{"id":"https://openalex.org/W15238672","doi":"https://doi.org/10.1007/978-3-0348-7432-8_42","title":"Effect of Japanese Herbal Medicine, Sho-Saiko-To-Go-Keishi-Kashakuyaku-To (TJ-960) on Aging","display_name":"Effect of Japanese Herbal Medicine, Sho-Saiko-To-Go-Keishi-Kashakuyaku-To (TJ-960) on Aging","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W15238672","doi":"https://doi.org/10.1007/978-3-0348-7432-8_42","mag":"15238672"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-0348-7432-8_42","doi":"https://doi.org/10.1007/978-3-0348-7432-8_42","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-0348-7432-8_42","pdf_url":null,"source":{"id":"https://openalex.org/S4306462920","display_name":"Birkh\u00e4user Basel eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2007927375","display_name":"Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111563519","display_name":"M. Hiramatsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Hiramatsu","raw_affiliation_strings":["Yamagata Technopolis Foundation, Yamagata, 990, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yamagata Technopolis Foundation, Yamagata, 990, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068750850","display_name":"Rei Edamatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"R. Edamatsu","raw_affiliation_strings":["Department of Neurochemistry, Institute for Neurobiology, Okayama University Medical School, Okayama, 700, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry, Institute for Neurobiology, Okayama University Medical School, Okayama, 700, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063490444","display_name":"Hideki Ohyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Ohyama","raw_affiliation_strings":["Department of Neurochemistry, Institute for Neurobiology, Okayama University Medical School, Okayama, 700, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry, Institute for Neurobiology, Okayama University Medical School, Okayama, 700, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075341990","display_name":"A. Mori","orcid":"https://orcid.org/0000-0003-3072-9241","observed_orcids":["https://orcid.org/0000-0003-3072-9241"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A. Mori","raw_affiliation_strings":["Department of Neurochemistry, Institute for Neurobiology, Okayama University Medical School, Okayama, 700, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry, Institute for Neurobiology, Okayama University Medical School, Okayama, 700, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.00486224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"535","last_page":"552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.5952000021934509,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.5952000021934509,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.07699999958276749,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.06689999997615814,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/japanese-herbal-medicine","display_name":"Japanese herbal medicine","score":0.9359999895095825},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9300000071525574},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.675000011920929},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.8709999918937683},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8259999752044678},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/thiobarbituric-acid-reactive-substances","display_name":"TBARS","score":0.9010000228881836},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.7919999957084656},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9300000071525574},{"id":"https://openalex.org/keywords/choline-acetyltransferase","display_name":"choline acetyltransferase","score":0.984000027179718},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.621999979019165},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.5754971504211426},{"id":"https://openalex.org/C2780222073","wikidata":"https://www.wikidata.org/wiki/Q649817","display_name":"Gerbil","level":3,"score":0.5534114837646484},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5015697479248047},{"id":"https://openalex.org/C2777504301","wikidata":"https://www.wikidata.org/wiki/Q418230","display_name":"Thiobarbituric acid","level":4,"score":0.48836442828178406},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.48626458644866943},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.48211121559143066},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4656672477722168},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4608554244041443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45413005352020264},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4236035645008087},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39708787202835083},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37863677740097046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3061683773994446},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.22357383370399475},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-0348-7432-8_42","doi":"https://doi.org/10.1007/978-3-0348-7432-8_42","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-0348-7432-8_42","pdf_url":null,"source":{"id":"https://openalex.org/S4306462920","display_name":"Birkh\u00e4user Basel eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W162147850","https://openalex.org/W186344272","https://openalex.org/W1684853394","https://openalex.org/W1965420525","https://openalex.org/W1971794055","https://openalex.org/W1979728517","https://openalex.org/W1982449770","https://openalex.org/W1991927506","https://openalex.org/W1992805656","https://openalex.org/W2001664582","https://openalex.org/W2016244372","https://openalex.org/W2027795892","https://openalex.org/W2031623169","https://openalex.org/W2032348825","https://openalex.org/W2032953905","https://openalex.org/W2037524236","https://openalex.org/W2040233653","https://openalex.org/W2045390584","https://openalex.org/W2048611589","https://openalex.org/W2053677725","https://openalex.org/W2061008498","https://openalex.org/W2063840239","https://openalex.org/W2077859295","https://openalex.org/W2095873344","https://openalex.org/W2170002980","https://openalex.org/W2171674972","https://openalex.org/W2317905881","https://openalex.org/W2765354461","https://openalex.org/W6614939632"],"related_works":["https://openalex.org/W124084636","https://openalex.org/W1979030027","https://openalex.org/W2479857229","https://openalex.org/W89016279","https://openalex.org/W2063840239","https://openalex.org/W7208319317","https://openalex.org/W2003186313","https://openalex.org/W2015909224","https://openalex.org/W2033532302","https://openalex.org/W2116625160"],"abstract_inverted_index":{"Japanese":[0],"herbal":[1,107],"medicine,":[2],"Sho-saiko-to-go-keishi-kashakuyaku-to":[3],"(TJ-960),":[4],"scavenged":[5],"hydroxyl":[6],"radicals,":[7],"superoxide":[8,68],"and":[9,27,34,45,77,85,91],"1,1-diphenyl-2-picrylhydrazyl":[10],"radicals.":[11],"It":[12,82],"also":[13],"diminished":[14],"carbon":[15,42],"centered":[16,43],"radicals":[17,30,44],"generated":[18],"by":[19],"oxygen":[20],"stress":[21],"in":[22,31,53,72,89,95,103],"the":[23,54],"rat":[24,32,56],"cortex":[25],"homogenate":[26],"quenched":[28],"alpha-tocopheroxyl":[29],"mitochondria":[33],"microsomes":[35],"of":[36,62,75,79,127],"vitamin":[37],"E":[38],"supplemented":[39],"rats.":[40,105],"The":[41],"thiobarbituric":[46],"acid":[47],"reactive":[48],"substances":[49],"(TBARS)":[50],"levels":[51,88],"decreased":[52,83],"aged":[55,80,104],"brain":[57],"after":[58],"3-week":[59],"oral":[60],"administration":[61],"5%":[63],"TJ-960":[64,66,97,116],"solution.":[65],"elevated":[67],"dismutase":[69],"(SOD)":[70],"activity":[71,102],"cytosol":[73],"fraction":[74],"hippocampus":[76],"hypothalamus":[78,90],"animals.":[81],"norepinephrine":[84],"5-hydroxytryptamine":[86],"(5-HT)":[87],"increased":[92,99],"5-HT":[93],"level":[94],"cerebellum.":[96],"treatment":[98],"choline":[100],"acetyltransferase":[101],"As":[106],"medicines":[108],"do":[109],"not":[110],"generally":[111],"have":[112],"harmful":[113],"side":[114],"effects,":[115],"appears":[117],"as":[118],"a":[119],"suitable":[120],"prophylactic":[121],"agent":[122],"against":[123],"some":[124],"neuronal":[125],"symptoms":[126],"aging.":[128]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}