{"id":"https://openalex.org/W1523282014","doi":"https://doi.org/10.1007/s10286-003-0087-5","title":"The \u03b12B adrenergic receptor deletion/insertion polymorphism in morbid obesity","display_name":"The \u03b12B adrenergic receptor deletion/insertion polymorphism in morbid obesity","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W1523282014","doi":"https://doi.org/10.1007/s10286-003-0087-5","mag":"1523282014","pmid":"https://pubmed.ncbi.nlm.nih.gov/12822042"},"language":"en","primary_location":{"id":"doi:10.1007/s10286-003-0087-5","doi":"https://doi.org/10.1007/s10286-003-0087-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10286-003-0087-5","pdf_url":null,"source":{"id":"https://openalex.org/S134483451","display_name":"Clinical Autonomic Research","issn_l":"0959-9851","issn":["0959-9851","1619-1560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Autonomic Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020492229","display_name":"Gerasimos P. Sykiotis","orcid":"https://orcid.org/0000-0002-9565-4941","observed_orcids":["https://orcid.org/0000-0002-9565-4941"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Gerasimos P. Sykiotis","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, University of Patras, 26110 Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, University of Patras, 26110 Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040742366","display_name":"Effie Polyzogopoulou","orcid":"https://orcid.org/0000-0001-7585-1203","observed_orcids":["https://orcid.org/0000-0001-7585-1203"]},"institutions":[{"id":"https://openalex.org/I2801754460","display_name":"General University Hospital of Patras","ror":"https://ror.org/03c3d1v10","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2801754460"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eftihia Polyzogopoulou","raw_affiliation_strings":["Dept. of Internal Medicine (EP), Divisions of Endocrinology, (NAG, AGV) & Pulmonology (GT, KS), Patras University Hospital, Patras, Greece, , GR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine (EP), Divisions of Endocrinology, (NAG, AGV) & Pulmonology (GT, KS), Patras University Hospital, Patras, Greece, , GR","institution_ids":["https://openalex.org/I2801754460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050988427","display_name":"Neoklis A. Georgopoulos","orcid":"https://orcid.org/0000-0002-3754-4082","observed_orcids":["https://orcid.org/0000-0002-3754-4082"]},"institutions":[{"id":"https://openalex.org/I2801754460","display_name":"General University Hospital of Patras","ror":"https://ror.org/03c3d1v10","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2801754460"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Neoklis A. Georgopoulos","raw_affiliation_strings":["Dept. of Internal Medicine (EP), Divisions of Endocrinology, (NAG, AGV) & Pulmonology (GT, KS), Patras University Hospital, Patras, Greece, , GR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine (EP), Divisions of Endocrinology, (NAG, AGV) & Pulmonology (GT, KS), Patras University Hospital, Patras, Greece, , GR","institution_ids":["https://openalex.org/I2801754460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017513274","display_name":"Georgia Trakada","orcid":"https://orcid.org/0000-0003-0037-1269","observed_orcids":["https://orcid.org/0000-0003-0037-1269"]},"institutions":[{"id":"https://openalex.org/I2801754460","display_name":"General University Hospital of Patras","ror":"https://ror.org/03c3d1v10","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2801754460"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgia Trakada","raw_affiliation_strings":["Dept. of Internal Medicine (EP), Divisions of Endocrinology, (NAG, AGV) & Pulmonology (GT, KS), Patras University Hospital, Patras, Greece, , GR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine (EP), Divisions of Endocrinology, (NAG, AGV) & Pulmonology (GT, KS), Patras University Hospital, Patras, Greece, , GR","institution_ids":["https://openalex.org/I2801754460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068182859","display_name":"Kostas Spyropoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801754460","display_name":"General University Hospital of Patras","ror":"https://ror.org/03c3d1v10","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2801754460"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Kostas Spyropoulos","raw_affiliation_strings":["Dept. of Internal Medicine (EP), Divisions of Endocrinology, (NAG, AGV) & Pulmonology (GT, KS), Patras University Hospital, Patras, Greece, , GR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine (EP), Divisions of Endocrinology, (NAG, AGV) & Pulmonology (GT, KS), Patras University Hospital, Patras, Greece, , GR","institution_ids":["https://openalex.org/I2801754460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113630730","display_name":"Fotios Kalfarentzos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801754460","display_name":"General University Hospital of Patras","ror":"https://ror.org/03c3d1v10","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2801754460"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Fotios Kalfarentzos","raw_affiliation_strings":["Nutrition Support & Morbid Obesity Clinic, Dept. of Surgery, Patras University Hospital, Patras, Greece, , GR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition Support & Morbid Obesity Clinic, Dept. of Surgery, Patras University Hospital, Patras, Greece, , GR","institution_ids":["https://openalex.org/I2801754460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077783091","display_name":"Athanasios G. Papavassiliou","orcid":"https://orcid.org/0000-0001-5803-4527","observed_orcids":["https://orcid.org/0000-0001-5803-4527"]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Athanasios G. Papavassiliou","raw_affiliation_strings":["Dept. of Biochemistry, Medical School, University of Patras, Patras, Greece, GR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biochemistry, Medical School, University of Patras, Patras, Greece, GR","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025190422","display_name":"Apostolos G. Vagenakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801754460","display_name":"General University Hospital of