{"id":"https://openalex.org/W1522444632","doi":null,"title":"Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation.","display_name":"Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation.","publication_year":2001,"publication_date":"2001-06-01","ids":{"openalex":"https://openalex.org/W1522444632","mag":"1522444632","pmid":"https://pubmed.ncbi.nlm.nih.gov/11389085"},"language":"en","primary_location":{"id":"pmid:11389085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11389085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049339424","display_name":"Leopold Ludwig","orcid":"https://orcid.org/0000-0003-3322-2948","observed_orcids":["https://orcid.org/0000-0003-3322-2948"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L Ludwig","raw_affiliation_strings":["Department of Internal Medicine I, University of Ulm, Robert-Koch-Street 8, D-89081 Ulm, Germany","Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Ulm, Robert-Koch-Street 8, D-89081 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015435968","display_name":"Heidi Kessler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Kessler","raw_affiliation_strings":["Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101584177","display_name":"Martin Wagner","orcid":"https://orcid.org/0000-0001-5735-3462","observed_orcids":["https://orcid.org/0000-0001-5735-3462"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Wagner","raw_affiliation_strings":["Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111607815","display_name":"Cuong Hoang\u2010Vu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Hoang-Vu","raw_affiliation_strings":["Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040072236","display_name":"Henning Dralle","orcid":"https://orcid.org/0000-0003-4710-8193","observed_orcids":["https://orcid.org/0000-0003-4710-8193","https://orcid.org/0000-0002-3169-9251"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Dralle","raw_affiliation_strings":["Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113489149","display_name":"Guido Adler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Adler","raw_affiliation_strings":["Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112777569","display_name":"Bernhard Otto B\u00f6hm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B O B\u00f6hm","raw_affiliation_strings":["Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I68956291"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101473723","display_name":"Roland Michael Schmid","orcid":"https://orcid.org/0009-0000-8976-3300","observed_orcids":["https://orcid.org/0009-0000-8976-3300","https://orcid.org/0000-0002-6945-7581","https://orcid.org/0000-0002-5751-7313"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R M Schmid","raw_affiliation_strings":["Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Ulm, 89081 Ulm [L. L., H. K., M. W., G. A., B. O. B., R. M. S.], and Department of Surgery I, University of Halle-Wittenberg, 06097 Halle [C. H-V., H. D.], Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I68956291"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5332,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.89338354,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"61","issue":"11","first_page":"4526","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-factor-kappab","display_name":"nuclear factor-kappaB","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ret-proto-oncogene","display_name":"RET proto-oncogene","score":0.9919999837875366},{"id":"https://openalex.org/keywords/c-cell-carcinoma","display_name":"C-cell carcinoma","score":0.8429999947547913},{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/multiple-endocrine-neoplasia-type-2","display_name":"multiple endocrine neoplasia type 2","score":0.9190000295639038},{"id":"https://openalex.org/keywords/ret-mutations","display_name":"RET mutations","score":0.734000027179718},{"id":"https://openalex.org/keywords/ikappab-kinase-beta","display_name":"I\u03baB kinase \u03b2","score":0.7870000004768372},{"id":"https://openalex.org/keywords/ikappabalpha-phosphorylation","display_name":"I\u03baB\u03b1 phosphorylation","score":0.972000002861023},{"id":"https://openalex.org/keywords/ras","display_name":"Ras","score":0.4410000145435333},{"id":"https://openalex.org/keywords/mekk1","display_name":"MEKK1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/raf","display_name":"Raf","score":0.6269999742507935},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.47099998593330383},{"id":"https://openalex.org/keywords/constitutive-nf-kappab-activation","display_name":"constitutive NF-\u03baB activation","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5757424831390381},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5681804418563843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5295665860176086},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.49755480885505676},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4458954334259033},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4282698333263397},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.400138258934021},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3312002420425415},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3299848139286041},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2944396138191223},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.28138941526412964},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12210914492607117}],"mesh":[{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018276","descriptor_name":"Carcinoma, Medullary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018276","descriptor_name":"Carcinoma, Medullary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018276","descriptor_name":"Carcinoma, Medullary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051096","descriptor_name":"Proto-Oncogene