{"id":"https://openalex.org/W1522866645","doi":null,"title":"The Role Of Sertonin And Vesicular Monoamine Transporters In The Adverse Responses To Methylenedioxymethamphetamine","display_name":"The Role Of Sertonin And Vesicular Monoamine Transporters In The Adverse Responses To Methylenedioxymethamphetamine","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1522866645","mag":"1522866645"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/332686","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/332686","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010399141","display_name":"Lucina E. Lizarraga","orcid":"https://orcid.org/0000-0001-5395-9192","observed_orcids":["https://orcid.org/0000-0001-5395-9192"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lucina Eridna Lizarraga-Zazueta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010399141"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.05700000002980232,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mdma","display_name":"MDMA","score":0.7950000166893005},{"id":"https://openalex.org/keywords/ecstasy","display_name":"ecstasy","score":0.9190000295639038},{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.8629999756813049},{"id":"https://openalex.org/keywords/vmat2","display_name":"vesicular monoamine transporter 2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/serotonin-depletion","display_name":"serotonin depletion","score":0.6610000133514404},{"id":"https://openalex.org/keywords/serotonergic-neurotoxicity","display_name":"serotonergic neurotoxicity","score":0.9190000295639038},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.828000009059906},{"id":"https://openalex.org/keywords/hyperactivity","display_name":"hyperactivity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mdma-neurotoxicity","display_name":"MDMA neurotoxicity","score":0.6790000200271606},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.7919999957084656},{"id":"https://openalex.org/keywords/neurotransmitter-storage","display_name":"neurotransmitter storage","score":0.5960000157356262},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.3160000145435333},{"id":"https://openalex.org/keywords/amphetamine-abuse","display_name":"amphetamine abuse","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C2780876324","wikidata":"https://www.wikidata.org/wiki/Q69488","display_name":"MDMA","level":2,"score":0.9399529695510864},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.8217231035232544},{"id":"https://openalex.org/C99631742","wikidata":"https://www.wikidata.org/wiki/Q22290476","display_name":"Reuptake","level":4,"score":0.7445665597915649},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.6681029200553894},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6572278141975403},{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.6510472297668457},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6244306564331055},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.6056890487670898},{"id":"https://openalex.org/C2778406628","wikidata":"https://www.wikidata.org/wiki/Q2521094","display_name":"Vesicular monoamine transporter 2","level":5,"score":0.5843589305877686},{"id":"https://openalex.org/C2777193897","wikidata":"https://www.wikidata.org/wiki/Q179452","display_name":"Amphetamine","level":3,"score":0.5539810657501221},{"id":"https://openalex.org/C2776291748","wikidata":"https://www.wikidata.org/wiki/Q4105920","display_name":"Vesicular monoamine transporter","level":5,"score":0.5308662056922913},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5113091468811035},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.509648323059082},{"id":"https://openalex.org/C42251903","wikidata":"https://www.wikidata.org/wiki/Q18391002","display_name":"Monoaminergic","level":4,"score":0.4508242607116699},{"id":"https://openalex.org/C2993285035","wikidata":"https://www.wikidata.org/wiki/Q2643251","display_name":"Synaptic