Patras","ror":"https://ror.org/03c3d1v10","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2801754460"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Apostolos G. Vagenakis","raw_affiliation_strings":["Dept. of Internal Medicine (EP), Divisions of Endocrinology, (NAG, AGV) & Pulmonology (GT, KS), Patras University Hospital, Patras, Greece, , GR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine (EP), Divisions of Endocrinology, (NAG, AGV) & Pulmonology (GT, KS), Patras University Hospital, Patras, Greece, , GR","institution_ids":["https://openalex.org/I2801754460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111688283","display_name":"Christodoulos S. Flordellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Christodoulos S. Flordellis","raw_affiliation_strings":["Dept. of Pharmacology, School of Medicine, University of Patras, 26110 Patras, Greece. flordell@med.upatras.gr, GR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology, School of Medicine, University of Patras, 26110 Patras, Greece. flordell@med.upatras.gr, GR","institution_ids":["https://openalex.org/I174878644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111688283"],"corresponding_institution_ids":["https://openalex.org/I174878644"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.7264,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.66616105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"13","issue":"3","first_page":"203","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7134000062942505,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7134000062942505,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.062300000339746475,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha2b-adrenergic-receptor","display_name":"alpha2B-adrenergic receptor","score":0.972000002861023},{"id":"https://openalex.org/keywords/insertion-deletion-polymorphism","display_name":"insertion/deletion polymorphism","score":0.847000002861023},{"id":"https://openalex.org/keywords/morbid-obesity","display_name":"morbid obesity","score":0.9729999899864197},{"id":"https://openalex.org/keywords/basal-metabolic-rate","display_name":"basal metabolic rate","score":0.9559999704360962},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9440000057220459},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.9070000052452087},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.8560000061988831},{"id":"https://openalex.org/keywords/genotype-association","display_name":"genotype association","score":0.5230000019073486},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6499999761581421},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.6209999918937683},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7933157086372375},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7739742994308472},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6386227011680603},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6094900965690613},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.602682888507843},{"id":"https://openalex.org/C82736064","wikidata":"https://www.wikidata.org/wiki/Q623293","display_name":"Basal metabolic rate","level":2,"score":0.5314795970916748},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5284941792488098},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.5194689631462097},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.47918617725372314},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4762832522392273},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.45173344016075134},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36344367265701294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2789510488510132},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14631342887878418},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001481","descriptor_name":"Basal Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009767","descriptor_name":"Obesity, Morbid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009767","descriptor_name":"Obesity, Morbid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012146","descriptor_name":"Rest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018341","descriptor_name":"Receptors, Adrenergic, alpha-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10286-003-0087-5","doi":"https://doi.org/10.1007/s10286-003-0087-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10286-003-0087-5","pdf_url":null,"source":{"id":"https://openalex.org/S134483451","display_name":"Clinical Autonomic Research","issn_l":"0959-9851","issn":["0959-9851","1619-1560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Autonomic Research","raw_type":"journal-article"},{"id":"pmid:12822042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12822042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W82809700","https://openalex.org/W1975624728","https://openalex.org/W1976375554","https://openalex.org/W1976964530","https://openalex.org/W1980956469","https://openalex.org/W1985908429","https://openalex.org/W2009115249","https://openalex.org/W2009717522","https://openalex.org/W2015425683","https://openalex.org/W2018452659","https://openalex.org/W2024870060","https://openalex.org/W2030765035","https://openalex.org/W2050614675","https://openalex.org/W2054010051","https://openalex.org/W2056487865","https://openalex.org/W2067415293","https://openalex.org/W2077168170","https://openalex.org/W2085771688","https://openalex.org/W2108313468","https://openalex.org/W2113674930","https://openalex.org/W2126327417","https://openalex.org/W2131716859","https://openalex.org/W2137213939","https://openalex.org/W2141599040","https://openalex.org/W2150110990","https://openalex.org/W2151448177","https://openalex.org/W2312451657","https://openalex.org/W2321598419","https://openalex.org/W2322463216","https://openalex.org/W2332468137","https://openalex.org/W2333875985","https://openalex.org/W4406065459"],"related_works":["https://openalex.org/W2015425683","https://openalex.org/W2058796097","https://openalex.org/W2105806188","https://openalex.org/W1991235407","https://openalex.org/W2319709303","https://openalex.org/W2312451657","https://openalex.org/W82809700","https://openalex.org/W2151448177","https://openalex.org/W2241612520","https://openalex.org/W7026618502"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}