{"id":"https://openalex.org/W1523706997","doi":null,"title":"Managing breast cancer in the older patient.","display_name":"Managing breast cancer in the older patient.","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W1523706997","mag":"1523706997","pmid":"https://pubmed.ncbi.nlm.nih.gov/24472802","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3906632"},"language":"en","primary_location":{"id":"pmid:24472802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24472802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical advances in hematology & oncology : H&O","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3906632","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031159195","display_name":"Tracey L. O\u2019Connor","orcid":"https://orcid.org/0000-0002-9549-7173","observed_orcids":["https://orcid.org/0000-0002-9549-7173"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracey O'Connor","raw_affiliation_strings":["Roswell Park Cancer Institute, Buffalo, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Cancer Institute, Buffalo, New York","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046103656","display_name":"Arvind Manohar Shinde","orcid":"https://orcid.org/0000-0003-1903-7332","observed_orcids":["https://orcid.org/0000-0003-1903-7332"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arvind Shinde","raw_affiliation_strings":["City of Hope, Duarte, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope, Duarte, California","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066946020","display_name":"Caroline Doan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Doan","raw_affiliation_strings":["City of Hope, Duarte, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope, Duarte, California","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087277907","display_name":"Vani Katheria","orcid":"https://orcid.org/0000-0001-5193-7299","observed_orcids":["https://orcid.org/0000-0001-5193-7299"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vani Katheria","raw_affiliation_strings":["City of Hope, Duarte, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope, Duarte, California","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041339246","display_name":"Arti Hurria","orcid":"https://orcid.org/0000-0001-7983-9615","observed_orcids":["https://orcid.org/0000-0001-7983-9615"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arti Hurria","raw_affiliation_strings":["City of Hope, Duarte, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope, Duarte, California","institution_ids":["https://openalex.org/I1301076528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2393,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.2236671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"11","issue":"6","first_page":"341","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.14820000529289246,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/older-women","display_name":"older women","score":0.921999990940094},{"id":"https://openalex.org/keywords/geriatric-oncology","display_name":"geriatric oncology","score":0.9589999914169312},{"id":"https://openalex.org/keywords/early-breast-cancer","display_name":"early breast cancer","score":0.9570000171661377},{"id":"https://openalex.org/keywords/treatment-decision-making","display_name":"treatment decision-making","score":0.8889999985694885},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.8690000176429749},{"id":"https://openalex.org/keywords/functional-status","display_name":"functional status","score":0.8579999804496765},{"id":"https://openalex.org/keywords/life-expectancy","display_name":"life expectancy","score":0.8999999761581421},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/risk-of-recurrence","display_name":"recurrence risk","score":0.6610000133514404},{"id":"https://openalex.org/keywords/patient-preferences","display_name":"patient preferences","score":0.7329999804496765},{"id":"https://openalex.org/keywords/evidence-based-treatment","display_name":"evidence-based treatment","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9455695152282715},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8308466672897339},{"id":"https://openalex.org/C133925201","wikidata":"https://www.wikidata.org/wiki/Q188419","display_name":"Life expectancy","level":3,"score":0.6390961408615112},{"id":"https://openalex.org/C2777319248","wikidata":"https://www.wikidata.org/wiki/Q5550843","display_name":"Geriatric oncology","level":3,"score":0.6188173294067383},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5461349487304688},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5239707827568054},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47945061326026917},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4792632758617401},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.45947426557540894},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.41250497102737427},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3259044885635376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2459999918937683},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006299","descriptor_name":"Health Services for the Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:24472802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24472802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical advances in hematology & oncology : H&O","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2890426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3906632","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3906632","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3906632/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Adv Hematol Oncol","raw_type":"Text"},{"id":"mag:1523706997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24472802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2890426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3906632","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1300612210","display_name":"Clinical and Biological Predictors of Chemotherapy Toxicity in Older Adults","funder_award_id":"R01AG037037","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W95552543","https://openalex.org/W572930562","https://openalex.org/W1539962883","https://openalex.org/W1542091095","https://openalex.org/W1604299870","https://openalex.org/W1805599263","https://openalex.org/W1961026612","https://openalex.org/W1969997959","https://openalex.org/W1982853521","https://openalex.org/W1991020867","https://openalex.org/W2000870730","https://openalex.org/W2008290411","https://openalex.org/W2013600972","https://openalex.org/W2016985265","https://openalex.org/W2017186744","https://openalex.org/W2019311984","https://openalex.org/W2023626365","https://openalex.org/W2028680600","https://openalex.org/W2031629413","https://openalex.org/W2038674170","https://openalex.org/W2039034858","https://openalex.org/W2052438254","https://openalex.org/W2052913193","https://openalex.org/W2065654897","https://openalex.org/W2088078003","https://openalex.org/W2088882392","https://openalex.org/W2089995111","https://openalex.org/W2093577980","https://openalex.org/W2093938512","https://openalex.org/W2096785769","https://openalex.org/W2101580858","https://openalex.org/W2102486244","https://openalex.org/W2107823290","https://openalex.org/W2107978467","https://openalex.org/W2110938744","https://openalex.org/W2115527491","https://openalex.org/W2120083524","https://openalex.org/W2122428334","https://openalex.org/W2122798303","https://openalex.org/W2124965894","https://openalex.org/W2129594345","https://openalex.org/W2134350728","https://openalex.org/W2138624842","https://openalex.org/W2141540896","https://openalex.org/W2144133819","https://openalex.org/W2149110691","https://openalex.org/W2153294383","https://openalex.org/W2156402672","https://openalex.org/W2158615473","https://openalex.org/W2161837929","https://openalex.org/W2167014559","https://openalex.org/W2169997573","https://openalex.org/W2172164484","https://openalex.org/W2321807901","https://openalex.org/W3021967651"],"related_works":["https://openalex.org/W2005679575","https://openalex.org/W2547801487","https://openalex.org/W2003242667","https://openalex.org/W2204680448","https://openalex.org/W4404216920","https://openalex.org/W2594803202","https://openalex.org/W2261502163","https://openalex.org/W1997552068","https://openalex.org/W4231099391","https://openalex.org/W2141751399"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,17,38,72,193],"is":[2,6,76,134],"a":[3,48,160,207],"disease":[4],"that":[5,35,122,137,205],"associated":[7],"with":[8,10,108,149],"aging,":[9],"almost":[11],"one-half":[12],"of":[13,50,80,102,132,145,171,190],"all":[14],"new":[15],"breast":[16,37,89,150,192],"cases":[18],"diagnosed":[19],"annually":[20],"in":[21,26,40,52,58,71,100,125,194],"the":[22,56,91,98,109,126,135,143,167,172,184,201],"United":[23],"States":[24],"occurring":[25],"women":[27,42,60],"ages":[28],"65":[29],"and":[30,54,169,178,197],"older.":[31],"Recent":[32],"data":[33,199],"suggest":[34],"although":[36],"outcomes":[39],"younger":[41],"have":[43,61,68],"shown":[44],"substantial":[45],"improvement":[46],"as":[47],"result":[49],"advances":[51],"treatment":[53,85,94,153],"screening,":[55],"benefits":[57,170],"older":[59,66,127,147,195],"been":[62,69],"less":[63],"pronounced.":[64],"Although":[65],"patients":[67],"underrepresented":[70],"clinical":[73],"trials,":[74],"there":[75],"an":[77,146],"emerging":[78],"body":[79],"literature":[81,204],"to":[82,176,211],"help":[83],"guide":[84,142],"decisions.":[86],"For":[87],"early-stage":[88,191],"cancer,":[90],"discussion":[92],"regarding":[93],"options":[95],"involves":[96],"balancing":[97],"reduction":[99],"risk":[101],"recurrence":[103],"gained":[104],"by":[105,117],"specific":[106],"therapies":[107],"potential":[110,174],"for":[111,187],"increased":[112],"treatment-related":[113],"toxicity,":[114],"potentially":[115],"exacerbated":[116],"physiological":[118],"decline":[119],"or":[120],"comorbidities":[121],"often":[123],"co-exist":[124],"population.":[128],"A":[129],"key":[130],"component":[131],"care":[133],"recognition":[136],"chronologic":[138],"age":[139],"alone":[140],"cannot":[141],"management":[144,189],"patient":[148,179],"cancer.":[151],"Rather,":[152],"decisions":[154],"must":[155],"also":[156],"take":[157],"into":[158],"account":[159],"patient's":[161],"functional":[162],"status,":[163],"estimated":[164],"life":[165],"expectancy,":[166],"risks":[168],"therapy,":[173],"barriers":[175],"treatment,":[177],"preference.":[180],"This":[181],"article":[182],"reviews":[183],"available":[185],"evidence":[186],"therapeutic":[188],"patients,":[196],"highlights":[198],"from":[200],"geriatric":[202],"oncology":[203],"provide":[206],"basis":[208],"on":[209],"which":[210],"facilitate":[212],"evidence-based":[213],"treatment.":[214]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
