.8939999938011169},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7120000123977661},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.8740000128746033},{"id":"https://openalex.org/keywords/suppressor-screen","display_name":"suppressor screen","score":0.6710000038146973},{"id":"https://openalex.org/keywords/sterol-biosynthesis","display_name":"sterol biosynthesis","score":0.6019999980926514},{"id":"https://openalex.org/keywords/long-chain-fatty-acid-synthesis","display_name":"long-chain fatty acid synthesis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/yeast","display_name":"yeast","score":0.5019999742507935},{"id":"https://openalex.org/keywords/sterol-composition","display_name":"sterol composition","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.8408412933349609},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7874695062637329},{"id":"https://openalex.org/C2777910421","wikidata":"https://www.wikidata.org/wiki/Q143263","display_name":"Ergosterol","level":2,"score":0.7563767433166504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5985078811645508},{"id":"https://openalex.org/C85051948","wikidata":"https://www.wikidata.org/wiki/Q416064","display_name":"Sterol regulatory element-binding protein","level":4,"score":0.5425546765327454},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5145806670188904},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49216240644454956},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.47072258591651917},{"id":"https://openalex.org/C26567756","wikidata":"https://www.wikidata.org/wiki/Q2146845","display_name":"Suppressor mutation","level":4,"score":0.46341413259506226},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.46264398097991943},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4525163173675537},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43275177478790283},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4281836748123169},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35791507363319397},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35169586539268494},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33569636940956116},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004875","descriptor_name":"Ergosterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004875","descriptor_name":"Ergosterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013489","descriptor_name":"Suppression, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11745-004-1291-6","doi":"https://doi.org/10.1007/s11745-004-1291-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11745-004-1291-6","pdf_url":null,"source":{"id":"https://openalex.org/S115623499","display_name":"Lipids","issn_l":"0024-4201","issn":["0024-4201","1558-9307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids","raw_type":"journal-article"},{"id":"pmid:15638242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15638242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipids","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G218403217","display_name":"The Yeast Ergosterol Pathway","funder_award_id":"R01GM062104","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G266799824","display_name":null,"funder_award_id":"GM 62104","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W53557829","https://openalex.org/W1601258312","https://openalex.org/W1993357003","https://openalex.org/W2002672521","https://openalex.org/W2019497539","https://openalex.org/W2028015487","https://openalex.org/W2072274588","https://openalex.org/W2080408951","https://openalex.org/W2091602891","https://openalex.org/W2112866008","https://openalex.org/W2120328280","https://openalex.org/W2154666531","https://openalex.org/W2159316863","https://openalex.org/W2159654630","https://openalex.org/W2160849328"],"related_works":["https://openalex.org/W2035700705","https://openalex.org/W2154666531","https://openalex.org/W2120328280","https://openalex.org/W1981820708","https://openalex.org/W1985137291","https://openalex.org/W2129944356","https://openalex.org/W2059550531","https://openalex.org/W1989450689","https://openalex.org/W2355071727","https://openalex.org/W2028649651"],"abstract_inverted_index":{"A":[0],"mutation":[1,54],"in":[2,15,55,94],"an":[3,60,91],"otherwise":[4],"nonessential":[5],"ERG2":[6],"gene":[7],"is":[8],"synthetically":[9],"lethal":[10],"when":[11,84],"combined":[12],"with":[13],"mutations":[14],"two":[16,158],"transcription":[17,149],"factors":[18],"encoded":[19],"by":[20,144],"the":[21,34,44,50,56,67,73,110,119,129,137,141,145],"UPC2":[22],"and":[23,147,162],"ECM22":[24],"genes.":[25],"Employing":[26],"UV":[27],"mutagenesis,":[28],"we":[29,78],"isolated":[30],"a":[31,53,103,154],"suppressor":[32,45,51],"of":[33,43,105,112,128,136,140],"triple":[35,123],"mutant":[36,133],"erg2delta":[37,120],"upc2delta":[38,121,130],"ecm22delta.":[39],"The":[40,125],"morpholine-resistant":[41],"phenotype":[42],"was":[46,86],"used":[47],"to":[48,72],"identify":[49],"as":[52],"ELO3":[57,74,85,89],"gene.":[58],"In":[59],"expression":[61],"study":[62,152],"on":[63],"tridemorph-containing":[64],"medium,":[65],"using":[66],"inducible":[68],"GAL1":[69],"promoter":[70],"fused":[71],"open":[75],"reading":[76],"frame,":[77],"demonstrated":[79],"that":[80],"suppression":[81],"occurred":[82],"only":[83],"not":[87,117],"expressed.":[88],"encodes":[90],"enzyme":[92],"involved":[93],"sphingolipid":[95],"synthesis":[96,111,143],"required":[97,108],"for":[98,109],"long-chain":[99,114],"FA":[100],"synthesis.":[101],"Surprisingly,":[102],"deletion":[104],"ELO2,":[106],"also":[107],"sphingolipid-containing":[113],"FA,":[115],"did":[116],"suppress":[118],"ecm22delta":[122,131],"mutant.":[124],"sterol":[126],"composition":[127],"double":[132],"reflected":[134],"regulation":[135],"latter":[138],"part":[139],"ergosterol":[142],"Upc2p":[146],"Ecm22p":[148],"factors.":[150],"This":[151],"demonstrates":[153],"synergistic":[155],"relationship":[156],"between":[157],"lipid":[159],"species,":[160],"sterols":[161],"sphingolipids.":[163]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
