{"id":"https://openalex.org/W1523970566","doi":"https://doi.org/10.35790/ebm.3.1.2015.7504","title":"GAMBARAN HISTOPATOLOGIK PAYUDARA MENCIT (Mus musculus) YANG DIINDUKSI BENZO(\u03b1)PYRENE DAN DIBERIKAN EKSTRAK KUNYIT (Curcuma longa L.)","display_name":"GAMBARAN HISTOPATOLOGIK PAYUDARA MENCIT (Mus musculus) YANG DIINDUKSI BENZO(\u03b1)PYRENE DAN DIBERIKAN EKSTRAK KUNYIT (Curcuma longa L.)","publication_year":2015,"publication_date":"2015-02-07","ids":{"openalex":"https://openalex.org/W1523970566","doi":"https://doi.org/10.35790/ebm.3.1.2015.7504","mag":"1523970566"},"language":"en","primary_location":{"id":"doi:10.35790/ebm.3.1.2015.7504","doi":"https://doi.org/10.35790/ebm.3.1.2015.7504","is_oa":true,"landing_page_url":"https://doi.org/10.35790/ebm.3.1.2015.7504","pdf_url":null,"source":{"id":"https://openalex.org/S4210227840","display_name":"Jurnal e-Biomedik","issn_l":"2337-330X","issn":["2337-330X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal e-Biomedik","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.35790/ebm.3.1.2015.7504","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085342985","display_name":"Eka M. Nansi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55214057","display_name":"Sam Ratulangi University","ror":"https://ror.org/01cn6ph21","country_code":"ID","type":"education","lineage":["https://openalex.org/I55214057"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Eka M. Nansi","raw_affiliation_strings":["Bagian Patologi Anatomi Fakultas Kedokteran Universitas Sam Ratulangi","Kandidat Skripsi Fakultas Kedokteran Universitas Sam Ratulangi Manado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bagian Patologi Anatomi Fakultas Kedokteran Universitas Sam Ratulangi","institution_ids":["https://openalex.org/I55214057"]},{"raw_affiliation_string":"Kandidat Skripsi Fakultas Kedokteran Universitas Sam Ratulangi Manado","institution_ids":["https://openalex.org/I55214057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042019677","display_name":"Meilany Feronika Durry","orcid":"https://orcid.org/0000-0003-3672-9162","observed_orcids":["https://orcid.org/0000-0003-3672-9162"]},"institutions":[{"id":"https://openalex.org/I55214057","display_name":"Sam Ratulangi University","ror":"https://ror.org/01cn6ph21","country_code":"ID","type":"education","lineage":["https://openalex.org/I55214057"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Meilany F. Durry","raw_affiliation_strings":["Bagian Patologi Anatomi Fakultas Kedokteran Universitas Sam Ratulangi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bagian Patologi Anatomi Fakultas Kedokteran Universitas Sam Ratulangi","institution_ids":["https://openalex.org/I55214057"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000223381","display_name":"Carla F. Kairupan","orcid":"https://orcid.org/0000-0002-6835-3908","observed_orcids":["https://orcid.org/0000-0002-6835-3908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carla Kairupan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"3","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-histopathology","display_name":"breast histopathology","score":0.6669999957084656},{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.921999990940094},{"id":"https://openalex.org/keywords/turmeric-extract","display_name":"turmeric extract","score":0.8429999947547913},{"id":"https://openalex.org/keywords/turmeric","display_name":"turmeric","score":0.9660000205039978},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.9049999713897705},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5699999928474426},{"id":"https://openalex.org/keywords/mammary-hyperplasia","display_name":"mammary gland hyperplasia","score":0.7639999985694885},{"id":"https://openalex.org/keywords/histopathological-changes","display_name":"histopathological changes","score":0.4909999966621399},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.722000002861023},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.5680000185966492},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.5910000205039978},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.7965885400772095},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.7562584280967712},{"id":"https://openalex.org/C2777230291","wikidata":"https://www.wikidata.org/wiki/Q33551","display_name":"Curcuma","level":2,"score":0.7169760465621948},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.7084342241287231},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6275445222854614},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.6134233474731445},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6069278120994568},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49091464281082153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3891350030899048},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3589054048061371},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3588641583919525},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3484004735946655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34072548151016235},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31048041582107544},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2700214982032776},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.24808081984519958},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.2410247027873993},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17203879356384277},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05829766392707825}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.35790/ebm.3.1.2015.7504","doi":"https://doi.org/10.35790/ebm.3.1.2015.7504","is_oa":true,"landing_page_url":"https://doi.org/10.35790/ebm.3.1.2015.7504","pdf_url":null,"source":{"id":"https://openalex.org/S4210227840","display_name":"Jurnal e-Biomedik","issn_l":"2337-330X","issn":["2337-330X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal e-Biomedik","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.35790/ebm.3.1.2015.7504","doi":"https://doi.org/10.35790/ebm.3.1.2015.7504","is_oa":true,"landing_page_url":"https://doi.org/10.35790/ebm.3.1.2015.7504","pdf_url":null,"source":{"id":"https://openalex.org/S4210227840","display_name":"Jurnal e-Biomedik","issn_l":"2337-330X","issn":["2337-330X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal e-Biomedik","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W207601583","https://openalex.org/W588803361","https://openalex.org/W2906146886","https://openalex.org/W2948420913"],"related_works":["https://openalex.org/W1515215186","https://openalex.org/W1523532873","https://openalex.org/W7062086941","https://openalex.org/W7099986767","https://openalex.org/W2135451101","https://openalex.org/W2343643031","https://openalex.org/W1971703827","https://openalex.org/W2098562843","https://openalex.org/W4205393269","https://openalex.org/W1967685864"],"abstract_inverted_index":{"Abstract:":[0],"Breast":[1],"cancer":[2,18,85],"(Carcinoma":[3,333],"mammae)":[4,334],"is":[5,19,49,75,80],"one":[6],"of":[7,16,33,96,111,119,122,226,237,274,290,293,304,312],"the":[8,31,58,109,116,120,162,173,184,194,198,242,262,280,291,313],"most":[9],"common":[10],"cancers":[11],"affecting":[12],"women.":[13],"The":[14,216,287],"etiology":[15],"breast":[17,34,121,227,292],"still":[20,260],"unknown,":[21],"however,":[22],"there":[23],"are":[24],"several":[25],"important":[26],"risk":[27],"factors":[28],"linked":[29],"to":[30,83,87,107,319],"occurence":[32],"cancer,":[35],"as":[36,47,247,249],"follows:":[37],"genetic,":[38],"hormonal,":[39],"and":[40,153,172,193,204,279],"environmental.":[41],"Polycyclic":[42],"aromatic":[43],"hydrocarbons":[44],"(PHA)":[45],"such":[46],"benzo(a)pyrene":[48,66,167,189,294,323],"a":[50,76,94],"carcinogenic":[51],"agent":[52],"that":[53,65,79,99,219,273],"can":[54,67],"be":[55],"found":[56],"in":[57,70,102,257],"surrounding":[59,241],"environment.":[60],"It":[61],"has":[62],"been":[63],"proven":[64],"induce":[68],"tumors":[69],"experimental":[71,130],"animal":[72],"models.":[73],"Turmeric":[74],"natural":[77],"biocompound":[78],"often":[81],"used":[82],"treat":[84],"due":[86],"its":[88],"curcumin":[89],"contents.":[90],"Curcumin":[91],"interacts":[92],"with":[93,125,166,188,213,251,298,308,322],"variety":[95],"genetic":[97],"molecules":[98],"undergo":[100],"mutation":[101],"cancer.":[103],"This":[104,127],"study":[105,131],"aimed":[106],"determine":[108],"effects":[110],"turmeric":[112,299,325],"extract":[113,200,300],"administration":[114],"on":[115,155,177,201,207],"hispathological":[117],"features":[118,225,289],"mice":[123,135,174,195,256,296],"induced":[124,165,187,295],"benzo(a)pyrene.":[126],"was":[128,146],"an":[129],"using":[132],"15":[133,452],"female":[134],"weighing":[136],"20-30g":[137,450],"divided":[138],"into":[139],"3":[140,456],"groups.":[141],"Group":[142,158,180,220,229],"A":[143,221,459,528],"(negative":[144],"control)":[145],"given":[147,197],"standard":[148,465],"food":[149],"for":[150,169,190],"28":[151,467],"days":