Proteins c-ret","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11389085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11389085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1522444632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11389085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W187263029","https://openalex.org/W1486001184","https://openalex.org/W1486965665","https://openalex.org/W1511134433","https://openalex.org/W1549679997","https://openalex.org/W1587892340","https://openalex.org/W1617532721","https://openalex.org/W1812993036","https://openalex.org/W1888783223","https://openalex.org/W1979634801","https://openalex.org/W1980768491","https://openalex.org/W1980815930","https://openalex.org/W1982745900","https://openalex.org/W1983779176","https://openalex.org/W1987566228","https://openalex.org/W1989480480","https://openalex.org/W1993216157","https://openalex.org/W1995819749","https://openalex.org/W1996160829","https://openalex.org/W1997509253","https://openalex.org/W1999636391","https://openalex.org/W2000347396","https://openalex.org/W2011496352","https://openalex.org/W2030996806","https://openalex.org/W2036789689","https://openalex.org/W2044761914","https://openalex.org/W2066868766","https://openalex.org/W2069158176","https://openalex.org/W2070853191","https://openalex.org/W2075614349","https://openalex.org/W2082584428","https://openalex.org/W2084336363","https://openalex.org/W2092436145","https://openalex.org/W2101151768","https://openalex.org/W2104324075","https://openalex.org/W2110682302","https://openalex.org/W2118986158","https://openalex.org/W2125941855","https://openalex.org/W2126718146","https://openalex.org/W2128805986","https://openalex.org/W2131727513","https://openalex.org/W2139680027","https://openalex.org/W2142764103","https://openalex.org/W2152105216","https://openalex.org/W2157720667","https://openalex.org/W2166655452","https://openalex.org/W2172010722","https://openalex.org/W2299422902","https://openalex.org/W2300396009","https://openalex.org/W2318334567","https://openalex.org/W2326148782","https://openalex.org/W2326198834","https://openalex.org/W2415587741","https://openalex.org/W2418413408"],"related_works":["https://openalex.org/W2144747481","https://openalex.org/W2065675821","https://openalex.org/W2899868868","https://openalex.org/W7217981101","https://openalex.org/W1995965182","https://openalex.org/W2107919174","https://openalex.org/W1994043193","https://openalex.org/W2007464453","https://openalex.org/W1995564977","https://openalex.org/W2772835284"],"abstract_inverted_index":{"Specific":[0],"point":[1],"mutations":[2,90],"of":[3,85,124,169,177,188],"the":[4,66,89,117,144,153],"RET":[5,87,119,189],"proto-oncogene":[6],"have":[7],"been":[8],"demonstrated":[9],"to":[10,75,100],"be":[11],"responsible":[12],"for":[13,22,32],"multiple":[14],"endocrine":[15],"neoplasia":[16],"(MEN)":[17],"types":[18],"2A":[19,58],"and":[20,81,134,166,180,205],"2B,":[21],"familial":[23],"medullary":[24],"thyroid":[25],"carcinoma":[26,47],"(MTC)":[27],"syndromes,":[28],"as":[29,31],"well":[30],"sporadic":[33],"MTC.":[34],"Here":[35],"we":[36],"show":[37,115],"that":[38,116,197],"nuclear":[39],"factor":[40],"(NF)-kappaB":[41],"is":[42,73,162],"activated":[43],"in":[44,65,70,98,111,174,190],"RET-associated":[45],"C-cell":[46],"specimens.":[48],"TT":[49,178],"cells,":[50],"a":[51,104],"human":[52],"MTC":[53],"cell":[54,175],"line":[55],"expressing":[56],"MEN":[57],"type":[59],"RET,":[60,102],"display":[61],"transcriptionally":[62],"active":[63],"RelA(p65)":[64],"nucleus.":[67],"NF-kappaB":[68,133,160,171,207],"activity":[69,80,136,161,172,204],"these":[71],"cells":[72,179],"attributable":[74],"constitutive":[76,170],"IkappaB":[77],"kinase":[78,148,151],"(IKK)":[79],"high":[82],"turn":[83],"over":[84],"IkappaBalpha.":[86],"harboring":[88],"C634R":[91,121],"(MEN":[92,96],"2A)":[93],"or":[94],"M918T":[95],"2B),":[97],"contrast":[99],"wild-type":[101],"activates":[103],"NF-kappaB-dependent":[105],"reporter":[106],"construct":[107],"upon":[108],"transient":[109],"transfection":[110],"HeLa":[112],"cells.":[113,193],"We":[114],"prototype":[118],"mutation":[120],"enhances":[122],"phosphorylation":[123],"IkappaBalpha":[125],"by":[126,130,185],"IKKbeta":[127,135],"but":[128,140],"not":[129],"IKKalpha.":[131],"RET-induced":[132,159],"requires":[137],"Ras":[138],"function":[139],"does":[141],"neither":[142],"involve":[143],"classical":[145],"mitogen-activated":[146],"protein":[147],"kinase/extracellular":[149],"signal-regulated":[150],"nor":[152],"phosphoinositide":[154],"3-kinase/Akt":[155],"pathways.":[156],"In":[157],"contrast,":[158],"dependent":[163],"on":[164,202],"Raf":[165],"MEKK1.":[167],"Inhibition":[168],"results":[173,195],"death":[176],"blocks":[181],"focus":[182],"formation":[183],"induced":[184],"oncogenic":[186],"forms":[187],"NIH":[191],"3T3":[192],"These":[194],"suggest":[196],"RET-mediated":[198],"carcinogenesis":[199],"critically":[200],"depends":[201],"IKK":[203],"subsequent":[206],"activation.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