cleft","level":4,"score":0.41848641633987427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3976695239543915},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.31203168630599976},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.27409815788269043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2593490481376648},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2388801872730255},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.2148541808128357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1664595901966095},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.14065894484519958},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.11801618337631226},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11431491374969482},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.06966298818588257},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/332686","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/332686","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:1522866645","doi":null,"is_oa":false,"landing_page_url":"https://repository.arizona.edu/bitstream/10150/332686/1/azu_etd_13425_sip1_m.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":348,"referenced_works":["https://openalex.org/W5741895","https://openalex.org/W122051809","https://openalex.org/W162107846","https://openalex.org/W163773482","https://openalex.org/W174864995","https://openalex.org/W203710690","https://openalex.org/W1211550181","https://openalex.org/W1514135333","https://openalex.org/W1521791862","https://openalex.org/W1531892057","https://openalex.org/W1534557128","https://openalex.org/W1548015250","https://openalex.org/W1562529961","https://openalex.org/W1563298578","https://openalex.org/W1574496069","https://openalex.org/W1580711543","https://openalex.org/W1683600212","https://openalex.org/W1693348571","https://openalex.org/W1726725093","https://openalex.org/W1788048136","https://openalex.org/W1822409748","https://openalex.org/W1837126245","https://openalex.org/W1866357165","https://openalex.org/W1867008676","https://openalex.org/W1884253425","https://openalex.org/W1886032183","https://openalex.org/W1893475387","https://openalex.org/W1894300836","https://openalex.org/W1905743891","https://openalex.org/W1907118202","https://openalex.org/W1917168084","https://openalex.org/W1921401097","https://openalex.org/W1944049145","https://openalex.org/W1949070403","https://openalex.org/W1960526592","https://openalex.org/W1962934739","https://openalex.org/W1963510892","https://openalex.org/W1963719599","https://openalex.org/W1964055128","https://openalex.org/W1966305781","https://openalex.org/W1967306755","https://openalex.org/W1967567964","https://openalex.org/W1967871718","https://openalex.org/W1968241182","https://openalex.org/W1968385601","https://openalex.org/W1969156270","https://openalex.org/W1969418677","https://openalex.org/W1969431518","https://openalex.org/W1970115972","https://openalex.org/W1970290995","https://openalex.org/W1971746914","https://openalex.org/W1972349079","https://openalex.org/W1972490292","https://openalex.org/W1972681977","https://openalex.org/W1973256378","https://openalex.org/W1973830611","https://openalex.org/W1973845575","https://openalex.org/W1974766709","https://openalex.org/W1976456595","https://openalex.org/W1977301441","https://openalex.org/W1978363134","https://openalex.org/W1978406998","https://openalex.org/W1978450909","https://openalex.org/W1978787522","https://openalex.org/W1979170820","https://openalex.org/W1979968248","https://openalex.org/W1982558653","https://openalex.org/W1983048332","https://openalex.org/W1983621748","https://openalex.org/W1983689043","https://openalex.org/W1984186801","https://openalex.org/W1985500707","https://openalex.org/W1986988181","https://openalex.org/W1987252873","https://openalex.org/W1987686530","https://openalex.org/W1987686922","https://openalex.org/W1988318282","https://openalex.org/W1989038222","https://openalex.org/W1989460749","https://openalex.org/W1989796311","https://openalex.org/W1991141166","https://openalex.org/W1991240905","https://openalex.org/W1992568187","https://openalex.org/W1993036354","https://openalex.org/W1994094794","https://openalex.org/W1994731568","https://openalex.org/W1995790835","https://openalex.org/W1996128052","https://openalex.org/W1996222810","https://openalex.org/W1996895781","https://openalex.org/W1997306238","https://openalex.org/W1997460720","https://openalex.org/W1997491665","https://openalex.org/W1999266594","https://openalex.org/W2000579895","https://openalex.org/W2002116511","https://openalex.org/W2002143263","https://openalex.org/W2002412029","https://openalex.org/W2002861559","https://openalex.org/W2003329458","https://openalex.org/W2003500884","https://openalex.org/W2003770934","https://openalex.org/W2004193318","https://openalex.org/W2004895078","https://openalex.org/W2005277645","https://openalex.org/W2005867761","https://openalex.org/W2006269280","https://openalex.org/W2006643658","https://openalex.org/W2006874780","https://openalex.org/W2007549333","https://openalex.org/W2007649442","https://openalex.org/W2009328760","https://openalex.org/W2009371512","https://openalex.org/W2011365853","https://openalex.org/W2011428797","https://openalex.org/W2011854027","https://openalex.org/W2012172845","https://openalex.org/W2012252010","https://openalex.org/W2012609836","https://openalex.org/W2012979366","https://openalex.org/W2013045923","https://openalex.org/W2013923425","https://openalex.org/W2014027156","https://openalex.org/W2015485611","https://openalex.org/W2016532705","https://openalex.org/W2017136647","https://openalex.org/W2019474799","https://openalex.org/W2020142342","https://openalex.org/W2020337411","https://openalex.org/W2021015465","https://openalex.org/W2021217386","https://openalex.org/W2022395708","https://openalex.org/W2024371333","https://openalex.org/W2025239832","https://openalex.org/W2025479430","https://openalex.org/W2025984201","https://openalex.org/W2026261422","https://openalex.org/W2026812180","https://openalex.org/W2027133209","https://openalex.org/W2027687342","https://openalex.org/W2028372004","https://openalex.org/W2030778648","https://openalex.org/W2031965067","https://openalex.org/W2032470806","https://openalex.org/W2032816843","https://openalex.org/W2033243193","https://openalex.org/W2034878484","https://openalex.org/W2035738053","https://openalex.org/W2035784753","https://openalex.org/W2035993053","https://openalex.org/W2036111774","https://openalex.org/W2036629661","https://openalex.org/W2036982675","https://openalex.org/W2039997415","https://openalex.org/W2040309005","https://openalex.org/W2040336481","https://openalex.org/W2042201688","https://openalex.org/W2043078944","https://openalex.org/W2043576655","https://openalex.org/W2044165548","https://openalex.org/W2045897942","https://openalex.org/W2045951745","https://openalex.org/W2046438298","https://openalex.org/W2047944520","https://openalex.org/W2049261229","https://openalex.org/W2049444913","https://openalex.org/W2049804872","https://openalex.org/W2050063162","https://openalex.org/W2050585016","https://openalex.org/W2051180061","https://openalex.org/W2053176712","https://openalex.org/W2053314927","https://openalex.org/W2054487957","https://openalex.org/W2057528351","https://openalex.org/W2057766558","https://openalex.org/W2059348149","https://openalex.org/W2059484499","https://openalex.org/W2059551625","https://openalex.org/W2060519440","https://openalex.org/W2061414707","https://openalex.org/W2061489773","https://openalex.org/W2061733755","https://openalex.org/W2061832190","https://openalex.org/W2062337275","https://openalex.org/W2064004368","https://openalex.org/W2064431700","https://openalex.org/W2064496574","https://openalex.org/W2065376500","https://openalex.org/W2065524454","https://openalex.org/W2066213523","https://openalex.org/W2067055946","https://openalex.org/W2068769189","https://openalex.org/W2069412152","https://openalex.org/W2070382674","https://openalex.org/W2070596670","https://openalex.org/W2071214511","https://openalex.org/W2071419870","https://openalex.org/W2072630058","https://openalex.org/W2073494415","https://openalex.org/W2074134649","https://openalex.org/W2074163153","https://openalex.org/W2076211114","https://openalex.org/W2077950523","https://openalex.org/W2078046027","https://openalex.org/W2078704741","https://openalex.org/W2079883338","https://openalex.org/W2081792021","https://openalex.org/W2082609266","https://openalex.org/W2082768478","https://openalex.org/W2082884752","https://openalex.org/W2083146318","https://openalex.org/W2085674390","https://openalex.org/W2086362682","https://openalex.org/W2087295746","https://openalex.org/W2087561593","https://openalex.org/W2089306255","https://openalex.org/W2090085463","https://openalex.org/W2090563027","https://openalex.org/W2091064440","https://openalex.org/W2091075456","https://openalex.org/W2092569285","https://openalex.org/W2093419170","https://openalex.org/W2093897431","https