{"id":"https://openalex.org/W1522549867","doi":null,"title":"Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin-1.","display_name":"Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin-1.","publication_year":1996,"publication_date":"1996-12-15","ids":{"openalex":"https://openalex.org/W1522549867","mag":"1522549867","pmid":"https://pubmed.ncbi.nlm.nih.gov/8971176"},"language":"en","primary_location":{"id":"pmid:8971176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8971176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044685593","display_name":"Stephanie C. Hsu","orcid":"https://orcid.org/0000-0002-6003-3600","observed_orcids":["https://orcid.org/0000-0002-6003-3600"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S C Hsu","raw_affiliation_strings":["Department of Microbiology-Immunology, R.H. Lurie Cancer Center, Northwestern University Medical School, Chicago, Illinois 60611, USA","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology-Immunology, R.H. Lurie Cancer Center, Northwestern University Medical School, Chicago, Illinois 60611, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089397657","display_name":"Olga V. Volpert","orcid":"https://orcid.org/0000-0003-1381-5543","observed_orcids":["https://orcid.org/0000-0003-1381-5543"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O V Volpert","raw_affiliation_strings":["Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052687048","display_name":"Peter A. Steck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P A Steck","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069699492","display_name":"Tom Mikkelsen","orcid":"https://orcid.org/0000-0001-6285-2442","observed_orcids":["https://orcid.org/0000-0001-6285-2442"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Mikkelsen","raw_affiliation_strings":["Henry Ford Health System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Health System","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008563300","display_name":"Peter J. Polverini","orcid":"https://orcid.org/0000-0001-9832-967X","observed_orcids":["https://orcid.org/0000-0001-9832-967X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Polverini","raw_affiliation_strings":["Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029393047","display_name":"Sambasiva Rao","orcid":"https://orcid.org/0000-0001-7410-5911","observed_orcids":["https://orcid.org/0000-0001-7410-5911"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Rao","raw_affiliation_strings":["Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112820482","display_name":"Pauline M. Chou","orcid":"https://orcid.org/0000-0002-1114-8305","observed_orcids":["https://orcid.org/0000-0002-1114-8305"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Chou","raw_affiliation_strings":["Children's Memorial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Memorial Hospital","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026371165","display_name":"No\u00ebl Bouck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N P Bouck","raw_affiliation_strings":["Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9544,"has_fulltext":false,"cited_by_count":143,"citation_normalized_percentile":{"value":0.92186815,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"56","issue":"24","first_page":"5684","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.7649999856948853},{"id":"https://openalex.org/keywords/thrombospondin-1","display_name":"thrombospondin-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/chromosome-10","display_name":"chromosome 10","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8949999809265137},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8199999928474426},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.9330000281333923},{"id":"https://openalex.org/keywords/corneal-neovascularization","display_name":"corneal neovascularization","score":0.9890000224113464},{"id":"https://openalex.org/keywords/astrocytoma","display_name":"astrocytoma","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.47999998927116394},{"id":"https://openalex.org/keywords/nude-mouse-xenograft","display_name":"nude mouse xenograft","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8143494129180908},{"id":"https://openalex.org/C167814343","wikidata":"https://www.wikidata.org/wiki/Q419341","display_name":"Thrombospondin","level":4,"score":0.7977886199951172},{"id":"https://openalex.org/C99194444","wikidata":"https://www.wikidata.org/wiki/Q14906367","display_name":"Thrombospondin 1","level":3,"score":0.7660344839096069},{"id":"https://openalex.org/C2776056115","wikidata":"https://www.wikidata.org/wiki/Q574834","display_name":"Angiogenesis