{"id":"https://openalex.org/W1523044141","doi":"https://doi.org/10.4236/ojgen.2015.52005","title":"Synthetic Lethality Induced by Toxic Polyglutamine Tract II: A Survey in Drosophila","display_name":"Synthetic Lethality Induced by Toxic Polyglutamine Tract II: A Survey in Drosophila","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1523044141","doi":"https://doi.org/10.4236/ojgen.2015.52005","mag":"1523044141"},"language":"en","primary_location":{"id":"doi:10.4236/ojgen.2015.52005","doi":"https://doi.org/10.4236/ojgen.2015.52005","is_oa":true,"landing_page_url":"https://doi.org/10.4236/ojgen.2015.52005","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=57508","source":{"id":"https://openalex.org/S2765021627","display_name":"Open Journal of Genetics","issn_l":"2162-4453","issn":["2162-4453","2162-4461"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=57508","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111437406","display_name":"Ping Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ping Zhang","raw_affiliation_strings":["Department of Molecular and Cell Biology , University of Connecticut , Storrs , USA","University of Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology , University of Connecticut , Storrs , USA","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"University of Connecticut","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042516265","display_name":"Daniel F. Camacho","orcid":"https://orcid.org/0000-0002-1605-878X","observed_orcids":["https://orcid.org/0000-0002-1605-878X"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Camacho","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068908039","display_name":"Shashank Vodapally","orcid":"https://orcid.org/0000-0002-2672-5822","observed_orcids":["https://orcid.org/0000-0002-2672-5822"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shashank Vodapally","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073737527","display_name":"Shanado Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shanado Williams","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053156293","display_name":"Kavitha Kannan","orcid":"https://orcid.org/0000-0002-3727-1387","observed_orcids":["https://orcid.org/0000-0002-3727-1387","https://orcid.org/0009-0006-5257-4112"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kavitha Kannan","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA","institution_ids":["https://openalex.org/I140172145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111437406"],"corresponding_institution_ids":["https://openalex.org/I140172145"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02608916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"05","issue":"02","first_page":"58","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.9359999895095825},{"id":"https://openalex.org/keywords/polyglutamine-toxicity","display_name":"polyglutamine toxicity","score":0.6930000185966492},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7699999809265137},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7450000047683716},{"id":"https://openalex.org/keywords/modifier-genes","display_name":"genetic modifiers","score":0.4560000002384186},{"id":"https://openalex.org/keywords/eye-development","display_name":"eye development","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.7855203151702881},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.7757993936538696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7757408618927002},{"id":"https://openalex.org/C2777616661","wikidata":"https://www.wikidata.org/wiki/Q7226416","display_name":"Polyglutamine tract","level":5,"score":0.7286040782928467},{"id":"https://openalex.org/C20379349","wikidata":"https://www.wikidata.org/wiki/Q1720706","display_name":"Lethality","level":2,"score":0.6840230822563171},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6186515092849731},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5495268106460571},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5047577619552612},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.48616549372673035},{"id":"https://openalex.org/C136961756","wikidata":"https://www.wikidata.org/wiki/Q7431879","display_name":"Schneider 2 cells","level":5,"score":0.4704933166503906},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4500168561935425},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.4233802556991577},{"id":"https://openalex.org/C2781427258","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin","level":4,"score":0.22278088331222534},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.1887739598751068},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.11054688692092896}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4236/ojgen.2015.52005","doi":"https://doi.org/10.4236/ojgen.2015.52005","is_oa":true,"landing_page_url":"https://doi.org/10.4236/ojgen.2015.52005","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=57508","source":{"id":"https://openalex.org/S2765021627","display_name":"Open Journal of Genetics","issn_l":"2162-4453","issn":["2162-4453","2162-4461"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Genetics","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1024.1723","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1024.1723","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://file.scirp.org/pdf/OJGen_2015062914462272.