://openalex.org/W2094939014","https://openalex.org/W2095188030","https://openalex.org/W2097227947","https://openalex.org/W2098553992","https://openalex.org/W2099365218","https://openalex.org/W2100180911","https://openalex.org/W2100352065","https://openalex.org/W2100507133","https://openalex.org/W2103077274","https://openalex.org/W2103660407","https://openalex.org/W2103745296","https://openalex.org/W2105455639","https://openalex.org/W2105625596","https://openalex.org/W2106095564","https://openalex.org/W2106566412","https://openalex.org/W2106713530","https://openalex.org/W2106966110","https://openalex.org/W2107790349","https://openalex.org/W2108105119","https://openalex.org/W2109698385","https://openalex.org/W2109759840","https://openalex.org/W2111112265","https://openalex.org/W2111338351","https://openalex.org/W2112264361","https://openalex.org/W2112422249","https://openalex.org/W2113363590","https://openalex.org/W2114144700","https://openalex.org/W2114937850","https://openalex.org/W2117093911","https://openalex.org/W2118438870","https://openalex.org/W2120113858","https://openalex.org/W2120611477","https://openalex.org/W2121143255","https://openalex.org/W2121610524","https://openalex.org/W2121872553","https://openalex.org/W2122464153","https://openalex.org/W2122935241","https://openalex.org/W2124305193","https://openalex.org/W2125827417","https://openalex.org/W2127538073","https://openalex.org/W2127643876","https://openalex.org/W2127854642","https://openalex.org/W2128008585","https://openalex.org/W2128951033","https://openalex.org/W2129695646","https://openalex.org/W2131155943","https://openalex.org/W2131278093","https://openalex.org/W2131489415","https://openalex.org/W2131721815","https://openalex.org/W2131810465","https://openalex.org/W2132011757","https://openalex.org/W2132643262","https://openalex.org/W2133416128","https://openalex.org/W2133439321","https://openalex.org/W2136019384","https://openalex.org/W2137229007","https://openalex.org/W2141190015","https://openalex.org/W2141206715","https://openalex.org/W2142786692","https://openalex.org/W2143030301","https://openalex.org/W2143108928","https://openalex.org/W2143308851","https://openalex.org/W2143437320","https://openalex.org/W2143985916","https://openalex.org/W2144854315","https://openalex.org/W2144919948","https://openalex.org/W2145434123","https://openalex.org/W2145845829","https://openalex.org/W2147993424","https://openalex.org/W2148562084","https://openalex.org/W2148726772","https://openalex.org/W2149761960","https://openalex.org/W2150184757","https://openalex.org/W2150391426","https://openalex.org/W2151312380","https://openalex.org/W2151818435","https://openalex.org/W2152165298","https://openalex.org/W2154346380","https://openalex.org/W2154896179","https://openalex.org/W2155000996","https://openalex.org/W2156723449","https://openalex.org/W2159084784","https://openalex.org/W2160253297","https://openalex.org/W2161821412","https://openalex.org/W2162196924","https://openalex.org/W2162404750","https://openalex.org/W2164164342","https://openalex.org/W2165866163","https://openalex.org/W2165924165","https://openalex.org/W2166891211","https://openalex.org/W2168659851","https://openalex.org/W2168757036","https://openalex.org/W2169132085","https://openalex.org/W2171847604","https://openalex.org/W2182938492","https://openalex.org/W2186721544","https://openalex.org/W2218120369","https://openalex.org/W2221697324","https://openalex.org/W2227510260","https://openalex.org/W2236527316","https://openalex.org/W2252930795","https://openalex.org/W2256476897","https://openalex.org/W2271897004","https://openalex.org/W2272293723","https://openalex.org/W2275207943","https://openalex.org/W2283428982","https://openalex.org/W2295203871","https://openalex.org/W2299861533","https://openalex.org/W2313653727","https://openalex.org/W2317019713","https://openalex.org/W2322952716","https://openalex.org/W2329445637","https://openalex.org/W2336909377","https://openalex.org/W2345474755","https://openalex.org/W2400165548","https://openalex.org/W2400189451","https://openalex.org/W2409042762","https://openalex.org/W2409390952","https://openalex.org/W2412608935","https://openalex.org/W2413957499","https://openalex.org/W2419612826","https://openalex.org/W2757681131","https://openalex.org/W2779738636","https://openalex.org/W2896