[152,171,192],"terminated":[154,176,206],"day":[156,178,202,208],"29.":[157,179,209],"B":[159,230,276,475,539,582],"(treatment":[160,182],"I),":[161,477],"breasts":[163,185],"were":[164,175,186,196,211,270],"subcutaneously":[168],"14":[170,191,485,502],"C":[181,259,494,566],"II),":[183,496],"tumeric":[199],"15-28":[203,512],"then":[205],"Tissues":[210],"stained":[212],"hematoxylin":[214],"eosin.":[215,522],"results":[217],"showed":[218,231,301],"had":[222],"normal":[223],"microscopic":[224],"tissues.":[228],"PMN":[232,263],"inflammatory":[233,264],"cells,":[234,265],"thickening":[235],"layer":[236],"cuboidal":[238,267,305],"epithelial":[239,268,306],"cells":[240,250,281,307,316],"lactiferous":[243,314],"ducts":[244],"(>4":[245,554],"layers)":[246,278],"well":[248],"coarse":[252],"nucleus":[253,284,310],"chromatin.":[254,285],"Although":[255],"group":[258,275],"presented":[261],"their":[266],"layers":[269,303],"thinner":[271],"than":[272],"(2-3":[277,583],"contained":[282],"rough":[283,309],"Conclusion:":[286],"histopathological":[288],"administered":[297],"fewer":[302],"chromatin":[311],"duct":[315],"wall":[317],"compared":[318],"those":[320],"treated":[321],"without":[324],"extract.Keywords:":[326],"benzo(a)pyrene,":[327,633],"turmeric,":[328],"hyperplasia,":[329],"breastAbstrak:":[330],"Kanker":[331],"payudara":[332,349,362,433,478,497,533,594,625],"dikenal":[335],"sebagai":[336],"salah":[337],"satu":[338],"kanker":[339,348,361,397],"yang":[340,357,374,404,411,435,444,535,550,561,577,589,596,622,627],"paling":[341],"sering":[342,398],"menyerang":[343],"kaum":[344],"wanita.":[345],"Penyebab":[346],"pasti":[347],"belum":[350],"diketahui,":[351],"namun":[352],"ada":[353],"beberapa":[354],"faktor":[355],"risiko":[356],"penting":[358],"dalam":[359,377,455],"terjadinya":[360],"yaitu":[363],"keturunan,":[364],"hormonal":[365],"dan":[366,469,487,504],"lingkungan.":[367],"Senyawa":[368],"hidrokarbon":[369],"poliaromatik":[370],"(HPA)":[371],"merupakan":[372,440],"karsinogen":[373],"dapat":[375,387,405],"ditemukan":[376],"lingkungan":[378],"sekitar,":[379],"contohnya":[380],"ialah":[381],"benzo(\u03b1)pyrene.":[382,437],"Telah":[383],"terbukti":[384],"bahwa":[385],"benzo(\u03b1)pyrene":[386,481,500],"menyebabkan":[388],"tumor":[389],"pada":[390,413,471,490,509,515,526,564,580,613,624],"setiap":[391],"model":[392],"hewan":[393],"percobaan.":[394],"Beberapa":[395],"pengobatan":[396],"melibatkan":[399],"kunyit":[400,429,508,602],"karena":[401],"kandungan":[402],"kurkuminnya":[403],"berinteraksi":[406],"dengan":[407,448,520,558,609,621],"berbagai":[408],"molekul":[409],"genetik":[410],"bermutasi":[412],"510Nansi,":[414],"Durry,":[415],"Kairupan:":[416],"Gambaran":[417,592],"histopatologik":[418,432,593],"payudara...sel":[419],"kanker.":[420],"Penelitian":[421,438],"ini":[422,439],"bertujuan":[423],"untuk":[424],"mengetahui":[425],"pengaruh":[426],"pemberian":[427],"ekstrak":[428,507,601,630],"terhadap":[430],"gambaran":[431,530],"mencit":[434,446,462,479,488,498,505,534,595,626],"diinduksi":[436,480,499,597],"penelitian":[441,524],"eksperimental":[442],"laboratorik":[443],"menggunakan":[445],"betina":[447],"berat":[449],"sebanyak":[451],"ekor,":[453],"dibagi":[454],"kelompok.":[457],"Kelompok":[458,474,493],"(kontrol":[460],"negatif),":[461],"diberi":[463,506],"pelet":[464],"selama":[466,484,501],"hari":[468,472,486,491,503,510,516],"diterminasi":[470,489,514],"ke-29.":[473,492,517],"(perlakuan":[476,495],"secara":[482],"subkutan":[483],"ke-":[511],"kemudian":[513,599],"Jaringan":[518],"diwarnai":[519],"hematoksilin":[521],"Hasil":[523],"menunjukkan":[525,568,603],"kelompok":[527,538,565,581],"didapatkan":[529,540],"mikroskopik":[531],"jaringan":[532],"normal.":[536],"Pada":[537],"adanya":[541,569],"sel-sel":[542,557,570],"radang":[543,571],"PMN,":[544,572],"penebalan":[545],"lapisan":[546,573,605],"sel":[547,574,588,606],"epitel":[548,575,607],"kuboid":[549,576,608],"mengelilingi":[551],"duktus":[552,615],"laktiferi":[553,616],"lapis)":[555,584],"serta":[556,585],"kromatin":[559,586,610],"inti":[560,587,611],"kasar,":[562],"sedangkan":[563],"masih":[567],"tidak":[578,628],"setebal":[579],"kasar.":[590],"Simpulan:":[591],"benzo(\ud835\udefc)pyrene":[598],"diberikan":[600,629],"jumlah":[604],"kasar":[612],"dinding":[614],"tampak":[617],"lebih":[618],"sedikit":[619],"dibandingkan":[620],"terlihat":[623],"kunyit.Kata":[631],"kunci:":[632],"kunyit,":[634],"hiperplasia,":[635],"payudara.":[636]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
