{"id":"https://openalex.org/W1523928530","doi":"https://doi.org/10.1111/j.1365-2958.2012.07998.x","title":"An interplay between Centrin2 and Centrin4 on the bi\u2010lobed structure in Trypanosoma brucei","display_name":"An interplay between Centrin2 and Centrin4 on the bi\u2010lobed structure in Trypanosoma brucei","publication_year":2012,"publication_date":"2012-02-13","ids":{"openalex":"https://openalex.org/W1523928530","doi":"https://doi.org/10.1111/j.1365-2958.2012.07998.x","mag":"1523928530","pmid":"https://pubmed.ncbi.nlm.nih.gov/22324849"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2958.2012.07998.x","doi":"https://doi.org/10.1111/j.1365-2958.2012.07998.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2958.2012.07998.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2958.2012.07998.x","source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2958.2012.07998.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100340872","display_name":"Min Wang","orcid":"https://orcid.org/0000-0001-8816-3952","observed_orcids":["https://orcid.org/0000-0001-8816-3952"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Min Wang","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014132122","display_name":"Ladan Gheiratmand","orcid":"https://orcid.org/0000-0001-9475-3342","observed_orcids":["https://orcid.org/0000-0001-9475-3342"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ladan Gheiratmand","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082095695","display_name":"Cynthia Y. He","orcid":"https://orcid.org/0000-0001-5506-2661","observed_orcids":["https://orcid.org/0000-0001-5506-2661"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Cynthia Y. He","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082095695"],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":1.9284,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.83626893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"83","issue":"6","first_page":"1153","last_page":"1161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.061000000685453415,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-brucei","display_name":"Trypanosoma brucei","score":0.9359999895095825},{"id":"https://openalex.org/keywords/basal-bodies","display_name":"basal bodies","score":0.9039999842643738},{"id":"https://openalex.org/keywords/flagella","display_name":"flagella","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cell-division","display_name":"cell division","score":0.6520000100135803},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.7429999709129333},{"id":"https://openalex.org/keywords/calcium-binding-proteins","display_name":"calcium-binding proteins","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.6919999718666077},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9198247194290161},{"id":"https://openalex.org/C2779502636","wikidata":"https://www.wikidata.org/wiki/Q33244","display_name":"Trypanosoma brucei","level":3,"score":0.9059135317802429},{"id":"https://openalex.org/C115811362","wikidata":"https://www.wikidata.org/wiki/Q189998","display_name":"Flagellum","level":3,"score":0.827423095703125},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.6917416453361511},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6748239994049072},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.59796142578125},{"id":"https://openalex.org/C131151476","wikidata":"https://www.wikidata.org/wiki/Q809753","display_name":"Basal body","level":4,"score":0.5864953398704529},{"id":"https://openalex.org/C2779549974","wikidata":"https://www.wikidata.org/wiki/Q541987","display_name":"Trypanosoma","level":2,"score":0.46626242995262146},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.43799978494644165},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36997485160827637},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3639049232006073},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1650560200214386}],"mesh":[{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2958.2012.07998.x","doi":"https://doi.org/10.1111/j.1365-2958.2012.07998.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2958.2012.07998.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2958.2012.07998.x","source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},{"id":"pmid:22324849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22324849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/100071","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/100071","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2958.2012.07998.x","doi":"https://doi.org/10.1111/j.1365-2958.2012.07998.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2958.2012.07998.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2958.2012.07998.x","source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320709","display_name":"National Research Foundation Singapore","ror":"https://ror.org/03cpyc314"},{"id":"https://openalex.org/F4320335846","display_name":"Biomedical Research Council","ror":"https://ror.org/03xy0wx88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1523928530.pdf","grobid_xml":"https://content.openalex.org/works/W1523928530.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1982176828","https://openalex.org/W1986431188","https://openalex.org/W1994496764","https://openalex.org/W2005902064","https://openalex.org/W2011414653","https://openalex.org/W2013465778","https://openalex.org/W2023446808","https://openalex.org/W2052050987","https://openalex.org/W2059754953","https://openalex.org/W2060695219","https://openalex.org/W2064448884","https://openalex.org/W2094438335","https://openalex.org/W2099249575","https://openalex.org/W2103796418","https://openalex.org/W2112560211","https://openalex.org/W2113632542","https://openalex.org/W2116350092","https://openalex.org/W2117827903","https://openalex.org/W2118055121","https://openalex.org/W2133128874","https://openalex.org/W2142398823","https://openalex.org/W2148299252","https://openalex.org/W2150999583","https://openalex.org/W2168234700","https://openalex.org/W4238967661"],"related_works":["https://openalex.org/W2117827903","https://openalex.org/W2898954168","https://openalex.org/W7096292741","https://openalex.org/W2013465778","https://openalex.org/W2949057224","https://openalex.org/W2113632542","https://openalex.org/W2994825595","https://openalex.org/W2564600033","https://openalex.org/W2069285715","https://openalex.org/W2468256610"],"abstract_inverted_index":{"Centrins":[0],"are":[1],"conserved":[2,63],"calcium-binding":[3],"proteins":[4],"important":[5,38],"for":[6,39],"various":[7],"regulatory":[8],"functions.":[9],"In":[10],"procyclic":[11],"Trypanosoma":[12],"brucei,":[13],"TbCentrin2":[14,49,74,84,134],"and":[15,34,42,50,58],"TbCentrin4":[16,51,70,98,127],"have":[17],"distinct":[18],"effects":[19],"on":[20,135],"cell":[21,43,95,125],"division":[22],"but":[23],"both":[24,52],"localize":[25],"to":[26,54,89],"the":[27,32,55,62,77,94,107,124,131,136],"basal":[28,56],"bodies":[29,57],"that":[30,48],"seed":[31],"flagellum,":[33],"a":[35,115],"bi-lobed":[36,59,78,137],"structure":[37,60],"organelle":[40],"duplication":[41],"division.":[44],"Here":[45],"we":[46],"show":[47],"bind":[53],"through":[61],"C-terminal":[64],"domain.":[65],"Molecular":[66],"genetic":[67],"manipulation":[68],"of":[69,133],"levels":[71],"greatly":[72],"affects":[73],"association":[75],"with":[76],"structure.":[79,138],"Using":[80],"established":[81],"synchronization":[82],"methods,":[83],"expression":[85,128],"level":[86,99],"is":[87],"shown":[88],"be":[90],"relatively":[91],"constant":[92],"throughout":[93],"cycle":[96],"while":[97],"fluctuates,":[100],"decreasing":[101],"most":[102],"during":[103],"early":[104],"S-phase":[105],"when":[106],"bi-lobe":[108],"undergoes":[109],"duplication.":[110],"These":[111],"results":[112],"thus":[113],"suggest":[114],"co-ordinated":[116],"action":[117],"between":[118],"these":[119],"two":[120],"centrin":[121],"proteins,":[122],"where":[123],"cycle-dependent":[126],"could":[129],"regulate":[130],"abundance":[132]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}