{"id":"https://openalex.org/W1522299291","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.278.9","title":"Tmod3 participates in platelet formation and sizing in mouse fetal liver (278.9)","display_name":"Tmod3 participates in platelet formation and sizing in mouse fetal liver (278.9)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1522299291","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.278.9","mag":"1522299291"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.278.9","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.278.9","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.278.9","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072955541","display_name":"Zhenhua Sui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenhua Sui","raw_affiliation_strings":["The Scripps Research Institute San Diego CA United States","1The Scripps Research Institute San diego CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute San Diego CA United States","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"1The Scripps Research Institute San diego CA United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057211887","display_name":"Nowak Robeta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nowak Robeta","raw_affiliation_strings":["The Scripps Research Institute San Diego CA United States","1The Scripps Research Institute San diego CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute San Diego CA United States","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"1The Scripps Research Institute San diego CA United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011621241","display_name":"Chad D. Sanada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad Sanada","raw_affiliation_strings":["Department of Laboratory Medicine Yale Stem Cell Center Yale School of Medicine New Haven CT United States","3Department of Laboratory Medicine Yale Stem Cell Center, Yale School of Medicine New Haven CT United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine Yale Stem Cell Center Yale School of Medicine New Haven CT United States","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"3Department of Laboratory Medicine Yale Stem Cell Center, Yale School of Medicine New Haven CT United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054557581","display_name":"Stephanie Halene","orcid":"https://orcid.org/0000-0002-2737-9810","observed_orcids":["https://orcid.org/0000-0002-2737-9810"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Halene","raw_affiliation_strings":["Department of Internal Medicine Yale School of Medicine New Haven CT United States","2Department of Internal Medicine Yale School of Medicine New Haven CT United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Yale School of Medicine New Haven CT United States","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"2Department of Internal Medicine Yale School of Medicine New Haven CT United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004477857","display_name":"Diane S. Krause","orcid":"https://orcid.org/0000-0001-9420-6947","observed_orcids":["https://orcid.org/0000-0001-9420-6947"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Krause","raw_affiliation_strings":["Department of Laboratory Medicine Yale Stem Cell Center Yale School of Medicine New Haven CT United States","3Department of Laboratory Medicine Yale Stem Cell Center, Yale School of Medicine New Haven CT United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine Yale Stem Cell Center Yale School of Medicine New Haven CT United States","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"3Department of Laboratory Medicine Yale Stem Cell Center, Yale School of Medicine New Haven CT United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027610214","display_name":"Velia M. Fowler","orcid":"https://orcid.org/0000-0002-3161-8802","observed_orcids":["https://orcid.org/0000-0002-3161-8802"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Velia Fowler","raw_affiliation_strings":["The Scripps Research Institute San Diego CA United States","1The Scripps Research Institute San diego CA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute San Diego CA United States","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"1The Scripps Research Institute San diego CA United States","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.2156,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54928962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tropomodulin","display_name":"tropomodulin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/platelet-formation","display_name":"platelet formation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/platelet-size","display_name":"platelet size","score":0.9670000076293945},{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.9829999804496765},{"id":"https://openalex.org/keywords/fetal-liver","display_name":"fetal liver","score":0.8349999785423279},{"id":"https://openalex.org/keywords/proplatelet-formation","display_name":"proplatelet formation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/actin-dynamics","display_name":"actin dynamics","score":0.9760000109672546},{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.7300000190734863},{"id":"https://openalex.org/keywords/megakaryocyte-ploidy","display_name":"megakaryocyte ploidy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.7601969838142395},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7584781050682068},{"id":"https://openalex.org/C199528912","wikidata":"https://www.wikidata.org/wiki/Q165291","display_name":"Pseudopodia","level":3,"score":0.6087682843208313},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5935333371162415},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5878053903579712},{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.5353190302848816},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5236063599586487},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4975309669971466},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.47328680753707886},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45012497901916504},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.41495048999786377},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.39459410309791565},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.388680100440979},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37505868077278137},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.257977157831192},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.19897204637527466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1302575170993805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11317205429077148},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07810649275779724},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.06206732988357544},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.055406153202056885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.054970502853393555},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.0533159077167511},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.278.9","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.278.9","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.278.9","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1522349278","https://openalex.org/W7100037774","https://openalex.org/W7097623645","https://openalex.org/W2102482686","https://openalex.org/W2551726499","https://openalex.org/W2763759676","https://openalex.org/W7097827585","https://openalex.org/W2607245375","https://openalex.org/W2029573800","https://openalex.org/W2019067749"],"abstract_inverted_index":{"Tropomodulins":[0],"(Tmod)":[1],"bind":[2],"tropomyosin":[3],"and":[4,21,50,73,83,115,153,165,180,183,189,211],"cap":[5],"the":[6,14,57,128,161],"pointed":[7],"ends":[8],"of":[9,100,118,142],"actin":[10,216],"filaments.":[11],"Tmod3":[12,35,62,90,111,119,143,146,171,204],"is":[13,91,136,147,154],"only":[15,123],"Tmod":[16],"isoform":[17],"detected":[18],"in":[19,28,48,56,97,110,127,150,159,196,206],"human":[20],"mouse":[22,207],"platelets.":[23],"To":[24],"study":[25],"its":[26],"function":[27],"platelets":[29,33,55],"we":[30],"have":[31],"examined":[32],"from":[34,60,170],"\u2010/\u2010":[36,63,112,120,172],"embryos,":[37],"which":[38],"are":[39,65,106,176],"embryonic":[40,208],"lethal":[41],"(Sui":[42],"Z":[43],"et":[44],"al.":[45],"2013.":[46],"Blood":[47],"press),":[49],"occasionally":[51],"display":[52],"hemorrhage.":[53],"The":[54],"peripheral":[58],"blood":[59],"E14.5":[61],"embryos":[64],"larger":[66,181],"than":[67],"normal,":[68],"indicating":[69],"that":[70,89,133,145,203],"platelet":[71,209],"formation":[72,210],"sizing":[74],"might":[75],"be":[76],"impaired":[77],"without":[78,139],"Tmod3.":[79,140],"Both":[80],"X\u2010gal":[81],"staining":[82],"immunostaining":[84],"with":[85,157],"\u03b2\u2010gal":[86],"antibodies":[87],"show":[88,186,202],"expressed":[92,149],"at":[93],"relatively":[94],"high":[95],"levels":[96],"megakaryocytes":[98],"(MKs)":[99],"fetal":[101,113,173],"livers.":[102],"However,":[103],"MK":[104,130,134,151,162,168],"numbers":[105],"not":[107,137],"significantly":[108],"reduced":[109],"livers,":[114,174],"ploidy":[116],"analysis":[117],"MKs":[121,179],"shows":[122,144],"a":[124],"slight":[125],"increase":[126],"8N":[129],"population,":[131],"suggesting":[132],"differentiation":[135],"affected":[138],"Immunostaining":[141],"highly":[148],"pseudopods":[152],"partially":[155],"co\u2010localized":[156],"F\u2010actin":[158,191],"both":[160],"cell":[163],"bodies":[164],"proplatelets.":[166],"In":[167,198],"cultures":[169],"there":[175],"fewer":[177],"proplatelet\u2010forming":[178],"proplatelets,":[182],"released":[184],"proplatelets":[185],"abnormal":[187],"shapes":[188],"disrupted":[190],"structures,":[192],"but":[193],"no":[194],"changes":[195],"microtubules.":[197],"conclusion,":[199],"our":[200],"studies":[201],"participates":[205],"sizing,":[212],"likely":[213],"through":[214],"regulating":[215],"dynamics.":[217]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}