inhibitor","level":3,"score":0.6701958775520325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6215612888336182},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5554545521736145},{"id":"https://openalex.org/C2910422434","wikidata":"https://www.wikidata.org/wiki/Q419341","display_name":"Thrombospondins","level":5,"score":0.5154755711555481},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.4362730085849762},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33209019899368286},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3240189552307129},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22172024846076965},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.10323846340179443},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002879","descriptor_name":"Chromosomes, Human, Pair 10","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014410","descriptor_name":"Tumor Stem Cell Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019699","descriptor_name":"Thrombospondins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8971176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8971176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1522549867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8971176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7896065299","display_name":"REGULATION OF MACROPHAGE ANGIOGENIC ACTIVITY","funder_award_id":"R01HL039926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G887976463","display_name":"TUMOR SUPPRESSOR GENES AND ANGIOGENESIS","funder_award_id":"R01CA052750","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2150621343","https://openalex.org/W2323258413","https://openalex.org/W2486631444","https://openalex.org/W2132150602","https://openalex.org/W2059457785","https://openalex.org/W2300389549","https://openalex.org/W2125497603","https://openalex.org/W2086886635","https://openalex.org/W1994131389","https://openalex.org/W7096560493"],"abstract_inverted_index":{"Glioblastoma":[0],"multiforme":[1],"is":[2],"distinguished":[3],"from":[4],"its":[5],"less":[6],"malignant":[7],"astrocytoma":[8],"precursors":[9],"by":[10,28,68,152,161,240,248],"intense":[11],"angiogenesis":[12,83,244],"and":[13,60,76,120,142,155,192],"frequent":[14],"loss":[15,224],"of":[16,40,71,77,91,95,110,146,177,207,212,225,236],"tumor":[17,226],"suppressor":[18],"genes":[19],"on":[20,115,136,180,228,243],"chromosome":[21,34,122,162,178,199,215,229],"10.":[22],"Here":[23],"we":[24],"link":[25],"these":[26],"traits":[27],"showing":[29],"that":[30,222,245],"when":[31],"a":[32,92],"wild-type":[33],"10":[35,123,147,163,179,200,230],"was":[36,84,112,134,185],"returned":[37],"to":[38,54,62,87,172,197,232],"any":[39],"three":[41],"human":[42,166],"glioblastoma":[43],"cell":[44,74,139],"lines":[45],"U251,":[46],"U87,":[47],"or":[48],"LG11,":[49],"they":[50],"lost":[51],"their":[52],"ability":[53],"form":[55],"tumors":[56],"in":[57,82,149,158,183,187,238,250],"nude":[58],"mice":[59],"switched":[61],"an":[63,144],"antiangiogenic":[64,170],"phenotype,":[65],"as":[66],"measured":[67],"the":[69,88,104,107,210,223,233],"inhibition":[70],"capillary":[72],"endothelial":[73,138],"migration":[75],"corneal":[78],"neovascularization.":[79],"This":[80],"change":[81],"directly":[85],"due":[86,171],"increased":[89],"secretion":[90],"potent":[93],"inhibitor":[94],"angiogenesis,":[96],"thrombospondin-1,":[97],"because:":[98],"(a)":[99],"neutralizing":[100],"thrombospondin":[101,111,181,249],"completely":[102],"relieved":[103],"inhibition;":[105],"(b)":[106],"inhibitory":[108],"activity":[109,133],"not":[113,126],"dependent":[114,135],"transforming":[116],"growth":[117,140],"factor":[118,141],"beta;":[119],"(c)":[121],"introduction":[124],"did":[125,217],"alter":[127],"secreted":[128,173],"inducing":[129,132],"activity.":[130],"The":[131,175],"vascular":[137],"had":[143],"ED50":[145],"microg/ml":[148,157],"media":[150,159],"conditioned":[151,160],"parental":[153],"cells":[154],"9-13":[156],"revertants.":[164],"Normal":[165,190],"astrocytes":[167],"were":[168],"also":[169],"thrombospondin.":[174],"effect":[176],"production":[182],"vitro":[184],"reflected":[186],"patient":[188],"material.":[189],"brain":[191],"lower":[193,251],"grade":[194,252],"astrocytomas":[195],"known":[196],"retain":[198],"stained":[201],"strongly":[202],"for":[203],"thrombospondin,":[204],"but":[205],"12":[206],"13":[208],"glioblastomas,":[209],"majority":[211],"which":[213],"lose":[214],"10,":[216],"not.":[218],"These":[219],"data":[220],"indicate":[221],"suppressors":[227],"contributes":[231],"aggressive":[234],"malignancy":[235],"glioblastomas":[237],"part":[239],"releasing":[241],"constraints":[242],"are":[246],"maintained":[247],"tumors.":[253]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}