606877","https://openalex.org/W4232948725"],"related_works":["https://openalex.org/W2161294654","https://openalex.org/W2044674210","https://openalex.org/W2316795466","https://openalex.org/W2000732101","https://openalex.org/W2007549333","https://openalex.org/W2022418335","https://openalex.org/W2016532705","https://openalex.org/W4280638175","https://openalex.org/W1479952978","https://openalex.org/W2100507133"],"abstract_inverted_index":{"3,4-(\u00b1)-Methylenedioxymethamphetamine":[0],"(MDMA,":[1],"Ecstasy)":[2],"is":[3,147,267],"a":[4,46,126,148,195],"widely":[5],"abused":[6],"amphetamine":[7],"derivative":[8],"with":[9,190,237,284,293],"potent":[10],"stimulant":[11],"properties.":[12],"The":[13,92],"neuropharmacological":[14],"effects":[15,41,178,313],"of":[16,29,42,68,86,101,129,135,169,179,209,228,231,251,282,314,331,340],"MDMA":[17,22,43,75,90,153,180,244,326,341],"are":[18,181,307],"biphasic":[19],"in":[20,49,74,89,182,221,243,248,254,269,311,327,337],"nature.":[21],"initially":[23],"causes":[24],"synaptic":[25,139],"monoamine":[26,110,233,252],"release,":[27],"primarily":[28],"serotonin":[30,103,162],"(5-HT),":[31],"producing":[32],"hyperthermia":[33,213,291],"and":[34,51,65,107,118,154,191,214,257,289,305,343],"hyperactivity":[35,288],"(5-HT":[36],"syndrome).":[37],"Conversely,":[38],"the":[39,62,83,99,102,108,115,133,138,160,177,206,226,249,278,301,310,322,338],"long-term":[40,219],"manifest":[44],"as":[45,125,159,212],"prolonged":[47],"depletion":[48],"5-HT,":[50],"structural":[52],"damage":[53],"to":[54,97,114,121,188,309,325],"serotonergic":[55,174,295],"nerve":[56],"terminals.":[57],"Monoamine":[58],"transporter":[59,105,111,333],"systems":[60],"at":[61],"plasma":[63],"membrane":[64],"storage":[66,234,262],"vesicles":[67],"5-HT":[69,130,136,223,256],"neurons":[70],"have":[71],"been":[72,241],"implicated":[73,242],"toxicity.":[76],"Nonetheless,":[77],"many":[78,155],"mechanistic":[79],"questions":[80],"remain":[81],"regarding":[82],"precise":[84],"role":[85],"uptake":[87],"transporters":[88],"neurotoxicity.":[91,175,229,245],"present":[93],"study":[94],"was":[95],"designed":[96],"address":[98],"importance":[100],"reuptake":[104,134,163],"(SERT)":[106],"vesicular":[109,232],"2":[112],"(VMAT2)":[113],"physiological,":[116],"behavioral":[117,323],"neurotoxic":[119],"responses":[120],"MDMA.":[122,315],"SERT":[123,146,170,203,304],"functions":[124],"primary":[127],"regulator":[128],"homeostasis,":[131],"mediating":[132],"from":[137],"space":[140],"following":[141],"its":[142],"release":[143],"during":[144],"neurotransmission.":[145],"molecular":[149],"target":[150],"site":[151],"for":[152],"antidepressant":[156],"agents":[157],"such":[158,211],"selective":[161],"inhibitor":[164],"(SSRI)":[165],"class.":[166],"Pharmacological":[167,280],"inhibition":[168,281,320],"protects":[171],"against":[172],"MDMA-induced":[173,287],"Thus,":[176],"part":[183],"mediated":[184],"by":[185,273],"an":[186],"ability":[187],"interact":[189],"inhibit":[192],"SERT.":[193],"Using":[194],"SERT-knockout":[196],"(SERT-KO)":[197],"rat":[198],"model,":[199],"we":[200],"determined":[201],"that":[202,303,318],"deficiency":[204],"modulated":[205],"acute":[207],"toxicities":[208],"MDMA,":[210],"hyperactivity,":[215],"whilst":[216],"completely":[217],"preventing":[218,274],"depletions":[220],"tissue":[222],"levels,":[224],"indicating":[225],"abolishment":[227],"Disruption":[230],"via":[235],"interaction":[236],"VMAT2":[238,246,266,283,306,319],"has":[239],"also":[240],"participates":[247],"transport":[250],"neurotransmitters,":[253],"particular":[255],"dopamine":[258],"(DA),":[259],"into":[260],"intra-neuronal":[261],"vesicles.":[263],"As":[264],"such,":[265],"critical":[268,308],"maintaining":[270],"neuronal":[271],"health":[272],"neurotransmitter":[275],"oxidation":[276],"within":[277],"cytosol.":[279],"Ro4-1284":[285],"reduced":[286],"averted":[290],"along":[292],"persistent":[294],"deficits.":[296],"Overall,":[297],"our":[298],"results":[299],"corroborate":[300],"hypothesis":[302],"vivo":[312],"Furthermore,":[316],"given":[317],"diminished":[321],"response":[324],"rats,":[328],"pharmacological":[329],"manipulation":[330],"this":[332],"could":[334],"be":[335],"used":[336],"treatment":[339],"abuse":[342],"overdose.":[344]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}