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.4236/ojgen.2015.52005","doi":"https://doi.org/10.4236/ojgen.2015.52005","is_oa":true,"landing_page_url":"https://doi.org/10.4236/ojgen.2015.52005","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=57508","source":{"id":"https://openalex.org/S2765021627","display_name":"Open Journal of Genetics","issn_l":"2162-4453","issn":["2162-4453","2162-4461"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310017","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1523044141.pdf","grobid_xml":"https://content.openalex.org/works/W1523044141.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1008499258","https://openalex.org/W1533261981","https://openalex.org/W1617816798","https://openalex.org/W1971858157","https://openalex.org/W1975931018","https://openalex.org/W1986015652","https://openalex.org/W1986865371","https://openalex.org/W1988101585","https://openalex.org/W2009441114","https://openalex.org/W2011045269","https://openalex.org/W2011242261","https://openalex.org/W2013444252","https://openalex.org/W2014279843","https://openalex.org/W2025687167","https://openalex.org/W2029440153","https://openalex.org/W2033325995","https://openalex.org/W2037449788","https://openalex.org/W2043980852","https://openalex.org/W2062682951","https://openalex.org/W2069048146","https://openalex.org/W2072081532","https://openalex.org/W2074052524","https://openalex.org/W2076334629","https://openalex.org/W2086689509","https://openalex.org/W2091681614","https://openalex.org/W2093479824","https://openalex.org/W2097704427","https://openalex.org/W2098013039","https://openalex.org/W2102671926","https://openalex.org/W2108570063","https://openalex.org/W2111531780","https://openalex.org/W2111700402","https://openalex.org/W2112780379","https://openalex.org/W2124320739","https://openalex.org/W2127647363","https://openalex.org/W2130196517","https://openalex.org/W2135124405","https://openalex.org/W2145170335","https://openalex.org/W2146826338","https://openalex.org/W2148621565","https://openalex.org/W2153561150","https://openalex.org/W2154492443","https://openalex.org/W2159460045","https://openalex.org/W2161597083","https://openalex.org/W2169397639","https://openalex.org/W2188284059"],"related_works":["https://openalex.org/W2014279843","https://openalex.org/W115970423","https://openalex.org/W2999807059","https://openalex.org/W2146826338","https://openalex.org/W2496149561","https://openalex.org/W2166443571","https://openalex.org/W2936353551","https://openalex.org/W2104218495","https://openalex.org/W7051930743","https://openalex.org/W2011045269"],"abstract_inverted_index":{"Mutant":[0],"proteins":[1,16,255],"containing":[2],"an":[3,90,121,164],"expanded":[4,91,122,165],"polyglutamine":[5,92,123,166],"tract":[6,93,124,167],"induce":[7],"cell":[8,160],"death":[9],"and":[10,31,89,132,173,179,256],"cause":[11],"neurodegenerative":[12],"diseases.":[13],"These":[14],"toxic":[15,170,254],"interfere":[17],"with":[18,76,119],"a":[19,97,184,217],"variety":[20],"of":[21,67,71,155],"physiological":[22,258],"pathways,":[23],"but":[24],"the":[25,29,38,42,54,58,65,77,85,136,146,156,176,180,191,226,241,245,249,253,257],"key":[26],"interactions":[27,247],"between":[28,252],"toxins":[30],"cellular":[32],"factors":[33],"remain":[34],"unclear.":[35],"To":[36],"model":[37],"diseases":[39],"in":[40,53,64,183,221,248],"Drosophila,":[41],"GMR-Gal4/UAS":[43,95],"gene":[44,88,147],"expression":[45,148,153,178],"system":[46,149],"has":[47],"been":[48],"used":[49,220],"extensively,":[50],"which":[51],"operates":[52],"eyes.":[55],"By":[56],"using":[57],"system,":[59],"genome-wide":[60],"studies":[61],"have":[62,134],"resulted":[63],"isolation":[66],"functionally":[68],"diverse":[69],"groups":[70],"Drosophila":[72,86],"genes":[73],"that":[74,83,115,144],"interact":[75],"disease":[78,192,250],"proteins.":[79],"We":[80,100],"previously":[81],"reported":[82],"coexpressing":[84],"Dikar":[87],"by":[94],"induced":[96],"synthetic":[98,108,116,200,203,229],"lethality.":[99,201],"carried":[101],"out":[102],"follow-up":[103],"experiments":[104],"to":[105,130,171,190,199,224,243],"isolate":[106,225],"additional":[107],"lethal":[109,204],"alleles.":[110],"Our":[111,140],"data":[112],"provide":[113],"evidence":[114],"lethality":[117,230],"associated":[118],"expressing":[120,163],"is":[125,150,168],"more":[126],"common":[127],"than":[128],"thought":[129],"be":[131],"could":[133,196],"escaped":[135],"conventional":[137,210],"genetic":[138,188,233],"screens.":[139],"results":[141,182],"also":[142],"suggest":[143],"1)":[145],"leaky,":[151],"allowing":[152],"outside":[154],"primary":[157],"target":[158],"eye":[159],"types;":[161],"2)":[162],"extremely":[169],"cells;":[172],"3)":[174],"combining":[175],"leaky":[177],"toxicity":[181,195],"lethal-prone":[185],"condition.":[186],"Thus,":[187],"modifications":[189],"proteins\u2019":[193],"acute":[194],"frequently":[197],"lead":[198],"However,":[202],"alleles":[205,238],"are":[206],"excluded":[207],"from":[208],"most":[209],"screens,":[211],"necessitating":[212],"alternative":[213],"approaches":[214],"such":[215],"as":[216],"two-step":[218],"method":[219],"this":[222],"study":[223],"modifiers.":[227],"Since":[228],"reflects":[231],"essential":[232],"buffering":[234],"networks,":[235],"studying":[236],"these":[237],"may":[239],"hold":[240],"keys":[242],"identify":[244],"critical":[246],"development":[251],"pathways.":[259]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}